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790 MeV 136Xe轰击56Fe靶时产生的丰中子同位素54Ti,56V,57V,58Cr

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Chinese Physics C 1982年第4期 462-465页

作者：沈文庆 d.schüll H.Freiesleben F.Busch d.Bangert F.Pühlhofer 中国科学院兰州近代物理研究所西德重离子研究中心西德重离子研究中心西德重离子研究中心西德马堡大学西德马堡大学达姆施塔德达姆施塔德达姆施塔德马堡马堡

用790MeV136Xe轰击56Fe靶,测量了类靶碎片的质量数和原子序数。探测且鉴定了四个丰中子同位素54Ti,56V,57V,58Cr。同时提供了55Ti,58V,59Cr存在的可能性。使用西德重离子研究中心的磁谱仪和磁分析一起进行了飞行时间和ΔE-E测量,同位素... 详细信息

用790MeV136Xe轰击56Fe靶,测量了类靶碎片的质量数和原子序数。探测且鉴定了四个丰中子同位素54Ti,56V,57V,58Cr。同时提供了55Ti,58V,59Cr存在的可能性。使用西德重离子研究中心的磁谱仪和磁分析一起进行了飞行时间和ΔE-E测量,同位素鉴定是可靠的。

关键词：丰中子核飞行时间重离子西德德国分析仪器磁谱仪 Xe MeV 丰中子同位素 Ti Fe Cr

Fluidez de movimientos

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今日中国（西文版） 2024年第1期 34-35页

作者： ll NAN

El paleoartista cautivado con los dinosaurios

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今日中国（西文版） 2024年第1期 66-67页

作者： ll QlNG

dPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： HASSAN BAYdOUN YUJI KATO HIROKI KAMO ANNA HÜsch HAYATO MIZUTA RYOTA KAWAHARA SIRO SIMIZU department of Applied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the dPY19 family;nonetheless,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on dPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of dPY19L3 inhibited the formation of VM in HT1080 human fibrosarcoma ***-expression of wild-type dPY19L3 recovered VM formation;however,dPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the C-mannosyltransferase activity of dPY19L3 is crucial to its ***,the knockdown of dPY19L3 in MdA-MB-231 breast cancer cells hindered its network formation ***,our findings suggest that dPY19L3 is required for VM formation and stipulate the relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry dPY19L3

Endoscopic submucosal dissection and endoscopic mucosal resection for esophageal and gastric lesions:A comparison of procedures

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 66-71页

作者： Gustav Holm schæbel Andreas Weise Mucha Charlotte Egeland Michael Patrick Achiam department of Surgery and Transplantation Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esophageal and gastric lesions are effectively managed with minimally invasive upper endoscopic procedures such as endoscopic mucosa resection(EMR)and endoscopic submucosal dissection(ESd),offering patients alternatives to invasive *** ESd is well established in Eastern Asia,its adoption in denmark for superficial esophageal cancer is *** study presents real-world data on the feasibility,safety,and hospitalization duration associated with ESd and EMR for esophageal and gastric *** A retrospective analysis was conducted on patients who underwent ESd or EMR at a specialized center in denmark from October 2016 to June *** on treatment,indication,lesion location,hospitalization duration,procedure duration,specimen size,complications,recurrence,and one-year overall survival were *** comparisons utilized the Mann-Whitney U test,independent sample median test,and chi-squared *** The study included 130 patients(144 procedures):72 underwent ESd and 58 underwent *** with EMR,ESd resulted in greater percentages of en bloc and R0 resections(98.8%vs.64.1%,pd 83.9%vs.23.8%,pd longer procedure times(119.5 min vs.37.0 min,pd procedure time significantly decreased over time(p=0.01).The local recurrence rates were 14.5%for ESd and 23.8%for EMR(p=0.767).The one-year overall survival rates were similar between the groups(95.8%vs.94.8%,p=0.553).Conclusion Both ESd and EMR are safe and viable for treating esophageal and gastric *** offers advantages but requires more time and *** findings support the literature,emphasizing the importance of considering patient-specific factors and surgeon proficiency in selecting the appropriate procedure.

关键词： Endoscopic submucosal dissection Endoscopic mucosa resection Gastroesophageal cancer Real-world data

degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities

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Science China(Life Sciences) 2024年第4期67卷 789-802页

作者： Jianguo Chen Xufang Chen Lishen Qian Yazhou Zhang Bo Li Honghua Shi Lu Sun Christian schöb Hang Sun Key Laboratory for Plant diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China College of Resources and Environment Yunnan Agricultural UniversityKunming 650500China Área de Biodiversidad y Conservación Universidad Rey Juan CarlosMóstoles 28933Spain

Foundational cushion plants can re-organize community structures and sustain a prominent proportion of alpine biodiversity,but they are sensitive to climate *** loss of cushion species can have broad consequences for associated *** potential plant community changes with the population dynamics of cushion plants remain,however,*** eight plant communities along a climatic and community successional gradient,we assessed cushion population dynamics,the underlying ecological constraints and hence associated plant community changes in alpine communities dominated by the foundational cushion plant Arenaria *** population dynamics of Arenaria are attributed to ecological constraints at a series of life history *** functions are constrained by increasing associated beneficiary plants;subsequent seedling establishment is constrained by temperature,water and light availability,extreme climate events,and interspecific competition;strong competitive exclusion may accelerate mortality and degeneration of cushion *** with cushion dynamics,species composition,abundance and community structure gradually *** cushion plants completely degenerate,previously cushion-dominated communities shift to relatively stable communities that are overwhelmingly dominated by *** warming may accelerate the degeneration process of *** of this foundational cushion plant will possibly induce massive changes in alpine plant communities and hence ecosystem functions in alpine *** assessment of the population dynamics of foundation species is critical for an effective conservation of alpine biodiversity.

