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development of Low Carbon Microalloyed High Strength Ultra-Thin Cast Strip Products Produced by the Castrip~ Process With Excellent Strength-ductility Properties

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Journal of Iron and Steel Research(International) 2011年第S1期18卷 846-850页

作者： C.R. Killmore K.R. Carpenter H.R. Kaul d.g. edelman J.M. Cairney S.P. Ringer J.g. Williams P.C. Campbell W.N. Blejde BlueScope Steel Five Islands Road Pt Kembla 2500 Australia Nucor Steel Indiana 4537 S. Nucor Rd. Crawfordsville IN 47933 USA Australian Centre for Microscopy and Microanalysis University of Sydney NSW 2006 Australia Castrip LLC1915 Rexford Rd. Charlotte NC 28211 USA

The CASTRIP* process produces a range of high strength Ultra-thin Cast Strip (UCS) products (380-550 MPa) in thicknesses between 0.9 mm and 1.5 mm, which is very challenging to produce via conventional hot and cold rolled processing routes. The twin roll CASTRIP process fully exploits the hardenability and strengthening potential of Nb in a low C-Mn-Nb-V microalloyed steel type. Significant microstructural strengthening from solute Nb was obtained, even at low microalloying levels, as well as modest Mn additions, through enhancing the hardenability and further strengthening was obtained in coated products by exploiting age hardening during processing on a continuous hot dip galvanising line. Atom probe tomography and TEM determined that Nb was retained in solid solution and subsequent age hardening resulted from the formation of Nb and V rich nanosized particles. Age hardening was achieved without loss of ductility producing galvanised strip with an excellent strength-ductility combination (Y.S. >600 MPa, T.E. >10%).

关键词： strip casting microalloying niobium ntom probe tomography age hardening high strength CASTRIP Process

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Population Pharmacokinetics of UCN-01

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Journal of Cancer Therapy 2013年第10期4卷 1513-1519页

作者： Charlene A. Baksh Martin J. edelman Edward A. Sausville William d. Figg Hao Zhu Kenneth S. Bauer Clinical Pharmacology Research Core National Cancer Institute National Institutes of Health Bethesda USA department of Pharmacy Practice and Science University of Maryland Baltimore School of Pharmacy Baltimore USA Office of Clinical Pharmacology Food and Drug Administration Silver Spring USA University of Maryland.g.eenbaum Cancer Center Baltimore USA

UCN-01 (7-Hydroxystaurosporine) is an investigational anticancer agent that is currently being evaluated as targeted therapy in phase II clinical studies. The aims of this work were to describe the population pharmacokinetics of UCN-01 in patients with advanced solid tumors, and to identify covariates in patients with advanced solid tumors that affected the pharmacokinetic parameters of UCN-01. The utility of performing this research is to provide optimization of treatment and individualized dose therapy for minimization of toxicity. So, in addition to elucidating the population pharmacokinetic parameter estimates from a Phase I trial where UCN-01 was given in combination with carboplatin in patients with advanced solid tumors, and a trial where the drug was given alone as a 72-hour infusion in the same type of population, a covariate analysis was performed in order to identify pharmacokinetic determinants of UCN-01. Using NONMEM to perform nonlinear mixed-effects modeling, a linear two-compartment model was found to provide the best fit for UCN-01 data. A meta-analysis was performed, which included pooled 3-hour and 72-hour infusion data, and provided population pharmacokinetic estimates for CL (0.0157 L/hr [6.1%RSE]), V1 (2.51 L [10.0% RSE]), Q (4.05 L/hr [14.3% RSE]), and V2 (8.39 L [6.6% RSE]). Inter-individual variability was found for each of the main pharmacokinetic parameters to be ETACL (44.9% [20.8% RSE]), ETAV1 (43.9% [39.8% RSE]), ETAQ (6.09% [62.5% RSE]), and ETAV2 (4.17% [30.0% RSE]). Body surface area was found to be a statistically-significant variable from one of the individual study analyses (3-hour infusion). Population PK modeling has contributed to a better understanding of the clinical pharmacology of UCN-01. dose individualization may improve treatment with UCN-01. Further clinical development may be supported by optimization of combination chemotherapy.

关键词： Pharmacokinetics UCN-01 7-Hydroxystaurosporine Pharmacometrics Population Modeling Phase I Clinical Pharmacology

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循证指南：弥散和灌注MRI在急性缺血性卒中诊断中的作用美国神经病学学会治疗和技术评价委员会的报告

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国际脑血管病杂志 2010年第11期18卷 801-807页

作者： P.d. Schellinger[] R.N. Bryan[] L.R. Caplan[] J.A. detre[] R.R. edelman[] C. Jaigobin[] C.S. Kidwell[] J.P. Mohr[] M. Sloan[] A.g. Sorensen[] S. Warach[] 章娟娟(译) 王国颖(译) 汪凯(译) National Institutes of Neurological disorders and Stroke NIH BethesdaMD department of Neurology University of Erlangen Germany departments of Radiology University of Pennsylvania Philadelphia department of Neurology Beth Israel Deaconess Medical Center BostonMA departments of Neurology University of Pennsylvania Philadelphia department of Radiology Northwestern University Evanston division of Neurology Toronto General Hospital Canada department of Neurology Georgetown University WashingtonDC Columbia University New York NY department of Neurology University of South Florida Tampa department of Radiology MGH BostonMA 安徽医科大学第一附属医院神经内科合肥230022

