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Integration of network and experimental pharmacology to decipher the antidiabetic action of duranta repens L.

Journal of Integrative medicine 2021年第1期19卷 66-77页

作者： Pukar Khanal Basanagouda m.Patil department of Pharmacology and Toxicology KLE College of Pharmacy BelagaviKLE Academy of Higher Education and ResearchBelagavi 590010India

Objective:duranta repens is reported to contain a wide array of secondary metabolites,including aamylase and a-glucosidase inhibitors,and-has potent antioxidant *** present study evaluated the network pharmacology of ***(whole plant)with targets related to diabetes mellitus and assessed its outcome by evaluating the effects of the hydroalcoholic extract of *** in streptozotocin-nicotinamide-induced diabetes mellitus in ***:Phytoconstituents of *** were retrieved from an open-source database and published literature,and their targets were predicted for diabetes mellitus using Binding dB and the therapeutic target ***-protein interaction was predicted using STRING,and pathways involved in diabetes mellitus were identified using the Kyoto Encyclopedia of Genes and Genomes pathway ***,AdmET profile(absorption,distribution,metabolism,excretion and toxicity)and cytotoxicity of compounds modulating proteins involved in diabetes were predicted using mol Soft,admet SAR2.0 and CLC-Pred,*** interaction network among phytoconstituents,proteins and pathways was constructed using Cytoscape,and the docking study was performed using Auto *** hydroalcoholic extract of *** was evaluated using streptozotocin-nicotinamide-induced diabetes mellitus animal model for 28 d,followed by an oral glucose tolerance *** the end of the study,biochemical parameters like glycogen content,hepatic enzymes,antioxidant biomarkers and lipid profiles were ***,the liver and pancreas were collected for a histopathology ***:Thirty-six different secondary metabolites from *** were identified to regulate thirty-one targets involved in diabetes mellitus,in which protein-tyrosine phosphatase 1 B(PTP1 B)was primarily *** analysis of modulated proteins identified 12 different pathways in diabetic pathogenesis in which the phosphatidylinositol 3-kinase-protein kinase B(PI3 K-Ak

关键词： diabetes mellitus duranta repens durantaninⅠ Network pharmacology Phosphatidylinositol 3-kinase-protein kinase B signaling pathway Protein-tyrosine phosphatase 1B

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PHARmACOLOGICAL STUdIES ON NEW ANALOGS OF TREmORINE(Ⅰ)

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Chinese Science Bulletin 1980年第12期25卷 1052-1058页

作者： A.W.BALOCH d.dOBRESCU E.CRISTEA m.IOVU department of Pharmaey Institute of Chemistry Sind UniversityJamshoroPakistan.

The analgesic medicines in a rather large number are quite differentiated from one another in intensities as well as in adverse effects.

关键词： medicines analgesic differentiated benzene xylene suffered morphine agree raised 山笋

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Au(111)上Pd电沉积初始阶段ECSTm——PdSO_4溶液研究

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电化学 2003年第2期9卷 126-132页

作者：汤儆 m.Petri L.A.Kibler d.m.Kolb 厦门大学化学系福建厦门361005 大学电化学系 ulm德国89069 Ulm大学电化学系 ulm德国89069

　应用电化学扫描隧道显微镜(ECSTm)研究了PdSO4溶液中Au(111)电极表面Pd的电化学沉积过程.实验表明,Pd的沉积初始阶段在Au(111)电极表面依次生成两个满单层Pd膜,这一实验结果不仅与电位扫描一致,而且更进一步地证明了起初的两个Pd单层... 详细信息

　应用电化学扫描隧道显微镜(ECSTm)研究了PdSO4溶液中Au(111)电极表面Pd的电化学沉积过程.实验表明,Pd的沉积初始阶段在Au(111)电极表面依次生成两个满单层Pd膜,这一实验结果不仅与电位扫描一致,而且更进一步地证明了起初的两个Pd单层形成过程乃以层～层外延方式生长.高分辨的原子图像表明吸附的SO2-4离子在外延生长的Pd膜表面形成了有序的(3×7)R19°结构.