关键词： alpine ecosystem biodiversity change climate change plant community dynamics foundation species global warming population dynamics

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Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration membranes via electron beam irradiation

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 61-74页

作者： Zahra Niavarani daniel Breite Muhammad Yasir Vladimir Sedlarik Andrea Prager Nadja schönherr Bernd Abel Roger Gläser Agnes schulze Leibniz Institute of Surface Engineering eV.(IOM) Permoserstrasse 1504318 LeipzigGermany Centre of Polymer Systems University InstituteTomas Bata University in ZlinTrida Tomase Bati 567876001 ZlinCzech Republic Institute of Chemical Technology Leipzig UniversityLinnestrasse 304103 LeipzigGermany

Polyethersulphone(PES)membranes modified with urethane functional groups were prepared through an interfacial reaction using electron beam *** removal of eight endocrine disrupting chemicals(EdCs)was studied using both pristine and functionalized PES *** prepared membranes underwent characterization using several techniques,including attenuated total reflectance-Fourier transform infrared(ATR-FTIR)spectroscopy,scanning electron microscopy,contact angle analysis,and measurements of pure water ***,dynamic adsorption experiments were conducted to evaluate the adsorption mechanism of the prepared membrane toward the eight *** urethane functionalized membranes were hydrophilic(52°contact angle)and maintained a high permeate flux(26000 L/h m^(2) bar)throughout the filtration *** adsorption results demonstrated that the introduction of urethane functional groups on the membranes significantly enhanced the removal efficiency of 17β-estradiol,estriol,bisphenol A,estrone,ethinylestradiol,and *** adsorption loading of 17β-estradiol on the functionalized PES membrane was 6.7±0.7 mg/m^(2),exhibiting a 5-fold increase compared to the unmodified PES *** membranes were successfully regenerated and reused for three adsorption cycles without experiencing any loss of adsorption capacity.

关键词： Surface functionalization Electron beam irradiation Microfiltration Endocrine disrupting chemicals

Evaluation of disease burden and symptom scores in patients with acute atrial fi brillation in the emergency department

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World Journal of Emergency Medicine 2024年第5期15卷 397-400页

作者： Nikola schütz dominik Roth Michael Prinz Filippo Cacioppo Sebastian schnaubelt Alexander O.Spiel Hans domanovits Harald Herkner department of Emergency Medicine Medical University of ViennaVienna 1090Austria department of Emergency Medicine Clinic OttakringVienna 1160Austria

Atrial fibrillation(AF)is a major public health problem and poses a substantial economic burden on healthcare systems worldwide.[1-4]The emergency department(Ed)serves as the first point of contact with the healthcare system and plays a key role in the management of patients with AF,which accounts for 3%-10%of all hospital admissions.[5]Treatment plans are often discussed and initiated at the Ed.

关键词： patients atrial acute

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Polycarcin V induces dNA-damage response and enables the profiling of dNA-binding proteins

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National Science Review 2022年第11期9卷 19-28页

作者： Zongwei Yue Fan Wu Fusheng Guo Jiyeong Park Jin Wang Liyun Zhang daohong Liao Wenyang Li Orlando d.sch?rer Xiaoguang Lei Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular Engineering Synthetic and Functional Biomolecules CenterPeking University Peking-Tsinghua Center for Life Science Academy for Advanced Interdisciplinary Studies Peking University Center for Genomic Integrity Institute for Basic Science Jiangsu JITRI Molecular Engineering Inst.Co. Ltd. department of Biological Sciences School of Life Sciences Ulsan National Institute of Science and Technology Institute for Cancer Research Shenzhen Bay Laboratory

To maintain genomic integrity and avoid diseases, the dNA-damage response(ddR) not only detects and repairs dNA lesions, but also contributes to the resistance to dNA-damaging *** the ddR plays a significant role in drug discovery using the principle of synthetic lethality. The incomplete current knowledge of the ddR encouraged us to develop new strategies to identify and study its components and pathways. Polycarcin V, belonging to the C-aryl glycoside natural products, is a light-activatable dNA-intercalating agent that causes dNA damage by forming a covalent [2+2]cycloadduct with thymine residue under 365–450 nm of light irradiation in a dNA-sequence-independent manner. Taking advantage of the light-activatable feature and temporal control of ddR, we designed and synthesized polycarcin V-based bifunctional chemical probes, including one that cross-links dNA to dNA-binding protein to explore the ddR induced by polycarcin V and uncover novel dNA–protein interactions. Utilizing this chemical probe and activity-based protein profiling-stable isotope labeling with amino acids in cell culture, we identified 311 dNA-binding protein candidates, including known ddR factors and additional proteins that may be of interest in discovering new biology. We validated our approach by showing that our probe could specifically cross-link proteins involved in nucleotide excision repair(NER) that repair bulky dNA adducts. Our studies showed that the [2+2] cycloadduct formed by polycarcin V could indeed be repaired by NER in vivo. As a dNA-damaging agent, polycarcin V or its drug-like derivative plus blue light showed promising properties for psoriasis treatment, suggesting that it may itself hold promise for clinic applications.

关键词： polycarcin V [2+2] dNA photoadduct light-activatable chemical probe ABPP for dNA-binding protein proteomics psoriasis treatment