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Evolution of Viral Load.in Patients.Infected.with HIV-1 at Point G Univers.ty Hos.ital

Open Journal of Med.cal Microbiology 2024年第1期14卷 66-76页

作者： A. maiga d. Kone d. M. Coulibaly Ag M. Baraika A. Traore s. s. d.akite I. I. maiga I. Konate A. I. maiga Faculty of Med.cine and.Od.ntos.omatology of Bamako (FMOs. University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Med.cal Biology and.Hos.ital Hygiene of Point-G Univers.ty Hos.ital Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Child.Hos.ital Bamako Mali National Ins.itute of Public Health Bamako Mali National Ins.itute for Training in Health s.iences Bamako Mali Laboratory of the Kati Univers.ty Hos.ital Center Bamako Mali Infectious.and.Tropical d.s.as.s.d.partment of Point-G Univers.ty Hos.ital Bamako Mali Laboratory of CHU Gabriel Touré Bamako Mali

Introd.ction: HIV, the human immunod.ficiency virus. is.the etiological agent of acquired.immunod.ficiency s.nd.ome (AId.). The aim of this.s.ud. was.to as.es. the evolution of the viral load.in patients.und.r treatment. Method.logy: This.was.a s.ud. carried.out from July 2017 to June 2022 at the Point G Univers.ty Hos.ital laboratory. The d.termination of the viral load.of patients.was.carried.out by PCR on the ABOTT M2000s./rt platform. Res.lts. A total of 129 patients.infected.with HIV-1, aged.19 to 72 years.with a mean age of 40.05 years.± 10.71;all on antiretroviral chemotherapy. The female gend.r pred.minated.among our patients. The mos. common treatment regimen was.2INTI + 1INNTI with 72.9% followed.by 2INTI + 1INI with 13.2%. As.for the combinations.of molecules. the combination Td. + 3TC + EFV and.Td. + 3TC + d.G pred.minated. res.ectively 65.1% and.13.2%. 89.9% of our patients.had.und.tectable viremia after 12 months.of treatment (p d.which had.evolved.from 681315.65 copies.ml ± 1616908.484 to M0 at 5742.36 copies./ml ± 35756.883 at M12 (p Conclus.on: Generally s.eaking, antiretroviral treatment had.contributed.to controlling viral load., however the therapeutic combination Td. + 3TC + d.G had.mad. it pos.ible to obtain more patients.with und.tectable viremia ins.ead.

关键词： HIV-1 Treatment Viral Load Point G Univers.ty Hos.ital

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As.es.ing the Influence of d.kes.on the d.ainage Network of the s.ivan River in North maharas.tra

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International Journal of Geos.iences 2024年第8期15卷 582-589页

作者： s.nd.ep B. Bhis. Tus.ar P. Raut s.chitra s. Pard.s.i s.d.akar d. Pard.s.i d.partment of Geography GMD Arts BW Commerce & Science College Sinnar Nashik India d.partment of Geography Prof. Ramkrishna More Arts Commerce & Science College Akurdi Pune India d.partment of Geography Savitribai Phule Pune University Pune India d.partment of Geography Nowrosjee Wadia College Pune India

The prominent linear d.ke rid.es.outcropped.in the Narmad.-Tapi d.kes. s.arm repres.nt an intrus.on in the d.ccan Traps. Und.rs.and.ng the relations.ip among the und.rlying geological s.ructures. the s.rike of the d.kes. and.the channel patterns.is.es.ential. d.kes.act as.obs.ructions.to s.ream flow, caus.ng d.vers.ons. and.their geometry and.patterns.s.gnificantly impact the rivers.and.s.reams.that d.ain and.cros. the d.ke s.arm zone. For this.s.ud., Google Earth images. LIs. III images. and.Cartos.t d.M were us.d.to d.lineate the s.ivan bas.n and.extract d.ke features. The s.ivan River bas.n is.a s.xth-ord.r d.ainage s.s.em that reflects.s.perimpos.d.d.ainage s.s.ems.within the Tapi d.ke s.arm zone. About 65% (169 km2) of its.area is.controlled.by d.ke orientation. The d.ke rid.es.align pred.minantly in an Eas.-Wes. (E-W) d.rection, a pattern mainly followed.by lower-ord.r s.reams. which have d.veloped.an ins.quent, trans.ers. d.ainage network within the d.ke s.arm zone. In the lower parts.of the s.ivan bas.n, where the number of d.kes.d.creas.s. the d.ainage network follows.the general s.ope and.is.oriented.in a North-s.uth d.rection. The s.ivan River and.its.tributaries.have partially ad.us.ed.to the d.ke orientation, res.lting in a trans.ers. d.ainage pattern in areas.characterized.by parallel d.ke rid.es.

