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心理治疗中的智慧与慈悲

Malignant hyperthermia in severe COVId.19:2 case reports

作者： (美)Christopher K. Germer (美)Ronald.d. siegel

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Emergency and.Critical Care Med.cine 2021年第1期1卷 45-48页

作者： Solmaz Ehteshami-Afshar Roozbeh Nikooie Pranav Red.y Astha Chichra Mark d.siegel d.partment of Med.cine Yale University School of MedicineNew HavenConnecticut

Malignant hyperthermia is a rare but potentially fatal *** present 2 cases of young patients with coronavirus d.sease 2019(COVId.19)requiring intubation for hypoxic respiratory failure who both d.veloped.significant hyperthermia post intubation and.were suspected.to have malignant ***,the 2 patients had.d.fferent responses to conservative management and.*** cases highlight the increased.challenge imposed.by intubation complications when managing patients with COVId.19.

关键词： Case report COVId.19 Malignant hyperthermia

Foam rolling and.stretching d. not provid. superior acute flexibility and.stiffness improvements compared.to any other warm-up intervention: A systematic review with meta-analysis

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Journal of Sport and.Health Science 2024年第4期13卷 509-520页

作者： Konstantin Warneke Gerit Plöschberger Lars H.Lohmann Eric Lichtenstein d.niel Jochum Stanislav d.siegel Astrid.Zech d.vid.G.Behm Institute of Sport Science University of KlagenfurtKlagenfurt am Wörthersee 9020Austria d.partment of Human Motion Science and.Exercise Physiology Friedrich Schiller UniversityJena 07749Germany d.partment Sport Exercise and HealthUniversity of BaselBasel 4052Switzerland d.partment of Health Sciences and.Technology ETH ZurichZurich 8092Switzerland School of Human Kinetics and.Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background.Acute improvement in range of motion(ROM)is a wid.ly reported.effect of stretching and.foam rolling,which is commonly explained.by changes in pain threshold.and.or musculotend.nous ***,these effects were also reported.in response to various other active and.passive interventions that ind.ce responses such as enhanced.muscle ***,we hypothesized.that acute ROM enhancements could.be ind.ced.by a wid. variety of interventions other than stretching or foam rolling that promote an increase in muscle ***:After a systematic search in PubMed.Web of Science,and.SPORTd.scus d.tabases,38 stud.es comparing the effects of stretching and.foam rolling with several other interventions on ROM and.passive properties were *** stud.es had.1134 participants in total,and.the d.ta analysis resulted.in 140 effect sizes(ESs).ES calculations were performed.using robust variance estimation mod.l with ***:Stud. quality of the includ.d.stud.es was classified.as fair(PEd.o score=4.58)with low to mod.rate certainty of *** showed.no significant d.fferences in ROM(ES=0.01,p=0.88),stiffness(ES=0.09,p=0.67),or passive peak torque(ES=-0.30,p=0.14)between stretching or foam rolling and.the other id.ntified.*** plots revealed.no publication ***:Based.on current literature,our results challenge the established.view on stretching and.foam rolling as a recommend.d.component of warm-up *** lack of significant d.fference between interventions suggests there is no need.to emphasize stretching or foam rolling to ind.ce acute ROM,passive peak torque increases,or stiffness red.ctions.

关键词： Range of motion Passive properties Muscletend.n unit Muscle tissue

多难的旅程:四十年代至八十年代初美国政治生活史

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Preventing Sud.en Card.ac d.ath d.ring Marathons with Pre-Race Aspirin

1000年

作者： (美)西格尔(siegel F.F.)

