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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

The Use of Far Infrared Treatment Prior to Exercise in Horses: An mfBIA and Acoustic Myography Three Case Study

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Open Journal of Veterinary Medicine 2024年第4期14卷 69-89页

作者： Adrian Harrison d.Phil department for Veterinary and Animal Sciences (IVH) Faculty of Health & Medical Sciences University of Copenhagen K&#248benhavn Denmark

Background: Acute effects of Far Infrared (FIR) treatment in horses are unknown, especially short periods of 30 minutes, as is any effect on such muscle parameters as warm-up balance, overall exercise balance and laterality asymmetries. Aim: This study examines three equine cases in detail to measure any effects of a short period of FIR treatment. Methods: Multi-frequency bioimpedance (mfBIA) and acoustic myography (AMG), non-invasive techniques, were applied pre- and post-treatment with FIR to the back (T5-L4/5) and for *** dorsi and *** medius was recorded during a 15-minute warm-up regimen. mfBIA parameters included extracellular resistance (Re), centre frequency (fc), membrane capacitance (Mc), intracellular resistance (Ri) and phase angle (PA) which indicates level of training and health status. Results: FIR treatment responses for mfBIA parameters were found to be horse-specific and different, whilst in terms of AMG, FIR treatment for 30 minutes had a beneficial effect on overall balance in all three horses (5 out of 6 muscles), and a beneficial effect on the AMG parameter ST (force symmetry) in all three horses (6 out of 6 muscles). An overall improvement for combined balance and ST values for both muscles and all three horses of 86% was noted with FIR treatment, compared to 56% without. Conclusions: This preliminary study of FIR treatment in three horses, has been found to result in an overall improvement in combined balance and ST values for both muscles. FIR has potential as a promising treatment to reduce the risk of warm-up-related injuries in athletic horses.

关键词： Equine FIR Muscle Balance Muscle Force Injury Prevention

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Sustainable Ride

ChinAfrica 2024年第9期16卷 54-55页

作者： JEAN d’AMOUR MBONYINSHUTI 不详

Chinese electric vehicle makers fuel Rwanda’s drive for pollution-free *** a growing demand to electrify Rwanda’s public transport,companies are rushing into the sector to import electric vehicles(EVs)and related se... 详细信息

关键词： companies Sustainable China.

Protective and Regenerative Efficacy of a Plant Oil-Based day and Night Cream: Investigated by a Novel Approach to Reveal the Impact of Blue Light Irradiation on Epidermal Barrier Integrity and Lipid Matrix

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Journal of Cosmetics, dermatological Sciences and Applications 2024年第3期14卷 227-241页

作者： dorothee dähnhardt Stephan dähnhardt-Pfeiffer Isabel Simon dana ditgen Inge Holland dörte Segger Peter Staib Microscopy Services dhnhardt GmbH Flintbek Germany Research & development and Regulatory Affairs Kneipp GmbH Wuerzburg Germany SGS INSTITUT FRESENIUS GmbH Hamburg Germany

In recent years, the harmful effects of blue light (400 - 500 nm) as a component of visible light (400 - 700 nm) have increasingly gained attention of science, industry, and consumers. To date, only a few in vivo test methods for measuring the effects of blue light on the skin have been described. A direct measurement method that can detect the immediate effects of blue light on the epidermal permeability barrier (EPB) is still lacking. In this study, we present a new methodological approach that can be used to investigate both the protective and regenerative effects of cosmetic products on the EPB after blue light irradiation. In a study with 14 female volunteers, it was investigated whether the regular application of an O/W emulsion (day cream) can strengthen and protect the epidermal barrier against damaging blue light radiation of 60 J/cm2 (protective study design) and also whether a disruption of the epidermal barrier caused by blue light radiation is restored faster and better by the regular application of another O/W emulsion (night cream) than in product-untreated skin (regenerative study design). The two O/W emulsions are different in plant oil, active ingredient composition and texture. The seven-day treatment with the day cream initially led to a significant increase in the normalized lipid lamellae length in the intercellular space, whereas the irradiation with blue light after 24 hours led to a significant decrease in the lipid lamellae length in the untreated test area, but not in the area previously treated with the product. Regarding the regenerative study design, a two-day treatment with the night cream was able to restore a blue-light-induced decrease in lipid lamellae length in the intercellular space. In summary, with the study designs presented here, the protective and regenerative effect of two cosmetic products could be demonstrated for the first time on the integrity of the EPB after blue light irradiation and the data showed that the Lipbarv

关键词： Skin Care Blue Light Irradiation Skin Barrier Intercellular Lipid Lamellae Electron Microscopy

Creep-induced redistribution of alloying elements in CZ1 zirconium alloys

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Journal of Materials Science & Technology 2024年第6期173卷 31-44页

