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Targets for high repetition rate laser facilities:needs,challenges and perspectives

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High Power Laser Science and Engineering 2017年第3期5卷 10-40页

作者： I.Prencipe J.Fuchs S.Pascarelli d.W.Schumacher R.B.Stephens N.B.Alexander R.Briggs M.Büscher M.O.Cernaianu A.Choukourov M.de Marco A.Erbe J.Fassbender G.Fiquet P.Fitzsimmons C.Gheorghiu J.Hund L.G.Huang M.Harmand N.J.Hartley A.Irman T.Kluge Z.Konopkova S.Kraft d.Kraus V.Leca d.Margarone J.Metzkes K.Nagai W.Nazarov P.Lutoslawski d.papp M.Passoni A.Pelka J.P.Perin J.Schulz M.Smid C.Spindloe S.Steinke R.Torchio C.Vass T.Wiste R.Zaffino K.Zeil T.Tschentscher U.Schramm T.E.Cowan Lawrence Berkeley National Laboratory USA 25Institute of Microelectronics of Barcelona National Center of Microelectronic Spanish Research Council Spain 26University of St. Andrews UK

A number of laser facilities coming online all over the world promise the capability of high-power laser experiments with shot repetition rates between 1 and 10 Hz. Target availability and technical issues related to the interaction environment could become a bottleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fabrication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to establish a sustainable target provision infrastructure for advanced laser facilities.

关键词： high-energy density physics target design and fabrication

deactivation of Streptococcus mutans Biofilms on a Tooth Surface Using He dielectric Barrier discharge at Atmospheric Pressure

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Plasma Science and Technology 2013年第6期15卷 535-541页

作者： Imola MOLNAR Judit papp Alpar SIMON Sorin dan ANGHEL Babes-Bolyai University Faculty of Biology and GeologyCluj-Napoca 400015Romania Babes-Bolyai University Faculty of PhysicsCluj-Napoca 400084Romania

This paper presents a study of the effect of the low temperature atmospheric helium dielectric barrier discharge（dBd） on the Streptococcus mutans biofilms formed on tooth surface. Pig jaws were also treated by plasma to detect if there is any harmful effect on the *** plasma was characterized by using optical emission *** data indicated that the discharge is very effective in deactivating Streptococcus mutans *** can destroy them with an average decimal reduction time（d-time） of 19 s and about 98%of thein were killed after a treatment time of 30 *** to the survival curve kinetic an overall 32 s treatment time would be necessary to perform a complete *** experimental results presented in this study indicated that the helium dielectric barrier discharge,in plan-parallel electrode configuration,could be a very effective tool for deactivation of oral bacteria and might be a promising technique in various dental clinical applications.

关键词： Streptococcus mutans dielectric barrier discharge plasma treatment biofilm deactivation sterilization

Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第11期30卷 1621-1635页

作者： Armand Csontos Alíz Fazekas Lajos Szakó Nelli Farkas Csenge papp Szilárd Ferenczi Szabolcs Bellyei Péter Hegyi András papp department of Surgery University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Institute of Bioanalysis University of PécsMedical SchoolPécs H-7624BaranyaHungary Institute for Translational Medicine University of PécsMedical SchoolPécs H-7624BaranyaHungary department of Emergency Medicine Clinical CenterUniversity of PécsMedical SchoolPécs 7624BaranyaHungary department of Oncotherapy University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute of Pancreatic diseases Semmelweis UniversityBudapest H-1083Hungary

BACKGROUNd Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer;however,the superiority of neoadjuvant chemotherapy(nCT)or neoadjuvant chemoradiotherapy(nCRT)is ***,a discussion of these two modalities is *** To investigate the benefits and complications of neoadjuvant *** To address this concern,predefined criteria were established using the PICO *** independent authors performed comprehensive searches using predetermined *** analyses were performed to identify significant differences between *** publication bias was visualized using funnel *** quality of the data was evaluated using the Risk of Bias Tool 2(RoB2)and the GRAdE *** Ten articles,including 1928 patients,were included for the *** difference was detected in pathological complete response(pCR)[Pdds ratio(OR):0.27;95%CI:0.16-0.46],30-d mortality(P=0.015;OR:0.4;95%CI:0.22-0.71)favoring the nCRT,and renal failure(P=0.039;OR:1.04;95%CI:0.66-1.64)favoring the *** significant differences were observed in terms of survival,local or distal recurrence,or other clinical or surgical *** result of RoB2 was moderate,and that of the GRAdE approach was low or very low in almost all *** Although nCRT may have a higher pCR rate,it does not translate to greater long-term ***,nCRT is associated with higher 30-d mortality,although the specific cause for postoperative complications could not be *** the case of nCT,toxic side effects are suspected,which can reduce the quality of *** the quality of available studies,further randomized trials are required.

