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International Journal of digital Earth 2011年第S01期4卷 8-24页

作者： C.Corbane d.carrion M.Broglia European Commission Joint Research CentreIspraItaly

Validation is an emerging topic in the field of geospatial information for emergency *** the framework of the Global Monitoring for Environment and Security initiative,the Services and Applications for Emergency Response project seeks to implement and validate the pre-operational version of Emergency Response Core *** that context,a dedicated effort has been made in the development and implementation of a comprehensive,productoriented validation protocol tailored to crisis maps and data *** paper presents the approach for validation of crisis maps and its application in the context of rapid mapping of forest fires in Corsica during the summer of *** also discusses the main challenges and the critical aspects of validation of geospatial information in emergency response services.

关键词： validation protocol crisis mapping remote sensing forest fires

First extensive and cost-effective quality check of Crisis Maps: presentation of assessment parameters and results

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International Journal of digital Earth 2013年第S02期6卷 50-66页

作者： d.carrion C.Corbane M.Broglia M.Pesaresi Politecnico di Milano DIIARSurveyingMilanoItaly European Commission Joint Research CentreInstitute for the Protection and Security of the CitizenIspra(VA)Italy

The digital representation of disaster situations into maps,mainly based on remotely sensed observations,is becoming a widely used instrument for emergency *** of maps are being produced all over the world and big attention is paid by international institutions,such as the World Bank,the United Nations and the European Commission to these *** quality of crisis maps is a crucial element to ensure effectiveness in the disaster response chain,but it is often neglected with respect to the need for a rapid *** this paper a sample of crisis maps produced between 2005 and 2010 by world leader providers has been evaluated through around 40 parameters assessed by visual analysis and extracted from the validation protocol designed at the Joint Research Centre(JRC)of the European *** maps turned out to be in most cases clearly readable,but some gaps and inconsistencies have been singled out,due to the lack of international standard *** results are analysed in detail and some remarks are presented.

关键词： emergency maps quality assessment readability metadata cartographic standards

Validation of EO-derived information for crisis management: a digital Earth perspective in the VALgEO expert community

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International Journal of digital Earth 2011年第S01期4卷 1-7页

作者： C. Corbane[a][*] M. Pesaresi[a] & d. carrion[a] [a] European Commission Joint Research Centre Italy

New generation remote sensing technologies today open new application areas and demonstrate their effectiveness providing geo-information in support of disaster *** the same time,new challenges can be identified and among them the validation of geo-information under the new specific constraints dictated by the disaster management application area has a crucial *** the frame of the digital Earth concept,geo-information is a sharable resource,and a resource is truly shareable not only if we know the formal code used to make itand then we can read itbut alsoand in particular during disasterif we know the reliability of this *** is crucial in order to avoid information overflow and time wasting during the decision-making process in support of disaster ***‘International workshop on validation of geo-information products for crisis management,’VALgEO 2009,was held at the Joint Research Centre,in Ispra,Italy on 2123 November *** purpose of this first workshop was to initiate a dialog between the main actors of Emergency Response Services around validation and to raise awareness of the necessity for an independent formal assessment of geoinformation for disaster *** special issue includes a collection of invited papers presented at the *** gathers interdisciplinary initiatives where the majority of the contributions either directly or implicitly address different aspects of validation of geo-information generated following a disaster,ranging from flood information to forest fires and earthquake damage assessments.

关键词： disaster Earth flood

The IgH 3′ regulatory region super-enhancer does not control IgA class switch recombination in the B1 lineage

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Cellular & Molecular Immunology 2018年第3期15卷 289-291页

作者： Hussein Issaoui Nour Ghazzaui Alexis Saintamand Claire carrion Christelle Oblet Yves denizot CNRS UMR 7276 CRIBLUniversitéde LimogesLimogesFrance INSERM U1236 UniversitéRennes 1RennesFrance

The bone marrow-derived B2 population represents the vast majority of bone marrow,blood,lymph node and splenic *** B1 B-cells mostly originate during embryonic life in the liver and represent the main B-cell population in the pleural and peritoneal cavities.1,2,3,4,5 B1 and B2 B-cells differ in their origin,antigen specificity,cell surface markers,tissue distribution and capacity for class switch recombination(CSR).Schematically,B1 B-cells appear earlier than B2 B-cells during fetal development and maintain their self-renewal ability throughout their life.

