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dietary supplementation of valine,isoleucine,and tryptophan may overcome the negative effects of excess leucine in diets for weanling pigs containing corn fermented protein

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Journal of Animal Science and Biotechnology 2025年第1期16卷 267-281页

作者： Andrea P.Mallea Charmaine d.Espinosa Su A lee Minoy A.Cristobal leidy J.Torrez‑mendoza Hans H.Stein division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA department of Animal Sciences University of IllinoisUrbanaIL 61801USA Present Address:EnviroFlight RaleighNCUSA.

Background diets with high inclusion of corn co-products such as corn fermented protein(CFP)may contain excess leu,which has a negative impact on feed intake and growth performance of pigs due to increased catabolism of Val and Ile and reduced availability of Trp in the brain for serotonin ***,we hypothesized that the negative effect of using CFP in diets for weanling pigs may be overcome if diets are fortified with crystalline sources of Val,Trp,and(or)*** Three hundred and twenty weanling pigs were randomly allotted to one of 10 dietary treatments in a com-pletely randomized design,with 4 pigs per pen and 8 replicate pens per treatment.A corn-soybean meal diet and 2 basal diets based on corn and 10%CFP or corn and 20%CFP were *** additional diets were formu-lated by fortifying the basal diet with 20%CFP with Ile,Trp,Val,Ile and Val,Ile and Trp,Trp and Val,or Ile,Trp and Val.A two-phase feeding program was used,with d 1 to 14 being phase 1 and d 15 to 28 being phase *** scores were recorded every other *** samples were collected on d 14 and 28 from one pig per *** d 14,fecal samples were collected from one pig per pen in 3 of the 10 treatments to determine volatile fatty acids,ammonium concen-tration,and microbial *** pigs were also euthanized and ileal tissue was *** There were no effects of dietary treatments on any of the parameters evaluated in phase *** of 10%or 20%CFP in diets reduced(Pl body weight on d 28,and average daily gain(AdG)and average daily feed intake(AdFI)in phase 2 and for the entire experimental ***,pigs fed the CFP diet supplemented with Val,Ile,and Trp had final body weight,AdFI,AdG and gain to feed ratio in phase 2 and for the entire experiment that was not different from pigs fed the control *** scores in phase 2 were reduced(Pd protein may be included by up to 20%in diets for weanling pi

关键词： Branched-chain amino acids Corn fermented protein leucine Tryptophan Valine Weanling pigs

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George d.Bittner department of Molecular Biosciences University of Texas at AustinAustinTXUSA department of Neuroscience University of Texas at AustinAustinTXUSA division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord

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Neural Regeneration Research 2025年第7期20卷 2095-2107页

作者： Emily A.Hibbard liwen zhou Cathy z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George d.Bittner dale R.Sengelaub Program in Neuroscience Indiana UniversityBloomingtonINUSA department of Neuroscience University of Texas at AustinAustinTXUSA

Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically *** used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic *** have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor ***,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target *** this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic *** adult male and female rats(Sprague–dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of *** action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury *** success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days *** 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish ***-fusion repair reestablished axonal *** to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal ***,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repa

关键词： axotomy dorsal horn peripheral nerve injury plasticity polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically dNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease dNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

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Neural Regeneration Research 2025年第9期20卷 2667-2681页

作者： liwen zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy z.Yang Adelaide leung Varun Gokhale Guhan Periyasamy zeal Pathak dale R.Sengelaub George d.Bittner department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-dawley and inbred lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

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Morphometric and Biochemical Changes in Agave americana *** Induced By Ethyl Methanesulfonate

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Phyton-International Journal of Experimental Botany 2019年第3期88卷 277-284页

作者： S.J.Reyes-zambrano M.l.Ramírez-Merchant C.Arias-Castro M.A.Rodríguez-Mendiola C.A.lecona-Guzmán V.M.Ruíz-Valdiviezo d.gonzál.z-mendoza F.A.Gutiérrez-Miceli laboratorio de Biotecnología Vegetal Instituto Tecnológico de Tuxtla GutiérrezTecnológico Nacional de México.Carretera Panamericana Km.1080TeránTuxtla GutiérrezChiapasC.P.29050México laboratorios de Análisis Instrumental Bioquímico DEPI del Instituto Tecnológico de TlajomulcoTecnológico Nacional de México.Tlajomulco de ZuñigaC.P.45640México Instituto de Ciencias Agrícolas Universidad Autónoma de Baja California(ICA-UABC)Carretera a Delta s/n Ejido Nuevo LeónCP.21705Baja CaliforniaMéxico

*** *** a crop with very little genetic *** order to evaluate the effect of ethyl methanesulfonate(EMS)to induce variability in in vitro plantlets of ***,different explants(meristems,leaves and roots)were evaluated for the production of *** medium supplemented with ANA(2.68μM)and BAP(2.68μM)was *** obtained from apical meristem were treated with 15 mM EMS for two hours after which shoot formation was induced using 2,4-d(0.11μM)and BAP(44μM).The EMS induced variations in the morphometric and morphological parameters of the plantlets obtained,with 60%of the plantlets presenting differences such as dwarfism and different leaf forms,without the presence of spines,as well as an increase in fructan content of 30%with respect to the control *** was increased and this activity is related with higher anthocyanins concentration in *** ***.

关键词： Fructans callus mutagenesis flavonoids anthocyanins phenylalanine ammonia lyase activity

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Total Phenols,Flavonoids and Antioxidant Activity in Annona muricata and Annona purpurea Callus Culture

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Phyton-International Journal of Experimental Botany 2019年第2期88卷 139-147页

作者： M.Y.Ovando-domínguez M.C.luján-Hidalgo d.gonzál.z-mendoza A.A.Vargas-díaz N.Ruiz-lau F.A.Gutiérrez-Miceli C.A.lecona-Guzmán laboratorio de Cultivo de Tejidos Vegetales.Tecnológico Nacional de México/Instituto Tecnológico de Tuxtla Gutiérrez Carretera Panamericana Km.1080.Tuxtla GutiérrezChiapasC.P.29050México Instituto de Ciencias Agrícolas de la Universidad Autónoma de Baja California(ICA-UABC).Carretera a delta s/n C.P.21705 Ejido Nuevo LeónBaja CaliforniaMéxico CONACYT-Colegio de Postgraduados Campus CampecheCarretera Federal Haltunchén-Edzna km 17.5.SihochacChampotónCampecheCP 24450México CONACYT-Tecnológico Nacional de México/Instituto Tecnológico de Tuxtla Gutiérrez.Carretera Panamericana Km.1080.Tuxtla Gutiérrez ChiapasC.P.03940México

Callus cultures of Annona muricata and Annona purpurea were induced in Murashige and Skoog(MS)medium supplemented with different concentrations of 1-naphthylacetic acid(NAA),6-benzyladenine(BA)and 2,4-dichlorophenoxyacetic acid(2,4-d)util.zed hypocotyls with *** highest percentage of callus formation was the treatment supplemented with 3 mg l-1 NAA for ***(100%)while for *** in lower percentage(75%).BA stimulated the formation of shoots in all the evaluated concentrations,being the concentration of 2 mg l-1 the one that induced the greater formation of shoots for ***(23 shoots/explant)and ***(28 shoots/explant).The content of total phenols,flavonoids and antioxidant activity was measured in the callus obtained from both *** results showed that a higher content of total phenols was quantified in callus of ***(27.8 mg g-1 dw)compared to ***(23.2 mg g-1 dw).The highest content of total flavonoids was observed in the callus of ***(8.0μg g-1 dw).Antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydracil radical *** concentration required for 50%inhibition(IC50)of the 2,2-diphenyl-1-picrylhydracil radicals were 4.22μg ml-1 in methanolic extracts of callus of ***,while in extracts of callus of *** was 2.86μg ml-1,in both cases was greater than that found for *** culture of the species studied in this work represents an alternative for the production of natural antioxidants.

关键词： Annonaceae antioxidant activity 6-benzyladenine secondary metabolites tissue culture

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Sickle Crisis Precipitated by Pneumonia: A diagnostic and Therapeutic Challenge

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Journal of Biosciences and Medicines 2025年第1期13卷 255-263页

作者： david Fernando Ortiz-Pérez luisa María Petro-Noriega Margarita Rosa Burgos-Peña Marlon José Rosado-mendoza Santiago Sánchez-Rojas Cristina de Jesús Portillo-Monterrosa daniel de Jesús gonzál.z-Villarreal Juan Pablo de la Ossa díaz John Sebastián Osorio-Muñoz Manuel Esteban Ortiz Pérez Ana María García-Suárez department of Internal Medicine Cartagena del Mar Medical Center Cartagena Colombia Internal Medicine Program Universidad del Sin Cartagena Colombia Faculty of General Medicine Universidad del Sin Cartagena Colombia Faculty of General Medicine Universidad Surcolombiana Neiva Colombia Faculty of General Medicine Universidad de Sucre Sincelejo Colombia Faculty of General Medicine Universidad Libre Barranquilla Colombia Faculty of General Medicine Fundacin Universitaria Navarra Neiva Colombia Faculty of General Medicine Universidad de Cartagena Cartagena Colombia

Sickle cell anemia (SCA) is a prevalent genetic disorder primarily affecting individuals of African descent and populations in malaria-endemic regions, with significant global public health implications. Sickle cell crises are their most common acute complication, characterized by episodes of intense pain and systemic manifestations that impair quality of life and impose a high healthcare burden. We present the case of a 19-year-old male diagnosed with SCA since the age of two, who developed a sickle cell crisis precipitated by right basal pneumonia. The patient exhibited sudden-onset, cyclic lumbar pain with progressive dyspnea. Initial management included multimodal pain control, volume optimization, and targeted antimicrobial therapy to achieve clinical stabil.zation. This case underscores the importance of a comprehensive approach to managing sickle cell crises, addressing both symptomatic relief and the prevention and treatment of complications. It also highlights the need for public health strategies promoting early diagnosis, access to disease-modifying therapies such as hydroxyurea, and interdisciplinary follow-up to mitigate the socioeconomic and clinical impact of SCA.

关键词： Sickle Cell Anemia Sickle Cell Crisis Pain Management Pneumonia Hydroxyurea

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Morphology and phylogeny of two species of Bathypathes from the tropical western Pacific,with description of a new species

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Journal of Oceanology and limnology 2025年第1期43卷 248-260页

作者： Ting lÜ zifeng zHAN Kuidong XU laboratory of Marine Organism Taxonomy and Phylogeny Qingdao Key Laboratory of Marine Biodiversity and ConservationInstitute of OceanologyChinese Academy of SciencesQingdao 266071China laboratory for Marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

The black coral genus Bathypathes Brook,1889 represents a relatively diverse and ecologically important assemblage comprising the deep-sea hard substrate *** phylogenetic investigations have revealed the polyphyletic nature of Bathypathes,urging further morphological analysis to understand its *** combing morphological and molecular data,we describe Bathypathes multifurcata *** report *** Molodtsova,Opresko&Wagner,2022based on the specimens collected from the tropical western *** phylogenetic topology reconstructed using nuclear ITS1-5.8S-ITS2 and three mitochondrial fragments suggests the separation of Bathypathes into four *** analysis of morphological characters,particularly the colony branch and pinnule patterns also roughly classify Bathypathes into four morphological groups A–*** A is characterized by the unbranched colony and the subopposite arrangement of *** contrast to Group A,Groups B–d have the alternately arranged *** these,Group C exhibits a distinctly long unpinnulated stem compared to Groups B and *** B has unbranched colony,relatively short unpinnulated stem,and spines on pinnules have blunt *** Group d,large colonies(higher than 40 cm)have one or a few branches,small colonies(less than 40 cm)are unbranched,and spines on pinnules have acute *** data particularly those species without sequences are necessary to verify the classification of these groups.

关键词： Antipatharia black coral taxonomy phylogeny seamount western Pacific

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deep view of composite SNR CTA1 with lHAASO in γ-rays up to 300 TeV

