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A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

Marine Life Science & Technology 2024年第1期6卷 168-181页

作者： jiwen Liu da-Wei Li Xinxin He Ronghua Liu Haojin Cheng Chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk david j.Lea-Smith jonathan d.Todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

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Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 67-88页

作者： Manickam Ashokkumar Wenwen Mei jackson j.Peterson Yuriko Harigaya david M.Murdoch david M.Margolis Caleb Kornfein Alex Oesterling Zhicheng Guo Cynthia d.Rudin Yuchao jiang Edward P.Browne department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA HIV Cure Center University of North Carolina at Chapel HillChapel HillNC 27599USA department of Biostatistics University of North Carolina at Chapel HillChapel HillNC 27599USA department of Microbiology and Immunology University of North Carolina at Chapel HillChapel HillNC 27599USA department of Genetics University of North Carolina at Chapel HillChapel HillNC 27599USA department of Medicine Duke UniversityDurhamNC 27708USA department of Computer Science Duke UniversityDurhamNC 27708USA department of Statistics Texas A&M UniversityCollege StationTX 77843USA department of Biology Texas A&M UniversityCollege StationTX 77843USA department of Biomedical Engineering Texas A&M UniversityCollege StationTX 77843USA

despite the success of antiretroviral therapy,human immunodeficiency virus(HIV)cannot be cured because of a reservoir of latently infected cells that evades *** understand the mechanisms of HIV latency,we employed an integrated single-cell RNA sequencing(scRNA-seq)and single-cell assay for transposase-accessible chromatin with sequencing(scATAC-seq)approach to simultaneously profile the transcriptomic and epigenomic characteristics of~125,000 latently infected primary Cd4^(+)T cells after reactivation using three different latency reversing *** expressed genes and differentially accessible motifs were used to examine transcriptional pathways and transcription factor(TF)activities across the cell *** identified cellular transcripts and TFs whose expression/activity was correlated with viral reactivation and demonstrated that a machine learning model trained on these data was 75%-79%accurate at predicting viral ***,we validated the role of two candidate HIV-regulating factors,FOXP1 and GATA3,in viral *** data demonstrate the power of integrated multimodal single-cell analysis to uncover novel relationships between host cell factors and HIV latency.

关键词： HIV latency reversal Primary Cd4þT cell Single-cell multiomics HIV-regulating factor Machine learning

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Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature

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World journal of Orthopedics 2024年第9期15卷 870-881页

作者： Christian j Rajkovic Matthew L Merckling Alyssa W Lee Galadu Subah Aryan Malhotra Zachary d Thomas Sabrina L Zeller john V Wainwright Merritt d Kinon department of Neurosurgery Westchester Medical CenterValhallaNY 10595United States

BACKGROUNd Chronic inflammatory pain is associated with increased expression of interleukin(IL)-1,an inflammatory cytokine,and activity on its receptor(IL-1R).In response,the body produces IL-1R antagonist(IL-1Ra)to reduce this *** conditioned serum(ACS)is the only biologic therapy for spinal pathologies that enhances the action of endogenous IL-1Ra reserves to improve *** systematic review investigates the effectiveness of ACS in treating pain and dis-ability caused by spinal *** To evaluate the use of ACS as a conservative management option for spinal *** A systematic review of PubMed/Medline was performed to identify studies inve-stigating administration of ACS for treatment of any spinal *** Six articles were included,comprising 684 patients treated with epidural(n=133)or transforaminal(n=551)ACS *** had an average age of 54.0 years with slight female predominance(53.2%).The lumbar spine was most com-monly treated,with 567 patients(82.9%)receiving injections for lumbar radicu-lopathy(n=67),degenerative disc disease(ddd)(n=372),or spinal stenosis(n=128);cervical injections were performed in 109 patients(15.9%).Mean(Sd)follow-up was 21.7(4.8)weeks from first ACS *** studies investigating mecha-nical lumbar and lumbar or cervical radicular pain reported significant pain re-duction at final follow-up compared to *** achieved comparable or su-perior results to lumbar epidural steroid *** events were reported in 21 patients(3.1%),with no serious adverse *** ACS injection is a safe and effective intervention for pain reduction in many spinal pathologies,including cervical and lumbar radiculopathies.

