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Inspection strategies for quality products withrewards in a multi-stage production

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Journal of Control and decision 2023年第4期10卷 596-609页

作者： r.Satheesh Kumar A.Nagarajan department of Mathematics PSNA College of Engineering and TechnologyDindigulIndia

In a multi-stage manufacturing system,defective components are generated due to deteriorating machine parts and failure to install the feed *** these circumstances,the system requires inspection counters to distinguish imperfect items and takes a few discreet decisions to produce impeccable *** the prioritisation of employee appreciation and working on reward is one of the important policies to improve *** we look at the multistage manufacturing system as an M/PH/1 queue model and rewards are given for using certain inspection strategies to produce the quality items.A matrix analytical method is proposed to explain a continuous-time Markov process in which the reward points are given to the strategy of inspection in each state of the *** constructing the value functions of this dynamic programming model,we derive the optimal policy and the optimal average reward of the entire system in the long *** addition,we obtain the percentage of time spent on each system state for the probability of conformity and non-conformity of the product over the long *** results of our computational experiments and case study suggest that the average reward increases due to the actions are taken at each decision epoch for rework and disposal of the non-conformity items.

关键词： Sequential process infinitesimal operator Markov decision processes value function optimal policy optimal average reward

Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old Mongolian gerbils

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Asian Journal of Andrology 2017年第2期19卷 160-167页

作者： Manoel F Biancardi Ana PS Perez Cassia rS Caires Luiz r Falleiros Jr rejane M Goes Patricia SL Vilamaior diogenes r Freitas Jr Fernanda CA Santos Sebastiao r Taboga department of Structural and Functional State University of Campinas Av. Bertrand Russel s/n Campinas Sao Paulo 13084864 Brazil 2department of Histology Embryology and Cell BiologyFederal University of Goias Samambaia II Goiania Goias 74001970 Brazil University Estadual Paulista - UNESP Department of Biology Laboratory of Microscopy and Microanalysis Rua Cristovao Colombo 2265 Sao Jose do Rio Preto Sao Paulo 15054000 Brazil Medical School Federal University of Goias Colemar Natal e Silva Goiania Goias 74001970 Brazil

The prostate is an accessory sex gland that develops under precise androgenic control. It is known that hormonal imbalance may disrupt its development predisposing this gland to develop diseases during aging. Although the hypothesis regarding earlier origins of prostate diseases was proposed many years ago, the mechanisms underlying this complex phenomenon are poorly understood. Therefore, the aim of this study was to evaluate the prostates of old male gerbils exposed to testosterone during intrauterine and postnatal life using morphological, biometrical, stereological, Kariometric, immunohistochemical, and immunofluorescence analyses. Our findings demonstrate that prenatal and pubertal exposure to testosterone increases the susceptibility to the development of prostate diseases during aging. The presence of a more proliferative gland associated with foci of adenomatous hyperplasia in animals exposed to testosterone during the prenatal and pubertal phase show that the utero life and the pubertal period are important phases for prostatic morphophysiology establishment, which is a determinant for the health of the gland during aging. Therefore, these findings reinforce the idea that prostate disease may result from hormonal disruptions in early events during prostate development, which imprint permanently on the gland predisposing it to develop lesions in later stages of life.

关键词： adenomatous hyperplasia endocrine-disrupting chemicals gerbil prostate development testosterone

Glial cell line-derived neurotrophic factor as a treatment after spinal cord injury

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Neural regeneration research 2018年第10期13卷 1733-1734页

作者： stephen d.ortmann daniel j.hellenbrand department of neurological surgery university of wisconsinmadisonwiusa

Spinal cord injury（SCI）is a devastating trauma that currently affects 54 people out of every million,which is approximately 270,000people in the United States（National Spinal Cord Injury Statistical Center,2013）.The effects of such an injury can cause a loss of both motor and sensory function below the injury site,normally leaving the patient unable to care for themselves entirely and relying on family and friends to provide personal *** there are no.

关键词： Glial cell line-derived neurotrophic factor as a treatment after spinal cord injury GFr SCI

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dual enzyme activated fluorescein based fluorescent probe

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 117-121页

作者： Maria L.Odyniec Jordan E.Gardiner Adam C.Sedgwick Xiao-Peng He Steven d.Bull Tony d.James department of Chemistry University of BathBathBA27AYUK department of Chemistry University of Texas at AustinAustinTX 78712-1224USA Key Laboratory for Advanced Materials&Feringa Nobel Prize Scientist Joint research Center East China University of Science and TechnologyShanghai 200237China

A simple dual analyte fluorescein-based probe(PF3-Glc)was synthesised containingβ-glucosidase(β-glc)and hydrogen peroxide(H2O2)trigger *** presence ofβ-glc,resulted in fragmentation of the parent molecule releasing glucose and the slightly fluorescent mono-boronate fluorescein(PF3).Subsequently,in the presence of glucose oxidase(GOx),the released glucose was catalytically converted to d-glucono-δ-lactone,which produced H2O2 as a *** GOx-produced H2O2,resulted in classic H2O2-mediated boronate oxidation and the release of the highly emissive fluorophore,*** unique cascade reaction lead to an 80-fold increase in fluorescence intensity.