作者： W.T.Lin Q.Y.Lv d.Jiao L.B.Zhang J.Tan G.Sha J.Hu China Nuclear Power Technology Research Institute Shenzhen 518026China School of Material Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Introducing minor alloying elements is an effective strategy to improve the corrosion and mechanical properties of zirconium alloys for nuclear *** in-reactor service,external environment and stress can affect the distribution of alloying elements,substantially changing the degradation process of zirconium *** date,there is a lack of in-depth understanding of the interaction between creep and microchemistry ***,we conducted systematic transmission electron microscopy(TEM)and atom probe tomography(APT)investigations to address creep-induced redistribution of alloying elements in CZ1(Zr-Sn-Nb-Fe-Cr-Cu)zirconium alloy with different initial ***,Fe,Sn,and Cu are found to co-segregate at grain *** higher the intermediate annealing temperature,the larger the Gibbsian interfacial excesses of solute elements *** further demonstrate that creep can reduce the excess value of Fe at grain boundaries due to the coarsening of Zr-Fe-Cr second phase particles via grain boundary and dislocation pipe *** the same time,the excess value of Sn is increased by diffusing from the matrix to grain ***,Cu as a minor element in the concentration range of 0.05-0.3 wt.%is found to segregate at dislocations to form the Cottrell atmosphere and develop Cu-rich nanoclusters for suppressing dislocation *** new understanding of the segregation and clustering of minor alloying elements provides guidance for developing zirconium alloys with enhanced creep resistance.

关键词： Zirconium alloy Thermal creep Grain boundary segregation dislocation segregation Cu-rich nanoclusters

Energy design and Optimization of Greenhouse by Natural Convection

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Fluid dynamics & Materials Processing 2024年第8期20卷 1903-1913页

作者： H.Benzzine H.Labrim Aouatif Saad Y.Achour d.Zejli R.El Bouayadi Advanced Systems Engineering Laboratory(ASELab) National School of Applied SciencesIbn Tofail UniversityKenitraMorocco

This study addresses the pressing need for energy-efficient greenhouse management by focusing on the innovative application of natural *** primary objective of this study is to evaluate various ventilation strategies to enhance energy efficiency and optimize crop production in agricultural *** advanced numerical simulation tools,the study conducts a comprehensive assessment of natural ventilation’s effectiveness under real-world *** results underscore the crucial role of the stack effect and strategic window positioning in greenhouse cooling,providing valuable insights for greenhouse *** findings shed light on the significant benefits of optimized ventilation and also offer practical implications for improving greenhouse design,ensuring sustainable and efficient agricultural *** study demonstrated energy savings in cooling from November to April,with a maximum saving of 680 kWh in March,indicating the effectiveness of strategically positioning windows to leverage the stack *** approach enhances plant growth and reduces the need for costly cooling systems,thereby improving overall energy efficiency and lowering operational expenses.

关键词： Energy greenhouse cooling natural ventilation simulation temperature

2024 Wheelchair Compendium of Physical Activities:An update of activity codes and energy expenditure values

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Journal of Sport and Health Science 2024年第1期13卷 18-23页

作者： Scott A.Conger Stephen d.Herrmann Erik A.Willis Tom E.Nightingale Joseph R.Sherman Barbara E.Ainsworth department of Kinesiology Boise State UniversityBoiseID 83725USA Kansas Center for Metabolism and Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and Health Shanghai University of SportShanghai 200438China

Purpose:This paper presents an update of the 2011 Wheelchair Compendium of Physical Activities designed for wheelchair users and is referred to as the 2024 Wheelchair *** Wheelchair Compendium aims to curate existing knowledge of the energy expenditure for wheelchair physical activities(PAs).Methods:A systematic review of the published energy expenditure of PA for wheelchair users was completed between 2011 and May *** added these data to the 2011 Wheelchair Compendium data that was compiled previously in a systematic review through ***:A total of 47 studies were included,and 124 different wheelchair PA reported energy expenditure values ranging from 0.8 metabolic equivalents for wheelchair users(filing papers,light effort)to 11.8 metabolic equivalents for wheelchair users(Nordic sit skiing).Conclusion:In introducing the updated 2024 Wheelchair Compendium,we hope to bridge the resource gap and challenge the prevailing narratives that inadvertently exclude wheelchair users from physical fitness and health PAs.

