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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

dual Zariski Spaces of Modules

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Algebra Colloquium 2023年第4期30卷 569-584页

作者： seçilÇeken department of Mathematics Trakya UniversityEdirneTurkey

Let R be a commutative ring with identity,M be an R-module,L(M)denote the set of all submodules of M and g■(M)\{OM}.For any submodule N of M,we set gV^(d)(N)={K∈g:K■N}and gζ^(d)(M)=(GV^(d)(N):N■L(M)).Consider χ■L(R)\{R},where L(R)is the set of all ideals of *** set χV(I)=(J∈x:I■J)and χζ(R)={xV(I):I■L(R)}for any ideal I of *** this paper,we investigate when,for arbitrary χ and g as above,χζ(R)and gζ^(d)(M)form a topology and a semimodule,*** investigate the structure of gζ^(d)(M)in the case that it is a semimodule.

关键词： dual Zariski semimodule χ-Zariski semiring ·-coprime submodule subtractive subspace

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Prediction of design parameters of pneumatic cleaners with MARS method

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International Journal of Agricultural and Biological Engineering 2021年第2期14卷 106-111页

作者： Ali Tekgüler Emre dünder Tuğba Karaköse department of Agricultural Machinery Samsun Vocational SchoolOndokuz Mayıs UniversityİlkadımSamsun 55070Turkey Statistics department Faculty of Science-LiteratureOndokuz Mayis UniversityAtakumSamsun 55200Turkey department of Agricultural Machinery and Technologies Engineering Faculty of AgricultureOndokuz Mayis UniversityAtakumSamsun 55200Turkey

One of the cleaning methods for agricultural materials is based on aerodynamic *** cleaners are developed on this *** purpose of this study is to predict the parameters such as fan angle,air velocity,and tunnel length,which are used in the design of pneumatic cleaners,through the multivariate adaptive regression splines(MARS)*** parameters have been estimated using the MARS method in order to use pneumatic cleaners under optimum conditions and adapt them to automation *** cleaners have a collection box which was installed at the outlet of the *** different product collection boxes of 400 mm(defined as the first box)and 800 mm(defined as the second box)from the storage outlet section were *** the results obtained,it was observed that the first box R2 was *** looking at the cross validation,it was observed that the results of the first box were more *** this study,MARS equations were used to obtain dependent variables at desired *** these equations,independent variables have been demonstrated to be *** the application results obtained,cleaning efficiency values were obtained in a wide *** cleaning efficiency values reached up to 100%,the loss rate was found to be very *** variables have been made identifiable to reduce the loss *** highest and feasible of these values were determined by MARS as 41°fan angle and 15 m/s air velocity in order to be able to apply at 97%CE and 1%LR determined for the first *** MARS method allows for the use of more dependent and independent *** equations were obtained as a result of statistical *** precise values can be obtained with these *** will contribute to the design of the parameters of the machine manufactured,such as speed,angle,and feeding amount.

关键词： MARS pneumatic cleaner cleaning efficiency loss ratio

Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals

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Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： Ying Lu se Wang Yifan Shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic *** this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(FLU)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond *** addition,the indirect photodegradation of FLU in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water *** results provide a theoretical basis for understanding the phototransformation process of FLU in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism direct photolysis Free radical reaction dFT

Re-visiting supersymmetric Janus solutions: a perturbative construction

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Chinese Physics C 2020年第7期44卷 43-54页

作者： Nakwoo Kim se-Jin Kim department of Physics and Research Institute of Basic Science Kyung Hee UniversitySeoul 02447Republic of Korea

We construct holographic Janus solutions,which describe a conformal interface in the theory of M2-branes,in four-dimensional gauged supergravities using a perturbative *** particular,we study three Einsteinscalar systems and their BPS equations,which are derived by Bobev,Pilch,and Warner(2014).The actions of our interest are all consistent truncations of d=11 supergravity,chosen to be invariant under SO(4)×SO(4),SU(3)×U(1)×U(1),and G2 symmetry subgroups of SO(8).The utility of our semi-analytic result is illustrated by the calculation of minimal area surface and the associated holographic entanglement entropy.

关键词： holography Janus solutions supergravity entanglement entropy

On the Function of Wall Sculpturing in Xylem Conduits

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Journal of Bionic Engineering 2009年第4期6卷 324-329页

作者： Mika M.Kohonen se Helland department of Physical Sciences University of HullCottingham RoadHU6 7RX UK

The water-conducting network of capillaries in vascular plants has evolved over hundreds of millions of years in order to be able to cope with bubble clogging,a problem which also affects modern microfluidic *** of anatomical studies have revealed that plants growing in habitats in which the formation of bubbles,or emboli,is likely to be a frequent occurrence often have various forms of geometrical sculpturing on the internal surfaces of the xylem *** possible function of such wall sculpturing has long been the subject of *** have investigated the hypothesis that wall sculpturing is a functional adaptation designed to increase the wettability of the walls of xylem conduits,an effect which could be described as the inverse of the well-known *** results show that wall sculpturing does enhance ***,theoretical calculations reveal that the geometric parameters of various types of wall sculpturing are such that the resulting surfaces are sufficiently rough to enhance wettability,but not significantly *** results provide an appealing answer to the long-standing debate on the function of wall sculpturing in xylem conduits,and may provide biomimetic clues for new approaches to the removal of bubbles in microfluidic channels.

关键词： xylem wettability capillary wall sculpturing bubble emboli microfluidic