关键词： maintain specificity mostly

Three-dimensional mapping and comparative analysis of the distal human corpus cavernosum and the inflatable penile prosthesis

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Asian Journal of Andrology 2013年第4期15卷 567-570,I0012页

作者： Tariq S Hakky daniel Ferguson Philippe E Spiess Paul Bradley Tom FLue Rafael E carrion department of Urology University of South Florida Tampa General Circle Tampa FL 33602 USA 23d3Solutions Burnaby BCV5J 5M8 Canada and department of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The intricate anatomy of the corpus cavernosum in both the flaccid and tumescent state has not been fully elucidated. We report our experience using a three-dimensional （3d） scanner to reconstruct cadaveric casts and compare them with 3d images of two prototypes of penile prosthesis. Two different models of the Titan Coloplast inflatable penile prosthesis were analyzed using a 3d scanner. The first was the standard model and the second was a newer model with a rounder silicone tip. Two cadaveric phalluses were harvested using Smooth-Cast 300Q polyurethane molding. The molds were excised and scanned along side the penile prosthesis. 3d scans were completed and analyzed using Leios Mesh software, and GOM Inspect software. The 3d scans demonstrated the mean human corporal radii 2 mm from the distal tip to be 36.51 mm （36.01-37.0 mm）, which is an obtuse angle. The standard Titan penile prosthesis spherical radius at the same level was 202.52 mm, while the new silicone tip prosthesis had a radius of 139.33 mm. 3d mapping further demonstrated the trajectory of the cavernosa appeared curvilinear and the distal ends appeared blunt. The use of cadaveric cavernosal molds in combination with the 3d scanner allowed us to accurately image the corpus cavernosum for the first time. Our findings suggest that anatomically accurate corporal tips appear to be relatively blunt and that the new Titan silicone tip penile prosthesis more closely resembles the human corporal tip.

关键词： corpus cavernosum penile prosthesis three-dimensional analysis

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

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Cellular & Molecular Immunology 2023年第10期20卷 1114-1126页

作者： Morgane Thomas Charlotte Bruzeau Ophélie Alyssa Martin Justine Pollet Sébastien Bender Claire carrion Sandrine Le Noir Eric Pinaud Laboratoire Contrôle de la Réponse Immune B et des Lymphoproliférations(CRIBL) Universitéde LimogesCNRS UnitéMixte de Recherche 7276Inserm Unité1262LimogesFrance Centre Hospitalier Universitaire dupuytren Service d’ImmunopathologieLimogesFrance Centre Hospitalier Universitaire de Limoges Centre National de l’Amylose AL et Autres Maladies par Dépôt d’Immunoglobulines MonoclonalesLimogesFrance Laboratoire Suivi des Therapies Innovantes Institut de Genetique HumaineUMR 9002 CNRS-UMMontpellierFrance

SATB1(Special A-T rich Binding protein 1)is a cell type-specific factor that regulates the genetic network in developing T cells and *** T cells,SATB1 is required for lineage commitment,VdJ recombination,development and *** that its expression varies during B-cell differentiation,the involvement of SATB1 needs to be clarified in this *** a KO mouse model in which SATB1 was deleted from the pro-B-cell stage,we examined the consequences of SATB1 deletion in naive and activated B-cell *** model indicates first,unlike its essential function in T cells,that SATB1 is dispensable for B-cell development and the establishment of a broad IgH ***,we show that SATB1 exhibits an ambivalent function in mature B cells,acting sequentially as a positive and negative regulator of Ig gene transcription in naive and activated cells,***,our study indicates that the negative regulatory function of SATB1 in B cells extends to the germinal center response,in which this factor limits somatic hypermutation of Ig genes.

关键词： B cells Nuclear factor Ambivalent Somatic hypermutation

用生物信息学和系统基因组学作为解决热带树木进化中复杂问题的工具

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用生物信息学和系统基因组学作为解决热带树木进化中复杂问题的工...

作者： Armijos carrion Angelo damian 广西大学

学位级别：硕士

叶绿体序列由于其高度保守的性质,已被广泛用作系统发育研究的有用工具。使用二代测序方法(NGS)可以容易地从植物中获得完整的叶绿体基因组,为物种划分和系统学提供了宝贵的数据。此外,这些基因组已经广泛用于农业、进化和生态研究、食... 详细信息

