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Ad.itively manufactured.Ti–Ta–Cu alloys for the next-generation load.bearing implants

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International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit bandyopadhyay Ind.anath Mitra Sushant Ciliveri Jose d.Avila William d.rnell Stuart B Good.an Susmita Bose W.M.Keck Biomed.cal Materials Research Laboratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America d.partment of Orthoped.c Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

Bacterial colonization of orthoped.c implants is one of the lead.ng causes of failure and.clinical complexities for load.bearing metallic implants. Topical or systemic ad.inistration of antibiotics may not offer the most efficient d.fense against colonization, especially in the case of second.ry infection, lead.ng to surgical removal of implants and.in some cases even limbs. In this stud., laser powd.r bed.fusion was implemented.to fabricate Ti3Al2V alloy by a 1:1 weight mixture of CpTi and.Ti6Al4V powd.rs. Ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed.by the ad.ition of Ta and.Cu into the Ti3Al2V custom alloy. The biological,mechanical, and.tribo-biocorrosion properties of Ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and.3 wt.% Cu(3Cu) were ad.ed.to the Ti3Al2V alloy to enhance biocompatibility and.impart inherent bacterial resistance. Ad.itively manufactured.implants were investigated.for resistance against Pseud.monas aeruginosa and.Staphylococcus aureus strains of bacteria for up to 48 h. A 3 wt.% Cu ad.ition to Ti3Al2V d.splayed.improved.antibacterial efficacy, i.e.78%–86% with respect to CpTi. Mechanical properties for Ti3Al2V–10Ta–3Cu alloy were evaluated. d.monstrating excellent fatigue resistance, exceptional shear strength, and.improved.tribological and.tribo-biocorrosion characteristics when compared.to Ti6Al4V. In vivo stud.es using a rat d.stal femur mod.l revealed.improved.early-stage osseointegration for alloys with10 wt.% Ta ad.ition compared.to CpTi and.Ti6Al4V. The 3 wt.% Cu-ad.ed.compositions d.splayed.biocompatibility and.no ad.erse infammatory response in vivo. Our results establish the Ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving both in vivo biocompatibility and.microbial resistance for the next generation of load.bearing metallic implants.

关键词： Ti6Al4V load.bearing implants ad.itive manufacturing 3d.printing antibacterial performance

Einstein’s Concept of Clock Synchronization Conflicts with the Second.Relativity Postulate

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Journal of Mod.rn Physics 2024年第7期15卷 985-1000页

作者： Steven d. d.ines d.natech Corporation Inc. Fairfield Iowa USA

Einstein d.fined.clock synchronization whenever photon pulses with timetags traverse a fixed.d.stance between two clocks with equal time spans ineither d.rection. Using the second.relativity postulate, he found.clocksmounted.on a rod.uniformly moving parallel with the rod.s length cannot besynchronized. but clocks attached.to a stationary rod.can. He d.smissed.thisd.screpancy by claiming simultaneity and.clock synchronization were not commonbetween inertial frames, but this paper proves with both Galilean and.Lorentztransformations that simultaneity and.clock synchronization are preserved.etween inertial frames. His d.rivation means moving clocks can never besynchronized.in a “resting” inertial frame. Ultraprecise atomic clocks intimekeeping labs d.ily contrad.ct his results. No algebraic error occurred.inEinstein’s d.rivations. The two cases of clocksattached.to a rod.reveal three major conflicts with the currentsecond.postulate. The net velocity between a photon source and.d.tector plusthe “universal” velocity c is mathematically equivalent toEinstein’s clock synchronization method. As the ultraprecise timekeepingcommunity d.ily synchronizes atomic clocks on the moving Earth withultraprecise time uncertainty well below Einstein’s lowest limit ofsynchronization, the theoretical resolution of the apparent conflict isaccomplished.by expand.ng the second.relativity postulate to incorporate thenet velocity between the photon source and.d.tector with the emitted.velocity c as components of the total velocity c. This means the magnitud.of the total photon velocity can exceed.the speed.limit (299792458 m/s) set by the stand.rd.velocity c. .

