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Jetting-based bioprinting:process,dispense physics,and applications

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Bio-design and Manufacturing 2024年第5期7卷 771-799页

作者： Wei long ng Viktor Shkolnikov Singapore Centre for 3d Printing(SC3dP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore HP Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based *** review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet ***,we highlight recent accomplishments in jetting-based *** present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting.

关键词： 3d bioprinting Biofabrication Jetting-based dispense physics Machine learning

Potential Hydrodynamic Performance Enhancement of Hydrokinetic Turbine with Hydrophobic Coatings

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China Ocean Engineering 2021年第6期35卷 924-932页

作者： CHEN long ng Kai-Wern School of Hydraulic and Environmental Engineering Changsha University of Science and TechnologyChangsha 410114China department of Civil Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Key laboratory of Water-Sediment Sciences and Water disaster Prevention of Hunan Province Changsha University of Science and TechnologyChangsha 410114China

Hydrokinetic energy is a promising technology to harness predictable renewable energy from free-flowing water,tides and ocean *** studies have been conducted by researchers and engineers to find out ways to enhance the performance of the hydrokinetic *** current paper reports the experimental study of using hydrophobic coating as an alternative way to improve the performance of hydrokinetic turbine.A hydrophobic coating can lower the friction drag of a surface that is in contact with *** hydrokinetic turbine blade,reduction in friction drag may allow a blade section to have a better lift/drag ratio and have its efficiency *** this study,a formula to predict the pattern of drag reduction over a hydrophobic surface has been *** hydrophobic coatings were applied on NACA 63418 hydrofoils and their performances were *** was found that NACA 63418 hydrofoil with the hydrophobic coatings had its drag reduced by an average of 3%−4.0%.When the coatings were applied on a 350 mm diameter three-bladed turbine,the maximum increment of rotational speed of the turbine was found to be 2.5%.The performance of the two coatings against marine fouling was also *** weight of plate with and without the coatings increased by 10%and 100%,respectively.

关键词： hydrophobic coating hydrokinetic energy marine fouling

A New Triterpenoid Saponin from Aralia subcapitata

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Chinese Chemical letters 2000年第10期11卷 913-914页

作者： Zou, Ml Sang, SM Xia, zh lao, AN Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

A new oleanane-type saponin, named subcapitatoside A, has been isolated from the roots of Aralia subcapitata. On the basis of chemical and spectral evidence: the structure of subcapitatoside A has been established as:... 详细信息

关键词： Aralia subcapitat oleanane-type saponin subcapitatoside A

Indexing Non-merohedrally Twinned Crystals by Bruker'sAPEX2 and Agilent's CrysAlis^(PRO), an Example of a Crystal Structure That Can Be Refined through Either the PlATONRoute or the ‘HKlF 5' Route, and, Simultaneous data Collection of Two Crystals in a Two-in-one Run

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Chinese Journal of Structural Chemistry 2014年第2期33卷 294-303页

作者： ng Seik Weng department of Chemistry University of Malaya 50603 Kuala Lumpur Malaysia Chemistry department King Abdulaziz University

The first part of this report describes the data reduction of non-merohedrally twinned crystals measured on Bruker and Agilent area-detector diffractometers. The image frames of methyl-2-aminopyrazine-3-carboxylate were processed with APEX2 to furnish a set of overlapping diffraction indices that were used for solution and refinement. CrysAlisPRO was used for processing the frames of bis（diethyldicarbamato）nickel, which exists in monoclinic and tetragonal polymorphs, and in untwinned and twinned forms. In the second part, the crystal structure of [（3-formyl-4- hydroxyphenyl）methyl]triphenylphosphanium chloride was refined through the ‘HKlF 5＇（based on a combined set of diffraction indices） and PlATON（based on one set of diffraction indices） routes to give identical outcomes because the amount of overlap of the twin domains is small. For the third part, in a proof-of-concept investigation, the diffraction pattern of untwinned and twinned 4-{（E）-（4-aminophenyl）diazenyl]phenylamine was recorded simultaneously in one run; the three domains could be indexed and the crystal structure satisfactorily refined. The refinement was identical to those derived from independent measurements; the crystal structure features two independent centrosymmetric molecules, one of which is ordered and the other whole-molecule-disordered. This two-in-one run opens up the possibility that two or more crystals having different atomic compositions can be measured simultaneously if their reciprocal lattices do not overlap significantly.

