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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

OPTICAL COHERENCE TOMOGRAPHY MEASUREMENT OF MACULAR ANd NERVE FIBER LAYER THICKNESS IN NORMAL ANd GLAUCOMATOUS HUMAN EYES

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国际眼科杂志 2003年第1期3卷 22-22页

作者： V.Guedes J.S.Schuman E.Hertzmark G.Wollstein A.Correnti R.Mancini d.lederer S.Voskani-an L.Velazquez H.M.Pakter T.Pedut-Kloizman J.G.Fujimoto C.Mattox R.Susanna Jr. Universidade de Sao Paulo Instituto Benjamin Constant Brazil New England Eye Center Tufts School of Medicine Harvard School of PublicHealth MA USA Universidade Federal do Rio Grande do Sul Brazil Massachusetts Institute of Tecnology MA USA

This cross-sectional study evaluates the hypothesis that macular thickness and nerve fiber layer thickness correlate with the diagnosis of glaucoma It was used prototype optical coherence tomography unit to measure macular and nerve fiber layer thickness, and to analyze their correlation with glaucoma status. It was studied 367 subjects (534 eyes), including 166 eyes of 109 normals, 83 eyes of 58 glaucoma suspects, 196 eyes of 132.

关键词：体层摄影术光学相干人类

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Accuracy of training blood volume quantifi cation using a visual estimation tool

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World Journal of Emergency Medicine 2021年第3期12卷 174-178页

作者： Janett Kreutziger Philip Puchner Stefan Schmid Wolfgang Mayer Harald Prossliner Wolfgang lederer department of General and Surgical Intensive Care Medicine Medical University of InnsbruckInnsbruck 6020Austria department of Anesthesiology and Critical Care Medicine Wels-Grieskirchen HospitalWels 4600Austria department of Transfusion Medicine Medical University of InnsbruckInnsbruck 6020Austria department of Anaesthesia and Intensive Care Medicine Medical University of InnsbruckInnsbruck 6020Austria

BACKGROUNd:We investigated whether the use of a specially designed visual estimation tool may improve accuracy in quantifying blood volumes related to surface ***:A prospective,paired-control,single-blinded experimental study was performed at a medical *** and emergency medical personnel estimated various blood volumes on surfaces with varying absorptivity(carpet,towel,polyvinyl chloride,wooden fl ooring)in an experimental *** assessed the sensitivity of training blood volume quantifi cation using a self-designed visual estimation tool by comparing the accuracy of visual blood volume estimations before and after practical training with the ***:A total of 352 estimations by 44 participants were *** estimations improved significantly from pre-training to post-training(Pd volume quantifi cation was 33.0%after training with the visual estimation *** did not depend on age,profession,gender or years of the estimator’s professional ***:Training with a visual estimation tool by professional rescuers can improve the estimation accuracy of blood volumes spread on surfaces with varying absorptivity.

关键词： Academic training Emergency medicine Hemorrhage control Major bleeding

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.KIRAN d.SINGH R.VAISH V.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSdT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports

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World Journal of Clinical Cases 2020年第1期8卷 103-109页

作者： Sophia Chikhladze Ann-Kathrin lederer Stefan Fichtner-Feigl Uwe A Wittel Martin Werner Konrad Aumann department of General and Visceral Surgery Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Center for Complementary Medicine Department of Infection Prevention and Hospital EpidemiologyMedical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute of Surgical Pathology Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany

BACKGROUNd Sclerosing angiomatoid nodular transformation(SANT)is a rare benign disease of the spleen with unknown *** symptoms are inhomogeneous,and suspicious splenic lesion often found incidentally,leading to splenectomy,as malignancy cannot securely be ruled *** is made histologically after *** SUMMARY Two cases of German,white,non-smoking,and non-drinking patients of normal weight are *** first one is a 26-year-old man without medical history who was exhibiting an undesired weight loss of 10 kg and recurring vomiting for about 18 *** second one is a 65-year-old woman with hypertension who had previously undergone gynecological surgery,suffering from a lasting feeling of abdominal *** showed radiologically an inhomogeneous splenic lesion leading to splenectomy approximately 6 and 9 wk after surgical *** diagnoses of SANT were made ***-up went well,and both were treated according to the recommendation for asplenic *** SANT is a rare cause of splenectomy and an incidental histological *** research should focus on clinical and radiological diagnosis of SANT as well as on treatment of patients with asymptomatic and small findings.

关键词： Splenectomy Sclerosing angiomatoid nodular transformation Spleen Abdominal discomfort Gastrointestinal dysfunction Case report

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英语学习 1999年第2期 62-63页

作者： Richard.lederer

One of the fringe benefitsof being an English orhistory teacher is receiv-ing the occasional jewelof a student blooper in an *** pasted together the following"history"of the world from certifi-ably genuine,authentic,and unre-touched student bloopers collectedby teachers throughout the UnitedStates,from eighth grade *** carefully and you willlearn a lot.

关键词： THE WORLd ACCORdING TO STUdENT BLOOPERS