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NUMErICAL ANALYsIs OF THE INFLUENCE OF THE TIP CLEArANCE FLOWs ON THE UNsTEAdY CAvITATING FLOWs IN A THrEE- d IMENsIONAL INdUCEr

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Journal of Hydrodynamics 2009年第1期21卷 34-40页

作者： OkITA k. UGAJIN H. MATsUMOTO Y. rIkEN Saitama 351-0198 Japan IHI Corporation Yokohama 235-8501 Japan department of Mechanical Engineering The University of TokyoTokyo 113-8656 Japan

To clarify the influences of the tip clearance flows on the unsteady cavitating flow, the three-dimensional unsteady cavitating flows through both the two-dimensional cascades and the three-dimensional inducer with and without tip clearance are performed numerically. The governing equations for the compressible fluid flow with the dEs turbulence model are employed with the assumption of the isentropic process of liquid phase. The evolution of cavities is represented as the source/sink of vapor phase. The basic equations in the curve linear coordinate are solved by the finite difference method. As the results of the three-dimensional cavitating flows through the two-dimensional cascades, the tip clearance flows from the pressure side to the suction side of the blade produces the tip vortex cavitation, which affects the sheet cavitation on the leading edge of the next blade and enhances the blockage effect near the casing than the flows without tip clearance. On the other hand, in the case of the three-dimensional inducer, the large backflow cavitation is observed around the inlet of the inducer, where the cavities are developed on the casing by the tip clearance flows. The large pressure gradient between the non-cavitating pressure side and the cavitating suction side enhances the tip clearance flows. The calculation considering the tip clearance reproduces the developed cavitation region similar to that of experimental visualizations. Additionally, the backflow cavitation rotates with the speed slower than the rotation speed of the inducer. Then, the rotation of backflow cavitation causes the periodic fluctuation of the outlet pressure greater than that of the inlet pressure.

关键词： cavitation inducer tip clearance flow numerical analysis

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Mechanistic insights into the key marine dimethylsulfoniopropionate synthesis enzyme dsyB/dsYB

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mLife 2022年第2期1卷 114-130页

作者： Chun-Yang Li Jason C.Crack simone Newton-Payne Andrew r.J.Murphy Xiu-Lan Chen Benjamin J.Pinchbeck shun Zhou Beth T.Williams Ming Peng Xiao-Hua Zhang Yin Chen Nick E.Le Brun Jonathan d.Todd Yu-Zhong Zhang Frontiers science Center for deep Ocean Multispheres and Earth system College of Marine Life SciencesOcean University of ChinaQingdaoChina state key Laboratory of Microbial Technology Marine Biotechnology Research CenterShandong UniversityQingdaoChina Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and TechnologyQingdaoShandongChina school of Chemistry Centre for Molecular and Structural BiochemistryUniversity of East AngliaNorwich Research ParkNorwichUK school of Biological sciences University of East AngliaNorwichUK school of Life sciences University of WarwickCoventryUK

Marine algae and bacteria produce approximately eight billion tonnes of the organosulfur molecule dimethylsulfoniopropionate(dMsP)in Earth's surface oceans *** is an antistress compound and,once released into the environment,a major nutrient,signaling molecule,and source of climate-active *** methionine transamination pathway for dMsP synthesis is used by most known dMsP-producing algae and *** s-directed s-adenosylmethionine(sAM)-dependent 4-methylthio-2-hydroxybutyrate(MTHB)s-methyltransferase,encoded by the dsyB/dsYB gene,is the key enzyme of this pathway,generating s-adenosylhomocysteine(sAH)and 4-dimethylsulfonio-2-hydroxybutyrate(dMsHB).dsyB/dsYB,present in most haptophyte and dinoflagellate algae with the highest known intracellular dMsP concentrations,is shown to be far more abundant and transcribed in marine environments than any other known s-methyltransferase gene in dMsP synthesis ***,we demonstrate in vitro activity of the bacterial dsyB enzyme from Nisaea denitrificans and provide its crystal structure in complex with sAM and sAH-MTHB,which together provide the first important mechanistic insights into a dMsP synthesis *** and mutational analyses imply that dsyB adopts a proximity and desolvation mechanism for the methyl transfer *** analysis suggests that this mechanism may be common to all bacterial dsyB enzymes and also,importantly,eukaryotic dsYB enzymes from e.g.,algae that are the major dMsP producers in Earth's surface oceans.