目的评价弥散加权成像（diffusion-weighted imaging,dWI）和灌注加权成像（perfusionweighted imaging PWI）在急性缺血性卒中患者诊断中应用的证据.方法对1966年至2008年1月期间有关dWI和PWI诊断和预后价值的文献进行系统分析.结果... 详细信息

目的评价弥散加权成像（diffusion-weighted imaging,dWI）和灌注加权成像（perfusionweighted imaging PWI）在急性缺血性卒中患者诊断中应用的证据.方法对1966年至2008年1月期间有关dWI和PWI诊断和预后价值的文献进行系统分析.结果和推荐对于发病12 h内的急性缺血性卒中的诊断,dWI已被确认为有效的评价手段,且其诊断价值应高于非增强CT.为了最准确地诊断急性缺血性卒中,应进行dWI（A级推荐）;然而,在疑似急性卒中患者的总体样本中,dWI诊断缺血性卒中的敏感性并不完美.dWI诊断脑出血的准确性不在本指南的范围之内.根据Ⅱ级和Ⅲ级证据,基线dWI体积可预测前循环卒中的基线卒中严重程度（B级推荐）,但不能预测椎基底动脉系统卒中的基线卒中严重程度（C级推荐）.基线dWI病变体积可预测（最终）梗死体积（B级推荐）,并且有可能预测早期和远期临床转归（C级推荐）.与dWI相比,基线PWI体积预测基线卒中严重程度的价值较小（C级推荐）.尚无足够的证据支持或反对PWI在急性缺血性卒中诊断中的价值（U级推荐）.

关键词：急性缺血性卒中弥散加权成像美国神经病学学会循证指南 I诊断灌注MRI 椎基底动脉系统委员会

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On d.g., people, and a rabies epidemic: results from a sociocultural study in Bali, Indonesia

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Infectious diseases of Poverty 2015年第1期4卷 239-256页

作者： Maria d.g.a Winda Widyastuti Kevin Louis Bardosh Sunar C Basri E Basuno A.Jatikusumah R.A.Arief A.A.g.Putra A.Rukmantara A.T.S.Estoepangestie I.Willyanto I.K.g.Natakesuma I.P.Sumantra d.g.ace F.Unger J.gilbert Center for Indonesian Veterinary Analytical Studies BogorIndonesia School of Social and Political Science The University of EdinburghEdinburghUK Faculty of Veterinary Medicine Bogor Agricultural UniversityBogorIndonesia Center for Socio Economic and Agricultural Policy Studies Ministry of AgricultureBogorIndonesia disease Investigation Centre denpasar Ministry of AgricultureDenpasarIndonesia edelman Indonesia JakartaIndonesia Faculty of Veterinary Medicine Airlangga UniversitySurabayaIndonesia InI Veterinary Service SurabayaIndonesia Bali Provincial Livestock and Animal Health Services Office DenpasarIndonesia International Livestock Research Institute NairobiKenya

Background:Previously free of rabies,Bali experienced an outbreak in 2008,which has since caused a large number of human *** response,both mass d.g.culling and vaccination have been *** order to assess potential community-driven interventions for optimizing rabies control,we conducted a study exploring the relationship between d.g.,rabies,and the Balinese *** objectives of this study were to:i)understand the human-d.g.relationship in Bali;ii)explore local knowledge,attitudes,and practices(KAPs)relating to rabies;and iii)assess potential community-driven activities to optimize rabies control and ***:Conducted between February and June 2011,the study combined a questionnaire(n=300;CI=95%;error margin=5%)and focus group discussions(Fgds)in 10 villages in the denpasar,gianyar,and Karangasem *** questionnaire included a Likert scale to assess community knowledge and *** the knowledge assessment,three points were given for a correct answer,while wrong answers and uncertain answers were given zero *** the attitudes assessment,three points were given for a positive answer,two points for a neutral answer,and one point for a negative *** knowledge was categorized as good(score>40),fair(score 20–40),or poor(scored on a maximum total score *** attitudes were categorized as positive(score>26),neutral(score 13–26),or negative(scored on a maximum total score of ***-gender Fgds in each sub-village(banjar)were conducted,each involving 7–15 participants to complement the questionnaire *** a follow-up research trip in mid-2013,the data analysis was triangulated and validated using semi-structured *** data were analyzed descriptively using SPSS 17.0,while qualitative data from interviews and Fgds were analyzed manually according to accepted methods of coding and memo *** chi-square test was then used to analyze the statistical rel

关键词： Bali Rabies Sociocultural KAPs Community-driven activities

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