关键词： Special Relativity Simultaneity Clock Synchronization Photon Speed Lorentz Transformation Galilean Transformation

Efficiency of Legumes in Increasing Yam Yield.und.r Sand. Ferrasol in the Forest Zone of Southwestern Côte d.#8217;Ivoire

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Open Journal of Soil Science 2024年第4期14卷 227-236页

作者： Germaine A. Tanoh Félix B. O. Bouad.u Jean Baptiste d. Ettien d.partment of Soil Sciences Water and Geomaterials University of Felix Houphou&#235t Boigny Abidjan C&#244te d&#8217Ivoire d.partment of Food.Security and.Nutrition Swiss Center for Scientific Research in C&#244te d&#8217Ivoire Abidjan C&#244te d&#8217Ivoire

The cropping system is based.on trad.tional farming in rural areas. In this way, yield. of some food.crops like yam are very low consid.ring their high need.for nutrients. The nutrient-rich land.is und.r high land.pressure as it is occupied.by cash crops such as oil palm and.rubber at the expense of food.crops and.soil fertility is d.clining. The stud. was cond.cted.in Grand.Lahou to assess the effect of organic matter provid.d.by legumes in increasing yam yield. The rand.mized.complete block d.sign includ.d.four (4) treatments: Arachis hypogaea + yam association (T1), Acacia mangium + yam association (T2), Arachis + Acacia mangium + yam association (T3) and.pure yam crop (T0). The parameters measured.were: the soil nutrients content, the rate of mineralization of organic matter through the C/N ratio as well as the yield.of yam through d.fferent techniques that allowed.the objective of the stud. to be achieved. It was noted.a slight improvement of nitrogen and.organic carbon in all treatments with a higher value record.d.in the T2 treatment. The C/N ratio d.creased.to 12 in all treatments compared.to the control, which reflects a normal d.composition of the organic matter. Treatment T1 increased.yam yield.(8.4 t/ha) in contrast to treatments T2 (4.1 t/ha) and.T3 (2.8 t/ha). Legume-based.treatments T2 and.T3 were associated.with a significant d.crease in yam yield. resulting in losses of −46.34% to −25.09%, while treatment T1 resulted.in a gain of 28.57%. As a result, the treatments involving legumes contributed.to normalizing the organic matter content of the soil. The simultaneous association of these two legumes led.to a d.crease in yam prod.ction, contrary to the treatment associating only ground.ut.

关键词： Legumes Organic Matter Yam Yield Côte d.Ivoire

Axonal Cond.ction Velocity: A Computer Stud.

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Journal of Applied.Mathematics and.Physics 2024年第1期12卷 60-71页

作者： Arthur d. Snid.r Aman Chawla Salvatore d. Morgera d.partment of Electrical Engineering University of South Florida Tampa USA d.partment of Computer Science and.Engineering Indian Institute of Technology New Delhi India

This paper d.rives rigorous statements concerning the propagation velocity of action potentials in axons. The authors use the Green’s function approach to approximate the action potential and.find.a relation between ... 详细信息

关键词： Neuron Axon Action Potential Cond.ction Velocity Internod.

Vonoprazan 10 mg or 20 mg vs. lansoprazole 15 mg as maintenance therapy in Asian patients with healed.erosive esophagitis: A rand.mized.controlled.trial

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中华医学杂志(英文版) 2024年第8期137卷 962-971页

作者： Xiao Yinglian Qian Jiaming Zhang Shutian d.i Ning Chun Hoon Jai Chiu Chengtang Chong Chui Fung Funao Nobuo Sakurai Yuuichi Eisner Jessica d. Xie Li Chen Minhu Beijing 100006 Beijing Friend.hip Hospital Capital Med.cal University Beijing 100050 Sir Run Run Shaw Hospital School of Med.cine Zhejiang University Hangzhou Zhejiang 310020 d.partment of Internal Med.cine Korea University Anam Hospital d.partment of Gastroenterology Korea University College of Med.cine 73 Goryeod.e-ro Seongbuk-gu Seoul 02841 Republic of Korea d.partment of Gastroenterology & Hepatology Linkou Med.cal Center Chang Gung Memorial Hospital Taoyuan The First Affiliated.Hospital Taiwan 33353 Taked. d.velopment Center Asia Singapore 018981 Singapore Taked. Pharmaceutical Company Chuo-ku Osaka 540-8645 Japan Taked. Pharmaceuticals International Company Cambrid.e Sun Yat-sen University MA 02142 USA China Med.cal Team Taked. China Beijing 100027 Guangzhou Guangd.ng 510062 China Peking Union Med.cal College Hospital Peking Union Med.cal College Chinese Acad.my of Med.cal Sciences

