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Trends in characteristics of neurologists who provide stroke consultations in the UsA,2008-2021

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stroke & Vascular Neurology 2023年第1期8卷 86-88页

作者： Carter H Nakamoto Andrew d Wilcock lee H schwamm Jennifer J Majersik Kori s Zachrison Ateev Mehrotra department of Health Care Policy Harvard Medical SchoolBostonMassachusettsUSA department of Family Medicine University of Vermont Larner College of MedicineBurlingtonVermontUSA department of Neurology Massachusetts General HospitalBostonMassachusettsUSA department of Neurology University of UtahSalt Lake CityUtahUSA department of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA division of General Medicine and Primary Care Beth Israel Deaconess Medical CenterBostonMassachusettsUSA

Introduction Patients with acute ischaemic strokes(AIs),on average,fare better with timely neurologist consultation,and a growing proportion of them receive ***,little is known about trends in the characteristics of neurologists who treat *** We identified AIs and transient ischaemic attack(TIA)episodes with neurologist consults in fee-for service Medicare from January 2008 to september *** each episode,we determined whether the neurologist was a vascular neurologist,was a high-volume provider,whether the patient was transferred between hospitals and the distance between the patient’s home and physician’s *** From 2008 to 2021,the share of AIs/TIA episodes(n=5073294)with neurologist consults increased(52.9%to 61.7%).Among episodes with consults,the fraction conducted by a vascular neurologist(5.2%to 13.7%)or by a high-volume neurologist(13.2%to 14.9%)also *** fraction with the patient’s home and neurologist greater than 100 miles apart(4.8%to 9.6%)or in different states(5.1%to 8.1%)increased,as did the fraction with transfers(4.2%to 8.5%).discussion Over the study period,the proportion of AIs/TIA episodes with consultations from neurologists with either vascular neurology certifications or high volumes increased substantially.

关键词： acute characteristics consultation

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生态环境损害赔偿磋商的法律性质思辨及展开

重庆大学学报（社会科学版） 2018年第4期24卷 175-186页

作者：郭海蓝陈德敏重庆大学法学院重庆400044

生态环境损害赔偿磋商制度借助私法领域常用之平等协商方式实现环境公共治理过程的行权方式创新,为政府环境保护行政管理职能的履行提供了引入契约式公私合作的转型契机。主流学说对赔偿磋商属于纯粹的私法民事行为抑或涉及公法元素的... 详细信息

生态环境损害赔偿磋商制度借助私法领域常用之平等协商方式实现环境公共治理过程的行权方式创新,为政府环境保护行政管理职能的履行提供了引入契约式公私合作的转型契机。主流学说对赔偿磋商属于纯粹的私法民事行为抑或涉及公法元素的特殊私法民事行为的性质误读源自于手段论者和主体论者对磋商目的与手段关系、公共利益与私人利益处分边界的认知偏差,准确把握行政民主化改革潮流下的合作治理范式转换背景并对赔偿磋商本身作三阶段划分有助于更为客观真实地反映赔偿磋商所蕴含的公权行政属性。依托行政契约理论对作为赔偿磋商成果形式的磋商协议作映射关系检验为辨析赔偿磋商的行政行为性质开辟了新的道路。

关键词：赔偿磋商私法民事行为公权行政行为行政契约

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基于二维相关红外光谱鉴别鞋底材料

激光与光电子学进展 2024年第9期61卷 501-506页

作者：张景顺吕小宝蔡能斌于奎栋上海公安学院侦查系上海200137 上海市公安局物证鉴定中心上海200083 上海市现场物证重点实验室上海200083

鞋底是犯罪现场容易提取到的微量物证,使用傅里叶变换红外光谱法结合统计分析对检验鉴别鞋底物证具有重要意义。选择5个主要材料为顺丁橡胶的鞋底样品进行鉴别研究,主要橡胶材料相同的鞋底,其原始光谱相似,难以有效区分,因此选取1800~65... 详细信息

鞋底是犯罪现场容易提取到的微量物证,使用傅里叶变换红外光谱法结合统计分析对检验鉴别鞋底物证具有重要意义。选择5个主要材料为顺丁橡胶的鞋底样品进行鉴别研究,主要橡胶材料相同的鞋底,其原始光谱相似,难以有效区分,因此选取1800~650 cm-1范围的指纹谱图进行二阶导数分析和二维相关光谱分析。实验结果表明:样品间二阶导数谱图差异不显著,而二维相关光谱中交叉峰的个数、位置和响应顺序存在差异,可以用来区分不同的鞋底样品。基于二维相关红外光谱可对鞋底物证进行完全鉴别,且二维相关光谱分析技术在法庭科学领域应用潜力巨大。

关键词：二维相关光谱分析傅里叶变换红外光谱橡胶鞋底检验鉴别

Antioxidant effects of Phyllanthus niruri tea on healthy subjects

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Asian Pacific Journal of Tropical Medicine 2014年第2期7卷 113-118页