关键词： disability Exercise MET Mobility

Grindability Evaluation of Ultrasonic Assisted Grinding of Silicon Nitride Ceramic Using Minimum Quantity Lubrication Based SiO_(2)Nanofluid

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 115-136页

作者： Yusuf Suleiman dambatta Changhe Li Mohd Sayuti Ahmed A d Sarhan Min Yang Benkai Li Anxue Chu Mingzheng Liu Yanbin Zhang Zafar Said Zongming Zhou School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520China Mechanical Engineering department Ahmadu Bello UniversityZaria 810106Nigeria Mechanical Engineering department University of Malaya50603 Kuala LumpurMalaysia department of Mechanical Engineering King Fahd University of Petroleum&Minerals31261 DhahranSaudi Arabia State Key Laboratory of Ultra-Precision Machining Technology Department of Industrial and Systems Engineer-ingThe Hong Kong Polytechnic UniversityHong KongChina College of Engineering University of Sharjah27272 SharjahUnited Arab Emirates Hanergy(Qingdao)Lubrication Technology Co. Ltd.Qingdao 266100China

Minimum quantity Lubrication(MQL)is a sustainable lubrication system that is famous in many machining *** involve the spray of an infinitesimal amount of mist-like lubricants during machining *** MQL system is affirmed to exhibit an excellent machining performance,and it is highly *** nanofluids are understood to exhibit excellent lubricity and heat evacuation capability,compared to pure oil-based MQL *** have shown that the surface quality and amount of energy expended in the grinding operations can be reduced considerably due to the positive effect of these *** work presents an experimental study on the tribological performance of SiO_(2)nanofluid during grinding of Si_(3)N_(4)*** effect different grinding modes and lubrication systems during the grinding operation was also *** concentrations of the SiO_(2)nanofluid was manufactured using canola,corn and sunflower *** quantitative evaluation of the grinding process was done based on the amount of grinding forces,specific grinding energy,frictional coefficient,and surface *** was found that the canola oil exhibits optimal lubrication performance compared to corn oil,sunflower oil,and traditional lubrication ***,the introduction of ultrasonic vibrations with the SiO_(2)nanofluid in MQL system was found to reduce the specific grinding energy,normal grinding forces,tangential grinding forces,and surface roughness by 65%,57%,65%,and 18%***,regression analysis was used to obtain an optimum parameter *** observations from this work will aid the smooth transition towards ecofriendly and sustainable machining of engineering ceramics.

关键词： Minimum quantity lubrication(MQL) Ultrasonic assisted grinding(UAG) Eco-friendly lubricants Nanofluid Grinding Ceramic

Highly Active Interfacial Sites in SFT-SnO_(2) Heterojunction Electrolyte for Enhanced Fuel Cell Performance via Engineered Energy Bands:Envisioned Theoretically and Experimentally

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Energy & Environmental Materials 2024年第3期7卷 384-397页

作者： Sajid Rauf Muhammad Bilal Hanif Faiz Wali Zuhra Tayyab Bin Zhu Naveed Mushtaq Yatao Yang Kashif Khan Peter d.Lund Martin Motola Wei Xu College of Electronic and Information Engineering and State Key Laboratory of Radio frequency Heterogeneous Integration Shenzhen UniversityShenzhen 518000China department of Inorganic Chemistry Faculty of Natural SciencesComenius University in BratislavaIlkovicova 684215BratislavaSlovakia College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Energy and Environment Southeast UniversityNo.2 Si Pai LouNanjing 210096China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China New Energy Technologies Group Department of Applied PhysicsAalto University School of ScienceP.O.Box 15100Fl-00076AaltoEspoo Finland

Extending the ionic conductivity is the pre-requisite of electrolytes in fuel cell technology for high-electrochemical *** this regard,the introduction of semiconductor-oxide materials and the approach of heterostructure formation by modulating energy bands to enhance ionic conduction acting as an electrolyte in fuel ***(n-type;SnO_(2))plays a key role by introducing into p-type SrFe_(0.2)Ti_(0.8)O_(3-δ)(SFT)semiconductor perovskite materials to construct p-n heterojunction for high ionic ***,two different composites of SFT and SnO_(2)are constructed by gluing p-and n-type SFT-SnO_(2),where the optimal composition of SFT-SnO_(2)(6∶4)heterostructure electrolyte-based fuel cell achieved excellent ionic conductivity 0.24 S cm^(-1)with power-output of 1004 mW cm^(-2)and high OCV 1.12 V at a low operational temperature of 500℃.The high power-output and significant ionic conductivity with durable operation of 54 h are accredited to SFT-SnO_(2)heterojunction formation including interfacial conduction assisted by a built-in electric field in fuel cell ***,the fuel conversion efficiency and considerable Faradaic efficiency reveal the compatibility of SFT-SnO_(2)heterostructure electrolyte and ruled-out short-circuiting ***,the first principle calculation provides sufficient information on structure optimization and energy-band structure modulation of SFT-SnO_(2).This strategy will provide new insight into semiconductor-based fuel cell technology to design novel electrolytes.

关键词： high ionic conductivity interfacial conduction modulated energy band structure p-n heterojunction semiconductors