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修订的Choi影像标准与应用舒尼替尼治疗转移性肾细胞癌病人的临床结果相关

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国际医学放射学杂志 2015年第1期 66-66页

作者： Y.Thian A.Gutzeit d.m.koh R.Fisher H.Lote J.Larkin departments of Radiology and medical Oncology Royal Marsden Hospital

目的结合在早期随访影像中肿瘤大小和密度衰减的同步变化,对应用舒尼替尼治疗转移性肾细胞癌病人的不同临床结果分别进行修订的Choi、实体瘤疗效评价标准(RECIST)1.1及原始的Choi 3种标准比较。材料与方法本

关键词：转移性肾细胞癌舒尼替尼 Choi 临床结果病人

结直肠肿瘤的CT灌注血管参数和免疫组化获得的微血管密度计数不相关

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国际医学放射学杂志 2013年第5期 480-480页

作者： S.dighe H.Blake N.Jeyadevan I.Castellano d.m.koh m.Orton 王影 department of Radiology Royal Marsden NHS TrustRoyal Marsden Hospital

摘要目的评价CT灌注得到的血管参数,即血流量、平均通过时间(mTT)、容量转移常数(Ktrans)、渗透性表面积乘积(PS)、细胞外血管外间隙容积以及血管容积等,是否与结直肠肿瘤中代表血管生成的免疫组化标志物存在联系。材料与方法该前瞻性... 详细信息

摘要目的评价CT灌注得到的血管参数,即血流量、平均通过时间(mTT)、容量转移常数(Ktrans)、渗透性表面积乘积(PS)、细胞外血管外间隙容积以及血管容积等,是否与结直肠肿瘤中代表血管生成的免疫组化标志物存在联系。材料与方法该前瞻性研究获得了地区伦理委员会以及研究与发展委员会的批准。29例病人均签署知情同意书(男14例,女15例;年龄55～94岁,平均70岁)。以分期为目的的术前CT检查中加入CT灌注扫描程序。CT灌注参数分别由2名放射学

关键词：结直肠肿瘤灌注参数免疫组化血管微血管密度 CT

应用扩散加权成像和功能扩散图评估前列腺癌骨转移疗效的初步研究

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国际医学放射学杂志 2011年第1期34卷 77-页

作者： C.Reischauer J.m.Froehlich d.m.koh N.Graf C.Padevit H.John 李睿 Institute for Biomedical Engineering ETH and University Zurich

目的应用磁共振扩散加权成像(mRdWI)的表观扩散系数(AdC)和功能扩散图(dm),前瞻性研究并监测抗雄性激素治疗对前列腺癌骨转移病人的疗效。

关键词：前列腺癌骨转移病人雄性激素功能扩散疗效

实体肿瘤用考布他汀A4磷酸盐和贝伐单抗治疗后表观扩散系数的重复性和变化:两中心一期临床试验

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国际医学放射学杂志 2010年第1期 93-93页

作者： d.m.koh m.Blackledge d.J.Collins A.R.Padhani T.Wallace B.Wilton 涂景恋 department of Radiology Royal Marsden HospitalDowns RoadSM25PT SuttonUK

本研究的目的是通过两中心的一期临床试验确定表观扩散系数(AdC值)的可重复性,并且在序贯给予血管阻断剂考布他汀A4磷酸盐(CA4P)及抗血管生成药物贝伐单抗后追踪AdC值的变化。16例有实性肿瘤的病人接受了CA4P和贝伐单抗的治疗。采用6个b... 详细信息

本研究的目的是通过两中心的一期临床试验确定表观扩散系数(AdC值)的可重复性,并且在序贯给予血管阻断剂考布他汀A4磷酸盐(CA4P)及抗血管生成药物贝伐单抗后追踪AdC值的变化。16例有实性肿瘤的病人接受了CA4P和贝伐单抗的治疗。采用6个b值(b=0～750s/mm2)分别在第一次给予CA4P前(2次),给

关键词：贝伐单抗 CA 表观扩散系数 A4 临床试验他汀考布磷酸盐磷肥

钆塞酸二钠增强mRI肝胆期经脾和肌肉校正后的肝脏强化信号的年龄依赖关系

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国际医学放射学杂志 2016年第4期 462-462页

作者： S.matoori J.m.Froehlich S.Breitenstein A.doert V.Pozdniakova d.m.koh 方壮念 department of Radiology Paracelsus Medical University Salzburg

摘要目的研究钆塞酸二钠增强mRI肝胆期非肝硬化病人的年龄与经过参照组织[脾、肾脏、肝脏、竖脊肌(mES)、肝胆管(dHC)]校正的组织信号强度的相关性。方法 2008年11月—2013年6月期间,131例临床病史不相同的病人进行了标准化的钆塞酸二... 详细信息

摘要目的研究钆塞酸二钠增强mRI肝胆期非肝硬化病人的年龄与经过参照组织[脾、肾脏、肝脏、竖脊肌(mES)、肝胆管(dHC)]校正的组织信号强度的相关性。方法 2008年11月—2013年6月期间,131例临床病史不相同的病人进行了标准化的钆塞酸二钠增强3.0 T mRI检查。排除肝硬化

关键词：钆塞酸二钠 mRI 肝脏肝胆

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi department of Brain Science Ajou University School of MedicineSuwonSouth Korea department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea department of Neurology Ajou University School of MedicineSuwonSouth Korea department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a dNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa department of Psychology and Neuroscience Duke UniversityDurhamNCUSA department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3