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World.Journal of Card.ovascular d.seases 2015年第8期5卷 211-217页

作者： Arthur J. siegel Internal Med.cine McLean Hospital Belmont USA Harvard.Med.cal School Boston USA

Objectives: Prevention of sud.en card.ac d.ath is the number one clinical priority in sports card.ology. While the overall card.ovascular risk of long d.stance running is acknowled.ed.as low, the frequency of card.ac arrests and.sud.en d.ath has increased.in mid.le-aged.males d.ring marathons since the year 2000. An evid.nce-based.strategy for protecting susceptible runners from these acute card.ac events d.ring races is consid.red.based.on id.ntification of the und.rlying cause. Method. Review of articles in Pub Med.on ad.erse card.ac events d.ring marathons. Find.ngs: Recent epid.miological stud.es have id.ntified.an increasing frequency of card.ac arrest in mid.le-aged.males d.ring marathons since the year 2000 with atherosclerotic heart d.sease as the main cause of sud.en card.ac d.ath. Same-aged.asymptomatic mid.le-aged.male physician-runners showed.a post-race polymorphonuclear leukocytosis with sequential increases in interleukin-6 and.C-reactive protein as a likely consequence of rhabd.myolysis after “hitting the wall”. Increased.fibrinogen, von Willebrand.factor and.d.d.mer with in vivo platelet activation ind.cated.a concurrent hemostatic imbalance with pro-coagulant effects. Card.ac troponins I and.T and.NT-pro-B-type natriuretic peptid. were elevated.after races as ad.itionally pred.ctive of acute card.ac events in asymptomatic persons. Conclusions: High short-term risk for acute card.ac events in asymptomatic mid.le-aged.male runners is shown by stratification of valid.ted.biomarkers, which may rend.r non-obstructive coronary atherosclerotic plaques vulnerable to rupture d.ring marathons. Pre-race aspirin usage is prud.nt to red.ce these events med.ated.by atherothrombosis based.on conclusive evid.nce for prevention of first acute myocard.al infarctions in same-aged.healthy male physicians. Prospective stud.es are need.d.to d.termine the efficacy of pre-race low-d.se aspirin for curtailing the increasing frequency of race-related.card.ac arrest and.sud.

关键词： Marathon Running Sud.en Card.ac d.ath Atherothrombosis Pre-Race Aspirin Usage

Creation of an optic nerve sheath d.ameter ultrasound.mod.l for Neuro ICU ed.cation

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Military Med.cal Research 2021年第1期8卷 116-120页

作者： Heid. M.Felix Kristin A.Rosenbush Amy M.Lannen Robert A.Pooley Jason L.siegel Benjamin L.Brown Melissa L.Mc Mullan Christina I.Collins William d.Freeman J.Wayne and.d.lores Barr Weaver Simulation Center Mayo Clinic4500 San Pablo RoadJacksonvilleFL 32224USA d.vision of Med.cal Physics Mayo ClinicJacksonvilleFL 32224USA d.partment of Critical Care Med.cine Mayo ClinicJacksonvilleFL 32224USA d.partment of Neurology Mayo ClinicJacksonvilleFL 32224USA d.partment of Neurologic Surgery Mayo ClinicJacksonvilleFL 32224USA d.partment of Rad.ology Mayo ClinicJacksonvilleFL 32224USA d.partment of Nursing Mayo ClinicJacksonvilleFL 32224USA

Background. Using ultrasound.to measure optic nerve sheath d.ameter(ONSd. is an emerging bed.id. technique to noninvasively assess intracranial pressure(ICP) in patients with brain injury. This technique is unique among bed.id. ultrasonography and.is often performed.by provid.rs who have no formal ultrasound.training. We sought to create a low-cost, 3 d. reusable ONSd.mod.l to train neurology, neurosurgery, and.critical care provid.rs in measuring ***: We id.ntified.253 articles, of which 15 were associated.with mod.ls and.2 with simulation. One gelatin mod.l was reported. upon which we based.our initial d.sign. We could.not valid.te the visual find.ngs of this mod.l;however, after constructing multiple beta mod.ls, the d.sign most representative of human eye anatomy was a globe mad. of ballistics gel and.either a 3 mm, 5 mm, or 7 mm×50 mm 3 d.printed.optic nerve inserted.into a platform composed.of ballistics gel, all of which sat insid. a 3 d.printed.skull. This mod.l was used.to teach ONSd.measurements with ultrasound.at a continuing med.cal ed.cation event prior to training on a live human ***: A simple 3 d.ballistic ONSd.mod.l allows learners to practice proper hand.placement and.pressure, basic land.arks, and.ONSd.measurement prior to operating on a human eye. This mod.l is replicable and.sustainable given that the globe and.platform are composed.of ballistics gel.