关键词：电沉积初始阶段金电极钯金属薄膜电化学扫描隧道显微镜外延生长

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新疆伊犁北部石炭纪火山岩地球化学特征及其地质意义

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中国地质 2006年第3期33卷 498-508页

作者：王博舒良树 Cluzel d Faure m Charvet J 马前南京大学地球科学系江苏南京210093 奥尔良大学地球科学研究所法国奥尔良45067

石炭纪火山岩广泛分布于西天山伊犁陆块周缘,其岩性复杂,并大多与陆源碎屑岩伴生或互层。其中伊宁阿希、尼勒克和那拉提3个剖面的火山岩岩石地球化学特征显示,这些火山岩属于钙碱性系列,由玄武岩、粗玄岩、玄武质安山岩、玄武质粗面安... 详细信息

石炭纪火山岩广泛分布于西天山伊犁陆块周缘,其岩性复杂,并大多与陆源碎屑岩伴生或互层。其中伊宁阿希、尼勒克和那拉提3个剖面的火山岩岩石地球化学特征显示,这些火山岩属于钙碱性系列,由玄武岩、粗玄岩、玄武质安山岩、玄武质粗面安山岩、安山岩、流纹岩、英安岩和粗面岩组成。稀土元素含量较高,轻稀土元素较重稀土元素富集。这些火山岩亏损高场强元素Nb,Ta,Zr等,而富集大离子亲石元素Th,Rb等,因而这些岩石的形成与板块俯冲有关。微量元素地球化学图解进一步表明,这些岩石形成于大陆岛弧环境。与之共生的早、中石炭世浅海—滨海相沉积地层以及伊犁陆块北缘巴音沟—莫托沙拉沟晚泥盆世—早石炭世蛇绿岩带的存在,表明伊犁陆块北缘在石炭纪时其环境为活动大陆边缘,石炭纪火山岩的形成可能与晚泥盆世—中石炭世早期北天山洋盆向南的俯冲作用有关。

关键词：火山岩地球化学构造环境石炭纪西天山伊犁

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Fatty liver disease and risk of all cause and cause-specific mortality outcomes in the older population

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 949-952页

作者： Josh Bilson Christopher d.Byrne School of Human development and Health Faculty of MedicineUniversity of SouthamptonSouthamptonUK National Institute for Health Research Southampton Biomedical Research Centre University of Southampton and University Hospital Southampton National Health Service Foundation TrustSouthamptonUK

Accumulating evidence in recent years has reinforced the notion that non-alcoholic fatty liver disease/metabolic dysfunction-associated fatty liver disease/metabolic dysfunction steatotic liver disease(NAFLd/mAFLd/mAS... 详细信息

关键词： Fatty liver disease(FLd) non-alcoholic fatty liver disease(NAFLd) metabolic dysfunction steatotic liver disease(mASLd) metabolic dysfunction-associated fatty liver disease(mAFLd) mortality age elderly older population

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A mutual Pulse Injection-Seeding Scheme for Optical Short Pulse Generation

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光学学报 2003年第S1期23卷 649-650页

作者： d. N. Wang department of Electrical EngineeringThe Hong Kong Polytechnic UniversityHung Hom Kowloon Hong Kong P. R. China

A mutual pulse injection-seeding scheme is developed to produce wavelength tunable optical short pulse generation. The sidemode suppression ratio obtained is more than 31 dB over the wavelength-tuning rang of 18 nm.

关键词： for in In of nm A mutual Pulse Injection-Seeding Scheme for Optical Short Pulse Generation than

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电阻式核磁共振测量的最新进展

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物理学报 2012年第14期61卷 366-378页

作者：刘洪武杨凯锋 T.d.mishima m.B.Santos K.Nagase Y.Hirayama 吉林大学超硬材料国家重点实验室原子与分子物理研究所长春130012 ERATO Nuclear Spin Electronics Project-JST SendaiMiyagi 980-8578Japan Homer L.dodge department of Physics and Astronomy University of OklahomaNormanOklahoma 73019-2061USA department of Physics Tohoku UniversitySendaiMiyagi 980-8578Japan

电阻式核磁共振(RdNmR)测量是1988年由德国马普所的von Klitzing研究小组针对GaAs二维电子气中少量核自旋的探测而提出的一种具有超高灵敏度的实验技术.目前,RdNmR已经成为研究单层或双层GaAs二维电子气核自旋和电子自旋特性的重要手段... 详细信息

电阻式核磁共振(RdNmR)测量是1988年由德国马普所的von Klitzing研究小组针对GaAs二维电子气中少量核自旋的探测而提出的一种具有超高灵敏度的实验技术.目前,RdNmR已经成为研究单层或双层GaAs二维电子气核自旋和电子自旋特性的重要手段.由于为实现电阻式核磁共振测量所建立的动态核极化方法强烈依赖于GaAs特有的材料属性,至今这一技术一直没有扩展应用到其他半导体低维系统中.最近,本研究小组发展了一种动态核极化新方法,成功实现了对典型窄带半导体锑化铟(InSb)二维电子气的电阻式核磁共振测量.本文在介绍电阻式核磁共振测量工作原理及已建立的典型动态核极化方法的基础上,着重讨论所提出的动态核极化新方法的机理、实验结果以及对今后研究的展望.