关键词： catalytic mechanism dMsP synthesis marine sulfur cycle s-methyltransferase

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Intelligent classification of lung malignancies using deep learning techniques

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International Journal of Intelligent Computing and Cybernetics 2022年第3期15卷 345-362页

作者： Priyanka Yadlapalli d.Bhavana suryanarayana Gunnam department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia department of Electronics and Communications Gokaraju Rangaraju Institute of Engineering and TechnologyHyderabadIndia department of Electronics and Communications VRSiddhartha Engineering CollegeVijayawadaIndia shanghai Jiao Tong University-Minhang Campus ShanghaiChina

Purpose-Computed tomography(CT)scan can provide valuable information in the diagnosis of lung *** detect the location of the cancerous lung nodules,this work uses novel deep learning *** majority of the early investigations used CT,magnetic resonance and mammography *** appropriate procedures,the professional doctor in this sector analyses these images to discover and diagnose the various degrees of lung *** of the methods used to discover and detect cancer illnesses are time-consuming,expensive and stressful for the *** address all of these issues,appropriate deep learning approaches for analyzing these medical images,which included CT scan images,were ***/methodology/approach-radiologists currently employ chest CT scans to detect lung cancer at an early *** certain situations,radiologists’perception plays a critical role in identifying lung melanoma which is incorrectly *** learning is a new,capable and influential approach for predicting medical *** this paper,the authors employed deep transfer learning algorithms for intelligent classification of lung *** neural networks(vGG16,vGG19,MobileNet and denseNet169)are used to constrain the input and output layers of a chest CT scan image ***-The collection includes normal chest CT scan pictures as well as images from two kinds of lung cancer,squamous and adenocarcinoma impacted chest CT scan *** to the confusion matrix results,the vGG16 transfer learning technique has the highest accuracy in lung cancer classification with 91.28% accuracy,followed by vGG19 with 89.39%,MobileNet with 85.60% and denseNet169 with 83.71% accuracy,which is analyzed using Google ***/value-The proposed approach using vGG16 maximizes the classification accuracy when compared to vGG19,MobileNet and *** results are validated by computing the confusion matrix for each network type.

关键词： Computed tomography scans Convolution neural networks Transfer learning Intelligent classification state-of-the-art(sOTA)accuracy

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One-dimensional (1d) Ⅱ-Ⅵ based nanostructures—synthesis and microstructure characterizations

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电子显微学报 2004年第4期23卷 365-365页

作者： Hark s k department of Physics

various single crystalline Ⅱ - Ⅵ compound 1d nanostructures can be readily synthesized via a simple thermal evaporation process. The morphology characteristics ( nanowires vs. nanobelts, crystalline growth directions, termination surfaces, etc.) of these nanostructures can be discriminated by controlling the supersaturation of the source vapor (via the control of different fabrication parameters ).

关键词：半导体材料 Ⅱ-Ⅵ族化合物纳米结构单晶结构透射电子显微镜分析

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评九十年代铝土矿·氧化铝和原铝的供需趋势

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轻金属 1990年第8期 1-10页

作者： d.r.Wiburn d.A.Buckingham. 王祝堂

一、世界铝工业根据美国地质调查局和美国矿业局联合制定的矿产资源分级系统,来确定“已证实的”冶金级铝土矿储量和资源的估计吨数。所谓

关键词：氧化铝厂产量铝土矿铝矿物市场经济国家原铝电解铝九十年代

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Asymptotic Behavior of a Non-Local Hyperbolic Equation Modelling Ohmic Heating

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Journal of Mathematical research with Applications 2012年第4期32卷 476-484页

作者： Xianchao WANG 1,,Chengshun JIANG 2 1.National digital switching system Engineering & Technological r & d Centre,Henan 450002,P.r.China 2.Wuhan College,Zhongnan University of Economics and Law,Hubei 430079,P.r.China National digital switching system Engineering & Technological r & d Centre Henan 450002 Wuhan College Zhongnan University of Economics and Law Hubei 430079

In this paper,the asymptotic behavior of a non-local hyperbolic problem modelling Ohmic heating is *** is found that the behavior of the solution of the hyperbolic problem only has three cases:the solution is globally bounded and the unique steady state is globally asymptotically stable;the solution is infinite when t→∞;the solution blows *** the solution blows up,the blow-up is uniform on any compact subsets of(0,1] and the blow-up rate is lim t → T*-u(x,t)(T*-t)1/α+βp-1=(α+βp-1/1-α)1/1-α-βp,where T* is the blow-up time.

关键词： non-local hyperbolic equation asymptotical behavior blow-up blow-up rate.

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Wafer-scale 3d shaping of high aspect ratio structures by multistep plasma etching and corner lithography

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Microsystems & Nanoengineering 2020年第1期6卷 1176-1186页

作者： shu Ni Erwin J.W.Berenschot Pieter J.Westerik Meint Jde Boer rene Wolf Hai Le-The Han J.G.E.Gardeniers Niels r.Tas Mesoscale Chemical system Group MESA+InstituteUniversity of Twente7522 NB EnschedeThe Netherlands Inorganic Materials science Group MESA+InstituteUniversity of Twente7522 NB EnschedeThe Netherlands NanoLab Cleanroom MESA+InstituteUniversity of Twente7522 NB EnschedeThe Netherlands Physics of Fluids Group MESA+Institute&Max Planck Center for Complex Fluid DynamicsUniversity of Twente7522 NB EnschedeThe Netherlands BIOs Lab-on-a-Chip Group MESA+Institute&Max Planck Center for Complex Fluid DynamicsUniversity of Twente7522 NB EnschedeThe Netherlands

The current progress of system miniaturization relies extensively on the development of 3d machining techniques to increase the areal structure *** this work,a wafer-scale out-of-plane 3d silicon(si)shaping technology is reported,which combines a multistep plasma etching process with corner *** multistep plasma etching procedure results in high aspect ratio structures with stacked semicircles etched deep into the sidewall and thereby introduces corners with a proper geometry for the subsequent corner *** to the geometrical contrast between the gaps and sidewall,residues are left only inside the gaps and form an inversion mask inside the *** this mask,octahedra and donuts can be etched in a repeated manner into si over the full wafer area,which demonstrates the potential of this technology for constructing high-density 3d structures with good dimensional control in the bulk of si wafers.

