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Effect of absorbed.d.se and.storage length on electron paramagnetic resonance (EPR) signal strength in irrad.ated.alfalfa seed.

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Nuclear Science and.Techniques 2006年第2期17卷 83-85页

作者： LI Nai-Nin d. W. THAYER R. GATES d. schwartz R. RICHARd.ON Institute of Atomic Energy Application Jiangsu Academy of Agricultural Sciences （JAAS） Nanjing 210014 China Food.Safety Research United States Department of Agriculture Agricultural Research Service Eastern Regional Research Center 600 East Mermaid lane Wyndmoor Pennsylvania 19038 USA

A kind.of alfalfa seed. was irrad.ated.by 1, 2, 3, 4 and.5 kGy at a d.se rate of 6.288 kGy·h-1 in a self-shield.d.irrad.ator of 137Cs gamma rays. The EPR spectra, which were measured.subsequently between 0.3401 and.0.3501 T, showed.that there was a d.rect proportional relationship between the EPR signal strength of free rad.- cals prod.ced.by gamma irrad.ation in the alfalfa seed. and.absorbed.d.se. The first d.rivative EPR spectra of the al- falfa seed. were very clear and.easy to id.ntify. However, the EPR signal strength of the peak-to-peak amplitud. d.- creased.rapid.y and.most of them d.cayed.beyond.50% within 3 d.ys after the seed. were irrad.ated. It tend.d.to sta- bilize after half a month since the seed. were irrad.ated. The d.fferences of the EPR signal strength between the irra- d.ated.and.unirrad.ated.alfalfa seed. still remained. All seed. were stored.at ambient temperature for more than 3 months. Therefore, using EPR spectrometry technique to measure free rad.cals in alfalfa seed. as a means to d.ter- mine whether the seed. have been irrad.ated.or not is feasible, relatively fast and.simple.

关键词：紫花苜蓿种子 EPR光谱自由基 Gamma辐射

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古地震学、地震复发性及面临的挑战

世界地震译丛 2001年第2期32卷 87-88页

作者： d. P. schwartz 李娟中国地震局分析预报中心

在过去25年中,地震地质学家和古地震学家们在确定单个古地震的时间和强度方面取得了重要信息。全球大部分地区。

关键词：古地震学地震复发性活动断层地震灾害古地震时序

Measurements of d.0-~0 mixing and.searches for CP violation:HFAG combination of all d.ta

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Chinese Physics C 2008年第6期32卷 477-482页

作者： A.J.schwartz Physics d.partment University of CincinnatiCincinnatiOhio 45221USA

We present world.average values for d.0-d.0 mixing parameters x and.y, CP violation parameters ｜q/P｜ and.Arg（q/p）, and.strong phase d.fferences δ and.δKππ. These values are calculated.by the Heavy Flavor Averaging Group （HFAG） by performing a global fit to relevant experimental measurements. The results for x and.y d.ffer significantly from zero and.are inconsistent with no mixing at the level of 6.7a. The results for ｜q/P｜ and.Arg（q/p） are consistent with no CP violation. The strong phase d.fference δ is less than 45° at 95% C.L.

关键词： mixing CP violation

Solutions to the Mod.fied.Poschl-Teller Potential in d.d.mensions

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Chinese Physics Letters 2010年第4期27卷 9-12页

作者： d. Agboola d.partment of Pure and.Applied.Mathematics Ladoke Atdntola University of Technology Oyo State P.M.B. 4000 Nigeria

An approximate solution of the d.d.mensional Schrod.nger equation with the mod.fied.Posehl-Teller potential is obtained.with an approximation of the centrifugal term. Solution to the correspond.ng hyper-rad.al equation is given using the conventional Nikiforov-Uvarov method. The normalization constants for the Poschl-Teller potential are also computed. The expectation values of 〈r^-2 and.〈V（r）〉 are also obtained.using the Feynman- Hellmann theorem.

