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Targeting cAMP in d1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy

Acta Pharmaceutica Sinica B 2024年第2期14卷 667-681页

作者： Yue Zhang Jingwen Gao Na Li Peng Xu Shimeng Qu Jinqian Cheng Mingrui Wang Xueru Li Yaheng Song Fan Xiao Xinyu Yang Jihong Liu Hao Hong Ronghao mu Xiaotian Li Youmei Wang Hui Xu Yuan Xie Tianming Gao Guangji Wang Jiye Aa Jiangsu Provincial Key Laboratory of drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesResearch Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical SciencesChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of drug Monitoring and Control Drug Intelligence and Forensic CenterMinistry of Public SecurityBeijing 100193China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Foreign Languages China Pharmaceutical UniversityNanjing 211198China department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China department of Pharmacology China Pharmaceutical UniversityNanjing 211198China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

Studies have suggested that the nucleus accumbens(NAc)is implicated in the pathophysiology of major depression;however,the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been ***,we identified a specific reduction of cyclic adenosine monophosphate(cAMP)in the subset of dopamine d1 receptor medium spiny neurons(d1-MSNs)in the NAc that promoted stress susceptibility,while the stimulation of cAMP production in NAc d1-MSNs efficiently rescued depression-like *** treatment enhanced cAMP both in d1-MSNs and dopamine d2 receptor medium spiny neurons(d2-MSNs)of depressed mice,however,the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc *** discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration,but not a lower *** fast onset property of crocin was verified through multicenter ***,crocin specifically targeted at d1-MSN cAMP signaling in the NAc to relieve depression and had no effect on *** findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in d1-MSNs in the NAc,and provide a potential rapid antidepressant drug candidate,crocin.

关键词： CAMP Nucleus accumbens depression d1-MSN d2-MSN

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关于动力方程的建立及其相关证明之历史探析:从泊松到斯托克斯

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自然辩证法通讯 2024年第1期46卷 64-74页

作者：穆蕊萍西北大学科学史高等研究院陕西西安710127

通过建立动力方程来描述流体运动状态,是早期流体动力学发展历史中的重要目标。在伯努利、达朗贝尔、欧拉、拉格朗日等人的流体静力学工作基础上,泊松、柯西、斯托克斯等人给出了流体动力学中相对完整的方程,重要的是他们证明了动力方... 详细信息

通过建立动力方程来描述流体运动状态,是早期流体动力学发展历史中的重要目标。在伯努利、达朗贝尔、欧拉、拉格朗日等人的流体静力学工作基础上,泊松、柯西、斯托克斯等人给出了流体动力学中相对完整的方程,重要的是他们证明了动力方程在什么条件下是可积的重要定理。对欧拉给出的流体力学基本方程进一步完善,这为19世纪英国以斯托克斯为中心的流体动力学研究奠定了基础。追溯泊松、柯西、斯托克斯三人的数学思想方法,有助于我们更好地认识18世纪末到19世纪数学知识的认知和应用过程。

关键词：流体动力学动力方程重要定理恰当方程

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Seismic anisotropy and upper mantle dynamics in Alaska:A review of shear wave splitting analyses

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Earthquake Research Advances 2024年第2期4卷 72-81页

作者： Zhaofeng Jin Yuchen Yang muhammad Ishaidir Siregar Zihao mu S.M.Ariful Islam Qichao Zhao dan Wang Fan Zhang Xugang Yang Liwei Song School of Earth Sciences Northeast Petroleum UniversityDaqing163318China department of Geoscience University of IndonesiaDepok16424Indonesia School of Computer and Information Technology Northeast Petroleum UniversityDaqing163318China Center for Earthquake Research and Information University of MemphisMemphis38152USA College of Environment and Civil Engineering Chengdu University of TechnologyChengdu610059China School of Petroleum Engineering China University of PetroleumQingdao266555China School of Physics and Electronic Engineering Northeast Petroleum UniversityDaqing163318China

