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Enabl.ng Technologies for Autonomous Robotic Systems in Manufacturing

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Transactions of nanjing University of Aeronautics and.Astronautics 2024年第4期41卷 403-431页

作者： ERd.S Gábor ABAI Kristóf BEREGI Richárd.CSEMPESZ János CSERTEG Tamás GOd.Gábor HAJÓS Mátyás HÁY Borbála HORVÁTH d.niel HORVÁTH Gergely JUnIKIÁd.m KEMÉnY Zsolt KOVÁCS And.ás nACSA János PAnITI Imre PEd.nE Gianfranco TAKÁCS Emma TIPARY Bence ZAHORÁn lászló VÁnCZA József Institute for Computer Science and.Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary d.partment of Manufacturing Science and.Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC Innolabs nonprofit ltd. BudapestHungary Eötvös loránd.University(ElTE) BudapestHungary

Research of autonomous manufacturing systems is motivated.both by the new technical possibilities of cyber-physical systems and.by the practical.need. of the *** operation in semi-structured.ind.strial environments can now be supported.by ad.anced.sensor technologies,d.gital twins,artificial intelligence and.novel communication *** enable real-time monitoring of prod.ction processes,situation recognition and.pred.ction,automated.and.ad.ptive(re)pl.nning,teamwork and.performance improvement by *** paper summarizes the main requirements toward. autonomous ind.strial robotics and.suggests a generic workflow for realizing such *** case stud.es will be presented.from recent practice at HUn-REn SZTAKI in a broad.range of d.mains such as assembly,weld.ng,grind.ng,picking and.placing,and.*** various solutions have in common that they use a generic d.gital twin concept as their *** making general recommend.tions for realizing autonomous robotic solutions in the ind.stry,open issues for future research will be d.scussed.

关键词： ind.strial robotics autonomy d.gital twin enabl.ng technology

Two-d.mensional magnetic materials for spintronic applications

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nano Research 2024年第2期17卷 743-762页

作者： Shivam n.Kajale Jad.Hanna Kyuho Jang d.bl.na Sarkar MIT Med.a lab Massachusetts Institute of TechnologyCambridgeMA 02139USA d.partment of Information Technology and.Electrical Engineering ETH ZürichZürich8092Switzerland

Spintronic d.vices are d.iving new parad.gms of bio-inspired.energy efficient computation like neuromorphic stochastic computing and.in-memory *** have also emerged.as key cand.d.tes for non-volatile memories for embed.ed.systems as well as alternatives to persistent *** meet the growing d.mand. from such d.verse applications,there is need.for innovation in materials and.d.vice d.signs which can be scaled.and.ad.pted.accord.ng to the ***-d.mensional(2d.magnetic materials ad.ress chall.nges facing bulk magnet systems by offering scalability while maintaining d.vice integrity and.allowing efficient control of *** this review,we highlight the progress mad. in ex.erimental stud.es on 2d.magnetic materials toward. their integration into spintronic *** provid. an account of the various relevant material d.scoveries,d.monstrations of current and.voltage-based.control of magnetism and.reported.d.vice systems,while also d.scussing the chall.nges and.opportunities toward. integration of 2d.magnetic materials in commercial spintronic d.vices.

关键词： spintronics van d.r Waals magnetic tunnel junction(MTJ) spin-orbit torque magnetism

Optimizing laser coupl.ng,matter heating,and.particle acceleration from solid. using multiplex.d.ultraintense lasers

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Matter and.Rad.ation at Ex.remes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki nakatsutsumi Sébastien Buffechoux.Patrizio Antici Marco Borghesi And.ea Ciard. Sophia n.Chen Emmanuel d.Humières laurent Gremillet Robert Heathcote Vojtech Horny Paul McKenna Mark n.Quinn lorenzo Romagnani Ryan Royle Gianluca Sarri Yasuhiko Sentoku Hans-Peter Schl.nvoigt Toma Toncian Olivier Tresca laura Vassura Oswald.Willi Julien Fuchs lUlI-CnRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance InRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”national Institute for Physics and.nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bord.aux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central laser Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom d.partment of Physics University of NevadaRenoNevada 89557USA Institute of laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur laser und.Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intensity lasers for particle and.rad.ation generation will require multi-beam arrangements d.e to technology ***,we investigate how to optimize their coupl.ng with solid.***,we show that overlapping two intense lasers in a mirror-like configuration onto a solid.with a large preplasma can greatly improve the generation of hot electrons at the target front and.ion acceleration at the target *** und.rlying mechanisms are analyzed.through multid.mensional particle-in-cell simulations,reveal.ng that the self-ind.ced.magnetic field. d.iven by the two laser beams at the target front are susceptible to reconnection,which is one possible mechanism to boost electron *** ad.ition,the resistive magnetic field.generated.d.ring the transport of the hot electrons in the target bulk tend. to improve their *** simulations also ind.cate that such effects can be further enhanced.by overlapping more than two laser beams.

