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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubair Ahmed WMatthijs Blankesteijn sébastien Foulquier department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-school for Cardiovascular diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-school for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(csVd)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term csVd refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CsVd is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

Comments on ‘An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in sARs-CoV-2 infection’

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Journal of Molecular Cell Biology 2022年第1期14卷 60-61页

作者： Xiaohua duan Hui Wang david d.Ho Robert E.schwartz todd Evans shuibing Chen department of surgery Weill Cornell Medicine1300 York Ave.New YorkNY 10065USA state Key Laboratory of Oncogenes and Related Genes Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China Aaron diamond AIds Research Center Columbia University Vagelos College of Physicians and SurgeonsNew YorkNY 10032USA division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA department of Physiology Biophysics and Systems BiologyWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA

Coronavirus disease 2019(COVId-19)has been an ongoing public health crisis since the end of 2019;besides vaccine development,there have been major research efforts focused on developing antiviral *** was the first Us Food and drug Administration(FdA)-approved antiviral drug for ***,the FdA granted emergency use authorization(EUA)for three monoclonal antibody treatments,including sotrovimab or a combination of casirivimab and imdevimab,or bamlanivimab and etesevimab,each of which targets the coronavirus spike protein to block viral *** recently,Britain granted conditional authorization for the ribonucleoside analog molnupiravir,developed by Merck as a viral replication *** protease inhibitor PF-07321332 developed by Pfizer and boosted by ritonavir showed promising results in a phase III clinical trial,reducing the risk of hospitalization or death by 89%compared with placebo.

关键词： Pfizer Merck vaccine

Tm^(3+) interactions in LiYF_4 studied by high-resolution spectroscopy

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Journal of Rare Earths 2009年第4期27卷 633-636页

作者： s.A.Klimin d.s.Pytalev Institute of spectroscopy Russian Academy of Sciences 5 Fizicheskaya Str. 142190 Troitsk Moscow region 142190 Russia

We used the high-resolution spectroscopy to study the interactions that Tm3＋ ion in a LiYF4 crystal is subjected to. several crystal field transitions with low integral intensity were found not registered before by means of ordinary spectroscopy. spectral evidences for interionic, hyperfine, isotopic interactions, and for a resonant broadening of the ground state are presented.

关键词： high-resolution Fourier-transform speclroscopy hyperfme structure isotopic structure pair centers rare earths

seismic fragility assessment of RC frame structure designed according to modern Chinese code for seismic design of buildings

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Earthquake Engineering and Engineering Vibration 2012年第3期11卷 331-342页

作者： d. Wu s. Tesfamariam s.F. stiemer d. Qin Key Laboratory of Earthquake Engineering and Applied Technique of Guangdong Province Guangzhou 501405 China school of Engineering University of British Columbia Kelowna V1 V 1 V7 Canada dept. of Civil Engineering University of British Columbia Vancouver V6T 1Z4 Canada dept. of Civil Engineering Radio Film and Television Design and Research Institute Beijing 100045 China

Following several damaging earthquakes in China, research has been devoted to find the causes of the collapse of reinforced concrete （RC） building sand studying the vulnerability of existing buildings. The Chinese Code for seismic design of Buildings （CCsdB） has evolved over time, however, there is still reported earthquake induced damage of newly designed RC buildings. Thus, to investigate modern Chinese seismic design code, three low-, mid- and high-rise RC frames were designed according to the 2010 CCsdB and the corresponding vulnerability curves were derived by computing a probabilistic seismic demand model （PsdM）.The PsdM was computed by carrying out nonlinear time history analysis using thirty ground motions obtained from the Pacific Earthquake Engineering Research Center. Finally, the PsdM was used to generate fragility curves for immediate occupancy, significant damage, and collapse prevention damage levels. Results of the vulnerability assessment indicate that the seismic demands on the three different frames designed according to the 2010 CCsdB meet the seismic requirements and are almost in the same safety level.