Shear wave splitting(SWS)is regarded as the most effective geophysical method to delineate mantle flow fields by detecting seismic azimuthal anisotropy in the earth's upper mantle,especially in tectonically active regions such as subduction *** Aleutian-Alaska subduction zone has a convergence rate of approximately 50 mm/yr,with a trench length reaching nearly 2800 *** a long subduction zone has led to intensive continental deformation and numerous strong earthquakes in southern and central Alaska,while northern Alaska is relatively *** sharp contrast makes Alaska a favorable locale to investigate the impact of subduction on mantle ***,the uniqueness of this subduction zone,including the unusual subducting type,varying slab geometry,and atypical magmatic activity and composition,has intrigued the curiosity of many *** identify different sources of seismic anisotropy beneath the Alaska region and probe the influence of a geometrically varying subducting slab on mantle dynamics,extensive SWS analyses have been conducted in the past ***,the insufficient station and azimuthal coverage,especially in early studies,not only led to some conflicting results but also strongly limited the in-depth investigation of layered anisotropy and the estimation of anisotropy *** the completion of the Transportable Array project in Alaska,recent studies have revealed more detailed mantle structures and characteristics based on the dense station coverage and newly collected massive seismic *** this study,we review significant regional-and continental-scale SWS studies in the Alaska region and conclude the mantle flow fields therein,to understand how a geometrically varying subducting slab alters the regional mantle *** summarized mantle flow mechanisms are believed to be conducive to the understanding of seismic anisotropy patterns in other subduction zones with a complicated tectonic setting.

关键词： Seismic anisotropy Shear wave splitting Mantle flow Alaska subduction zone Slab

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Influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 563-580页

作者： N.HUMNEKAR d.SRINIVASACHARYA department of Mathematics National Institute of TechnologyWarangal 506004TelanganaIndia

The influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is *** darcyBrinkman model is used to characterize the fluid flow dynamics in porous *** analytical solutions are obtained for the unidirectional and completely developed *** on a normal mode analysis,the generalized eigenvalue problem under a perturbed state is *** eigenvalue problem is then solved by the spectral ***,the critical Rayleigh number with the corresponding wavenumber is evaluated at the assigned values of the other flow-governing *** results show that increasing the darcy number,the Lewis number,the dufour parameter,or the Soret parameter increases the stability of the system,whereas increasing the inclination angle of the channel destabilizes the ***,the flow is the most unstable when the channel is vertically oriented.

关键词： nanofluid inclined channel variable viscosity linear stability double dif-fusion porous medium

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基于挤出式小麦粉3d打印的工艺研究

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粮食与饲料工业 2024年第4期 33-37页

作者：穆王君陕西工业职业技术学院陕西咸阳712000

为提高基于3d打印的食品加工效果,以挤出式的小麦粉3d打印为研究对象,分析了水温、挤出头相对高度、喷嘴直径、水与小麦粉材料配比、活塞进给速率、挤出头相对速度6个工艺参数,对面团3d打印效果的影响,并确定了最佳工艺参数组合为:水温... 详细信息

为提高基于3d打印的食品加工效果,以挤出式的小麦粉3d打印为研究对象,分析了水温、挤出头相对高度、喷嘴直径、水与小麦粉材料配比、活塞进给速率、挤出头相对速度6个工艺参数,对面团3d打印效果的影响,并确定了最佳工艺参数组合为:水温100℃,挤出头相对高度为0.8 mm,喷嘴直径为0.6 mm,去离子水与小麦粉比例为0.8∶1,活塞进给速率为0.66 mm/min,挤出头相对速度为700 mm/min;实例应用表明,在上述最佳工艺参数组合下,3d打印的面团层数更高,精度更多,有效提高了面团3d打印效果。

关键词：面团3d打印小麦粉加工机械设备工艺参数优化

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1950~2020年中国沿海海平面上升

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中国科学：地球科学 2024年第3期54卷 821-829页

作者：穆大鹏徐天河闫昊明山东大学空间科学研究院威海264209 中国科学院精密测量科学与技术创新研究院武汉430071 Institute of Marine and Antarctic Science University of TasmaniaHobartTasmania 7004Australia

验潮站能够观测海平面长期变化,并被用于重构全球平均海平面上升.然而,中国沿海区域的海平面长期变化尚未被揭示.本文构建了一种数据同化方法,可以重构中国沿海地区1950年以来的海平面上升.该方法以全球验潮站观测为约束,同时利用气候... 详细信息

