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Effect of spark plasma sintering and reinforcements on the formation of ultra-fine and nanograins in AA2024-TiB2-Y hybrid composites

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Progress in Natural Science:Materials International 2022年第1期32卷 79-86页

作者： ch.Suresh Vidyasagar d.B.Karunakar department of Architecture and Planning Indian Institute of Technology Roorkee Mechanical and Industrial Engineering department Indian Institute of Technology Roorkee

This study reports the influence of sintering mechanism and reinforcement materials on the formation of ultra-fine and nanograins in Al-TiB-Y nanohybrid composites. The mechanical properties of the composites and their corresponding micro and nanostructures are correlated. The experimental and characterization results revealed that despite the addition of TiB, the hard and brittle AlTi phase formation in the composites was suppressed and hence, their ductility was retained. It was found that yttrium content of 0.3 wt% was the optimum amount which created advantageous spark plasma sintering conditions, and the addition of 0.3 wt% promoted the formation of bi-modal size grains（ultra-fine and nano） along with micro grains, Ω and other nano precipitates, resulting in a significant enhancement in the composite properties. The formation of ultra-fine and nanograins may be attributed to the combined effect of melting and rapid solidification at necking zones due to Joule’s heating and thermomechanical fatigue. Among all the sintered composites, the highest hardness（137 HV）, ultimate tensile strength（UTS）(496 MPa), yield strength（YS）(438 MPa) with 15.7% elongation were obtained in the sintered sample reinforced with 1.0 wt% TiBand 0.3 wt% yttrium.

关键词： Hybrid composites Ultra-fine grains Nano grains Spark plasma sintering Nano precipitates Microstructure

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Mixed Convection Heat and Mass Transfer in a Micropolar Fluid with Soret and dufour Effects

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Advances in Applied Mathematics and Mechanics 2011年第4期3卷 389-400页

作者： d.Srinivasacharya ch.RamReddy department of Mathematics National Institute of TechnologyWarangal-506004Andhra PradeshIndia

A mathematical model for the steady,mixed convection heat and mass transfer along a semi-infinite vertical plate embedded in a micropolar fluid in the presence of Soret and dufour effects is *** non-linear governing equations and their associated boundary conditions are initially cast into dimensionless forms using local similarity *** resulting system of equations is then solved numerically using the Keller-box *** numerical results are compared and found to be in good agreement with previously published results as special cases of the present *** non-dimensional velocity,microrotation,temperature and concentration profiles are displayed graphically for different values of coupling number,Soret and dufour *** addition,the skin-friction coefficient,the Nusselt number and Sherwood number are shown in a tabular form.

关键词： Mixed convection heat and mass transfer micropolar fluid Soret and dufour effects

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Voice-driven fleet management system for agricultural operations

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Information Processing in Agriculture 2019年第4期6卷 471-478页

作者： ch.Achillas d.Bochtis d.Aidonis V.Marinoudi d.Folinas epartment of Logistics Technological Educational Institute of Central MacedoniaGR 60100 KateriniGreece Institute for Bio-Economy and Agri-Technology(IBO) Centre for Research and Technology-Hellas(CERTH)6th km Charilaou-Thermi RdGR 57001 ThermiThessalonikiGreece Lincoln Institute for Agri-Food Technology University of LincolnBrayford PoolLincoln LN67TSUK Engineers for Business S.A.(EfB) Doiranis 17GR 54639ThessalonikiGreece

Food consumption is constantly increasing at global *** this light,agricultural production also needs to increase in order to satisfy the relevant demand for agricultural ***,due to by environmental and biological factors(*** compaction)the weight and size of the machinery cannot be further physically ***,only marginal improvements are possible to increase equipment *** the contrary,late technological advances in ICT provide the ground for significant improvements in agriproduction *** this work,the V-Agrifleet tool is presented and *** is developed to provide a “hands-free”interface for information exchange and an “Olympic view”to all coordinated users,giving them the ability for decentralized *** proposed tool can be used by the end-users(***,contractors,farm associations,agri-products storage and processing facilities,etc.)order to optimize task and time *** visualized documentation of the fleet performance provides valuable information for the evaluation management level giving the opportunity for improvements in the planning of next *** vendorindependent architecture,voice-driven interaction,context awareness functionalities and operation planning support constitute V-Agrifleet application a highly innovative agricultural machinery operational aiding system.