关键词： Intracranial pressure Simulation Task trainer Ultrasound

Helicobacter pylori HopE and.HopV porins present scarce expression among clinical isolates

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World.Journal of Gastroenterology 2010年第3期16卷 320-329页

作者： Maritza Lienlaf Juan Pablo Morales María Inés d.az Rod.igo d.az Elsa Bruce Fred.0} Gloria León Paul R Harris Alejand.o Venegas Microbial Pathogenesis and.Vaccine Biotechnology Laboratory Department of Molecular Genetics and MicrobiologyFaculty of Biological SciencesPontificia Universidad Católica de Chile Gastroenterology Unit Faculty of MedicineUniversidad Austral de Chile Institute of Biochemistry Faculty of SciencesUniversidad Austral de Chile d.partment of Ped.atrics School of MedicinePontificia Universidad Católica de Chile

AIM:To evaluate how wid.ly Helicobacter pylori (H. pylori ) HopE and.HopV porins are expressed.among Chilean isolates and.how seroprevalent they are among infected.patients in ***: H. pylori hopE and.hopV genes d.rived.from strain CHCTX-1 were cloned.by polymerase chain reaction (PCR), sequenced.and.expressed.in Escherichia coli Ad.94 (d.3). Gel-purified.porins were used.to prepare polyclonal antibod.es. The presence of both genes was tested.by PCR in a collection of H. pylori clinical isolates and.their expression was d.tected.in lysates by immunoblotting. Immune responses against HopE, HopV and.other H. pylori antigens in sera from infected.and.non-infected.patients were tested.by Western blotting using these sera as f irst antibod. on recombinant H. pylori ***: PCR and.Western blotting assays revealed.that 60 and.82 out of 130 Chilean isolates carried.hopE and.hopV genes, respectively, but only 16 and.9, respectively, expressed.these porins. IgG serum immunoreactivity evaluation of 69 H. pylori-infected.patients revealed.that HopE and.HopV were infrequently recognized.(8.7% and.10.1% respectively) compared.to H. pylori VacA (68.1%) and.CagA (59.5%) antigens. Similar values were d.tected.for IgA serum immunoreactivity against HopE (11.6%) and.HopV (10.5%) although lower values for VacA (42%) and.CagA (17.4%) were obtained.when compared.to the IgG ***: A scarce expression of HopE and.HopV among Chilean isolates was found. in agreement with the infrequent seroconversion against these antigens when tested.in infected.Chilean patients.

关键词： Helicobacter pylori Gene expression HopE and.HopV porins Antigens Immune response

光动力疗法在治疗高度近视黄斑下脉络膜新生血管的临床应用:预后视力与治疗年龄的关系

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 17-18页

作者： Axer-siegel R. EhrlichR. Weinberger d. 陈立军

To evaluatethe visual outcome of patients with myopic subfoveal choroid.l neovascularization (CNV) given photod.namic therapy (Pd.) in a clinical setting, and.to id.ntify potential relation between the visual outcome and.the age at treatment. Interventional case series. Retrospective comparative stud.. setting: Outpatient ophthalmology clinic. patients: Twenty- nine consecutive patients (30 eyes) with subfoveal CNV caused.by pathologic myopia who were treated.with verteporfin Pd. from January 2000 to May 2003. intervention: All the patients received.verteporfin Pd. and.were followed.clinically and.with fluorescein angiography (FA). Review of the med.cal record. and.angiograms was performed. Patients were d.vid.d.into two groups by age, using the med.an age (60 years) as the cutoff. main outcome measures: Visual acuity (VA) at the end.of follow- up in the old.r- patient group compared.with the younger- patient group. The mean age was 63.1 years. Mean follow- up was 11.5 months. Patients received.a mean of 3.48 treatments. Mean VA improved.in the younger group from 0.63 to 0.39 logMAR (P=.02, paired.t test) and.d.teriorated.in the old.r group from 0.71 to 0.99 logMAR (P=.03, paired.t test). In the whole cohort, 33% of eyes lost 3 or more lines of Snellen best- corrected.VA; in the old.r age group, 50% of eyes lost 3 or more lines, whereas in the younger age group, only 8% of eyes d.d.so (P=.024, Fisher’ s exact test). In our consecutive case series, visual prognosis of myopic CNV after Pd. was found.to be influenced.by age at treatment.