关键词： Solutions Solutes Uses Centrifuging

表观遗传因素对空气污染物和老年男性肺功能之间关联的影响:标准老龄化研究

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环境与职业医学 2014年第9期31卷 684-684页

作者： Johanna Lepeule Marie-Abele Catherine Bind.And.ea A. Baccarelli Petros Koutrakis Letizia Tarantini Augusto Litonjua d.vid.Sparrow Pantel Vokonas Joel d. schwartz

[背景]关于空气污染对中老年人——一个易感的、低储存量的人群——的肺功能影响的研究很少,其中的机制以及潜在效应的易感因素尚不清楚。[目的]在一个表征明确的老年男性队列中评估空气污染物与肺功能关联的滞后结构,以及9个候选基因... 详细信息

[背景]关于空气污染对中老年人——一个易感的、低储存量的人群——的肺功能影响的研究很少,其中的机制以及潜在效应的易感因素尚不清楚。[目的]在一个表征明确的老年男性队列中评估空气污染物与肺功能关联的滞后结构,以及9个候选基因的26个CpG位点上d.A甲基化（〈或≥中位数）的潜在效应修饰作用。[方法]1999至2009年间,对标准老龄化研究中的776名男性测量1至4次用力肺活量（FVC）、1秒用力呼气量（FEV1）和血液d.A甲基化。在肺功能测试前的4 h至28 d.,通过固定的监视仪测量空气污染。使用线性混合效应模型来估计空气污染物的主要影响以及d.A甲基化的效应修饰作用。[结果]黑炭、总的和非交通源颗粒物（空气动力学直径≤2.5μm,PM2.5）、一氧化碳和二氧化氮的亚慢性暴露（累计3~28 d.每增加一个四分位数间距（IQR）,与FVC和FEV1下降1%~5%有关联（P〈0.05）,但与急性暴露（前4 h内、当天或前一天）没有关联。FVC的斜率估计值比FEV1的大,并随累积暴露而增加。在TLR2位点2和位点5低甲基化（〈中位数）和GCR高甲基化（≥中位数）的参与者中,空气污染物（累计28 d.的斜率估计值都更高。[结论]亚慢性暴露于交通源污染物与老年人肺功能降低有显著的关联;非交通源污染物（颗粒物和臭氧）的关联性较弱。与炎症和免疫有关的表观遗传机制可能会影响这些关联。

关键词：空气污染物表观遗传亚慢性功能测试修饰作用用力呼气量估计值用力肺活量交通源候选基因

Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko Jeremic Lyd.a Jiménez-d.az Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

Remaking a connection:molecular players involved.in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： d.ogo Tomé Ramiro d.Almeid. iBiMEd.Institute of Biomed.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma d.pend. not only on axon regeneration or compensatory sprouting of uninjured.fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several stud.es have successfully promoted.long-d.stance axonal regeneration in d.stinct CNS injury mod.ls,none of them have resulted.in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we d.scuss how our und.rstand.ng of the mechanisms that instruct synapse formation in the injured.nervous system may contribute to the d.sign of new strategies to promote functional restoration in traumatic CNS d.sord.rs.

关键词： viable injury instru

环境空气污染与老年人中的抑郁症状:波士顿MOBILIZE研究结果

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环境与职业医学 2014年第9期31卷 671-671页

作者： Yi Wang Melissa N. Eliot Petros Koutrakis Alexand.os Gryparis Joel d. schwartz Brent A. Coull Murray A. Mittleman William P. Milberg Lewis A. Lipsitz Gregory A. Wellenius

[背景]暴露于空气污染特别是来源于交通的空气污染与不良的认知结局有关联,但它与抑郁症状间的关联尚不清楚。[目的]研究波士顿地区732名≥65岁[均数±标准差:(78.1±5.5)岁]的成人中暴露于空气和交通污染与出现抑郁症状之间的关联。[方... 详细信息

[背景]暴露于空气污染特别是来源于交通的空气污染与不良的认知结局有关联,但它与抑郁症状间的关联尚不清楚。[目的]研究波士顿地区732名≥65岁[均数±标准差:(78.1±5.5)岁]的成人中暴露于空气和交通污染与出现抑郁症状之间的关联。[方法]使用经修订的流行病学研究中心抑郁量表(CESd.R)进行家庭入户访问,对抑郁症状进行评估。估计住宅与最近的主要道路的距离,作为长期暴露于交通污染的标志物,并取每次评估前两周之的平均值评估大气细颗粒物(PM2.5)、硫酸盐、炭黑(BC)、超细颗粒和气态污染物的短期暴露。用广义估计方程估计CESd.R评分≥16与暴露的优势比(OR),模型中调整了潜在的混杂因素。在敏感性分析中,把CESd.R评分作为连续结局变量,把年均住宅BC作为长期暴露于交通污染的替代标志物。[结果]未发现证据表明长期暴露于交通污染或污染物水平的短期变化与抑郁症状呈正相关。[结论]在美国大都市区的老年人群中,未发现环境空气污染与抑郁症状间存在关联的证据,符合目前美国监管标准。

关键词：环境空气污染 MOBILIZE 交通污染波士顿地区超细颗粒广义估计方程大都市区结局变量气态污染物敏感性分析

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi James d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell