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光学接触式微型三维测量系统

仪器仪表学报 2000年第1期21卷 95-97页

作者：吉贵军 h Schwenke E Trapet 罗震天津大学天津300072 德国联邦物理技术研究院

本文介绍了一种集光学方法的高准确度和快速性及机械接触方法的可靠性和不受材料特性影响的单一性优点于一体的光学接触式微型三维测量系统 ,用于测量微型工件的三维几何参数。该系统测头直径为 40～ 10 0 μm,测量准确度优于 1μm,测... 详细信息

本文介绍了一种集光学方法的高准确度和快速性及机械接触方法的可靠性和不受材料特性影响的单一性优点于一体的光学接触式微型三维测量系统 ,用于测量微型工件的三维几何参数。该系统测头直径为 40～ 10 0 μm,测量准确度优于 1μm,测量力小于 10 μN。

关键词：三维微型测头光学接触式微型工件

依据结肠镜下指征诊断晚期结肠直肠瘤:一项韩国肠病研究学会的调查

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 20-21页

作者： Park d.I. Kim Y.h. Kim h.S. 周智勇 Samsung Medical Center 50 Irwon-dongGangnam-ku135-230 SeoulSouth Korea

Background and Study Aims: The factors that more accurately predict the detection of colorectal cancers and adenomas at colonoscopy are different. We conducted a prospective multicenter study to evaluate which indications were most closely associated with advanced colorectal neoplasm (CRN), including colorectal cancer, in a group of patients undergoing colonoscopy. Patients and Methods: The 17468 patients were enrolled in this study between July 2003 and March 2004, from 11 tertiary medical centers in Korea. They were recruited according to 11 itemized colonoscopic indications. The term “advanced adenoma" refers here to tubular adenomas of diameter of 11 mm or more, or to tubulovillous, villous, or severely dysplastic adenomas, irrespective of their size. Cancer was defined as the invasion of malignant cells beyond the muscularis mucosa. Advanced CRN was defined as advanced adenoma or invasive cancer. Results: Advanced CRN was found in 1227/17 307 patients (1176 advanced adenomas plus 51 carcinomas, 7.1%). According to univariate and multivariate analysis, the factors associated with advanced CRN included age > 60 years (odds ratio (OR) 2.1, 95%confidence interval (CI) 1.8-2.4, P der (OR 2.1, 95%CI 1.7-2.7, P hysician (OR 3.1, 95%CI 2.5-3.7, P d several other indications (OR 1.8, 95%CI 1.5-2.3, P he yield of colonoscopy for advanced CRN was lower (2.2%) than expected in patients with iron-deficiency anemia (OR 0.5, 95%CI 0.2-0.9, P=0.03). Conclusions: Age, gender, and referral for colonoscopy from primary care physician constituted important independent predictors of advanced CRN in patients undergoing colonoscopy.

关键词：结肠直肠结肠镜检查研究学会浸润性癌不典型增生恶性细胞黏膜肌层三级医疗瘤形成单变量

表达新型冠状病毒奥密克戎BA.1变异株S1基因重组dNA疫苗的构建及免疫原性

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中国兽医学报 2023年第5期43卷 964-970页

作者：周可悦冯生范泽昌梁明征马杉姗金宁一李太元哈卓鲁会军延边大学农学院吉林延吉133002 中国农业科学院长春兽医研究所吉林长春130122 北京诺思兰德生物技术股份有限公司北京100085 吉林农业大学动物医学院吉林长春130118

旨在构建以S1蛋白为基础的新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)奥密克戎BA.1变异株(Omicron-BA.1)dNA疫苗并研究其免疫原性。首先,以真核表达载体pSN为骨架,使用PCR和无缝克隆方法构建含Omicron-BA.1变异株S1基因的pSN-S1重组质粒。使用无内毒素质粒大提试剂盒大量提取pSN-S1重组质粒,通过Western blot方法验证S1蛋白的表达。用pSN-S1重组质粒免疫C57BL/6小鼠后,使用ELISA方法检测小鼠血清针对S1蛋白的特异性IgG抗体效价及亚型。结果显示,pSN-S1重组质粒构建成功,S1蛋白表达良好,条带单一、大小正确。实验室制备的pSN-S1重组质粒的质量浓度(2168.2 mg/L)和纯度(d_(260)/d_(280)=1.92)较高,可用于后续小鼠免疫试验。pSN-S1重组质粒在C57BL/6小鼠中具有良好的免疫原性,第3次免疫后21 d,针对S1蛋白的特异性IgG抗体效价平均可达1∶1200,主要偏向于IgG2a亚型。本研究成功构建了以S1蛋白为基础的SARS-CoV-2 Omicron-BA.1变异株dNA候选疫苗,为针对SARS-CoV-2 Omicron变异株dNA疫苗的进一步研究奠定了基础。