关键词： Spine Autologous conditioned serum Orthokine Regenokine Epidural steroid injection Interleukin-1 Inter-leukin-1 receptor antagonist

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行业悄然迎来巨变:洞见中国车市年度趋势

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汽车与配件 2024年第1期 40-41页

作者： j.d.Power j.d.Power

回顾2023年,中国车市电动化、智能化全面爆发,新能源汽车的崛起成为世界瞩目的焦点。与此同时,价格战的硝烟弥漫了一整年。在这充满挑战与变化的一年,j.d. Power专业咨询团队持续深入调研中国汽车市场,发现行业正在悄然迎来巨大变革。

关键词：新能源汽车电动化车市价格战咨询团队世界瞩目中国汽车市场智能化

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座椅之争,智能化趋势下的新焦点

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汽车与配件 2024年第15期 64-65页

作者： j.d.Power 不详

中国汽车行业智能化浪潮奔涌,面对用户日益增多的消费需求,整车企业纷纷将目光投向能够直观提升驾乘体验的“汽车座椅”。作为与驾乘者最直接接触的部件,汽车座椅正经历着前所未有的革新。智能化:座椅技术“新革命”随着汽车向“移动的... 详细信息

中国汽车行业智能化浪潮奔涌,面对用户日益增多的消费需求,整车企业纷纷将目光投向能够直观提升驾乘体验的“汽车座椅”。作为与驾乘者最直接接触的部件,汽车座椅正经历着前所未有的革新。智能化:座椅技术“新革命”随着汽车向“移动的第三生活空间”迈进。

关键词：汽车座椅整车企业智能化趋势消费需求新焦点生活空间直接接触

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2023年中国车市,消费者、产品和服务体验都发生了哪些变化?

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汽车与配件 2024年第3期 70-71页

作者： j.d.Power 不详

2023年已然收官,中国车市经历了跌宕起伏的一年,用三个关键词可概括为:价格战、出口强国、智能化重构。从销量答卷上来看,据乘联会数据显示,2023年1-11月国内乘用车累计批发销量为2281.9万辆,同比增长8.9%。高增长的背后,却是竞争格局... 详细信息

2023年已然收官,中国车市经历了跌宕起伏的一年,用三个关键词可概括为:价格战、出口强国、智能化重构。从销量答卷上来看,据乘联会数据显示,2023年1-11月国内乘用车累计批发销量为2281.9万辆,同比增长8.9%。高增长的背后,却是竞争格局的巨变,新能源车以两位数的增速抢占燃油车市场份额,智能化配置的渗透率不断加深,智能化体验逐渐成为产品竞争的关键。2023年,***共发布12份联合研究报告及保值率报告,深入洞悉行业变化,从多个维度聆听消费者之声。

关键词：数据显示新能源车 j.d.Power 乘用车车市智能化配置竞争格局价格战

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Synthesis and characterization of ultra-soft alginate hydrogel mimicking lung tissue

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International journal of Smart and Nano Materials 2024年第3期15卷 593-609页

作者： Xiangpeng Li jihua Gou Chiranjit Maiti Olusegun j.Ilegbusi department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA

Alginate hydrogels possess properties analogous to those of the extracellular matrix(ECM).Thus,their mechanical behavior approx-imates soft tissue,which makes them desirable for the production of tissue-equivalent soft deformable *** study aims to determine the synthesis-structure-property relationship for alginate hydrogel with the Young’s modulus in the range of 10°~101 kPa,mimicking to that of human lung ***,a 3d polymer network embedded in a water-rich *** alginate hydrogels are synthesized by a direct mixture of sodium alginate and CaCO3,followed by the addition of d-glucono-δ-lactone(GdL)to initiate in-situ Ca^(2+)release and *** influence of alginate concentration and molar ratio of the constitu-ent calcium ion to carboxyl group from alginate monomer are evaluated while the Young’s modulus of the hydrogel is carefully controlled within the desired *** and SEM are used to characterize the influence of synthesis parameters at the molecular and microstructure *** and compression testing are performed to determine the Young’s modulus of the *** relations are established between synthesis parameters and the mechanical *** result of the study will be subse-quently used to guide the additive manufacturing of soft deform-able structures based on alginate hydrogels.