叶绿体序列由于其高度保守的性质,已被广泛用作系统发育研究的有用工具。使用二代测序方法(NGS)可以容易地从植物中获得完整的叶绿体基因组,为物种划分和系统学提供了宝贵的数据。此外,这些基因组已经广泛用于农业、进化和生态研究、食品检测等,并且目前它们是遗传序列数据库中保存最多的真核基因组,例如日本dNA数据库(国家遗传学研究所)、EMBL(欧洲生物信息学研究所)和基因银行(国家生物技术信息中心)。考虑到无论是通过NGS法还是在线平台获取这些遗传资源的高度可行性,如今许多高通量测序方法可用来揭示不同生物基因组的详细特征,从而进一步探索适用不同进化研究的的生物信息学流程。然而,许多用以重建质体序列的测序方法和生物信息学方法的快速发展,可能导致在选择最有效的方法和设置的混乱。对完整质体基因组进行大规模测序的趋势,凸显对标准化和有充分记录的生物信息学工作流的需求。对允许精确基因组序列再现性的高效工作流程的要求尤其明显。此外,大多数已发表的研究仍然没有提供必要的细节来复制他们的生物信息学分析,并且经常仅仅列出所使用的软件工具的名称和版本号。另一方面,随着NGS技术提供的基因组资源的快速增加,高效和标准化的元数据管理方法对于生物数据的后处理阶段变得越来越重要。特别是在使用环状叶绿体基因组数据的基于细胞器的研究中,主要结构区域的随机组合(顺序和方向)是对无论大小分类单元形成用于系统发育重建的“现成对齐”数据集的能力的主要限制。此外,在目前的实际操作中,在基因组中可帮助用来对比其他编码区的最多变的区域常被删掉。尽管如此,目前还没有一款软件可以通过对主要的质体区域的检测、组织和定位达到这种程度,这使得固化过程既耗时又容易出错。为了解决这两个主要问题,本论文将集中在四个主要章节:第一章介绍叶绿体基因组测序、组装、注释、比对、系统进化树推断中最常用的方法和工作流程,以及对软件选择和精确设置高度敏感的过程。在NGS驱动的基因组研究中,生物信息学工作流程的标准化和可重复性举足轻重。这是由以前几个植物系统发育学研究以及影响下游分析进而影响最终结果的软件工具获得的经验。第二章描述利用最新系统发育策略对孔药楠(Sinoporahongkongensis)叶绿体基因组重新组装的实际应用,主要由分子实验、生物信息学工作流程以及质体基因组测序和表征的结果三个部分组成。其中,组装和注释这个质体基因组的生物信息学步骤做详细描述。在组装和注释这个基因组后,将其与樟科和其他科的代表性物种进行比较。在此,我们比对18个物种的所有叶绿体dNA(cp dNA)区域然后进行一个简单的系统进化树推理,作为整个工作流完整性的概念证明。第三章介绍一个方便快捷且容易使用的软件---ECu AdOR。这个软件基于Perl脚本算法,专门用于自动检测和重组从任何来源(NGS,桑格测序或组装输出)获得的质体序列。ECu AdOR使用滑动窗口方法检测原始序列中的长重复序列,然后识别反向重复序列(IRs)(即使在人为或测序错误的情况下),并自动将序列重排为广泛使用的LSC-IRb-SSC-IRa顺序。这有助于快速的后续编辑步骤,例如基因组比对、可变区检测、单核苷酸多态性(SNP)检测和系统发育分析。ECu AdOR对被子植物不同科的161个质体测试成功。ECu AdOR首先为每个数据集鉴别并重新排序中心区域(LSC-IRb-SSC-IRa),然后为叶绿体序列进行新注释。该过程耗时不到20分钟,最大内存需求为150 MB,准确率超过99%。ECu AdOR是唯一一个从头开始的一步识别和重新排序工具,方便来自NGS数据的核外基因组的后续处理分析。这个程序可在https://***/Biodiv Genomic/ECu AdOR/下载。第四章为本研究最重要的结果的总结,强调主要目的、新颖性、发现和未来方向。此研究试图涵盖当今现代系统发育学所面临问题的广阔领域,并总结由于分子和基因组数据的出现,系统发育学领域正在经历的一些最紧迫的挑战。我们强调自动化数据挖掘方法仍然不完整且会随着时间的推移而变化,而这些方法可能会产生错误的数据和结果。这种错误可能会降低系统发育的准确性,并且在缺乏专业知识的情况下无法被发现。

关键词：生物信息学自动化工作流系统发育学二代测序质体完整叶绿体基因组

Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients

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World Journal of Hepatology 2020年第11期12卷 1076-1088页

