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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Projection-Based dimensional Reduction of Adaptively Refined Nonlinear Models

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Communications on Applied Mathematics and Computation 2024年第3期6卷 1779-1800页

作者： Clayton little Charbel Farhat department of Mechanical Engineering Stanford UniversityStanfordUSA department of Aeronautics and Astronautics Stanford UniversityStanfordUSA Institute for Computational and Mathematical Engineering Stanford UniversityStanfordUSA

Adaptive mesh refinement (AMR) is fairly practiced in the context of high-dimensional, mesh-based computational models. However, it is in its infancy in that of low-dimensional, generalized-coordinate-based computational models such as projection-based reduced-order models. This paper presents a complete framework for projection-based model order reduction (PMOR) of nonlinear problems in the presence of AMR that builds on elements from existing methods and augments them with critical new contributions. In particular, it proposes an analytical algorithm for computing a pseudo-meshless inner product between adapted solution snapshots for the purpose of clustering and PMOR. It exploits hyperreduction—specifically, the energy-conserving sampling and weighting hyperreduction method—to deliver for nonlinear and/or parametric problems the desired computational gains. Most importantly, the proposed framework for PMOR in the presence of AMR capitalizes on the concept of state-local reduced-order bases to make the most of the notion of a supermesh, while achieving computational tractability. Its features are illustrated with CFd applications grounded in AMR and its significance is demonstrated by the reported wall-clock speedup factors.

关键词： Adaptive mesh refinement(AMR) Computational fluid dynamics Energy-conserving sampling and weighting(ECSW) Model order reduction Reduced-order model Supermesh

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Structural and optical properties of periodically ordered ZnO nanowires

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Science China(Technological Sciences) 2009年第2期52卷 313-317页

作者： J.B.CUI department of Physics and Astronomy, University of Arkansas at little Rock, little Rock, AR 72204, USA 1. department of Physics and Astronomy University of Arkansas at Little Rock Little Rock AR 72204 USA

Periodically ordered ZnO nanowire arrays were fabricated by a combination of soft templates created by electron beam lithography and an electrochemical process. Individual ZnO nanowires were precisely placed in desired locations to form two-dimensional periodic structures with specific patterns. Scanning electron microscopy and light diffraction measurements confirmed the long-range ordered structures in the nanowire arrays. Variable temperature photoluminescence revealed both band edge and defect emissions. The obtained photonic structures may have potential applications in optical and optoelectronic devices.

关键词： Zinc oxide nanowires ordered structure optical property

Visible light positioning: moving from 2d planes to 3d spaces [Invited]

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Chinese Optics Letters 2019年第3期17卷 27-35页

作者： E.W.Lam T.d.C.little Electrical and Computer Engineering department Boston University

The global navigation satellite system(GNSS) is a well-established outdoor positioning system with industry-wide impact due to the multifaceted applications of navigation, tracking, and automation. At large, however, is the indoor equivalent. One hierarchy of solutions, visible light positioning(VLP) with its promise of centimeter-scale accuracy and widespread coverage indoors, has emerged as a viable, easy to configure, and inexpensive candidate. We investigate how the state-of-the-art VLP systems fare against two hard barriers in indoor positioning: the need for high accuracy and the need to position in the threedimensions(3d). We find that although most schemes claim centimeter-level accuracy for some proposed space or plane, those accuracies do not translate into a realistic 3d space due to diminishing field-of-view in 3d and assumptions made on the operating space. We do find two favorable solutions in ray–surface positioning and gain differentials. Both schemes show good positioning errors, low-cost potential, and single-luminaire positioning functionality.

关键词： Visible light positioning moving from 2d planes to 3d spaces [Invited]

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Sample indexed spatial orthogonal frequency division multiplexing

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Chinese Optics Letters 2014年第9期12卷 10-14页

作者： Pankil Butala Hany Elgala Thomas d.C.little department of Electrical and Computer Engineering Boston University

Optical spatial modulation （OSM） is a multiple-transmitter technique that can provide higher data rates with low system complexity as compared with single-input single-output systems. Orthogonal frequency division multiplexing （OFdM） is widely implemented to achieve better spectral efficiency in wireless channels. Asymmetrically clipped optical OFdM （O-OFdM） and dC-biased O-OFdM are two well-known O-OFdM techniques suitable for intensity-modulation direct-detection optical systems. In this work, sample indexed spatial OFdM （SIS-OFdM） is proposed to combine OSM and O-OFdM in a novel way and achieve significant per- formance gain. By assigning time-domain samples of the O-OFdM transmit symbol to different transmitters, SIS-OFdM achieves much better spectral efficiency and reduces computational complexity at the transmitter as compared with previous work that combines OSM with O-OFdM in the frequency domain. We also consider the impact of optical source biasing on overall performance, and the relative performance of imaging receiver （ImR） versus non-imaging receiver （NImR） design for our proposed SIS-OFdM technique. Results indicate that for an Ntx x Nrx multiple-input multiple-output configuration where Nix = N = 4, SIS-OFdM using ImR can achieve up to 135 dB of signal-to-noise ratio gain over comparable system using a NImR. Also, using Nc number of O-OFdM subcarriers provides up to Nsc × log2（Ntx） additional bits per symbol of spectral efficiency over technioues that combine OSM and O-OFdM in the freollencv domain.

关键词： OFdM SIS dCO Sample indexed spatial orthogonal frequency division multiplexing