验潮站能够观测海平面长期变化,并被用于重构全球平均海平面上升.然而,中国沿海区域的海平面长期变化尚未被揭示.本文构建了一种数据同化方法,可以重构中国沿海地区1950年以来的海平面上升.该方法以全球验潮站观测为约束,同时利用气候模式输出的动态海平面和陆地水质量迁移导致的海平面指纹效应.本文重构的全球平均海平面上升与之前的研究结果接近.中国沿海地区20个验潮站的重构结果显示,1950~2020年中国沿海平均海平面上升速率为(1.95±0.33)mm a^(-1),高于同时期的全球平均上升速率(1.71±0.17)mm a^(-1).此外,本文还发现,中国沿海平均海平面上升速率在1980年以后是之前速率的3倍以上,速率从1950~1980年的(0.84±0.28)mm a^(-1)增加到1980~2020年的(3.12±0.21)mm a^(-1).该发现说明中国沿海海平面存在显著的加速上升,这些结果增进了对中国沿海海平面长期变化的理解与认识.

关键词：海平面上升中国沿海验潮站数据同化

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decomposition mechanisms of nuclear-grade cationic exchange resin by advanced oxidation processes:Statistical molecular fragmentation model and dFT calculations

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Journal of Environmental Sciences 2024年第1期135卷 433-448页

作者： Xiang Meng Pierre désesquelles Lejin Xu department of Nuclear Engineering and Technology School of Energy and Power EngineeringHuazhong University of Science&TechnologyWuhan 430074China CNRS Laboratoire de Physique des Gaz et des PlasmasUniversitéParis-SaclayOrsay 91405France State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The treatment and disposal of radioactive waste are presently facing great *** ion exchange resins have become a focus of attention due to their high production and serious environmental *** this paper,a simplified model of cationic exchange resin is proposed,and the degradation processes of cationic resin monomer initiated by hydroxyl radicals(·OH)are clarified by combining statistical molecular fragmentation(SMF)model and density functional theory(dFT)*** prediction of active sites indicates that the S-O bonds and the C-S bond of the sulfonic group are more likely to react during the *** meta-position of the sulfonic group on the benzene ring is the most active site,and the benzene ring without the sulfonic group has a certain *** C11-C14 and C17-C20 bonds,on the carbon skeleton,are the most easily *** is also found that dihydroxy addition and elimination reactions play a major role in the process of desulfonation,carbon skeleton cleavage and benzene ring *** decomposition mechanisms found through the combination of physical models and chemical calculations,provide theoretical guidance for the treatment of complex polycyclic aromatic hydrocarbons.

关键词： Cationic exchange resin Statistical molecular fragmentation model density functional theory Hydroxyl radical decomposition mechanism

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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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Role of pituitary adenylate cyclase-activating polypeptide in peripheral nerve regeneration:a cellular and molecular perspective

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Neural Regeneration Research 2024年第7期19卷 1429-1430页

作者： Grazia Maugeri Velia d’Agata Section of Anatomy Histology and Movement SciencesDepartment of Biomedical and Biotechnological SciencesUniversity of CataniaCataniaItaly

Neuro regeneration is a very complex phenomenon characterized by the generation of new neurons and synapses,involving connections between adjacent cells and axonal *** supplies additional longterm resources to replace... 详细信息

关键词： replace functional regeneration

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The Impact of Bias Row Noise to Photometric Accuracy:Case Study Based on a Scientific CMOS detector

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Research in Astronomy and Astrophysics 2024年第2期24卷 228-246页

作者： Li Shao Hu Zhan Chao Liu Haonan Chi Qiuyan Luo Huaipu mu Wenzhong Shi National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China University of Chinese Academy of Sciences Beijing 100049China Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 100875China

We tested a new model of CMOS detector manufactured by the Gpixel Inc,for potential space astronomical *** laboratory,we obtain some bias images under the typical application *** these bias images,clear random row noise pattern is *** row noise also contains some characteristic spatial *** quantitatively estimated the impact of this feature to photometric measurements,by making simulated *** compared different bias noise types under strict parameter *** result shows the row noise will significantly deteriorate the photometric *** effectively increases the readout noise by a factor ***,if it is properly removed,the image quality and photometric accuracy will be significantly improved.

关键词： instrumentation detectors-methods statistical-techniques image processing

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