作者： Teresa Broquetas Montserrat Garcia-Retortillo Miquel Mico Lidia Canillas Marc Puigvehi Nuria Canete Susana Coll Ana Viu Juan Jose Hernandez Xavier Bessa JoseA carrion department of Gastroenterology Liver SectionHospital del Mar Medical Research InstituteBarcelona 08003Spain departament of de Medicina Universitat Autònoma de BarcelonaBarcelona 08003Spain Laboratori de Referencia de Catalunya El Prat de LlobregatBarcelona 08820Spain

BACKGROUNd Hepatitis B e antigen-negative chronic hepatitis B patients under nucleos(t)ids analogues(NAs)rarely achieve hepatitis B surface antigen(HBsAg)*** To evaluate if the addition of pegylated interferon(Peg-IFN)could decrease HBsAg and hepatitis B core-related antigen(HBcrAg)levels and increase HBsAg loss rate in patients under NAs *** Prospective,non-randomized,open-label trial evaluating the combination of Peg-IFN 180μg/week plus NAs during forty-eight weeks vs NAs in *** B e antigen-negative non-cirrhotic chronic hepatitis B patients of a tertiary hospital,under NAs therapy for at least 2 years and with undetectable viral load,were *** with hepatitis C virus,hepatitis d virus or human immunodeficiency virus co-infection and liver transplanted patients were *** and HBcrAg levels(log10 U/mL)were measured at baseline and during ninety-six *** loss rate was evaluated in both *** events were recorded in both *** kinetic of HBsAg for each treatment group was evaluated from baseline to weeks 24 and 48 by the slope of the HBsAg decline(log10 IU/mL/week)using a linear regression *** Sixty-five patients were enrolled,61%receiving tenofovir and 33%***-six(55%)were included in Peg-IFN-NA group and 29(44%)in NA *** matching by age and treatment duration,baseline HBsAg levels were comparable between groups(3.1 vs 3.2)(P=0.25).HBsAg levels at weeks 24,48 and 96 declined in Peg-IFN-NA group(-0.26,-0.40 and-0.44)and remained stable in NA group(-0.10,-0.10 and-0.10)(Pdecline in Peg-IFN-NA group(-0.02)was higher than in NA group(-0.00)(P=0.015).HBcrAg levels did not ***(22%)patients discontinued Peg-IFN due to adverse *** HBsAg loss was achieved in 3(8.3%)patients of the Peg-IFN-NA group and 0(0%)of the NA *** The addition of Peg-IFN to NAs caused a greater and faster decrease of HBsAg levels compared to N

关键词： Chronic hepatitis B Hepatitis B e antigen-negative Hepatitis B surface antigen Hepatitis B core-related antigen Pegylated-interferon Nucleos(t)ids analogues©The Author(s)2020.Published by Baishideng Publishing Group Inc.All rights reserved

Prospective of Medical Cost for Renal Failure for Sex and Age Group in Range 2012-2050： Case of Mexico

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通讯和计算机（中英文版） 2015年第5期12卷 228-236页

作者： dora E. Ledesma-carrion Lidia Hernandez-Hernandez Maria Teresa Leonor Mucifio-Porras direccion General Adjunta de Investigacion de la direceion General de Integracion Analisis e Investigacion lnstituto Nacional de Estadistica y Geografia Av. Patriotismo 711 Torre A Piso 4 Col. San Juan Mixcoac Mexico D. F. 03730 Mexieo Subdireccion de Capacitaeion de la direccion General de Administracion Instituto Naeional de Estadistica y Geografia Av. Patriotismo 711 Torre A Piso 2 Col. San Juan Mixeoae Mexieo D. F. 03730 Mexico

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地震反射数据的全波动方程向下延拓

油气藏评价与开发 1987年第5期 14-20页

作者： d.J.Foster Ph.M.carrion 纪少游

本文提出一种压制地震记录中多次反射的新方法。它是建立在应用全声波方程(双曲线形式)作为向下延拓算子的向下延拓方法基础上的。我们证明记录波场的向下延拓可绘成反射率函数曲线,而没有多次反射波。该方法成功地应用于单道平面波以分... 详细信息

本文提出一种压制地震记录中多次反射的新方法。它是建立在应用全声波方程(双曲线形式)作为向下延拓算子的向下延拓方法基础上的。我们证明记录波场的向下延拓可绘成反射率函数曲线,而没有多次反射波。该方法成功地应用于单道平面波以分解(倾斜叠加)合成记录和野外数据。

关键词：向下延拓野外数据倾斜叠加全波动方程波场震源子波偏移速度上行波地震波射线参数射线理论多次波多次反射波地震记录合成记录