关键词： chemosensors dual-activation GOx fluorescence β-glucosidase molecular logic

Nonlinear relativistic mean-field theory studies on He isotopes

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Chinese Physics C 2014年第12期38卷 25-27页

作者：樊广伟董铁矿 d.Nishimura School of Chemical Engineering Anhui University of Science and Technology Purple Mountain Observatory Chinese Academy of Sciences department of Physics Tokyo University of Science

The ground state properties of He isotopes are studied in the nonlinear relativistic mean-field（rMF）theory with force parameters NL-SH and TM2. The modified Glauber model is introduced as a gatekeeper to check the calculations. The investigation shows that the rMF theory provides a good description on the properties of He isotopes. The many-body space information of ^4He ＋ neutrons is obtained reliably. As a product, the calculation gives strong evidence for a neutron halo in ^5He.

关键词： He isotopes rMF glauber model nuclear structure

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Update on cell therapy for stroke

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Stroke & Vascular Neurology 2017年第2期2卷 59-64页

作者： Cynthia L Kenmuir Lawrence r Wechsler department of Neurology University of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA

Ischaemic stroke remains a leading cause of death and *** stroke treatment options aim to minimise the damage from a pending stroke during the acute stroke period using intravenous thrombolytics and endovascular thrombectomy;however,there are no currently approved treatment options for reversing neurological damage once a stroke is *** studies suggest that cell therapy may be safe and effective in improving functional *** recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke,which are *** therapy may provide a promising new treatment for stroke reducing stroke-related *** investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods,cell dosing,type of cells used,timing of delivery,infarct size and location of infarct that are likely to benefit from cell therapy.

关键词： damage acute treatment

Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第13期20卷 3552-3563页

作者： Branislav r Filipovic Branka F Filipovic Faculty of Medicine Institute of Anatomy "Niko Miljanic"11000 BelgradeSerbia Branislav R FilipovicBranka F FilipovicFaculty of MedicineUniversity of Belgrade11000 BelgradeSerbia department of Gastroenterohepatology Clinical and Hospital Center "Bezanijska Kosa"11080 BelgradeSerbia

Ulcerative colitis and Crohn’s disease, commonly known as inflammatory bowel disease (IBd), draw attention from specialists of various disorders, including gastroenterology, psychiatry, and radiology. The involvement of a cortical influence in the brain-gut axis as well as the interaction of the hypothalamic-pituitary-adrenal axis and the peripheral nervous system provide an initial explanation of the psychological symptoms associated with IBd. The involvement of structures the limbic system, such as the anterior cingulate cortex, the prefrontal cortex, and the amygdala, paves the way for the discovery of the mechanisms underlying depression depression, anxiety, alexithymia, personality traits, and other psychological impairments following the onset of IBd. Psychiatric therapy in IBd patients is almost as important as the gastroenterological approach and consists of pharmacological treatment and psychotherapy. Neither of the available psychiatric treatment methods is considered the golden standard because both methods have side effects, and psychotropic medication can provoke the worsening of IBd symptoms. Thus, both approaches must be applied with awareness of the possibility of side effects. We suggest that psychiatrists and gastroenterologists work together to reach a consensus on IBd therapy to ensure success and to reduce side effects and relapse to the lowest possible rates.

关键词： Inflammatory bowel disease Psychiatry Treatment Personality traits depression Anxiety

Effects of grass and shrub cover on the critical unit stream power in overland flow

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International Journal of Sediment research 2011年第3期26卷 385-392页

作者： M.J.M.rmkens USdA-ArS National Sedimentation Laboratory OxfordMississippiUSA.

Improved knowledge of the effects of grass and shrub cover in overland flow can provide valuable information for soil and water conservation *** simulated rainfall studies were conducted to determine effects of grass and shrub on runoff and soil loss and to ascertain the relationship between the rate of soil loss and the unit stream power of runoff for a 20°slope subjected to rainfall intensities of 45,87,and 127 mm/*** results indicated that the average runoff rates ranged from 4.2 to 73.1 mm/h for grass plots and from 9.3 to 58.2 mm/h for shrub *** rates from shrub plots were less than those from grass plots for all but the 45 mm/h rainfall intensity regime. Average soil loss rates varied from 5.7 to 120.3 g/min.m~2 for grass plots and from 5.6 to 84.4 g/min.m~2 for shrub *** loss rates from shrub plots were generally lower than those from grass *** and soil loss were strongly influenced by soil surface conditions due to the formation of erosion pits and *** rate of soil loss increased linearly with the unit stream power of runoff on both grass and shrub *** unit stream power values were 0.0127 m/s for grass plots and 0.0169 m/s for shrub *** plots showed a greater stability to resist soil detachment and transport by surface flow than grass plots.

关键词： Soil erosion Soil loss Unit stream power

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 311-314页

作者： Adam C. Sedgwick Alex Hayden Barry Hill Steven d. Bull robert B. P. Elmes Tony d. James department of Chemistry University of Bath Bath BA2 7AY UK department of Chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrobenzyl-umbelliferone （NCOU1） was synthesised containing a nitroreductase （NTr） trigger moiety. The presence of NTr, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umbelliferone via an NTr-catalyzed reduction of the nitro group. In the presence of the NTr enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTr over other reductive enzymes. These results indicate that NCOU1 can be used as a simple assay for the detection of NTr.

关键词： NITrO rAdICALS NTSr1 gene FLUOrESCENT PrOBES Skimmetin Nitroreductases noise-temperature ratio