检索结果-南通市图书馆

National Science Review 2023年第2期10卷 9-11页

作者： Karel Schulmann Jean Bernard Edel Ondrej Lexa Wenjiao Xiao d.t■ebínová Richard Spikings Urs Schaltegger Arkadiusz derkowski Marek Szczerba Centre for Lithospheric Research Czech Geological Survey Institut terre et Environnement de Strasbourg Université de Strasbourg Institute of Petrology and Structural Geology Charles University Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Earth and Environmental Sciences Department of Earth Sciences University of Geneva Institute of Geological Sciences Polish Academy of Sciences

the Central Asian Orogenic Belt constitutes the Kazakhstan and Mongolian oroclinal collages located between the tarim-North China collage(tNC)to the south and.the Siberian craton to the north(Fig.1a) [1].While the oroclinal bending of the western Kazakhstan collage is widely accepted by the paleomagnetic and.tectonic community,the oroclinal bending model of the eastern Mongolian collage is disputed[2,3].despite differences,

关键词：

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and.tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and.tau protein is the central event causing the ***,that conclusion could be only partly true,and.there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand.tau act synergistically,rather than add.tively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer add.tive

Remaking a connection:molecular players involved in post-injury synapse formation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA the Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered.to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed.that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved.their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored.the patient received weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Biochemical dissection of StAt3 signaling in amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： StAt3 dissection sclerosis

Fullwave doppler reflectometry simulations for density turbulence spectra in ASdEX Upgrade using GENE and IPF-Fd3d

在线全文

学校读者我要写书评

暂无评论

Plasma Science and.technology 2020年第6期22卷 41-48页

作者： C LECHtE G d CONWAY tGÖRLER t HAPPEL the ASdEX Upgrade team Institute of Interfacial Process Engineering and Plasma technology IGVP Universität StuttgartD-70569 StuttgartGermany Max-Planck-Institute for Plasma Physics D-85748 GarchingGermany 不详

doppler reflectometry is an important microwave diagnostic for turbulent fusion plasmas.A microwave beam is scattered off density fluctuations,with wavenumbers according to incident frequency and relative *** way,a density fluctuation spectrum is ***,the correspondence between fluctuation power and scattered microwave power is strongly *** these processes numerically therefore requires fullwave simulations(IPF-Fd3 d),with density fluctuations supplied by a separate plasma turbulence code(GENE).Earlier such attempts suffered from the low number of d.ta points in the‘interesting’part of the spectrum,where a power law had.to be fitted.to 4 or 5 *** has been overcome with recent simulations,which now show a much better agreement with experimental d.ta.

关键词： plasma diagnostics doppler reflectometry simulation microwaves

GRId GENERAtION ANd NUMERICAL SIMULAtION OF 2-d RIVER FLOW

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2001年第2期13卷 50-54页

作者： Zhao, M.d. Li, Y.t. dept. of River Eng. Wuhan Univ. Wuhan 430072 China

this paper presents new weighting functions in grid generation and new discretizing scheme of momentum equations in numerical simulation of river flow. By using the new weighting functions, the curvilinear grid could be concentrated as desired near the assigned points or lines in physical plane. By using the new discretizing scheme, the difficulties caused by movable boundary and dry riverbed can be overcome. As an application, the flow in the Wuhan Section of Yangtze River is simulated. the computational results are in good agreement with the measured results. the new method is applicable to the numerical simulation of 2-d river flow with irregular region and moveable boundary.

关键词： Computer simulation Flow of fluids Mathematical models Poisson equation two dimensional

Ultra‑transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal tukaram d.dongale Atul C.Khot Chenjie Yao Nahyun Kim tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to trad.tional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated.the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** add.tion,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

A　Possible　Origin　of　dark　Energy

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2004年第6期21卷 1187-1188页

作者： t.d.Lee Physicsdepartment ColumbiaUniversityNewYorkNY10027USA

We discuss the possibility that the existence of dark energy may be due to the presence of a spin zero field φ(x), either elementary or composite. In the presence of other matter field, the transformation φ(x)→φ(x) + constant can generate a negative pressure, like the cosmological constant. In this picture, our universe can be thought as a very large bag, similar to the much smaller MIt bag model for a single nucleon.

关键词： Gravitation and cosmology Particle physics and field.theory Astrophysics and astroparticles

Nonlinear thermo-mechanical stability of eccentrically stiffened functionally graded material sandwich doubly curved shallow shells with general sigmoid law and power law according to third-order shear deformation theory

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Ed.tion) 2017年第2期38卷 191-216页

作者： d.V.dUNG d.t.dONG Faculty of Mathematics Mechanics and Informatics Vietnam National University Hanoi 100000 Vietnam Faculty of Civil Engineering University of Transport Technology Hanoi 100000 Vietnam

In this paper, the nonlinear analysis of stability of functionally graded ma- terial （FGM） sandwich doubly curved shallow shells is studied under thermo-mechanical loads with material properties obeying the general sigmoid law and power law of four ma- terial models. Shells are reinforced by the FGM stiffeners and rest on elastic found.tions. theoretical formulations are derived by the third-order shear deformation theory （tSdt） with the von Karman-type nonlinearity taking into account the initial geometrical im- perfection and smeared stiffener technique. the explicit expressions for d.termining the critical buckling load and.the post-buckling mechanical and.thermal load-deflection curves are obtained by the Galerkin method. two iterative algorithms are presented. the effects of the stiffeners, the thermal element, the distribution law of material, the initial imper- fection, the found.tion, and.the geometrical parameters on buckling and post-buckling of shells are investigated.

关键词： functionally graded material (FGM) sandwich double curved shallow shell,thermo-mechanical stability FGM stiffener elastic found.tion