作者： Elisngela Colpo Carlos d.d.A.Vilanova Romaiana P.Pereira luis Gustavo B.Reetz liline Oliveira Iria l.G.Farias Aline A.Boligon Margareth l.Athayde Joo Batista T.Rocha departamento de Química Centro de Ciências Naturais e ExatasUniversidade Federal de Santa Maria(UFSM) laboratrio de Anlises Clínicas Hospital UniversitrioUniversidade Federal de Santa Maria(UFSM) departamento de Farmcia Industrial Universidade Federal de Santa Maria(UFSM)

Objective:To investigate the potential antioxidant effects of Phyllanthus niruri(***)tea on healthy ***:Five non-smoking,male healthy volunteers,20 to 31 years *** *** subject was treated twice,following a randomized crossover fashion regarding the ingestion of *** infusion(5 g/750 ml)(tea group)or 750 ml of water(control group).Fasting venous blood samples were collected prior to and at 1.2 and 4 h after infusion *** were tested for plasmatic gallic acid and ascorbic acid levels,erythrocytic catalase and superoxide dismutase activities,and intracellular dCFH fluorescence in granulocytes,monocytes and ***:Catalase and superoxide dismutase activities were not altered by tea *** levels of gallic acid were significantly increased at1,2 and 4 h after *** ingestion and plasma ascorbic acid at 1 h after *** ***:Ingestion of *** tea is associated with a slight increase in antioxidant markers in human blood(ascorbic acid and gallic acid),which may contribute to its pharmacological effects.

关键词： Antioxidants Polyphenols Phyllanthus niruri Human Ascorbic acid Gallic acid

A tissue-engineered rostral migratory stream for directed neuronal replacement

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Neural Regeneration Research 2018年第8期13卷 1327-1331页

作者： John C.O'donnell Kritika s.Katiyar Kate V.Panzer d.Kacy Cullen Center for Brain Injury & Repair Department of Neurosurgery Perelman School of Medicine University of Pennsylvania Center for Neurotrauma Neurodegeneration & Restoration Corporal Michael Crescenz Veterans Affairs Medical Center school of Biomedical Engineering Drexel University department of Bioengineering School of Engineering and Applied Science University of Pennsylvania

New neurons are integrated into the circuitry of the olfactory bulb throughout the lifespan in the mamma- lian brain--including in humans. These new neurons are born in the subventricular zone and subsequently mature as they are guided over long distances via the rostral migratory stream through mechanisms we are only just beginning to understand. Regeneration after brain injury is very limited, and although some neuroblasts from the rostral migratory stream will leave the path and migrate toward cortical lesion sites, this neuronal replacement is generally not sustained and therefore does not provide enough new neurons to alleviate functional deficits. Using newly discovered microtissue engineering techniques, we have built the first self-contained, implantable constructs that mimic the architecture and function of the rostral migratory stream. This engineered microtissue emulates the dense cord-like bundles of astrocytic somata and processes that are the hallmark anatomical feature of the glial tube. As such, our living microtissue-en- gineered rostral migratory stream can serve as an in vitro test bed for unlocking the secrets of neuroblast migration and maturation, and may potentially serve as a living transplantable construct derived from a patient＇s own cells that can redirect their own neuroblasts into lesion sites for sustained neuronal replace- ment following brain injury or neurodegenerative disease. In this paper, we summarize the development of fabrication methods for this microtissue-engineered rostral migratory stream and provide proof-of-princi- ple evidence that it promotes and directs migration of immature neurons.

关键词： rostral migratory stream glial tube astrocyte neuroblast brain injury neural repair neural regeneration tissue engineering

On-line defect detection of Aluminum Coating Using Fiber Optic sensor

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Photonic sensors 2015年第1期5卷 72-78页

作者： supriya s. PATIl A. d. sHAlIGRAM department of Electronic science Abasaheb Garware College Pune India department of Electronic science University of Pune Pune India

Aluminum metallization using the sprayed coating for exhaust mild steel （Ms） pipes of tractors is a standard practice for avoiding rusting. Patches of thin metal coats are prone to rusting and are thus considered as defects in the surface coating. This paper reports a novel configuration of the fiber optic sensor for on-line checking the aluminum metaUization uniformity and hence for defect detection. An optimally chosen high bright 440 nm BlUE lEd （light-emitting diode） launches light into a transmitting fiber inclined at the angle of 60° to the surface under inspection placed adequately. The reflected light is transported by a receiving fiber to a blue enhanced photo detector. The metallization thickness on the coated surface results in visually observable variation in the gray shades. The coated pipe is spirally inspected by a combination of linear and rotary motions. The sensor output is the signal conditioned and monitored with RIsHUBH dAs. Experimental results show the good repeatability in the defect detection and coating non-uniformity measurement.