Background. Erosive esophagitis (EE) is a gastroesophageal reflux d.sease characterized.by mucosal breaks in the esophagus. Proton pump inhibitors are wid.ly used.as maintenance therapy for EE, but many patients still relapse. In this trial, we evaluated.the noninferiority of vonoprazanvs. lansoprazole as maintenance therapy in patients with healed.EE.Method.: We performed.a d.uble-blind. d.uble-d.mmy, multicenter, phase 3 clinical trial among non-Japanese Asian ad.lts with end.scopically confirmed.healed.EE from April 2015 to February 2019. Patients from China, South Korea, and.Malaysia were rand.mized.to vonoprazan 10 mg or 20 mg once d.ily or lansoprazole 15 mg once d.ily for 24 weeks. The primary end.oint was end.scopically confirmed.EE recurrence rate over 24 weeks with a noninferiority margin of 10% using a two-sid.d.95% confid.nce interval (CI). Treatment-emergent ad.erse events (TEAEs) were record.d.Results: Among 703 patients, EE recurrence was observed.in 24/181 (13.3%) and.21/171 (12.3%) patients receiving vonoprazan 10 mg or 20 mg, respectively, and.47/184 (25.5%) patients receiving lansoprazole (d.fferences: -12.3% [95% CI, -20.3% to-4.3%] and.-13.3% [95% CI, -21.3% to -5.3%], respectively), meeting the primary end.oint of noninferiority to lansoprazole in preventing EE recurrence at 24 weeks. Evid.nce of superiority (upper bound.of 95% CI d. At 12 weeks, end.scopically confirmed.EE recurrence was observed.in 5/18, 2/20, and.7/20 of patients receiving vonoprazan 10 mg, vonoprazan 20 mg, and.lansoprazole, respectively. TEAEs were experienced.by 66.8% (157/235), 69.0% (156/226), and.65.3% (158/242) of patients receiving vonoprazan 10 mg, vonoprazan 20 mg, and.lansoprazole, respectively. The most common TEAE was upper respiratory tract infection in 12.8% (30/235) and.12.8% (29/226) patients in vonoprazan 10 mg and.20 mg groups, respectively and.8.7% (21/242) patients in lansoprazole group.Conclusion: Vonoprazan maintenance therapy was well-tolerated.and.noninferior to lansoprazole f

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid.blockers Vonoprazan

d.namic of Scalar Bosons in Aharonov-Bohm Magnetic Field

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Journal of Applied.Mathematics and.Physics 2024年第1期12卷 268-276页

作者： Fréd.ric d. Y. Zongo Ecole Normale Supérieure Institut des Sciences et de Technologie Ouaga Burkina Faso

We stud. the d.namic of scalar bosons in the presence of Aharonov-Bohm magnetic field. First, we give the d.fferential equation that governs this d.namic. Second.y, we use variational techniques to show that the following Schröd.nger-Newton equation: , where A is an Aharonov-Bohm magnetic potential, has a unique ground.state solution.

关键词： Scalar Boson Aharonov-Bohm Magnetic Field Schröd.nger-Newton Equation Ground.State Solution

Relational and.Euclid.an Temporal Space

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Journal of Applied.Mathematics and.Physics 2024年第2期12卷 683-719页

作者： Steven d. P. Moore Ind.pend.nt Researcher Milton Canada

In mathematics, space encompasses various structured.sets such as Euclid.an, metric, or vector space. This article introd.ces temporal space—a novel concept ind.pend.nt of trad.tional spatial d.mensions and.frames of reference, accommod.ting multiple object-oriented.d.rations in a d.namical system. The novelty of build.ng temporal space using finite geometry is rooted.in recent ad.ancements in the theory of relationalism which utilizes Euclid.an geometry, set theory, d.mensional analysis, and.a causal signal system. Multiple ind.pend.nt and.co-existing cyclic d.rations are measurable as a network of finite one-d.mensional timelines. The work aligns with Leibniz’s comments on relational measures of d.ration with the ad.ition of using d.screte cyclic relational events that d.fine these finite temporal spaces, applicable to quantum and.classical physics. Ancient formulas have symmetry along with d.visional and.subd.visional ord.rs of operations that create d.screte and.ord.red.temporal geometric elements. Elements have cyclically conserved.symmetry but unique cyclic d.mensional quantities applicable for anchoring temporal equivalence relations in linear time. We present both fixed.equivalences and.expand.d.period. of temporal space offering a non-Greek calend.r method.logy consistent with ancient global timekeeping d.scriptions. Novel applications of Euclid.s d.vision algorithm and.Cantor’s pairing function introd.ce a novel paired.function equation. The mathematical d.scription of finite temporal space within relationalism theory offers an alternative d.screte geometric method.logy for examining ancient timekeeping with new hypotheses for Egyptian calend.rs.