关键词： Neoadjuvant Chemotherapy Chemoradiotherapy Esophageal cancer Adenocarcinoma

Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer:The superiority of minimally invasive surgery

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World Journal of Gastroenterology 2022年第30期28卷 4201-4210页

作者： Lajos Szakó dávid Németh Nelli Farkas Szabolcs Kiss Réka Zsuzsa domotor Marie Anne Engh Péter Hegyi Balint Eross András papp Institute of Translational Medicine University of PécsMedical SchoolPécs 7624Hungary János Szentágothai Research Centre University of PécsMedical SchoolPécs 7624Hungary Institute for Translational Medicine University of PécsMedical SchoolPécs 7624Hungary of Bioanalysis University of PécsMedical SchoolPécs 7624Hungary Insittute of Translational Medicine University of PécsMedical SchoolPécs 7624Hungary doctoral School of Clinical Medicine University of SzegedMedical SchoolSzeged 6720Hungary First department of Medicine University of SzegedMedical SchoolSzeged 6725Hungary Institute of Translational Medicine University of PecsMedical SchoolPecs 7624Hungary department of Surgery Clinical CenterUniversity of PécsMedical SchoolPécs 7624Hungary

BACKGROUNd Previous meta-analyses,with many limitations,have described the beneficial nature of minimal invasive *** To compare all modalities of esophagectomies to each other from the results of randomized controlled trials(RCTs)in a network meta-analysis(NMA).METHOdS We conducted a systematic search of the MEdLINE,EMBASE,Reference Citation Analysis(https://***/)and CENTRAL databases to identify RCTs according to the following population,intervention,control,outcome(commonly known as PICO):P:Patients with resectable esophageal cancer;I/C:Transthoracic,transhiatal,minimally invasive(thoracolaparoscopic),hybrid,and robot-assisted esophagectomy;O:Survival,total adverse events,adverse events in subgroups,length of hospital stay,and blood *** used the Bayesian approach and the random effects *** presented the geometry of the network,results with probabilistic statements,estimated intervention effects and their 95% confidence interval(CI),and the surface under the cumulative ranking curve to rank the *** We included 11 studies in our *** found a significant difference in postoperative pulmonary infection,which favored the minimally invasive intervention compared to transthoracic surgery(risk ratio 0.49;95%CI:0.23 to 0.99).The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery(mean difference-85 min;95%CI:-150 to-29),hybrid intervention(mean difference-98 min;95%CI:-190 to-9.4),minimally invasive technique(mean difference-130 min;95%CI:-210 to-50),and robot-assisted esophagectomy(mean difference-150 min;95%CI:-240 to-53).Other comparisons did not yield significant *** Based on our results,the implication of minimally invasive esophagectomy should be favored.

关键词： Surgery Esophageal cancer Esophagectomy Network meta-analysis Minimally invasive Laparoscopy

Presepsin teardown- pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis

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World Journal of Gastroenterology 2016年第41期22卷 9172-9185页

作者： Maria papp Tamas Tornai Zsuzsanna Vitalis Istvan Tornai david Tornai Tamas dinya Andrea Sumegi Peter Antal-Szalmas department of Internal Medicine Division of Gastroenterology University of Debrecen Faculty of Medicine department of Laboratory Medicine University of Debrecen Faculty of Medicine Debrecen Institute of Surgery University of Debrecen Faculty of Medicine Vascular Biology Thrombosis and Haemostasis Research Group Hungarian Academy of Sciences

