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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.I.TOLUWALOJU C.K.THEIN d.halim department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEdAR)Coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEdAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio Coulomb damping preload tension/compression isolation band/depth offset potential

Effect of the Mesh Transparency on the Electrical Characteristics of dC Pseudo discharge

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Plasma Science and Technology 2015年第6期17卷 481-487页

作者： M.A.Abd AL-halim A.ABU-HASHEM d.I.MOUBARAK Physics department Faculty of ScienceBenha University Basic Science department Thebes High Institute of Engineering

A dC pseudo discharge for air has been studied. Air pressure is used in the range between 0.7 Torr and 12 Torr. The breakdown occurs between a plane cathode and a mesh anode at transparencies of 19%, 46%, and 65%. The current-voltage characteristic curves of the discharge, which are measured at different pressures, distances, and mesh transparences, take effect in the region of abnormal glow. The discharge voltage decreases as the air pressure increases, while more voltage is needed to maintain the discharge when either the mesh transparency or the inter- electrode distance is increased. An increment of mesh transparency causes high negative potential behind the mesh due to the high concentration of electrons, which accumulate and collide with neutral atoms. Paschen curves deviate from the expected regular one. The left side of Paschen curves appears at inter-electrode distance of 1 mm, whereas the right side appears at inter-electrode distance of 5 mm. The intermediate region is observed only at 3 mm distance between the two electrodes. For the transparency range used in this work, it is found that the decrement of the breakdown voltage, on the right side, depends on the mesh transparency. For different electrode separations, the measured Paschen curves are coincident and deviate from the standard ones of Paschen＇s law.

关键词： pseudo discharge mesh transparency Paschen curves

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Assessment of the consecutive harmful dinoflagellate blooms during 2015 in the Izmit Bay(the Marmara Sea)

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Acta Oceanologica Sinica 2018年第8期37卷 91-101页

作者： ERGüL halim Aytekin AKSAN Serdar IPSIROGLU Merve department of Biology Science and Arts FacultyKocaeli UniversityKocaeli 41380Turkey

A series of red tides were observed during 2015 in the Izmit Bay（the Marmara Sea） which is located in the most industrialized and populated region of Turkey. Six samplings were carried out in this area following the red ***-N, nitrate-N, ammonia, silica and orthophosphate concentrations were analyzed *** conditions were measured by CTd probe. Plankton quantification was performed using counting chambers under microscopes. Prorocentrum micans was the most abundant species, except on May 14,2015, when Noctiluca scintillans was dominant. The abundance of P. micans reached average 18×10~6 ind./L on May 3, 2015 in the Karamürsel station, simultaneously with elevated levels of NH_3 and o-PO_4^（3–）. The sample was also abundant in dead amphipods（（72±12） ind./L） that had been covered by mucilage aggregates produced by ***. The highest biomass（calculated by carbon） was recorded as（268±26.0） mg/L on May 14 in the Hereke station. Beside the anthropogenic wastewater discharges, unknown sources and resuspensions caused increases in nutrient levels. After long term northeaster gusts（35 km/h for 5 d） an upwelling occurred on November 6, 2015 after wind-induced sediment resuspension. Although nutrient discharges remarkably decreased over 30 years through established wastewater treatment plants, harmful phytoplankton blooms still occur. Comparing the present results with other studies in nearby Mediterranean seas reveals that the most intense harmful dinoflagellate bloom in recent years occurred in the Izmit Bay. Therefore, additional protection measures necessary for a cleaner Izmit Bay. These incidents also demonstrate that contaminants, accumulated in sediment,may have long-lasting effects on enclosed marine ecosystems.