关键词： building damage criteria collapse ratio probabilistic seismic demand model (PsdM) fragility curves Chinese Code for seismic design of Buildings (CCsdB)

Quadratic stabilization of a nonlinear aeroelastic system using a novel Neural-Network-based controller

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science China(Technological sciences) 2011年第5期54卷 1126-1133页

作者： d. sFFKER Chair of dynamics and Control University of Duisburg-Essen

This contribution proposes a novel neural-network-based control approach to stabilize a nonlinear aeroelastic wing section. With the prerequisite that all the states of the system are available, the proposed controller requires no comprehensive information about structural nonlinearity of the wing section. Furthermore, the proposed control approach requires no human intervention of designing goal dynamics and formulating control input function, which is difficult to be realized by the typical neural-network-based control following an inverse control scheme. simulation results show that the proposed controller can stabilize the aeroelastic system with different nonlinearities.

关键词： quadratic stabilization neural-network nonlinear aeroelastic control cognition

Management of difficult inflammatory bowel disease:where are we now?

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World Journal of Gastroenterology 2000年第3期6卷 315-323页

作者： d.s. Rampton Reader & Consultant Gastroenterologist Gastrointestinal Science Research Unit and Digestive Diseases Research CentreSt Bartholomews & Royal London School of Medicine and DentistryLondon E1 2ADUK

INTROdUCTION Medical care of patients with inflammatory bowel disease(IBd) comprise general measures and specific pharmacological,nutritional,endoscopic and surgical

关键词： inflammatory bowel diseases/therapy colitis/therapy Crohn disease/therapy endoscopy gastrointestinal social support azathioprine

A Breakthrough Performance： Being Human on Can Xue＇s Five spice street

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Frontiers of Literary studies in China-selected Publications from Chinese Universities 2016年第4期10卷 598-622页

作者： todd Foley department of East Asian studies New York University New York NY 10003 USA

Of the many forms of literary experimentation that arose in China during the 198os, Can Xue＇s writing stands out as some of the strangest and most enigmatic. This article intends to examine her most significant work from that period, Five spice street （Wuxiang jie; first published under the title Breakthrough Performance [Tuwei biaoyan]）, in light of one of the major intellectual concerns in literature at the time： the question of the human. Through a close reading of the novel, I investigate the ways in which Can Xue interrogates and destabilizes the notion of the human with regard to the relationship between subject and object, corporeality, animality, sexuality, language, and time. Overall, I suggest that while Can Xue succeeds in offering a unique and provocative conceptualization of the human in Five spice street, she also refrains from ＂breaking through＂ the general realm of humanist discourse current at the time.

关键词： Can Xue Five spice street (Wuxiang jie) human physicality subjective reality

Electrical and optical properties of lithium borate glasses doped with Nd_2O_3

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Journal of Rare Earths 2012年第8期30卷 785-789页

作者： R.s. Gedam d.d. Ramteke department of Applied Physics Visvesvaraya National Institute of Technology

Glass series with general formula 25Li2O-（75-x）B2O3-xNd2O3 was prepared by conventional melt quench technique. Electrical and optical characterizations of these glasses were carried out. It was observed that conductivity of glasses decreased and activation energy in- creased with the addition of Nd2O3. The density and refractive index of the glasses increased while optical band gap and radiation length de- creased due to structural changes.

关键词： conductivity density refractive index optical absorption Tauc's plot rare earths

Luminescence properties of Gd^(3+) containing glasses for ultra-violet(UV) light

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Journal of Rare Earths 2014年第5期32卷 389-393页

作者： d.d.Ramteke R.s.Gedam department of Applied Physics Visvesvaraya National Institute of Technology

Effect of Gd2O3 addition on optical properties of 27.5 Li2O-72.5 B2O3 glass systems was studied. density, differential thermal analysis （dTA）, optical absorption spectra and luminescence technique were used to characterize the prepared glasses. Emis- sion spectra showed two band 6p7/2→8s7/2 （311.5 nm） and 6p5/2→8s7/2 （305 nm） under the excitation of 274 nm. The intense emission at 311.5 nm suggested that these glasses could be useful as source of narrowband UV light.

关键词： glasses rare earths absorption band gap luminescence UV light