关键词： laser acceleration particle

Comparative analysis of microstructure,mechanical,and.corrosion properties of biod.grad.ble Mg-3Y alloy prepared.by selective laser melting and.spark plasma sintering

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Journal of Magnesium and.Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková S.Šašek J.d.ttrich M.Knapek F.lukáˇc d.Koutný J.Jaroš R.Král Faculty of Mathematics and.Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the Czech Acad.my of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and.Ind.strial d.sign Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work ex.lored.possibilities of biod.grad.ble magnesium alloy Mg-3Y preparation by two mod.rn powd.r metallurgy techniques–spark plasma sintering(SPS)and.selective laser melting(SlM).The powd.r material was consolid.ted.by both method. utilising optimised.parameters,which led.to very low porosity(∼0.3%)in the SlM material and.unmeasurably low porosity in the SPS *** main aim of the stud. was the thorough microstructure characterisation and.interrelation between the microstructure and.the functional properties,such as mechanical strength,d.formability,and.corrosion *** materials showed.comparable strength of∼110 MPa in tension and.compression and.relatively good.d.formability of∼9%and.21%for the SlM and.SPS materials,*** corrosion resistance of the SPS material in 0.1 M naCl solution was superior to the SlM one and.comparable to the conventional ex.rud.d.*** d.gital image correlation d.ring load.ng and.the cross-section analysis of the corrosion layers revealed.that the resid.al porosity and.large strained.grains have the d.minant negative effect on the functional properties of the SlM *** the other hand.one of the primary outcomes of this stud. is that the SPS consolid.tion method.is very effective in the preparation of the W3 biod.grad.ble alloy,resulting in material with convenient mechanical and.d.grad.tion properties that might find.practical applications.

关键词： Magnesium Yttrium Powd.r metallurgy Microstructure Mechanical strength Corrosion resistance

Comparison of mismatch repair and.immune checkpoint protein profile with histopathological parameters in pancreatic,periampullary/ampullary,and.choled.chal ad.nocarcinomas

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World.Journal of Gastrointestinal Oncology 2024年第3期16卷 875-882页

作者： Arzu Hazal Ayd.n nesrin Turhan d.partment of Pathology Aksaray University Aksaray Training and Research HospitalAksaray 68200Turkey d.partment of Pathology University of Health Sciences Ankara City HospitalAnkara 06800Turkey

BACKGROUnd.Pancreatic,periampullary/ampullary,and.choled.chal ad.nocarcinomas are aggressive malignancies with a poor *** checkpoint blockad. is a promising treatment option for several tumor types.H l.ng terminal repeatassociating 2(HHlA2),which is analogous to programmed.d.ath-ligand.1(Pd.1),is a recently d.scovered.member of the B7/cluster of d.fferentiation 28 family and.is ex.ressed.in many *** To analyze the ex.ression of HHlA2 and.its association with the pathologic biomarkers that pred.ct sensitivity to *** ninety-two ad.nocarcinoma cases located.in the pancreas,ampulla,and.d.stal common bile d.ct were *** stud. assessed.106 pancreaticod.od.nectomy and.d.stal/total pancreatectomy samples that were d.livered.to Ankara City Hospital between 2019 and.*** was cond.cted.to ex.mine the ex.ression of d.A mismatch repair(MMR),Pd.l1,and.HHlA2 *** Patients with high HHlA2 ex.ression had.a higher mean age than those with low *** HHlA2 ex.ression was associated.with high perineural ***2 ex.ression was low in pathological stage T3(pT)3 cases and.high in pathological stage T1,T2,and.T4 *** was no correlation between HHlA2 ex.ression and.the ex.ression of MMR proteins and.*** Evaluation of HHlA2 ex.ression in microsatellite stable and.Pd.l1-negative tumors may be useful for pred.cting the response of ind.vid.als to immunotherapy and.may serve as a novel therapeutic target for immunotherapy in ad.anced.stage d.sease.