关键词： merohedral non-merohedral twin APEX2 Crys Alis^PRO two-in-one data collection

A Nonstandard lévy-Khintchine Formula and lévy Processes

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Acta Mathematica Sinica,English Series 2008年第2期24卷 241-252页

作者： Siu Ah ng School of Mathematical Sciences University of KwaZulu-Natal Pietermaritzburg 3209 South Africa

We use methods from nonstandard analysis to obtain a short and simple derivation of the levy-Khintchine formula via an explicit construction of certain laws of the infinitesimal increments. Consequently, any arbitrary... 详细信息

关键词： levy processes levy-Khintchine formula nonstandard analysis infinitesimal hyperfinite

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

AN EXACT ANAlYSIS OF THERMAl BUCKlIng OF PIEZOElECTRIC lAMINATEd PlATES

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Acta Mechanica Solida Sinica 1997年第2期10卷 95-107页

作者： Shang, Fl Wang, ZK li, zh XIAN JIAOTOng UNIV DEPT ENGN MECHXIAN 710049PEOPLES R CHINA

In this paper, the governing differential equations of elastic stability problems in thermopiezoelectric media are deduced. The solutions of the thermal buckling problems for piezoelectric laminated plates are presented in the context of the mathematical theory of elasticity. Owing to the complexity of the eigenvalue problem involved, the critical temperature values of thermal buckling must be solved numerically. The numerical results for piezoelectric/non-piezoelectric laminated plates are presented and the influence of piezoelectricity upon thermal buckling temperature is discussed.

关键词： thermopiezoelectric media laminated plates thermal buckling

A FINITE-ElEMENT ANAlYSIS OF ElECTROMAGNETIC SHEET METAl-EXPANSION PROCESS

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中国有色金属学会会刊：英文版 1998年第3期8卷 135-140页

作者： Huang, SY Chang, zh Wang, ZR Wang, lF Yang, M Wuhan Automot Polytech Univ Sch Mat Engn Wuhan 430070 Peoples R China Harbin Inst Technol Sch Mat Sci & Engn Harbin 150006 Peoples R China

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１ＩＮＴＲＯＤＵＣＴＩＯＮＥｌｅｃｔｒｏｍａｇｎｅｔｉｃｆｏｒｍｉｎｇ，ｅｓｅｎｔｉａｌｙｂｅｉｎｇａｋｉｎｄｏｆａｐｐｌｉｃａｔｉｏｎｏｆｉｍｐｕｌｓｅｉｎｔｅｎｓｉｖｅｃｕｒｅｎｔｔｅｃｈｎｉｑｕｅｉｎｍｅｔａｌｗｏｒｋｉｎｇ，ｄｅａｌｓｗｉｔｈ...

关键词： finite element analysis electromagnetic forming magnetic pressure

A New Modification to Shear lag Model as Applied to Stiffness and Yield Strength of Short Fiber Reinforced Metal Matrix Composites

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Journal of Materials Science & Technology 1998年第6期14卷 516-522页

作者： Jiang, zh lian, JS Yang, dZ dong, Sl Jilin Univ Technol Dept Mat Sci & Engn Changchun 130025 Peoples R China Harbin Inst Technol Sch Mat Sci & Engn Harbin 150001 Peoples R China

A new modification for the shear lag model is given and the expressions for the stiffness and yield Strength of short fiber metal matri×composite are derived. These expressions are then compared with our experimental data in a SiCw/Al-li T6 composite and the published experimental data on different SiCw/Al T6 composites and also compared with the previous shear lag models and the other theoretical models.

关键词： SiC A New Modification to Shear lag Model as Applied to Stiffness and Yield Strength of Short Fiber Reinforced Metal Matrix Composites