AIM To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHOdS Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein(CRP) and procalcitonin(PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term *** Present 34.7 of patients had bacterial infection. Presepsin levels were significantly higher in patients with infection than without(median, 1002 pg/m L vs 477 pg/m L, P diagnostic accuracy of presepsin for severe infections was similar to PCT and superior to CRP(AUC-ROC: 0.85, 0.85 and 0.66, respectively, P = NS for presepsin vs PCT and P 1206 pg/m L sensitivity, specificity, positive predictive values and negative predictive values were as follows: 87.5%, 74.5%, 61.8% and 92.7%. The accuracy of presepsin, however, decreased in advanced stage of the disease or in the presence of renal failure, most probably because of the significantly elevated presepsin levels in non-infected patients. 28-d mortality rate was higher among patients with > 1277 pg/m L compared to those with ≤ 1277 pg/m L(46.9% vs 11.6%, P dependent risk factor for 28-d mortality after adjusting with MELd score and leukocyte *** Presepsin is a valuable new biomarker for defining severe infections in cirrhosis, proving same efficacy as PCT. However, it is not a useful marker of short-term mortality.

关键词： Presepsin Cirrhosis Bacterial infection Organ failure Mortality

Novel Insights into the Conservation Physiology and Ex situ Conservation of the Threatened and Rare Semi-Aquatic Moss drepanocladus lycopodioides (Amblystegiaceae)

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Phyton-International Journal of Experimental Botany 2024年第11期93卷 3039-3054页

作者： Jadranin, Bojana Z. Ćosić, Marija V. Božović, djordje P. Vujičić, Milorad M. papp, Beáta Sabovljević, Aneta d. Sabovljević, Marko S. Institute of Botany and Botanical Garden “Jevremovac” Faculty of Biology University of Belgrade Belgrade RS-11000 Serbia Center of Plant Biotechnology and Conservation (CPBC) Belgrade RS-11000 Serbia department of Botany Hungarian Natural History Museum Budapest HU-1476 Hungary department of Plant Biology Institute of Biology and Ecology Faculty of Science Pavol Jozef Šafárik University in Košice Košice SK-040 01 Slovakia

The rare and threatened semi-aquatic moss drepanocladus lycopodioides (Amblystegiaceae) was the subject of growth optimization under ex situ axenic laboratory conditions. The positioning of the plantlets on media, media types as well as selected growth regulators and sugars were parameters tested in optimizing growth promotion of this species in captivity. Out of the tested media types, the KNOP medium and the upright positioning of the explants were the best for propagation and biomass production of d. lycopodioides. The addition of sugars had no significant effect on this moss development axenically, while exogenously applied Benzylaminopurine (BAP) at a concentration of 3 µM induced the development of archegonia on the sterile gametophores and can be used as a marker for confirmation of the female sex, by inducing archegonia on the sterile female plants or clones. This study aimed to contribute to the conservation of this threatened moss species, by massive propagation for reintroduction and population straitening in natural and semi-natural habitats, in scenarios of rapid climate change and water shortage. Laboratory experiments were carried out to study the biological features of the species itself, as due to its rarity empirical data are lacking. This research contributed to the conservation and multiplication of d. lycopodioides and suggested an elegant method to prevent the extinction of this species from its natural habitats. This enables experimental investigation in this species and directs a plan of action for species survival both in captivity (ex situ) and in nature (in situ). © 2024 The Authors.

关键词： biomass Bryophytes development growth protection

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匈牙利学生汉语“了1”用法的偏误分析

匈牙利学生汉语“了1”用法的偏误分析

作者： papp Timea（包婷曼）浙江大学

学位级别：硕士

“了 1”的研究成果很丰富,对它们在汉语中作为第二语言习得中的研究也取得了很多的成果,但对匈牙利这样小语种国家的学生习得情况的研究还很少。但就我的了解来看,匈牙利学生学习和掌握“了 1”有很大的困难,可以说成为了他们学习中很... 详细信息