关键词： Fleet management Voice-driven Context awareness Operation planning Cross-vendor

An improved peak side lobe reduction method for linear array antenna for military applications

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International Journal of Intelligent Computing and Cybernetics 2021年第2期14卷 185-197页

作者： Ravi Tej d Sri Kavya ch K Sarat K.Kotamraju department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationGunturIndia

Purpose-The purpose of this paper is to improve energy efficiency and further reduction of side lobe level the algorithm proposed is firework *** this paper,roused by the eminent swarm conduct of firecrackers,a novel multitude insight calculation called fireworks algorithm(FA)is proposed for work *** FA is introduced and actualized by mimicking the blast procedure of *** the FA,two blast(search)forms are utilized and systems for keeping decent variety of sparkles are likewise all around *** approve the presentation of the proposed FA,correlation tests were led on nine benchmark test capacities among the FA,the standard PSO(SPSO)and the clonal PSO(CPSO).design/methodology/approach-The antenna arrays are used to improve the capacity and spectral efficiency of wireless communication *** latest communication systems use the antenna array technology to improve the spectral efficiency,fill rate and the energy efficiency of the communication system can be *** of the most important properties of antenna array is beam pattern.A directional main lobe with low side lobe level(SLL)of the beam pattern will reduce the interference and enhance the quality of *** classical methods for reducing the side lobe level are differential evolution algorithm and PSO *** this paper,roused by the eminent swarm conduct of firecrackers,a novel multitude insight calculation called fireworks algorithm(FA)is proposed for work *** FA is introduced and actualized by mimicking the blast procedure of *** the FA,two blast(search)forms are utilized and systems for keeping decent variety of sparkles are likewise all around *** approve the presentation of the proposed FA,correlation tests were led on nine benchmark test capacities among the FA,the standard PSO(SPSO)and the clonal PSO(CPSO).It is demonstrated that the FA plainly beats the SPSO and the CPSO in both enhancement exactness and combinat

关键词： Antenna arrays Spectral efficiency Fill rate Interference Evolution algorithm Side lobe level Paper type Research paper

Electronic factor in electron self-exchange reaction of hydrated redox ion pairs from thermodynamic data

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chinese Journal of chemistry 1997年第3期15卷 201-210页

作者： Bu, YX deng, ch SHANdONG UNIV INST THEORET CHEMSHANDONG 250100PEOPLES R CHINA

An accurate scheme for determining the electronic factor of the electron self-exchange reaction in solution is presented in this paper. The used various activation parameters and slopes of potential energy surfaces are obtained in terms of an improved activation model and the accurate potential function determined from the vibrational spectroscopic and thermodynamic data. The coupling matrix elements are determined using numerical integral method over the perturbed double-zeta Slater type state functions. Theoretical results of electronic factor in this work are found in close agreement with those extracted from experimental rate constant data and to be less than unity. Results indicate that outer-sphere electron transfer reactions in solution involving hydrated transition metal ions are nonadiabatic in nature.

关键词： electronic factor Landau-Zener probability activation model hydrated transition metal ions

Polygeneration Study of Low-to-Medium Enthalpy Geothermal Reservoirs in Mexico

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Journal of Thermal Science 2021年第3期30卷 1077-1087页

作者： chÁVEZ Oscar GOdÍNEZ Francisco Tecnológico Nacional de México/I.T.chihuahua.Av.Tecnológico 2909 C.P.31310ChihuahuaChihuahuaMéxico Instituto de Ingeniería Universidad Nacional Autónoma de MéxicoUNAMC.U.Ciudad de MéxicoC.P.04510México Polo Universitario de Tecnología Avanzada Universidad Nacional Autónoma de MéxicoVía de la Innovación No.410Autopista Monterrey-Aeropuertokm.10 PIITC.P.66629Apodaca Nuevo LeónMéxico

This study combines the thermodynamic analysis of a polygeneration system along with the numerical modelling of the thermal behavior of geothermal reservoirs in Mexico to exploit their *** reservoir was modeled as a porous medium assuming a five-spot well configuration and local thermal *** heat conduction-convection along with the Laplace equations were solved to compute temperature distributions,the useful life and the optimum distance between injection-extraction *** predicted temperature and pressure of the geothermal fluid at the outlet of the reservoir were exploited in the polygeneration system consisting of:(1)a Rankine cycle,(2)an absorption refrigeration cycle,and(3)a heat *** developed approach allows calculating both the optimal distance between injection-extraction wells and the global(utilization)efficiency of six arrangements(each composed by a reservoir connected to a polygeneration system)by assuming that reservoirs have a lifespan of 30 *** also show that:(a)due to the low efficiency of the Rankine cycle,very little thermal energy is converted into electrical one;(b)not only the temperature and the size are important when evaluating the power production performance of reservoirs,but also the permeability plays a fundamental role;(c)the first law efficiency of the polygeneration system ranges from 41.9%to 43.7%;(d)the utilization efficiency of the six arrangements lies in the range between 25.8%and 31%.

关键词： polygeneration system geothermal reservoir local thermal equilibrium low-to-medium enthalpy