检索结果-南通市图书馆

determining minimum sample size for the conditioned Latin hypercube sampling algorithm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2024年第3期34卷 530-539页

作者： daniel d.SAURETTE Asim BISWAS Richard J.heck Adam W.GILLESPIE Aaron A.BERG School of Environmental Sciences University of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada) Ontario Ministry of Agriculture Food and Rural Affairs1 Stone Rd WestGuelph ON N1G 2Y4(Canada) Geography Environment&GeomaticsUniversity of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada)

In digital soil mapping(dSM),a fundamental assumption is that the spatial variability of the target variable can be explained by the predictors or environmental *** to adequately sample the predictors have been well documented,with the conditioned Latin hypercube sampling(cLHS)algorithm receiving the most attention in the dSM *** ad.a.ces in sampling design,a critical gap remains in determining the number of samples required for dSM *** propose a simple workflow and function coded in R language to determine the minimum sample size for the cLHS algorithm based on histograms of the predictor variables using the Freed.a.-d.a.onis rule for determining optimal bin *** preprocessing was included to correct for multimodal and non-normally distributed data,as these can affect sample size determination from the *** on a user-selected quantile range(QR)for the sample plan,the densities of the histogram bins at the upper and lower bounds of the QR were used.a. a scaling factor to determine minimum sample *** technique was applied to a field-scale set of environmental covariates for a well-sampled.a.ricultural study site near Guelph,Ontario,Canada,and tested.a.ross a range of *** results showed increasing minimum sample size with an increase in the QR *** sample size increased from 44 to 83 when the QR increased from 50% to 95% and then increased exponentially to 194 for the 99%*** technique provides an estimate of minimum sample size that can be used.a. an input to the cLHS algorithm.

关键词： bin width digital soil mapping normal distribution quantile range sampling design

Microbial responses to combined oxidation and catalysis treatment of 1,4-dioxane and co-contaminants in ground.a.er and soil

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2018年第5期12卷 168-180页

作者： Yu Miao Nicholas W.Johnson Kimberly heck Sujin Guo Camilah d.Powell Thien Phan Phillip B.Gedalanga david T.Adamson Charles J.Newell Michael S.Wong Shaily Mahendra department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90095USA department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX 77005USA department of Health Science California State UniversityFullertonCA 92834USA GSI Environmental Inc. HoustonTX 77098USA

Post-treatment impacts of a novel combined hydrogen peroxide(H2O_(2))oxidation and WOx/ZrO_(2) catalysis used for the removal of 1,4-dioxane and chlorinated volatile organic compound(CVOC)contaminants were investigated in soil and ground.a.er microbial *** treatment train removed~90%1,4-dioxane regardless of initial concentrations of 1,4-dioxane and *** Illumina Miseq platform and bioinformatics were used to study the changes to microbial community *** approach determined that dynamic shifts of microbiomes were associated with conditions specific to treatments as well as 1,4-dioxane and CVOCs *** biodiversity was observed to decrease only after oxidation under conditions that included high levels of 1,4-dioxane and CVOCs,but increased when 1,4-dioxane was present without ***_(x)/ZrO_(2) catalysis reduced biodiversity across all *** classification demonstrated oxidative tolerance for members of the genera Massilia and Rhodococcus,while catalyst tolerance was observed for members of the genera Sphingomonas and *** discriminant analysis effect size was a useful statistical tool to highlight representative microbes,while the multidimensional analysis elucidated the separation of microbiomes under the low 1,4-dioxane-only condition from all other conditions containing CVOCs,as well as the differences of microbial population among original,post-oxidation,and post-catalysis *** results of this study enhance our understanding of microbial community responses to a promising chemical treatment train,and the metagenomic analysis will help practitioners predict the microbial community status during the post-treatment period,which may have consequences for long-term management strategies that include additional biodegradation treatment or natural attenuation.

关键词： Coupled treatments Chlorinated solvents diethylene ether Biological diversity Microbial populations Biomarkers

Bacterial Vector-Borne Plant diseases:Unanswered Questions and Future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2020年第10期13卷 1379-1393页

作者： Weijie Huang Paola Reyes-Caldas Marina Mann Shirin Seifbarghi Alexand.a.Kahn Rodrigo P.P.Almeida Laure Béven Michelle heck Saskia A.Hogenhout Gitta Coaker department of Crop Genetics John Innes CentreNorwich Research ParkNorwich NR47UHUK department of Plant Pathology University of CaliforniaDavisCA95616USA department of Plant Pathology and Plant-Microbe Biology Cornell UniversityIthacaNY 14853USA department of Environmental Science Policy and ManagementUniversity of CaliforniaBerkeleyCA 94720USA UMR 1332 Biologie du Fruit et Pathologie Univ.BordeauxINRAEVillenave d'Ornon 33882 France Boyce Thompson Institute IthacaNY 14853USA Emerging Pests and Pathogens Research Unit Robert W.Holley CenterUSDA ARSIthacaNY 14853USA School of Environmental Sciences University of East AngliaNorwich Research ParkNorwich NR47T JUK