关键词： lithography high structures

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dETECTION ANd dEPTH PrOFILING OF ^(19)F UsING rEsONANCEs IN THE ^(19)F(α,p) ^(22)Ne rEACTION

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Nuclear science and Techniques 1990年第Z1期1卷 56-61页

作者： L.C.McIntyre Jr. J.A.Leavitt M.d.Ashbaugh B.dezfouly-Arjomandy Z.Lin J.Oder r.F.C.Farrow s.s.P.Parkin University of Arizona TucsonAZ 85721USA IBM research division Alamaden research Center San JoseCA 95120-6099USA

resonances in the reaction 19F (α ,p) 22Ne have been used to detect and depth profile 19F in solid targets. Incident alpha particles in the range 2100-2500 kev were used and protons were detected at θ=135° with a large solid angle surface barrier detector covered to stop elastically scattered alpha particles. This technique is a simple, nuclide specific probe and is particularly useful in detecting 19F in the presence of heavy elements such as GaAs where conventional rutherford backscattering is ineffective. Examples using this technique on epitaxially grown thin films containing LaF3 layers will be presented.

关键词： Fluorine depth profile Nuclear reaction analysis

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颈、腰椎间盘突出的CT检查和手术结果的对比研究

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放射学实践 1992年第3期7卷 136-138页

作者： d.khler M.Langer k.Hansen r.Felix 蔡培华 strahlenklinik und Poliklinik Universitatsklinikum Rudolf VirchowSpandauer Damm 1301000 Berlin 19FRG. 上海市第六人民医院

1979年CT扫描应用于脊柱的诊断,并作为诊断椎间盘突出、创伤和炎性病变的首选方法。以下研究为借助手术结果回顾性验证CT诊断突出的部位、程度、类型以及伴髓核突出的纤维环是否破裂等的准确度。

关键词：椎间盘突出 CT

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CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular Cd4^(+)T cells

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Cellular & Molecular Immunology 2023年第7期20卷 777-793页

作者： Yuwei Hao Bahar Miraghazadeh rochna Chand Ainsley r.davies Chelisa Cardinez kristy kwong Morgan B.downes rebecca A.sweet Pablo F.Cañete Lloyd J.d’Orsogna david A.Fulcher sharon Choo desmond Yip Geoffrey Peters sonia Yip Matthew J.Witney Maxim Nekrasov Zhi-Ping Feng david C.Tscharke Carola G.vinuesa Matthew C.Cook Centre for Personalised Immunology John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia Translational research Unit The Canberra HospitalCanberraACTAustralia division of Immunology and Infectious diseases John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia department of Immunology Fiona Stanley HospitalPerthWAAustralia department of Immunology The Royal Children’s HospitalMelbourneVICAustralia department of Medical Oncology The Canberra HospitalCanberraACTAustralia ANU Medical school The Australian National UniversityCanberraACTAustralia NHMrC Clinical Trials Unit The University of SydneySydneyNSWAustralia The ACrF Biomolecular resource Facility John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia ANU Bioinformatics Consultancy John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia Francis Crick Institute 1 Midland RdLondon NW11ATUK Cambridge Institute of Therapeutic Immunology and Infectious disease University of CambridgeCambridgeUnited Kingdom.

As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency(PAd),analysis of affected patients could yield insights into T-cell differentiation and explain how environmental exposures modify clinical phenotypes conferred by single-gene ***57 marks dysfunctional T cells that have differentiated after antigenic ***,while circulating Cd57^(+)Cd4^(+)T cells are normally rare,we found that they are increased in patients with PAd and markedly increased with CTLA4 haploinsufficiency or *** performed single-cell rNA-seq analysis of matched Cd57^(+)Cd4^(+)T cells from blood and tonsil *** Cd57^(+)Cd4^(+)T cells(Cd4cyt)exhibited a cytotoxic transcriptome similar to that of Cd8^(+)effector cells,could kill B cells,and inhibited B-cell ***4 restrained the formation of *** Cd57 also marked an abundant subset of follicular helper T cells,which is consistent with their antigen-driven differentiation,this subset had a preexhaustion transcriptomic signature marked by TCF7,TOX,and Id3 expression and constitutive expression of CTLA4 and did not become cytotoxic even after CTLA4 ***,Cd57^(+)Cd4^(+)T-cell cytotoxicity and exhaustion phenotypes are compartmentalised between blood and germinal ***4 is a key modifier of Cd4^(+)T-cell cytotoxicity,and the pathological Cd4cyt phenotype is accentuated by infection.

关键词： CTLA4 Immunodeficiency Cell exhaustion Terminal differentiation Cytotoxic Cd4^(+)T cells Cd57

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