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao d.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen liang Chen lin Chen long Chen M.J.Chen M.l.Chen Q.H.Chen S.Chen S.H.Chen S.z.Chen T.l.Chen Y.Chen N.Cheng Y.d.Cheng M.C.Chu M.Y.Cui S.W.Cui X.H.Cui Y.d.Cui B.z.dai H.l.dai z.G.dai danzengluobu X.Q.dong K.K.duan J.H.Fan Y.z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng l.Feng S.H.Feng X.T.Feng Y.Feng Y.l.Feng S.Gabici B.Gao C.d.Gao Q.Gao W.Gao W.K.Gao M.M.Ge T.T.Ge l.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.l.Guo J.Guo X.l.Guo Y.Q.Guo Y.Y.Guo Y.A.Han O.A.Hannuksela M.Hasan H.H.He H.N.He J.Y.He Y.He Y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu C.Huang d.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.Y.Huang Y.Huang Y.Y.Huang X.l.Ji H.Y.Jia K.Jia H.B.Jiang K.Jiang X.W.Jiang z.J.Jiang M.Jin M.M.Kang I.Karpikov d.Khangulyan d.Kuleshov K.Kurinov B.B.li C.M.li Cheng li Cong li d.li F.li H.B.li H.C.li Jian li Jie li K.li S.d.li W.l.li W.l.li X.R.li Xin li Y.z.li zhe li zhuo li E.W.liang Y.F.liang S.J.lin B.liu C.liu d.liu d.B.liu H.liu H.d.liu J.liu J.l.liu M.Y.liu R.Y.liu S.M.liu W.liu Y.liu Y.N.liu Q.luo Y.luo H.K.lv B.Q.Ma l.l.Ma X.H.Ma J.R.Mao z.Min W.Mitthumsiri H.J.Mu Y.C.Nan A.Neronov K.C.Y.Ng l.J.Ou P.Pattarakijwanich z.Y.Pei J.C.Qi M.Y.Qi B.Q.Qiao J.J.Qin A.Raza d.Ruffolo A.Sáiz M.Saeed d.Semikoz l.Shao O.Shchegolev X.d.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su d.X.Sun Q.N.Sun X.N.Sun z.B.Sun J.Takata P.H.T.Tam Q.W.Tang R.Tang z.B.Tang W.W.Tian l.H.Wan C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang J.C.Wang Kai Wang Kai Wang l.P.Wang l.Y.Wang P.H.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.d.Wang Y.J.Wang z.H.Wang z.X.Wang zhen Wang zheng Wang d.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia G.M.Xiang d.X.Xiao G.Xiao Y.l.Xin Y.Xing d.R.Xiong z.Xiong d.l.Xu R.F.Xu R.X.Xu W.l.Xu l.Xue d.H.Yan J.z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang l.l.Yang M.J.Yang R.z.Yang W.X.Yang Y.H.Yao z.G.Yao l.Q.Yin N.Yin X.H.You z.Y.You Y.H Southwest Jiaotong University School of Astronomy and Space Science Nanjing University Center for Astrophysics Guangzhou University Tsung-dao lee Institute & School of Physics and Astronomy Shanghai Jiao Tong University Institute for Nuclear Research of Russian Academy of Sciences Hebei Normal University University of Science and Technology of China lHAASO Collaboration State Key laboratory of Particle detection and Electronics Key laboratory of dark Matter and Space Astronomy & Key laboratory of Radio Astronomy Purple Mountain Observatory Chinese Academy of Sciences Research Center for Astronomical Computing zhejiang laboratory Key laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Key laboratory of Particle Astrophysics & Experimental Physics division & Computing Center Yunnan University Key laboratory of Cosmic Rays (Tibet University) Ministry of Education department of Physics The Chinese University of Hong Kong Key laboratory of Radio Astronomy and Technology National Astronomical Observatories Chinese Academy of Sciences School of Physics and Astronomy (zhuhai) & School of Physics (Guangzhou) & Sino-French Institute of Nuclear Engineering and Technology (zhuhai) Sun Yat-sen University Institute of High Energy Physics Institute of Frontier and Interdisciplinary Science Shandong University APC Université Paris Cité CNRS/IN2P3 CEA/IRFU Observatoire de Paris department of Engineering Physics & department of Astronomy Tsinghua University School of Physics and Microelectronics Chinese Academy of Sciences zhengzhou University Yunnan Observatories Chinese Academy of Sciences China Center of Advanced Science and Technology College of Physics Sichuan University School of Physics Peking University Guangxi Key laboratory for Relativistic Astrophysics School of Physical Science and Technology University of Chinese Academy of Sciences Guangxi University department of Physics Faculty of Science Mahidol University Moscow Institute

The ultra-high-energy（UHE） gamma-ray source 1lHAASO J0007+7303u is positionally associated with the composite SNR CTA1 that is located at high Galactic latitude b ≈ 10.5°. This provides a rare opportunity to spatially resolve the component of the pulsar wind nebula（PWN） and supernova remnant（SNR） at UHE. This paper conducted a dedicated data analysis of 1lHAASO J0007+7303u using the data collected from december 2019 to July 2023. This source is well detected with significances of 21σ and 17σ at 8-100 TeV and >100 TeV, respectively. The corresponding extensions are determined to be 0.23°±0.03°and 0.17°±0.03°. The emission is proposed to originate from the relativistic electrons accelerated within the PWN of PSR J0007+7303. The energy spectrum is well described by a power-law with an exponential cutoff function dN/dE =（42.4 ± 4.1）(E/（20 TeV）)-2.31±0.11exp(-E/（110±25 TeV）) TeV-1cm-2s-1in the energy range from 8 to 300 TeV, implying a steady-state parent electron spectrum dNe/dEe∝(Ee/（100 TeV）)-3.13±0.16exp[(-Ee/（373±70 TeV）)2] at energies above ≈ 50 TeV. The cutoff energy of the electron spectrum is roughly equal to the expected current maximum energy of particles accelerated at the PWN terminal shock. Combining the X-ray and gamma-ray emission, the current space-averaged magnetic field can be limited to≈ 4.5 μG. To satisfy the multi-wavelength spectrum and the γ-ray extensions, the transport of relativistic particles within the PWN is likely dominated by the advection process under the free-expansion phase assumption.

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