关键词：新型冠状病毒奥密克戎BA.1变异株 dNA疫苗 S1蛋白免疫原性

热处理工艺对Al-Si-Mg合金组织和性能的影响

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热加工工艺 2010年第22期39卷 163-165页

作者：谭东刘昌明肖海波陈佳重庆大学材料科学与工程学院重庆400030

研究了双级固溶和双级时效对Al-Si-Mg合金组织、硬度和耐磨性的影响。结果表明:经520℃固溶8 h,然后再经145℃预时效3.5h和175℃终时效3.5h热处理后的试样硬度高,耐磨性好。

关键词：铝硅镁合金固溶时效硬度耐磨性

Slowed driving-reaction time following concussion-symptom resolution

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Journal of Sport and.h.alth Science 2021年第2期10卷 145-153页

作者： Landon B.Lempke Robert C.Lynall Nicole L.hoffman hannes devos Julianne d.Schmidt UGA Concussion Research Laboratory Department of KinesiologyUniversity of GeorgiaAthensGA 30602USA School of Kinesiology and Recreation Illinois State UniversityNormalIL 61790USA Laboratory for Advanced Rehabilitation Research in Simulation Department of Physical Therapy and Rehabilitation ScienceUniversity of Kansas Medical CenterKansas CityKS 66160USA

Background:Concussed patients have impaired reaction time(RT)and cognition following injury that may linger and impair driving *** research has used direct methods to assess driving-RT *** study compared driving RT during simulated scenarios between concussed and control individuals and examined driving-RT’s relationship with traditional computerized neurocognitive testing(CNT)***:We employed a cross-sectional study among 14 concussed(15.9±9.8 days post-concussion,mean±Sd)individuals and 14 healthy controls matched for age,sex,and driving *** completed a driving simulator and CNT(CNS Vital Signs)assessment within 48 h of symptom resolution.A driving-RT composite(ms)was derived from 3 simulated driving scenarios:stoplight(green to yellow),evasion(avoiding approaching vehicle),and pedestrian(person running in front of vehicle).The CNT domains included verbal and visual memory;CNT-RT(simple-,complex-,Stroop-RT individually);simple and complex attention;motor,psychomotor,and processing speed;executive function;and cognitive *** t tests and.h.dge d effect sizes assessed driving-RT differences between groups,Pearson correlations(r)examined driving RT and CNT domain relationships among cohorts separately,and p values were controlled for false discovery rate via Benjamini-hochberg procedures(a=0.05).Results:Concussed participants demonstrated slower driving-RT composite scores than controls(mean difference=292.86 ms;95%confidence interval(95%CI):70.18515.54;p=0.023;d=0.992).Evasion-RT(p=0.054;d=0.806),pedestrian-RT(p=0.258;d=0.312),and stoplight-RT(p=0.292;d=0.585)outcomes were not statistically significant after false-discovery rate corrections but demonstrated medium to large effect sizes for concussed *** concussed individuals,driving-RT outcomes did not significantly correlate with CNT domains(r-range:0.51 to 0.55;p>0.05).No correlations existed between driving-RT outcomes a

关键词： Mild traumatic brain injury Motor vehicle Neurocognitive function Response time Return to driving

Mo SILTCIdE SYNThISIS BY dUAL ION BEAM dEPOSITION

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Acta Metallurgica Sinica(English Letters) 2002年第2期15卷 187-190页

作者： T.h. Zhang, Z.Z. Yi, X. Y. Wu, S.J. Zhang, Y. G. Wu, X. Zhang, h.X. Zhang, A.d. Liu and X.J. Zhang Key Laboratory for Radiation Beam Technology and Material Modification, Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing Radiatio

Mo silicides Mo_5Si_3 with high quality were prepared using ion beamdeposition equipment with two Filter Metal Vacuum Are deposition (FMEVAd). When the number ofalternant deposition times was 198, total thickness of the coating is 40nm. The coatings withdroplet free can be readily obtained, so the surface is smooth. TEM observation shows that Mo and Sialternant deposition coating is compact structure. The fine Mo silicide grains densely distributedin the coating. The coating adherence on silicon is excellent.