关键词： Fiber optic sensors on-line defect detection aluminum coating corrosion resistance color detection,exhaust pipes of vehicles

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褪黑素在糖尿病视网膜病变中的作用研究进展

眼科新进展 2024年第8期44卷 658-662页

作者：李鉴峰杨凌齐吕洋中国人民解放军联勤保障部队第九四〇医院眼科中心甘肃省兰州市730050 甘肃中医药大学第一临床医学院甘肃省兰州市730000 中国人民解放军联勤保障部队第九四〇医院基础医学实验室甘肃省干细胞与基因药物重点实验室甘肃省兰州市730050

糖尿病是全球常见的代谢性疾病,在长期的高糖刺激下易引起氧化损伤、炎症、自噬受损,使得血-视网膜屏障遭到破坏,继而发生糖尿病视网膜病变(dR)。褪黑素是一种主要由松果体分泌的激素,视网膜也可少量分泌。它除了具有抗氧化活性外,还具... 详细信息

糖尿病是全球常见的代谢性疾病,在长期的高糖刺激下易引起氧化损伤、炎症、自噬受损,使得血-视网膜屏障遭到破坏,继而发生糖尿病视网膜病变(dR)。褪黑素是一种主要由松果体分泌的激素,视网膜也可少量分泌。它除了具有抗氧化活性外,还具有抗炎、抗癌、免疫调节、调节自噬和神经保护作用。褪黑素在控制血糖方面有着良好作用,能够减轻高糖诱导的视网膜Müller细胞的氧化应激和细胞凋亡;褪黑素通过调节内皮祖细胞的自噬和miRNA的表达,从而保护线粒体,减少神经元损伤,发挥抗炎和抗癌作用,影响新生血管。本综述总结了褪黑素在dR中的作用,并且阐明了褪黑素调控dR的相关因素,为dR的治疗提供了新思路。

关键词：褪黑素糖尿病视网膜病变氧化应激炎症细胞自噬

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本征型自愈合聚合物材料的研究进展

高分子材料科学与工程 2019年第6期35卷 183-190页

作者：王小萍程炳坤梁栋贾德民华南理工大学材料科学与工程学院

自愈合材料是一种具有自主修复机械损伤功能的特殊功能材料,最有研究前景的是具有完全自主型、无需外界刺激的本征型自愈合聚合物材料。这种材料实现自愈合的基础是分子链间存在着能够在温和条件下重复键合的、具有可逆性质的化学作用... 详细信息

自愈合材料是一种具有自主修复机械损伤功能的特殊功能材料,最有研究前景的是具有完全自主型、无需外界刺激的本征型自愈合聚合物材料。这种材料实现自愈合的基础是分子链间存在着能够在温和条件下重复键合的、具有可逆性质的化学作用力。文中围绕多种可逆键在自愈合功能化聚合物中的应用研究,着重介绍了近年可逆共价键、氢键、离子键及其它可逆键型自愈合聚合物材料的发展现状,从材料的制备、机理与性能等方面进行了阐述,并对本征型自愈合聚合物的未来发展进行了展望。

关键词：本征型自愈合聚合物可逆键

IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy

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Chinese Chemical letters 2024年第1期35卷 305-309页

作者： songtao Zhou Hao Tian Jie Yan Zhan Zhang Guohao Wang Xinying Yu Wei sang Bei li Greta s.P.Mok Jie song Yunlu dai Cancer Center and Institute of Translational Medicine Faculty of Health SciencesUniversity of MacaoMacao 999078China MoE Frontiers science Center for Precision Oncology University of MacaoMacao 999078China Institute of Basic Medicine and Cancer(IBMC) Chinese Academy of SciencesThe Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Biomedical Imaging laboratory(BIG) Department of Electrical and Computer EngineeringFaculty of Science and TechnologyUniversity of MacaoMacao 999078China

Photodynamic therapy (PdT) is a clinically approved cancer treatment that uses energy of light to generate active substances that cause damage to the cancer. Photosensitizers are employed to absorb light and generate toxic reactive oxygen species (ROs) to damage biomolecules like dNA. At the same time, some chemotherapy drugs like nucleotide analogues can provide mechanism-guided promotion in the treatment efficacy of PdT. However, the photosensitizer and chemotherapy drugs used in PdT is usually organic molecules, which suffers from bad solubility, fast clearance, and acute toxicity. To achieve targeted treatment, a reasonable delivery system is necessary. Therefore, we reported a metal-phenolic network where IR780 and gemcitabine were coupled chemically to overcome these shortcomings. The enhanced PdT effects can be realized by the promoted cell death both in vitro and in vivo. Moreover, the synergistic therapy also induced T-cell mediated anti-tumor immune response, which was significant for the inhibition of distant tumor growth. This work expanded the biomedical application of metal-phenolic materials and contribute to the wider application of photodynamic cancer therapy.

关键词： Metal phenolic network IR780 Photodynamic therapy Breast cancer Gemcitabine