Vector-borne plant diseases have significant ecological and economic impacts,affecting farm profitability and forest composition throughout the *** vector-borne pathogens have evolved sophisticated strategies to interact with their hemipteran insect vectors and plant *** pathogens reside in plant vascular tissue,and their study represents an excellent opportunity to uncover novel biological mechanisms regulating intracellular pathogenesis and to contribute to the control of some of the world's most invasive emerging *** this perspective,we highlight recent ad.a.ces and major unanswered questions in the realm of bacterial vector-borne disease,focusing on liberibacters,phytoplasmas,spiroplasmas,and Xylella fastidiosa.

关键词： liberibacter phytoplasma spiroplasma Xylella fastidiosa vector-borne disease effector plant immunity

N<sup>ω</sup>-Nitro-N<sup>ω’</sup>-Substituted Guanidines: A Simple Class of Nitric Oxide Synthase Inhibitors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modern Research in Inflammation 2014年第2期3卷 48-58页

作者： Christophe d. Guillon david d. Wisnoski Jaya Saxena Ned d. Heindel d.a.e E. heck donald J. Wolff Jeffrey d. Laskin department of Chemistry Lehigh University Bethlehem USA department of Environmental and Occupational Medicine Rutgers University—Robert Wood Johnson Medical School Piscataway USA department of Environmental Health Science New York Medical College Valhalla USA department of Pharmacology Rutgers University—Robert Wood Johnson Medical School Piscataway USA

A series of Nω-nitro-Nω’-substituted guanidines has been prepared.a. potential inhibitors of the human Nitric Oxide Synthase (NOS) isoforms. The reported utility of amino-guanidine and nitroarginine in iNOS inhibition points to a potential similar utility for analogs of nitro-guanidine. The compound library was tested.a.ainst the three isoforms of Nitric Oxide Synthase (eNOS, iNOS and nNOS). Several candidates showed excellent activity and good selectivity for nNOS. One particular compound even demonstrated good selectivity for iNOS. The potential usefulness of such selective inhibitors is discussed.

关键词： Nitro-Guanidines Nitric Oxide Synthase (NOS) Isoforms Selective Inhibitors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

利益法学

Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling

作者： (德)菲利普·黑克(Philipp heck)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第1期20卷 26-37页

作者： Kelly A.dingess Max Hoek danique M.Hvan Rijswijk Sem Tamara Maurits Aden Boer Tim Veth Mirjam J.A.damen Arjan Barendregt Michelle Romijn Hannah G.Juncker Britt Jvan Keulen Gestur Vidarsson Johannes Bvan Goudoever Albert Bondt Albert J.R.heck Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical SciencesUniversity of UtrechtPadualaan 8Utrecht 3584 CHThe Netherlands Netherlands Proteomics Center Padualaan 8Utrecht 3584 CHThe Netherlands Amsterdam UMC Vrije UniversiteitUniversity of AmsterdamEmma Children’s HospitalAmsterdam Reproduction&Development Research InstituteDepartment of PediatricsAmsterdamthe Netherlands department of Experimental Immunohematology Sanquin Research and Landsteiner LaboratoryAmsterdam UMCUniversity of AmsterdamAmsterdamNetherlands

The most abundant immunoglobulin present in the human body is IgA. It has the highest concentrations at the mucosal lining and in biofluids such as milk and is the second most abundant class of antibodies in serum. We assessed the structural diversity and clonal repertoire of IgA1-containing molecular assemblies longitudinally in human serum and milk from three donors using a mass spectrometry-based.a.proach. IgA-containing molecules purified from serum or milk were assessed by the release and subsequent analysis of their Fab fragments. Our data revealed that serum IgA1 consists of two distinct structural populations, namely monomeric IgA1 (∼80%) and dimeric joining (J-) chain coupled IgA1 (∼20%). Also, we confirmed that IgA1 in milk is present solely as secretory (S)IgA, consisting of two (∼50%), three (∼33%) or four (∼17%) IgA1 molecules assembled with a J-chain and secretory component (SC). Interestingly, the serum and milk IgA1-Fab repertoires were distinct between monomeric, and J-chain coupled dimeric IgA1. The serum dimeric J-chain coupled IgA1 repertoire contained several abundant clones also observed in the milk IgA1 repertoire. The latter repertoire had little to no overlap with the serum monomeric IgA1 repertoire. This suggests that human IgA1s have (at least) two distinct origins;one of these produces dimeric J-chain coupled IgA1 molecules, shared in human serum and milk, and.a.other produces monomeric IgA1 ending up exclusively in serum.