关键词： Mo silicide ion alternant deposition silicon

Squamous Cell Carcinoma over Cutaneous Verrucous Lichen: One Case in Parakou (Benin)

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Journal of Cosmetics, dermatological Sciences and Applications 2019年第4期9卷 284-291页

作者： Christiane Koudoukpo L. V. C. Brun F. Akpadjan B. dégboé N. Agbessi E. Mensah M. C. Ballé F. Malaté h. Adégbidi F. Atadokpèdé ChU Borgou/Alibori Parakou Benin CNhU hubert Koutoukou Maga Cotonou Benin

Introduction: We report an unusual case of squamous cell carcinoma on a verrucous lichen of chronic evolution taken in charge in Borgou/Alibori UhC in Parakou (Bénin). Observation: A 75-year old Beninese woman with a history of portal hypertension post-viral cirrhosis C treated with negative viral load, had consulted for a large chronic ulceration of the right foot back. The beginning of the symptomatology would go back to about 30 years, marked by lichenified, pruriginous popular lesions;these lesions would initially be treated as eczema and then mycosis by health personnel not specialised in dermatology and multitreated with unspecified topicals. General state was altered. In addition to ulceration, the dermatological examination found plates of hyperpigmented lichen lesion, homogeneous and well limited bilateral and symmetrical topography on the pelvic limbs making difficult to walk. Anatomopathological examination of the biopsy sample straddling the ulceration and its edges suggested a hypertrophic cutaneous lichen associated with keratinizing, infiltrating epidermal carcinoma. The chest-abdominal-pelvic scan showed no metastasis. A complete amputation of the right leg and knee was performed after a psychological interview. The follow-up was marked by an over-infection of the amputation stump by Escherichia coli, which was successfully treated. healed, she is waiting for orthopedic equipment and possible chemotherapy. Conclusion: This clinical case indicates the need for adequate management of certain potentially precancerous dermatoses, in order to limit the progression to carcinogenic transformation.

关键词： Cutaneous Verrucous Lichen Squamous Cell Carcinoma Amputation Parakou

A differentially Expressed Gene from a high Oil Producer Cultivar of Castor Bean (<i>Ricinus communis</i>) Is Involved in the Biosynthesis of Ricinoleic Acid

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作者： R.d.·布来克默原

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American Journal of Plant Sciences 2020年第3期11卷 393-412页

作者： héctor A. Rodríguez-Cabal Claudia Y. Jaramillo-Mazo Nicolás d. Franco-Sierra diego F. Villanueva-Mejía Javier C. Alvarez department of Biological Sciences and CIBIOP Research Group School of Sciences Universidad EAFIT Medellín Colombia

Ricinus communis or castor bean is a non-edible oilseed plant widely cultivated worldwide for the high content of castor oil in its seeds and the different uses the oil has in the industry. An increase in its oil content and production efficiency is difficult, making understanding the molecular mechanisms underlying the synthesis of oils in the seed necessary. here, a combined analysis of protein-protein interaction networks was performed using public data on differential gene expression in castor bean seeds at different stages of development. From this analysis, four key enzymes were selected and analyzed in the polyunsaturated fatty acids pathways, whose gene expression was subsequently quantified during the development of the seeds in a Colombian cultivar that produces high amounts of oils and contrasted with a lower producing cultivar. The gene coding FAh12 was differentially expressed in the early stages of seed development in the high oil-producing cultivar and.h.s differences in amino acids A242V and Q319h. The analysis presents this gene as one of those responsible for early ricinoleic acid synthesis, making it a candidate for use in crop genetic improvement programs to increase the oil content in castor bean.

关键词： Tropical Cultivars Castor Oil FAd2 FAh12 Oilseed Crop