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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Structure of Interphase Boundaries in Bimetallic Thin Films

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Journal of materials Science & Technology 2001年第1期17卷 59-60页

作者： m.d.Starostenkov G.m.Poletayev d.m.Starostenkov General Physics department Altai State Technical UniversityBarnaulRussia

The structural transformation in thin films of bimetals in the dependence on temperature and concentration of vacancies was investigated. The system Ni-Al structural transformation was realized by computer design according to the mechanism of self-sustained high(temperature synthesis. Structural transformation is characterized by the presence of dislocations, clusters of point defects and germs of intermetallic phases near interphase boundaries.

关键词： structural transformation intermetallic phases thin films

dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU W.m.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3d) braided composites into rotating blade components. In this paper, a dynamic model of 3d 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3d braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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The electrical impedance, AC conductivity and dielectric properties of phenol red compound investigated and modeled by an artificial neural network

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Communications in Theoretical Physics 2020年第10期72卷 139-148页

作者： H A m Ali d m Habashy Physics department Faculty of EducationAin Shams UniversityRoxyCairo 11757Egypt

The impedance spectroscopy,electrical conductivity and electric modulus of bulk phenol red were measured,as a function of both frequency and *** neural networks(ANNs)were used for modeling its electrical *** two parts(real and imaginary)of its complex impedance(Z^*)were analyzed and the activation energy related to the electrical relaxation process was *** curves were plotted showing semicircles for the different *** AC electrical conductivity follows a power lawσac(ω)αω^η.The maximum barrier height Bm was derived for specific temperatures.A plausible mechanism for the AC conduction of bulk phenol red was deduced from the temperature reliance of the frequency *** dielectric data was analyzed using electric modulus as a *** addition,ANNs were used to model the impedance parts and the total electrical *** runs were tried,to obtain the best *** training and prediction results were compared to the equivalent experimental results,with a good match *** equation describing the experimental results was obtained mathematically,based on the use of *** outputs demonstrated that ANNs are an admirable tool for modeling experimental results.

关键词： phenol red impedance spectroscopy electric modulus neural network

An Iterative Relaxation Approach to the Solution of the Hamilton-Jacobi-Bellman-Isaacs Equation in Nonlinear Optimal Control

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 360-366页

作者： m.d.S.Aliyu department of Electrical Engineering King Faisal University Al-Ahsa 31982 Saudi Arabia IEEE

In this paper, we propose an iterative relaxation method for solving the Hamilton-Jacobi-Bellman-Isaacs equation(HJBIE) arising in deterministic optimal control of affine nonlinear systems. Local convergence of the method is established under fairly mild assumptions, and examples are solved to demonstrate the effectiveness of the method. An extension of the approach to Lyapunov equations is also discussed. The preliminary results presented are promising, and it is hoped that the approach will ultimately develop into an efficient computational tool for solving the HJBIEs.

关键词： Affine nonlinear system bounded continuous function convergence Hamilton-Jacobi-Bellman-Isaacs equation Lyapunov equation relaxation method Riccati equation

Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim Vanmierlo Rudy Schreiber BIOmEd Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&d ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur Kimberly m.Alonge department of medicinal Chemistry University of WashingtonSeattleWAUSA department of Chemistry University of WashingtonSeattleWAUSA department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Solution of nonlinear cubic-quintic duffing oscillators using He’s Energy Balance method

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1263-1268页

作者： d.d.GANJI m.GORJI S.SOLEImANI m.ESmAEILPOUR department of mechanical Engineering University of Mazandaran

In this study, He＇s Energy Balance method （EBm） was applied to solve strong nonlinear duffing oscillators with cubic-quintic nonlinear restoring force. The complete EBm solution procedure of the cubic-quintic duffing oscillator equation is presented. For illustration of effectiveness and convenience of the EBm, different cases of cubic-quintic duffing oscillator with different parameters of α,β and y were compared with the exact solution. we found that the solutions were valid for small as well as large amplitudes of oscillation. The results show that the EBm is very convenient and precise, so it can be widely appli- cable in engineering and other sciences.

关键词： Energy Balance method (EBm) Cubic-quintic duffing equation Oscillator

Analysis of turbulent mHd Couette nanofluid flow and heat transfer using hybrid dTm-Fdm

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Particuology 2016年第3期14卷 95-101页

作者： S. mosayebidorcheh m. Sheikholeslami m. Hatami d.d. Ganji Young Researchers and Elite Club Najafabad Branch lslamicAzad University Ndjafabad Iran department of mechanical Engineering Lenjan Branch Islamic Azad University lsfahan Iron department of mechanical Engineering Babol University of Technology Babol Iran mechanical Engineering department Engineering and Technical College Esfarayen University Esfarayen North Khorasan lran

Unsteady turbulent magnetohydrodynamic nanofluid hydrothermal treatment is studied. The zero- equation turbulence model is used to simulate turbulent flow. The modeling results obtained by applying the hybrid differential transformation method-finite difference method to solve this problem confirm its viability. An analytical procedure is used for finding the effects of the problem parameters. Results indicate that the average Nusselt number over the lower plate depends linearly on volume fraction of nanofluid, Hall parameter, turbulent Eckert number, and Reynolds number whereas it is inversely proportional on the Hartmann number and the turbulent parameter.

关键词： Turbulent Hall effect Hybrid dTm-Fdm Nanofluid magnetohydrodynarnic couette flow