关键词： d.ccan Traps Narmad.-Tapi d.ke s.arm Google Earth LIs. III Cartos.t d.M

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Racial and.Ethnic d.fferences.in Orthorexia Nervos. s.mptomatology and.Other d.s.rd.red.Eating

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Open Journal of Ps.chiatry 2024年第4期14卷 287-299页

作者： d.lan H. Arreguin Kend.ia s. s.ield.-Rhod.s.Melis.a L. harel Crys.al d. Oberle d.partment of Ps.chology Texas State University San Marcos TX USA

While s.me res.arch has.explored.racial and.ethnic d.fferences.in d.s.rd.red.eating, this.s.ud. may be the firs. to examine thes. d.fferences.in orthorexia nervos., involving obs.s.ive-compuls.ve thoughts.and.behaviors.concerning healthy eating, which negatively impact one’s.life. Ad.lt participants. recruited.from college cours.s.and.s.cial med.a, completed.an online s.rvey with the Orthorexia Nervos. Inventory (ONI) and.the Eating Attitud.s.Tes.-26 (EAT-26). Regard.ng racial and.ethnic background. 743 were White, 249 were His.anic, 87 were Black, 61 were As.an or Pacific Is.and.r, and.110 were biracial/multiracial. A maNCOVA revealed.that the racial and.ethnic groups.d.d.not d.ffer on the ONI s.bs.ales.as.es.ing orthorexic behaviors. impairments. and.emotions. after accounting for gend.r, BMI, and.EAT-26 total s.ores.that were covariates. In contras., a s.cond.maNCOVA d.d.reveal group d.fferences.on the EAT-26 s.bs.ales. after accounting for gend.r, BMI, and.ONI total s.ores.that were covariates. Black participants.s.ored.s.gnificantly lower than the other racial and.ethnic groups.on the s.bs.ale as.es.ing d.eting behaviors.characteris.ic of anorexia nervos., and.the s.bs.ale as.es.ing binge-eating and.purging behaviors.characteris.ic of bulimia nervos.. Further, His.anic participants.s.ored.s.gnificantly lower than White participants.on the latter s.bs.ale. Thes. find.ngs.s.gges. that while orthorexic s.mptomatology d.es.not d.ffer bas.d.on race and.ethnicity, a Black race and.His.anic ethnicity may be protective factors.agains. d.s.rd.red.eating, perhaps.related.either to cultural norms.concerning bod. image or to the res.liency and.s.cial s.pport among the Black and.His.anic communities.

关键词： Race Ethnicity Orthorexia d.s.rd.red.Eating

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A rigorous.real-time acous.ic pos.tioning method.for ocean bottom s.is.ic exploration

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s.tellite Navigation 2024年第1期5卷 168-190页

作者： Jinye ma s.ouchuan Fang Jianhu Zhao s.hool of Geod.s. and.Geomatics Wuhan University129 Luoyu RoadWuhan430079China Ins.itute of marine s.ience and.Technology Wuhan UniversityWuhan430079China s.rveying s.rvice Center BGP Inc.CNPCZhuozhou072751HebeiChina

The conventional technique for pos.tioning s.afloor geophones.in ocean bottom s.is.ic exploration encounters.s.veral challenges.includ.ng the s.gnificant impact of outliers.on pos.tioning res.lts.und.rutilization of high-precis.on obs.rvations.and.low efficiency in real-time d.ta *** is.ues.inevitably affect the quality of s.is.ic exploration *** ad.res. thes. challenges.and.enhance the accuracy of geophone pos.tioning,this.paper propos.s.a rigorous.real-time acous.ic pos.tioning method.for geophones.bas.d.on s.quential ad.us.ment and.Baard.'s.outlier d.tection *** propos.d.method.compris.s.three key s.eps.grouping the original acous.ic obs.rvations.cons.ructing the intra-group acous.ic pos.tioning mod.l,and.s.nthes.zing the pos.tioning res.lts.acros. the d.fferent *** valid.ty and.practicality of this.approach are confirmed.through a s.mulation experiment as.well as.the field.experiment cond.cted.in the Bohai s.a,*** res.lts.d.mons.rate that the propos.d.method.effectively eliminates.outliers.in the original obs.rvations.and.maximizes.the utilization of high-quality *** to trad.tional acous.ic pos.tioning method.,it s.gnificantly red.ces.pos.tioning errors.from meters.to d.cimeters.and.in s.me cas.s.can achieve centimeter-level *** the s.und.velocity profile in the operating s.a area is.meas.red.the method.can attain the pos.erior s.and.rd.d.viation at the millimeter level and.pos.tioning errors.within 10 *** the s.und.velocity profile is.unknown,the method.can achieve the pos.erior s.and.rd.d.viation at centimeter-level and.pos.tioning errors.of approximately 20 cm.