关键词： Antigen binding fragment Immunoglobulin A1 Clonal repertoires human milk Serum

急性缺血性卒中的血管内治疗：神经介入外科学学会实践标准委员会的报告

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际脑血管病杂志 2012年第12期20卷 905-912页

作者： K A Blackham P M Meyers T A Abruzzo F C Alberquerque d Fiorella J Fraser d Frei C d Gandhi d V heck J A Hirsch d P Hsu M Jayaraman S Narayanan C Prestigiacomo J L Sunshine 包元飞(译) 李永坤(译) 刘新峰(译) 代表神经介入外科学学会南京大学医学院临床学院南京军区南京总医院神经内科 210002

目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会（American Heart Association，AHA）以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上，进行系统的文献回顾以评估支持急性缺血性... 详细信息

目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会（American Heart Association，AHA）以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上，进行系统的文献回顾以评估支持急性缺血性卒中血管内治疗的证据。根据AHA卒中委员会和牛津大学循证医学中心提出的循证医学证据分级指南进行评估。对操作安全性、技术效果以及对临床转归的影响进行特别审核。

关键词：急性缺血性卒中血管内治疗委员会神经介入外科学标准学会美国心脏协会

反应性神经刺激治疗成人局灶性药物难治性癫痫的中心试验结果

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

癫痫杂志 2016年第1期2卷 81-88页

作者： Christianne N heck david King-Stephens Andrew d Massey 樊京京(译) 杨华俊王群(审) 不详首都医科大学附属北京天坛医院神经病学中心癫痫科北京100050

为了验证在癫痫灶进行反应性神经刺激作为减少成人癫痫起源于一个或两个致痫灶的药物难治性部分性癫痫发作频率的辅助治疗方法的安全性及有效性.反应性局灶皮层刺激(Responsive focal cortical stimulation,RNS)的多中心随机对照双盲试... 详细信息

为了验证在癫痫灶进行反应性神经刺激作为减少成人癫痫起源于一个或两个致痫灶的药物难治性部分性癫痫发作频率的辅助治疗方法的安全性及有效性.反应性局灶皮层刺激(Responsive focal cortical stimulation,RNS)的多中心随机对照双盲试验.对起源于一个或两个致痫灶的药物难治性部分性癫痫受试者进行皮下植入,植入后1个月按1∶1随机分为真刺激及假刺激组.植入后第5个月过后,所有受试者在一个开放标签期(Open label period,OLP)接受反应性神经刺激开放标签来完成2年的植入后随访.所有191例受试者进行了随机化.盲法期结束时真刺激组癫痫发作改变的百分比为37.9%,假刺激组为17.3%(P=0.012,广义估计方程).开放标签期癫痫发作减少百分比中位数第1年为44%,第2年为53%,代表随着时间呈进行性且显著的改善(P<0.000 1).严重不良事件发生率在真刺激及假刺激组间无差异.不良事件与植入医疗设备、癫痫发作及其它癫痫治疗方法的已知风险是一致的.未出现神经心理功能或情绪方面的不良效应.反应性神经刺激治疗局灶性癫痫快速减少了部分性癫痫发作的频率,显示了随时间癫痫发作减少率的改善,耐受性良好,安全性可接受.RNS系统为药物难治性部分性癫痫发作患者提供了一种新的治疗选择.

关键词：皮层刺激部分性癫痫局灶性癫痫反应性神经刺激神经刺激器

三维动画创作软件3d Studio 4.0版的新特点

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计算机世界月刊 1995年第8期 36-37页

作者： Mike heck 徐卫东张树蔚北京918信箱11-4 100039

Autodesk公司的3d Studio开创了低价三维动画工具的先河。4年前该公司推出了零售价不到3千美元的3d Studio,与当时非常昂贵的专业动画软件形成了鲜明的对比。它最近推出的4.0最新版本售价仍然不到3千美元。使用3d Studio 4.0需要带有协... 详细信息

Autodesk公司的3d Studio开创了低价三维动画工具的先河。4年前该公司推出了零售价不到3千美元的3d Studio,与当时非常昂贵的专业动画软件形成了鲜明的对比。它最近推出的4.0最新版本售价仍然不到3千美元。使用3d Studio 4.0需要带有协处理器的386以上档次的机器。

关键词：动画创作软件三维应用程序