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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi keun-Young kim Yury I.Miller Won-kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-d-aspartate receptors and N-methyl-d-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-d-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-d-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-d-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-d-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-d-aspartate receptors N-methyl-d-aspartate receptor subunits pathogenesis preventive treatment

基于肌酐和体积法GFR测量肾移植供体肾功能的比较

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国际医学放射学杂志 2016年第1期 84-84页

作者： d.k.choi S.M.choi B.H.Park B.C.Jeong S.I.Seo S.S.Jeon 杨献峰 department of Urology Samsung Medical CenterSungkyunkwan University School of Medicine

摘要目的评价不同方法测量肾小球滤过率(GFR)并与直接法测量GFR(d GFR)进行比较,并尝试建立一个基于CT所测肾脏体积的测量GFR的公式。材料与方法采用肌酐法(MdRd、Cockcroft-Gault公式、Ckd-EPI公式和Mayo诊所公式)和Herts法(基于体积)... 详细信息

摘要目的评价不同方法测量肾小球滤过率(GFR)并与直接法测量GFR(d GFR)进行比较,并尝试建立一个基于CT所测肾脏体积的测量GFR的公式。材料与方法采用肌酐法(MdRd、Cockcroft-Gault公式、Ckd-EPI公式和Mayo诊所公式)和Herts法(基于体积)测量GFR(v GFR)。比较不同的GFR评价方法并通过多元线性回归分析建立了一个新的v GFR的模型。结果基于肌酐测量GFR的结果中,MdRd和C-G公式所测值均与d GFR相关(相关性和一致系数分别为0.359、0.369和0.354、0.318)。得出的基于肾脏体积的

关键词： GFR 肾脏体积肾功能肌酐

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young choi department of Brain Science Ajou University School of MedicineSuwonSouth Korea department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea department of Neurology Ajou University School of MedicineSuwonSouth Korea department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a dNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Organic micro-pollutant removal in liquid-phase using carbonized silk cotton hull

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Journal of Environmental Sciences 2008年第9期20卷 1046-1054页

作者： M Sathishkumar A R Binupriya d kavitha R Selvakumar k k Sheema J G choi department of Food Science and Technology Institute of Agricultural Science and Technology Chonbuk National University department of Chemical Engineering Yonsei University department of Biotechnology Bharathiar University department of Plant biology and Biotechnology Government Arts College National Agricultural Products Quality Management Services

Phenolic compounds constitute one of the major pollutants in the modern world. Although many physical and chemical treatment technologies for their removal exist, most of them are economically not feasible. The present study was aimed at using silk cotton hull, a potent agricultural waste as an adsobent for removal of 2,4-dichlorophenol (2,4-dCP), which was used as a model phenolic compound. The process parameters were investigated and optimized conditions were determined. The equilibrium time was found to ...

关键词： silk cotton hull carbon adsorption 2 4-dCP temperature kinetic study

Numerical modelling of a low power non-transferred arc plasma reactor for methane conversion

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Plasma Science and Technology 2019年第6期21卷 29-37页

作者： B I MIN d k dINH d H LEE T H kIM S choi Institute for Nuclear Science and Technology Jeju National University 102 Jejudaehak-ro Jeju 63243Republic of Korea University of Science and Technology(UST) 217 Gajeong-ro Yuseong-gu Daejeon 34113 Republic of Korea korea Institute of Machinery and Materials 156 Gajeongbuk-ro Yuseong-gu Daejeon 34103 Republic of Korea department of Nuclear and Energy Engineering Jeju National University 102 Jejudaehak-ro Jeju 63243Republic of Korea

Thermal flow characteristics and the methane conversion reaction in a low power arc plasma reactor for efficient storage and transport of methane,which is the main component of shale gas,were *** temperature and velocity distributions were calculated according to the type of discharge gases and arc current level by a self-developed magnetohydrodynamics (MHd)code and a commercial ANSYS-FLUENT code;the transport of chemical species was analyzed as including the chemical reactions of methane *** simulated results were verified by the comparison of calculated and measured arc voltages with permissible low error as under 4%.Three C2 hydrocarbon gases with ethane (C2H6),ethylene (C2H4),and acetylene (C2H2)were selected as the converted species of methane from experimental *** mass fraction of C2 hydrocarbons and hydrogen as the product of the conversion reaction at the reactor was also *** values show good agreement with the actual experimental results in that the major conversion reaction occurred in C2H2 and hydrogen,and the conversions to C2H6,C2H4,and hydrogen were minor reactions of methane pyrolysis conversion.

关键词： numerical modelling non-transferred arc plasma methane chemical reaction

Regression analysis of squeezing-induced hybrid nanofluid flow in darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAd M.SARFRAZ department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHd) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NdSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词：

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Probing the Variation of Reverberation Lags along with X-Ray Flux in the AGN Mrk 704

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Research in Astronomy and Astrophysics 2023年第3期23卷 75-84页

作者： k.Sriram deblina Lahiri Vivek k.Agrawal d.Nour C.S.choi department of Astronomy Osmania UniversityHyderabad 500007India korea Astronomy and Space Science Institute Daejeon 34055Republic of Korea Space Astronomy Group ISITE CampusU.R.Rao Satellite CentreOuter Ring Road.MarathahallBangalore 560037India department of Physics Faculty of ScienceAl Baath UniversityHomsSyria

Understanding the variation of lags with respect to the X-ray flux is important to explore the geometry of the inner region of the accretion disk in *** performed frequency-lag,energy–lag and spectral studies for two sets of observations,in order to investigate the variations in lags with respect to X-ray flux in the AGN source Mrk 704 using the XMM-Newton *** divided one of the light curves into two sections which were noticed to exhibit a flux *** frequency-lag spectra in different energy domains revealed that reverberation(soft)lags varied along with the *** the first time,we show that the blurred reflection model can consistently explain the soft excess observed in the X-ray spectra for this *** fluxes of soft(i.e.,reflection)and hard components were noted to vary by~18%and~9%respectively,across the *** soft lag amplitude was found to be larger at the high flux state than the amplitude at the low flux *** importantly,we found that both frequency-lag and energy–lag spectra do not display significant variation between two observational data sets despite a flux variation of 43%.This phenomenon cannot be explained by the reflection model because the soft lag amplitudes must be larger in the high flux *** probable scenario is that,in the low flux state,the obscuring cloud delays the reflected soft photons which increases the soft lag amplitude.

关键词： reflected curing AGN