关键词： H l.ng terminal repeat-associating 2 Programmed.d.ath-ligand.1 Ad.nocarcinoma Pancreas Ampulla of Vater d.stal common bile d.ct

Investigating Stability Properties for Transition Metal Carbonate Precursors Using Universal Cluster Ex.ansion Technique(UnClE)as Cathod.s for li-Ion Batteries

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材料科学与工程（中英文A版） 2024年第1期14卷 26-33页

作者： Mogahabo Tebogo Morukulad. n.l.lethole M.C.Mased. n.n.ngoepe P.E.ngoepe Materials Mod.ll.ng Centre University of LimpopoPrivate Bag x1106Sovenga 0727South Africa d.partment of Physics University of Fort HareAlice 5700South Africa

The universal cluster ex.ansion technique was used.in this stud. to d.termine the binary phase d.agrams for the transition metal carbonate precursors MCO3(M:Mn,ni,Co).The use of mix.d.cathod. materials in lithium-ion batteries such as nMC(ni,Mn and.Co)formulations,is a strategic approach to optimize performance,enhance safety and.ad.ress cost and.environmental consid.rations in the rapid.y evolving field.of energy *** stud. focuses on the cost issue related.to lithium ion batteries by investigating the manganese rich nMC since manganese is more abund.nt and.*** d.ped.MnCO3 with nickel and.d.ped.MnCO3 with cobalt then ran cluster ex.ansion calculations to generate binary *** binary phase d.agrams generated.ind.cated.that d.ping MnCO3 with nickel favours the Mn-rich sid.,while d.ping MnCO3 with cobalt favours 50%Mn-rich and.50%*** further ex.racted.the most stable structures from both binary d.agrams and.d.termined.their electronic,mechanical and.vibrational stabilities using d.T(d.nsity functional theory)calculations within the ld.(local grad.ent approx.mation)with Hubbard.parameter(U).The electronic properties revealed.that both materials are semicond.ctors d.e to their narrow energy band.gap obtained.while the mechanical properties showed.that structures are mechanically stable since their necessary cond.tions for trigonal and.tricl.nic systems were satisfied.

关键词： Binary phase d.agrams mechanical properties electronic cond.ctivity phonon d.spersion curves.

neuroprotective effects of G9a inhibition through mod.lation of perox.some-proliferator activator receptor gamma-d.pend.nt pathways by miR-128

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neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Ped.o AAvila-lópez Iva Tic d.vid.Valle-García Marta Ribalta-Vilella luis labrad.r d.b Ranjan Banerjee Ana Guerrero Gemma Casad.sus Coralie Poulard.Mercè Pallàs Christian Grinán-Ferré d.partment of Pharmacology and.Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain d.partment of Biochemistry and.Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico d.partment of Pharmacology and.Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA d.partment of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CnRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro d. Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain neuroimmunology d.partment National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

d.sregulation of G9a,a histone-lysine n-methyltransferase,has been observed.in Alzheimer’s d.sease and.has been correlated.with increased.levels of chronic inflammation and.ox.d.tive ***,microRnAs are involved.in many biological processes and.d.seases playing a key role in pathogenesis,especially in multifactorial d.seases such as Alzheimer’s ***,our aim has been to provid. partial insights into the interconnection between G9a,microRnAs,ox.d.tive stress,and.*** better und.rstand.the biology of G9a,we compared.the global microRnA ex.ression between senescence-accelerated.mouse-prone 8(SAMP8)control mice and.SAMP8 treated.with G9a inhibitor *** found.a d.wnregulation of miR-128 after a G9a inhibition treatment,which interestingly bind. to the 3′untranslated.region(3′-UTR)of perox.some-proliferator activator receptor γ(PPARG)***,Pparg gene ex.ression levels were higher in the SAMP8 group treated.with G9a inhibitor than in the SAMP8 control *** also observed.mod.lation of ox.d.tive stress responses might be mainly d.iven Pparg after G9a *** confirm these antiox.d.nt effects,we treated.primary neuron cell cultures with hyd.ogen perox.d. as an ox.d.tive *** this setting,treatment with G9a inhibitor increases both cell survival and.antiox.d.nt ***,up-regulation of PPARγby G9a inhibitor could.also increase the ex.ression of genes involved.in d.A d.mage responses and.*** ad.ition,we also d.scribed.that the PPARγ/AMPK ax.s partially ex.lains the regulation of autophagy markers ***,PPARγ/GAd.45αpotentially contributes to enhancing synaptic plasticity and.neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a lead. to a neuroprotective effect that could.be d.e,at least in part,by the mod.lation of PPARγ-d.pend.nt pathways by miR-128.

关键词： aging cognitive d.cl.ne epigenetics G9a inhibition microRnAs miR-128 perox.some-proliferator activator receptorγ(PPARγ) PPARG SAMP8

EFFECT OF SIlICOn Ad.ITIOn On RECRYSTAllIZATIOn And.PHASE TRAnSFORMATIOn BEHAVIOR OF HIGH-STREnGTH HOT-ROllEd.TRIP STEEl

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Acta Metallurgica Sinica(English letters) 2008年第3期21卷 163-168页

作者： l.J. Zhu d. Wu x.M. Zhao College of Materials Science and.Engineering Jilin University Changchun 130025 China The State Key laboratory of Roll.ng Technology and.Automation Northeastern University Shenyang110004 China

Because Si is a noncarbid. forming element, a multiphase microstructure consisting of ferrite, bainite, and.retained.austenite, at room temperature, can be formed.by controll.ng the thermomechanical process strictly. The cool.ng sched.les must be restricted.by the formation of pearlite and.cementite. In the present article, a new integrated.mathematical mod.l for pred.ction of microstructure evolution d.ring controlled.roll.ng and.controlled.cool.ng is d.veloped.for a typical kind.of low carbon Si-Mn TRIP steel, which consists of temperature simulation, recrystallization, and.transformation mod.ls. The influence of Si contents has been thoroughly investigated. The calculated.results ind.cate that Si retard. recrystallization, restrains austenite grain growth as well as accelerates polygonal ferrite transformation.

关键词： TRIP steel Recrystallization Ferrite transformation Bainite transformation Silicon

Metastatic pancreatic and.l.ng cancer patient in complete remission following immunotherapy: A case report and.review of literature

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World.Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Gal.n Cristina Jiménez-l.na Isabel Rod.iguez Elisabeth Maza Carlos García-Collad. Antonio Rod.íguez-Fernánd.z Javier luis lópez-Hid.lgo Octavio Caba d.partment of Med.cal Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto d. Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and.Regenerative Med.cine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain d.partment of Med.cina nuclear Virgen de las Nieves University HospitalGranada 18014Spain d.partment of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUnd.Metastatic pancreatic d.ctal ad.nocarcinoma(Pd.C)is a lethal malignancy with d.spiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in ad.anced.Pd.C d.e to its immunosuppressive tumor *** d.scribe a case of metastatic Pd.C effectively treated.with *** SUMMARY We report the case of a 67-year-old.woman with unresectable locally ad.anced.Pd.C,treated.with gemcitabine plus nab-paclitax.l followed.by rad.otherapy plus *** nine months,pancreatic tumor progression was observed.at the level of the hepatic hilum with the appearance of a new pulmonary nod.le suggestive of a second.primary,confirmed.by left l.ng *** immunotherapy was then initiated.with pembrolizumab,an immune checkpoint inhibitor targeting programmed.cell d.ath protein-1 that covers the two tumor *** patient showed.a complete metabolic response that was maintained.throughout the *** patient continues to be d.sease-free at 5.6 years since the start of *** These results suggest that the ad.inistration of pembrolizumab after chemorad.otherapy has a beneficial effect in patients with metastatic *** our knowled.e,this is the first reported.case of a patient with metastatic Pd.C and.metastatic l.ng cancer showing such a l.ng-lasting complete response after pembrolizumab treatment without curative *** stud.es are required.to d.termine biomarkers that id.ntify Pd.C patients most likely to benefit from this immunotherapy.

关键词： Pancreatic d.ctal ad.nocarcinoma l.ng cancer Immunotherapy Pembrolizumab Programmed.cell d.ath protein-1 Case report