关键词： red tide harmful algal bloom phytoplankton dinoflagellate Izmit Bay Marmara Sea mucilage

Long-term decay of the water pressure in the osmotic tensiometer

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 738-746页

作者： Hengshuo Liu Harianto Rahardjo Hejun du Abdul halim Hamdany Environmental Process Modelling Centre Nanyang Environment and Water Research InstituteNanyang Technological University1 Cleantech Loop637141Singapore Interdisciplinary Graduate School Nanyang Technological University50 Nanyang Avenue639798Singapore School of Civil and Environmental Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore

Matric suction is an important state variable required for the assessment of unsaturated soil *** are commonly used for direct matric suction measurement but have a limited measuring range up to 90 kPa due to the cavitation *** tensiometer(OT)can improve the measuring range of tensiometers by increasing the osmotic pressure of water to avoid the ***,the long-term water pressure decay that appeared in OTs caused a gradual decrease in their measuring *** this study,crosslinked poly(acrylamide-co-acrylic acid)potassium salt(PAM-co-PAAK)was used for the preparation of OTs(five in total)to explore the mechanism of water pressure decay of *** maximum water pressure in the OT versus the volume fraction of polymer filled in the OT was described based on the Flory-Huggins polymer theories and validated using WP4C dewpoint *** long-term pressure decay of OT-1,OT-2,and OT-3 was observed for 130 d and constant pressures were found for OT-1 and OT-2,indicating that the pressure decay of OT was mainly caused by the stress relaxation of the polymer hydrogels,and standard linear solid(SLS)rheological model was appropriate to fit the decay *** OT-1,OT-2 and OT-3,the theoretical osmotic pressure that was calculated based on the mass of retrieved polymer from OTs after 130-d pressure observation was higher than the actual osmotic pressure as observed,indicating that polymer leakage cannot explain the pressure decay of the *** ultravioletevisible(UVevisible)spectrophotometry examined the change in polymer concentrations in the water containers of OT-4 and OT-5 and demonstrated that there was no increase in polymer leakage during the period of pressure decay of OT-4 and *** a result,the pressure decay of OT was not caused by polymer *** results of this research suggested that the viscoelastic properties of polymers should be taken into consideration in further OT development.

关键词： High suction measurement Osmotic tensiometers Long-term pressure decay Polymer leakage Viscoelasticity of polymers

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

drawing highly ordered MXene fibers from dynamically aggregated hydrogels

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Nano Research 2024年第11期17卷 9815-9821页

作者： Shengyang Zhou Xuan Li Yilin Zhang Joseph halim Chao Xu Johanna Rosen Maria Strømme College of Materials Science and Engineering Sichuan University Chengdu 610065 China Nanotechnology and Functional Materials Department of Materials Sciences and Engineering The Ångström Laboratory Uppsala University Uppsala 751 03 Sweden Materials design Department of Physics Chemistry and Biology (IFM) Linköping University Linköping 581 83 Sweden

Assembly of two-dimensional (2d) nanomaterials into well-organized architectures is pivotal for controlling their function and enhancing performance. As a promising class of 2d nanomaterials, MXenes have attracted significant interest for use in wearable electronics due to their unique electrical and mechanical properties. However, facile approaches for fabricating MXenes into macroscopic fibers with controllable structures are limited. In this study, we present a strategy for easily spinning MXene fibers by incorporating polyanions. The introduction of poly(acrylic acid) (PAA) into MXene colloids has been found to alter MXene aggregation behavior, resulting in a reduced concentration threshold for lyotropic liquid crystal phase. This modification also enhances the viscosity and shear sensitivity of MXene colloids. Consequently, we were able to draw continuous fibers directly from the gel of MXene aggregated with PAA. These fibers exhibit homogeneous diameter and high alignment of MXene nanosheets, attributed to the shear-induced long-range order of the liquid crystal phase. Furthermore, we demonstrate proof-of-concept applications of the ordered MXene fibers, including textile-based supercapacitor, sensor and electrical thermal management, highlighting their great potential applied in wearable electronics. This work provides a guideline for processing 2d materials into controllable hierarchical structures by regulating aggregation behavior through the addition of ionic polymers.

关键词： two-dimensional(2d)materials liquid crystal phase fiber spinning wearable electronics

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination