检索结果-南通市图书馆

Mechanical and corrosion behaviour of hydroxyapatite reinforced Mg-Sn alloy composite by squeeze casting for biomedical applications

引用

Journal of Magnesium and Alloys 2020年第2期8卷 452-460页

作者： R Radha d.sreekanth School of Mechanical and Building Sciences Vellore Institute of TechnologyChennai 600127India

Magnesium alloys have gained increasing attention for biomedical applications due to their biocompatibility and the ***(HA)is known to be a highly bioactive because of its similar chemical and crystallographic structures to ***,HA is believed to be a potential ceramic material for the fabrication of Mg based composites,to combine the advantages of both Mg and ***,in general,the composites known to be more susceptible to corrosion attack than the matrix ***,in the present work,Sn is used as an alloying element to evaluate its effect on mechanical as well as corrosion properties of Mg/HA *** with 5 wt%HA and Mg-1 wt%Sn-5 wt%HA composites were prepared separately by stir assisted squeeze casting *** phase analysis and microstructure were characterized by X-ray diffraction(XRd)and scanning electron microscope(SEM)coupled with energy dispersive spectroscopy(EdS)*** properties were evaluated by conducting the compression and micro hardness *** properties of as-cast composites were studied by linear polarization,Tafel and electrochemical impedance spectroscopy(EIS)*** results of both XRd and SEM-EdS revealed that the main constitutional phases of as-cast Mg/HA composites were a-Mg and HA whereas,in Mg-Sn/HA composites,the phase Mg^Sn was observed along with fine distribution of HA *** both the cases,no interfacial reactions *** yield strength,ultimate compression strength and hardness were found to be increased with the addition of Sn in Mg/HA ***,the addition of Sn also played an important role in increasing the corrosion resistance of the Mg/HA composites which was attributed the refinement of grain size and the formation of Mg2Sn phase along the grain ***,it was concluded that the addition of Sn improves both mechanical and corrosion properties of Mg/HA composites.

关键词： Magnesium Composite Biomedical Corrosion Squeeze casting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insight of magnesium alloys and composites for orthopedic implant applications-a review

引用

Journal of Magnesium and Alloys 2017年第3期5卷 286-312页

作者： R Radha d.sreekanth School of Mechanical and Building Sciences VIT UniversityChennaiIndia

Magnesium(Mg)and its alloys have been widely researched for orthopedic applications *** alloys have stupendous advantages over the commercially available stainless steel,Co-Cr-Ni alloy and titanium *** date,extensive mechanical,in-vitro and in-vivo studies have been done to improve the biomedical performance of Mg alloys through alloying,processing conditions,surface modification *** review comprehensively describes the strategies for improving the mechanical and degradation performance of Mg alloys through properly tailoring the composition of alloying elements,reinforcements and processing *** also highlights the status and progress of research in to(i)the selection of nutrient elements for alloying,reinforcement and its effects(ii)type of Mg alloy system(binary,ternary and quaternary)and composites(iii)grain refinement for strengthening through severe plastic deformation *** it also emphasizes on the importance of Mg composites with regard to hard tissue applications.

关键词： Orthopedic implants Magnesium Alloy system Composites Grain refinement Processing,degradation,strengthening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

引用

Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

引用

Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Remaking a connection:molecular players involved in post-injury synapse formation

引用

Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structural Tuning of Low Band Gap Intermolecular Push/Pull Side-chain Polymers for Organic Photovoltaic Applications

引用

Chinese Journal of Polymer Science 2017年第9期35卷 1073-1085页

作者： Ansuman Nayak P.S. Rama sreekanth Santosh Kumar Sahu duryodhan Sahu department of Chemistry National Institute of Science and Technology Palur Hills Berhampur Odisha India 761008 department of Chemistry Gandhi Institute of Engineering and Technology Gunpur Odisha India department of Mechanical Engineering National Institute of Science and Technology Palur Hills Berhampur Odisha India 761008