“了 1”的研究成果很丰富,对它们在汉语中作为第二语言习得中的研究也取得了很多的成果,但对匈牙利这样小语种国家的学生习得情况的研究还很少。但就我的了解来看,匈牙利学生学习和掌握“了 1”有很大的困难,可以说成为了他们学习中很头痛的问题之一。本文打算对匈牙利学生学习汉语里的“了 1”偏误做初步的调查和分析,希望对匈牙利学生学习提供一些帮助。本文一共有五部分:第一章是绪论,论文前言。主要介绍了匈牙利语语法和其他的语言的语法有很大不同,不像汉语,也不像别的欧洲的英语德语法语。因此匈牙利学生要正确了解和应用现代汉语中的“了 1”有较大的困难。研究方法是分析匈牙利学生填了关于使用“了1”的问卷,介绍匈牙利学生犯的偏误,偏误的原因。第二章是介绍“了 1”的功能,语法结构。本章为了便于后来的叙述,本章首先列出以李晓琪《现代汉语虚词讲义》,梁鸿雁《HSK应试语法》与李大忠《外国人学汉语语法偏误分析》为基础,按动作的完成划分为三个类;动作已经完成,预计要完成,假设的完成。其次,使用“了 1”要注意的问题;不能用“了 1”的情况,“了1”的位置在句子里,“了 1”常见的偏误,“了 1”有时间词的句子中的功能。第三章是“了 1”的偏误分析。本章主要介绍匈牙利学生汉语里使用的“了 1”偏误情况问卷调查和统计分析。一共调查了 126名匈牙利学生,我们发现匈牙利学生使用“了 1”过程中出现的偏误类型:“了 1”的误加,“了 1”的遗漏,“了 1”的错位,“了 1”代替“过”。本文还得到了总体偏误率的表,偏误类率表,和对这些表进行的分析。匈牙利学生使用“了 1”时,可以轻松掌握心理动词句和经常或反复多次句子有很少犯偏误错,误率为29%,“是……的结构”偏误率为71.8%,时量补语的句子偏误率为75%。第四章介绍匈牙利学生使用“了 1”的过程中产生偏误的原因。本章主要介绍匈牙利学生学习汉语里的“了 1”时有什么困难,混淆:母语的负迁移,匈牙利语是黏著语,黏著语言主通过改变词形来产生词义,加词缀,词缀可以在词前,在词后,在词里面。在匈牙利语中用时态和过去时的标志或现在时的标志表达动词完成。仍然包含“了 1”与“了 2”混淆,结果补语混淆,“过”混淆,“着”混淆。匈牙利学生像很多其他的国家的学生学习汉语时一样经常受母语负迁移的影响,学生在学习汉语时常常使用母语的语法特征。迁移往往会对匈牙利学生的汉语学习产生负面影响,导致偏误。第五章介绍“了 1”偏误纠正或用法改进的建议。“了 1”教学方法和顺序不尽合理,应该改变教学顺序。通过前文的分析我们认为,教师应该注意教学生比较“了1”使用与使用类似知识点的规则,例如“过”和“了 1”的区别,“是……的”结构和“了 1”一起使用时,“了 1”和“了 2”的区别。另一方面,学生必须清楚理解中文使用“了 1”的规则与匈牙利语中“时态”表达方式的不同。“了 1”不是过去时的必然标志,句子中用不用“了 1”要根据句意和其他情况。学生开始学习“了 1”时,他们需要理解全部用法和所有使用情况。

关键词：了1 了1用法偏误偏误分析匈牙利学生

One stop shop IV: taxonomic update with molecular phylogeny for important phytopathogenic genera: 76-100 (2020)

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Fungal diversity 2020年第4期103卷 87-218页