关键词： Alginate hydrogels Ultra-low modulus lung tissue-mimicking materials

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Mathematical beauty and Palladian architecture:Measuring and comparing visual complexity and diversity

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Frontiers of Architectural Research 2024年第4期13卷 729-740页

作者： ju Hyun Lee Michael j.Ostwald School of Built Environment Faculty of ArtsDesign&ArchitectureThe University of New South WalesSydneyNSW 2052Australia

Palladio’s design principles,including proportion and harmony,have often been associated with mathematical definitions of ***,the geometric and semantic properties of his fac¸ades have rarely been analysed in a holistic *** is little evidence of how mathematical beauty may be embodied in his *** research investigates complexity(fractal dimension or d)and diversity(perplexity or PP)as aesthetic indices,aiming to capture distinct characteristics of Palladian *** d and PP values of 22 Palladian villa fac¸ades are measured and analysed,before being compared with those of three Renaissance facades by Sebastiano *** combination of d and PP captures the geometric and semantic aesthetic qualities of architectural ***,the developed scatter plot of d and PP results supports the identification of four distinct aesthetic types of Palladian fac¸ade *** novel combination of d and PP measures contributes to a better understanding of one definition of the mathematical beauty of architecture,wherein“the whole is other than the sum of the parts”in compositional terms(a famous Gestalt principle).Specifically,this research provides new mathematical insights into the visual character of Palladian architecture and compares two important measures thereof.

关键词： Palladian architecture Complexity diversity Mathematical beauty Perplexity Fac¸ade design

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Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

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journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： H.T.jeong S.W.Lee W.j.Kim department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and associated deformation mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the HCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2d and 3d formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

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Influence of Heavy Fuel Oil on the Thermo-Physical and Erodibility Properties of Earthen Materials

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journal of Minerals and Materials Characterization and Engineering 2024年第1期12卷 37-48页

作者： Ohindemi G. Yameogo donzala d. Some Souleymane Ouedraogo Philbert Nshimiyimana Sié Kam dieudonné j. Bathiebo Laboratoire d’Energies Thermiques Renouvelables (L.E.T.RE) Unité de Formation et de Recherche en Sciences Exactes et Appliquées (UFR-SEA) University Joseph Ki-Zerbo of Ouagadougou Ouagadougou Burkina Faso Ministry in Charge of Infrastructures Ouagadougou Burkina Faso department of Civil Engineering and Architectural design Graduate School of Science and Engineering Saga University Saga Japan Laboratoire Eco-Matériaux et Habitats durables (LEMHad) Institut International d’Ingénierie de l’Eau et de L’Environnement (Institut 2iE) Ouagadougou Burkina Faso

This study focuses on the use of heavy fuel oil in construction material in Burkina Faso. Its mixture with silty or clayey soil is used as a coating to reinforce the walls of raw earth constructions which are very sensitive to water. The interest of this study is to determine erodibility, water content, while highlighting the influence of the porosity accessible by water on thermal diffusion in construction material containing heavy fuel oil. The heavy fuel oil was mixed with a silty-clayey soil, in different proportions, and water to make bricks samples on which tests were carried out. At the end of the experimental tests, it appears that the water content increases gradually, but not significantly with the addition of heavy fuel oil, which causes a slight increase in the speed of heat propagation through the material with reduced porosity, particularly those containing higher quantities of heavy fuel oil. Conversely, we note a good performance of heavy fuel oil in terms of water resistance properties such as porosity accessible by water and erodibility. This allows us to conclude that the mixture of heavy fuel oil and silty-clayey soil used as a coating material could greatly reduce water infiltration into the walls of housing constructions with raw earthen materials.

关键词： Porosity Accessible by Water Erodibility Water Content Thermal diffusion

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