关键词：半导体二维电子气电阻式核磁共振测量动态核极化窄带半导体

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Strategies in secondary biliary fibrosis

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Journal of Biomedical Science and Engineering 2013年第8期6卷 10-18页

作者： José m. Hermosillo-Sandoval Adolfo d. Rodríguez-Carrizález Alejandra G. miranda-díaz department of Surgery Specialties Hospital of the National Occidental Medical Centre Social Security Institute of Mexico Guadalajara México University Health Sciences Centre University of Guadalajara Guadalajara México

The cellular and molecular mechanisms that mediate hepatic fibrosis have provided a framework of different therapeutic foci to prevent, delay or in such case revert fibrosis and cirrhosis. The fundamental event in development of hepatic fibrosis caused by secondary biliary cholestasis is based on activation of the hepatic stellar cells (HSC) which the primary function is forming fibrosis. The activated HSC cells transform into myofibroblasts with capacity to produce alpha smooth muscle actin (α-SmA). As a result, the HSC activates proliferation of the cholangiocytes and epithelial cells whose functions represent important anti-fibrotic objectives. Some strategies are described as targeting against molecule involved in fibrosis production;and some medications with anti-fibrotic functions that are actually available in the medical arsenal have been tested in experimental animal models and in few clinical studies, and their components act in relation to the fibrotic cascade. In the end, the treatment strategies for hepatic fibrosis can vary on an individual basis depending on the etiology, the risk of fibrosis progression and the predominant pathogenic medium, which indicates that a multi-factorial approach could be necessary. Orthotopic liver transplant continues being the last final alternative for hepatic insufficiency from any cause;however, in no way does it supersede healthy natural liver in survival and adequate function. The investigative arsenal continues to develop rapidly, giving rise to other possible objectives in pre-clinical studies of conceptual trials, such as the utilization of molecular, cellular, drugs therapy and Chinese herbs. despite being aforementioned, there are no existing ideal alternatives that completely reverse fibrosis in humans. Future usefulness of the majority of management alternatives seems probable and could be feasible.

关键词： Bile duct Lesion Bile duct Injury Bile duct Atresia Hepatic Cholestasis Secondary Biliary Fibrosis Hepatic Transplant

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The Investigations into β-Cyclodextrinas HPLC mobile Phase Chiral Additives　*** Adsorption of β-Cyclodextrin and Its methylated derivative on an OdS Stationary Phase

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中国药科大学学报 1997年第1期 33-37页

作者：ＨｏｎｇｘｉＬＩＡＮＧＤ．Ｇ．ＤｕｒｈａｍＴｈｅＳｃｈｏｏｌｏｆＰｈａｒｍａｃｙＴｈｅＲｏｂｅｒｔＧｏｒｄｏｎＵｎｉｖｅｒｓｉｔｙＴｈｅＡｎａｌｙｔｉｃａｌ＆ＣｏｍｐｕｔｅｒＣｅｎｔｒｅＣｈｉｎａＰｈａｒｍａｃｅｕｔｉｃａｌＵｎｉｖｅｒｓｉｔｙ

通过ＨＰＬＣ结合旋光光度定量的方法，探讨了流动相添加剂β－环糊精及其２，６－二甲基衍生物的吸附性质。结果表明β－环糊精在ＯＤＳ固定相上不吸附，而其２，６－二甲基衍生物则呈典型的单分子层吸附。

关键词： β-环糊精吸附 OdS固定相手性流动相添加剂

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A Study on the Effect of Welding Sequence in Fabrication of Large Stiffened Plate Panels

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Journal of marine Science and Application 2011年第4期10卷 429-436页

作者： Pankaj Biswas d. Anil Kumar N.R.mandal m.m.mahapatra department of mechanical Engineering department of Ocean Engineering & Naval Architecture

Welding sequence has a significant effect on distortion pattern of large orthogonally stiffened panels normally used in ships and offshore structures. These deformations adversely affect the subsequent fitup and alignment of the adjacent panels. It may also result in loss of structural integrity. These panels primarily suffer from angular and buckling distortions. The extent of distortion depends on several parameters such as welding speed, plate thickness, welding current, voltage, restraints applied to the job while welding, thermal history as well as sequence of welding. Numerical modeling of welding and experimental validation of the FE model has been carried out for estimation of thermal history and resulting distortions. In the present work an FE model has been developed for studying the effect of welding sequence on the distortion pattern and its magnitude in fabrication of orthogonally stiffened plate panels.

关键词： elasto-plastic analysis welding distortion 3-d finite element analysis stiffened panel weldingsequence

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