作者： Ruvishika S.Jayawardena Kevin d.Hyde Yi Jyun Chen Viktor papp Balázs Palla dávid.papp Chitrabhanu S.Bhunjun Vedprakash G.Hurdeal Chanokned Senwanna Ishara S.Manawasinghe dulanjalee L.Harischandra Ajay Kumar Gautam Shubhi Avasthi Boontiya Chuankid Ishani d.Goonasekara Sinang Hongsanan XiangYu Zeng Kapila K.Liyanage NingGuo Liu Anuruddha Karunarathna Kalani K.Hapuarachchi Thatsanee Luangharn Olivier Raspé Rashika Brahmanage Mingkwan doilom Hyang B.Lee Liu Mei Rajesh Jeewon Naruemon Huanraluek Napalai Chaiwan Marc Stadler Yong Wang department of Plant Pathology Agriculture CollegeGuizhou UniversityGuiyang 550025GuizhouChina Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang RaiThailand Key Laboratory for Plant diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China department of Botany Szent István UniversityVillányiút 29-43Budapest 1118Hungary Plant Pathology and Plant-Microbe Biology Section Cornell UniversityGenevaNY 614456USA department of Pomology Szent István UniversityVillányiút 29-43Budapest 1118Hungary School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityNo.9 of ShuguanghuayuanzhongluChiang Mai 50200Thailand Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesHaidian DistrictHaidian DistrictBeijing 100097People’s Republic of China School of Agriculture Abhilashi UniversityMandiHimachal Pradesh 175028India School of Studies in Botany Jiwaji UniversityGwalior 474011India Guangdong Provincial Key Laboratory for Plant Epigenetics College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518055PR China Environmental Microbiology Lab Dept.of Agricultural Biological ChemistryCollege of Agriculture and Life SciencesChonnam National UniversityGwangju 61186Korea department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius department of Microbial drugs Helmholtz Centre for Infection ResearchInhoffenstraße 738124 BraunschweigGermany Honghe Innovation Center for Mountain Futures Kunming Institute of BotanyHonghe CountyYunnan 654400People’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Institute of Plant Health Zhongkai University of Agriculture and EngineeringGuangzhou 510225China Faculty of Agriculture Natural Resources and EnvironmentNaresuan Uni

This is a continuation of a series focused on providing a stable platform for the taxonomy of phytopathogenic fungi and fungus-like *** paper focuses on one family:Erysiphaceae and 24 phytopathogenic genera:Armillaria,Barrio-psis,Cercospora,Cladosporium,Clinoconidium,Colletotrichum,Cylindrocladiella,dothidotthia,,Fomitopsis,Ganoderma,Golovinomyces,Heterobasidium,Meliola,Mucor,Neoerysiphe,Nothophoma,Phellinus,Phytophthora,Pseudoseptoria,Pythium,Rhizopus,Stemphylium,Thyrostroma and *** genus is provided with a taxonomic background,distribution,hosts,disease symptoms,and updated backbone *** confirmed with pathogenicity studies are denoted when data are *** of the genera are updated from previous entries as many new species have been described.

关键词： disease Plant pathology Phylogeny Taxonomy Symptoms

Carbon Paste Electrodes for the Analysis of Some Agricultural Pollutants and Trace Metals

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Journal of Agricultural Science and Technology 2011年第1期5卷 85-92页

作者： Zs. papp V. Guzsvany I. Svancara K. Vytras department of Chemistry Biochemistry and Environmental Protection Faculty of Sciences Trg D. Obradovida 3 Novi Sad RS21000 Republic of Serbia department of Analytical Chemistry Faculty of Chemical Technology University of Pardubice Studentsk6 573 Pardubice CZ53210 Czech Republic

The present work is concerned with the voltammetric application of unmodified tricresyl phosphate carbon paste electrode （TCP-CPE） and in situ bismuth-film modified tricresyl phosphate-based carbon paste electrode （BiF-TCP-CPE）. The TCP-CPE was examined with the main objective of using it for the differential pulse voltammetric analysis of some neonicotinoid insecticides in aqueous Britton-Robinson buffer solution pH 7.0 as supporting electrolyte. After comparing the performance of the TCP-CPE with that of silicone oil carbon paste electrode, quantitative analysis of imidacloprid, thiamethoxam and clothianidin was performed in model solutions and real samples （river water and commercial insecticide formulations）. The in situ prepared BiF-TCP-CPE was tested for a simultaneous detection of selected heavy metal ions （Cd^2＋ and Pb^2＋） at a μg/dm^3 concentration level, using square wave anodic stripping voltammetric technique. The influence of different electrochemical pretreatments of the working electrode on the bismuth deposition and analyte signals were investigated. Film formation was studied at untreated, pre-cathodized and pre-anodized TCP-CPEs in the acetic buffer solution pH 4.6, containing 1 μg/cm^3 Bi （III）.

关键词： Agricultural pollutants neonicotinoids heavy metals carbon paste electrode voltammetry