A series of novel low band gap donor-acceptor （d-A） type organic co-polymers （BT-F-TPA, BT-CZ-TPA and BT-SI-TPA） consisting of electron-deficient acceptor blocks both in main chains （M1） and at the pendant （M2） were polymerized with different electron rich donor （M3-M5） blocks, i.e., 9,9-dihexyl-9H-fluorene, N-alkyl-2,7-carbazole, and 2,6-dithinosilole, respectively, via Suzuki method. These polymers exhibited relatively low band gaps （1.65-1.88 eV） and broad absorption ranges （680-740 nm）. Bulk heterojunction （BHJ） solar cells incorporating these polymers as electron donors, blended with [6,6]-phenyl-C61-butyric acid methyl ester （PC61BM） or [6,6]-phenyl-Cvl-butyric acid methyl ester （PC71BM） as electron-acceptors in different weight ratios were fabricated and tested under 100 mW/cm2 of AM 1.5 with white-light illumination. The photovoltaic device containing donor BT-SI-TPA and acceptor PC71BM in 1：2 weight ratio showed the best power conversion efficiency （PCE） value of 1.88%, with open circuit voltage （Voc） = 0.75 V, short circuit current density （Jsc） = 7.60 mA/cm2, and fill factor （FF） = 33.0%.

关键词： Polymer solar cells Low band gap Conducting polymers Charge transfer donor-acceptor Bulk heterojunctionsolar cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

引用

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

引用

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

引用

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.KIRAN d.SINGH R.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSdT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Anatomical Modeling of Brain Vasculature in Two-Photon Microscopy by Generalizable deep Learning

引用

Biomedical Engineering Frontiers 2021年第1期2卷 103-114页

作者： Waleed Tahir sreekanth Kura Jiabei Zhu Xiaojun Cheng Rafat damseh Fetsum Tadesse Alex Seibel Blaire S.Lee Frédéric Lesage Sava Sakadžic david A.Boas Lei Tian department of Electrical and Computer Engineering Boston UniversityBostonMAUSA department of Biomedical Engineering Boston UniversityBostonMAUSA Biomedical Engineering Institute École Polytechnique de MontréalMontréalQCCanada Institute of Neurological Sciences and Psychiatry Hacettepe UniversityAnkaraTurkey department of Radiology Massachusetts General HospitalHarvard Medical SchoolCharlestownUSA Neurophotonics Center Boston UniversityBostonMAUSA

Objective and Impact *** of blood vessels from two-photon microscopy(2PM)angiograms of brains has important applications in hemodynamic analysis and disease ***,we develop a generalizable deep learning technique for accurate 2PM vascular segmentation of sizable regions in mouse brains acquired from multiple 2PM *** technique is computationally efficient,thus ideal for large-scale neurovascular *** segmentation from 2PM angiograms is an important first step in hemodynamic modeling of brain *** segmentation methods based on deep learning either lack the ability to generalize to data from different imaging systems or are computationally infeasible for large-scale *** this work,we overcome both these limitations by a method that is generalizable to various imaging systems and is able to segment large-scale *** employ a computationally efficient deep learning framework with a loss function that incorporates a balanced binary-cross-entropy loss and total variation regularization on the network’s *** effectiveness is demonstrated on experimentally acquired in vivo angiograms from mouse brains of dimensions up to 808×808×702μ*** demonstrate the superior generalizability of our framework,we train on data from only one 2PM microscope and demonstrate high-quality segmentation on data from a different microscope without any network ***,our method demonstrates 10×faster computation in terms of voxels-segmented-per-second and 3×larger depth compared to the *** work provides a generalizable and computationally efficient anatomical modeling framework for brain vasculature,which consists of deep learning-based vascular segmentation followed by *** paves the way for future modeling and analysis of hemodynamic response at much greater scales that were inaccessible before.

关键词： deep network overcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：