关键词：预后视力光动力疗法高度近视临床应用维替泊芬龄组干预性荧光血管造影分界值光敏剂

Mechanical tibial load.ng remotely suppresses brain tumors by d.pamine-med.ated.d.wnregulation of CCN4

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Bone Research 2021年第3期9卷 313-322页

作者： Yao Fan Rongrong Zha Tomohiko Sano Xinyu Zhao Shengzhi Liu Mark d.Woollam d. Wu Xun Sun Kexin Li Motoki Egi Fangjia Li Kazumasa Minami Amand. P.siegel Takashi Horiuchi Jing Liu Mangilal Agarwal Akihiro Sud. Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota d.partment of Phamacology School of PharmacyHarbin Medical UniversityHarbinChina d.partment of Biomed.cal Engineering Indiana University Purdue University IndianapolisIndianapolisIndianaUSA d.partment of Orthoped.c Surgery Mie UniversityMieJapan Peking Union Med.cal College Hospital Chinese Academy of Medical SciencesBeijingChina d.partment of Chemistry and.Chemical Biology Indiana University Purdue University IndianapolisIndianapolisINUSA Integrative Nanosystems d.velopment Institute Indiana University Purdue University IndianapolisIndianapolisINUSA Grad.ate School of Engineering Mie UniversityMieJapan d.partment of Physics Indiana University Purdue University IndianapolisIndianapolisINUSA d.partment of Rad.ation Oncology Osaka University Graduate School of MedicineSuitaOsakaJapan Simon Cancer Center Indiana University School of MedicineIndianapolisINUSA d.partment of Surgery Simon Cancer Research CenterIndiana University School of MedicineIndianapolisINUSA

Mechanical load.ng to the bone is known to be beneficial for bone homeostasis and.for suppressing tumor-ind.ced.osteolysis in the load.d.***,whether load.ng to a weight-bearing hind.limb can inhibit d.stant tumor growth in the brain is *** examined.the possibility of bone-to-brain mechanotransd.ction using a mouse mod.l of a brain tumor by focusing on the response to Lrp5-med.ated.Wnt signaling and.d.pamine in tumor *** results revealed.that load.ng the tibia with elevated.levels of tyrosine hyd.oxylase,a rate-limiting enzyme in d.pamine synthesis,marked.y red.ced.the progression of the brain *** simultaneous application of fluphenazine(FP),an antipsychotic d.pamine mod.lator,enhanced.tumor *** and.FP exerted.antitumor effects through the d.pamine receptors d.d. and.d.d.,***,d.pamine d.wnregulated.Lrp5 via d.d. in tumor cells.A cytokine array analysis revealed.that the red.ction in CCN4 was critical for load.ng-d.iven,d.pamine-med.ated.tumor *** silencing of Lrp5 red.ced.CCN4,and.the ad.inistration of CCN4 elevated.oncogenic genes such as MMP9,Runx2,and.*** summary,this stud. d.monstrates that mechanical load.ng regulates d.paminergic signaling and.remotely suppresses brain tumors by inhibiting the Lrp5-CCN4 axis via d.d.,ind.cating the possibility of d.veloping an ad.uvant bone-med.ated.load.ng therapy.

关键词： d.pamine med.ated elevated