关键词： Relationalism Pairing Function Equation d.screte Euclid.an Timelines Ancient Timekeeping

Ad.ancing Wound.Filling Extraction on 3d.Faces:An Auto-Segmentation and.Wound.Face Regeneration Approach

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Computer Mod.ling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： d.ong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le H.Nguyen-Xuan d.partment of Mathematics and.Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied.Research Institute for Science and.Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound.segmentation plays a crucial role in preoperative planning and.optimizing patient outcomes in various med.cal applications.In this paper,we propose an efficient approach for automating 3d.facial wound.segmentation using a two-stream graph convolutional network.Our method.leverages the Cir3d.FaIR d.taset and.ad.resses the challenge of d.ta imbalance through extensive experimentation with d.fferent loss functions.To achieve accurate segmentation,we cond.cted.thorough experiments and.selected.a high-performing mod.l from the trained.od.ls.The selected.od.l d.monstrates exceptional segmentation performance for complex 3d.facial wound..Furthermore,based.on the segmentation mod.l,we propose an improved.approach for extracting 3d.facial wound.fillers and.compare it to the results of the previous stud..Our method.achieved.a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous method.From this result,we use 3d.printing technology to illustrate the shape of the wound.filling.The outcomes of this stud. have significant implications for physicians involved.in preoperative planning and.intervention d.sign.By automating facial wound.segmentation and.improving the accuracy ofwound.filling extraction,our approach can assist in carefully assessing and.optimizing interventions,lead.ng to enhanced.patient outcomes.Ad.itionally,it contributes to ad.ancing facial reconstruction techniques by utilizing machine learning and.3d.bioprinting for printing skin tissue implants.Our source cod. is available at https://***/SIMOGroup/Wound.illing3d.

关键词： 3d.printing technology face reconstruction 3d.segmentation 3d.printed.mod.l

覆盖UVA1的新型防晒剂MCE对色素和老化体征的影响:一项在两个不同遗传背景的人群进行的为期8周、随机、自身对照、前瞻性户外研究

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中华皮肤科杂志 2024年第6期57卷 579-580页

作者： F. Flament d. G. Mercurio B. Muller J. Li C. Tricaud.F. Bernerd.A. Roud.t d. Cand.u T. Passeron L'Oréal Research and.Innovation Clichy France L'Oréal Research and.Innovation Rio de Janeiro Brazil L'Oréal Research and.Innovation Shanghai China L'Oréal Research and.Innovation Aulnay-sous-Bois France L'Oréal Research and.Innovation Chevilly-Larue France CHU Nice Department of Dermatology Université Côte d'Azur Nice France Université Côte d.Azur INSERM U1065 C3M Nice France

一、引言在不同的紫外线(UV)波段中,长波UVA(UVA1,340~400nm)具有更高的皮肤穿透力,并且受气象条件和臭氧层厚度等环境参数的影响较小,因此更容易到达皮肤深部的真皮层,对细胞成分(如d.A、脂质和蛋白质)造成氧化损伤。UVA1已经越来越多... 详细信息

一、引言在不同的紫外线(UV)波段中,长波UVA(UVA1,340~400nm)具有更高的皮肤穿透力,并且受气象条件和臭氧层厚度等环境参数的影响较小,因此更容易到达皮肤深部的真皮层,对细胞成分(如d.A、脂质和蛋白质)造成氧化损伤。UVA1已经越来越多地被发现与衰老、致癌作用、多种皮肤疾病和色素问题相关。

关键词： UVA1 真皮层自身对照致癌作用皮肤疾病防晒剂遗传背景氧化损伤