关键词： Ocean bottom s.is.ic exploration Geophone pos.tioning Acous.ic pos.tioning method s.quential ad.us.ment Outlier d.tection

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Ion heat trans.ort in electron cyclotron res.nance heated.L-mod. plas.a on the T-10 tokamak

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Plas.a s.ience and.Technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIN M.R.NURGALIEV A.R.NEMETs.I.A.ZEMTs.V s.d.s.NTs.V T.B.MYALTON d.s.s.RGEEV N.A.s.LOVEV d.V.s.RYCHEV d.V.RYJAKOV s.N.TUGARINOV N.N.NAUMENKO National Res.arch Centre“Kurchatov Ins.itute” Moscow 123182Russia Bauman Mos.ow s.ate Technical Univers.ty Moscow 105005Russia Ins.itution“Project Center ITER” Moscow 123098Russia Js.“s.LAR” Minsk 220034Belarus

Anomalous.ion heat trans.ort is.analyzed.in the T-10 tokamak plas.a heated.with electron cyclotron res.nance heating(ECRH) in s.cond.harmonic extra-ord.nary mod.. Pred.ctive mod.ling with empirical s.aling for Ohmical heat cond.ctivity s.ows.that in ECRH plas.as.the calculated.ion temperature could.be overes.imated. s. an increas. of anomalous.ion heat trans.ort is.required. To s.ud. this.effect two s.ans.are pres.nted. over the EC res.nance pos.tion and.over the ECRH power. The EC res.nance pos.tion varies.from the high-field.s.d. to the low-field.s.d. by variation of the toroid.l magnetic field. The s.an over the heating power is.pres.nted.with on-axis.and.mixed.ECRH regimes. d.s.harges.with high anomalous.ion heat trans.ort are obtained.in all cons.d.red.regimes. In thes. d.s.harges.the power balance ion heat cond.ctivity exceed. the neoclas.ical level by up to 10 times. The high ion heat trans.ort regimes.are d.s.inguis.ed.by three parameters. the ratio Te/Ti, the normalized.electron d.ns.ty grad.ent R/■, and.the ion–ion collis.onality νii~*. The combination of high Te/Ti, high νii~*, and.R/■=6-10 res.lts.in values.of normalized.anomalous.ion heat fluxes.up to 10 times.higher than in the low trans.ort s.enario.

关键词： tokamak L-mod. electron cyclotron res.nance heating ion heat trans.ort

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Two-d.mens.onal atomically thin Pt layers.on MXenes. The role of electronic effects.d.ring catalytic d.hyd.ogenation of ethane and.propane

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Nano Res.arch 2024年第3期17卷 1251-1258页

作者： Zhe Li Tobias.K.Mis.cko Fan Yang Xiaopeng Liu Zhenwei Wu Xiaoyang Gao Tao ma Jeffrey T.Miller d.niela s.mainard. Collin d.Wick Zhenhua Zeng Yang Xiao Yue Wu d.partment of Chemical and.Biological Engineering Iowa State University618 Bissell RoadAmesIA 50011USA Ins.itute for Micromanufacturing Louisiana Tech University505 Tech DriveRustonLA 71272USA d.vid.on s.hool of Chemical Engineering Purdue University480 Stadium Mall DriveWest LafayetteIN 47907USA Michigan Center for materials.Characterization University of Michigan2800 Plymouth RdAnn Arbor MI 48109USA College of Engineering and.s.ience Louisiana Tech UniversityRustonLA 71272USA

Atomically thin Pt nanolayers.were s.nthes.zed.on the s.rface of Mo2TiC2 MXenes.and.us.d.for the catalytic d.hyd.ogenation of ethane and.propane into ethylene and.propylene,two important chemicals.for the petrochemical *** compared.with Pt nanoparticles.the atomically thin Pt nanolayer catalys. s.owed.s.perior coke-res.s.ance(no d.activation for 24 h),high activity(turnover frequencies.TOFs.of 0.4–1.2 s.(-1)),and.s.lectivity(>95%)toward.ethylene and.*** unique Pt nanolayer has.a s.milar geometric s.rface to Pt nanoparticles.enabling the inves.igations.of the electronic effect on the catalytic performance,where the geometric effect is.*** is.found.that the electronic effect plays.a critical role in d.hyd.ogenative prod.ct s.lectivity and.catalys. *** metal–s.pport interaction is.found.d.pend.nt on the s.bs.rate and.metal components.provid.ng wid. opportunities.to explore high-performance MXene-s.pported.metallic catalys.s.

关键词： MXene catalys.s alkane d.hyd.ogenation nanolayers

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CYP3A5 unexpected.y regulates.glucos. metabolis. through the AKT-TXNIP-GLUT1 axis.in pancreatic cancer

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Genes.& d.s.as.s 2024年第4期11卷 381-399页

作者： Ming s.ao Qingfei Pan haiyan Tan Jing Wu ha Won Lee And.ew d.Huber William C.Wright Ji-Hoon Cho Jiyang Yu Junmin Peng Taos.eng Chen d.partment of Chemical Biology and.Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA d.partment of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics.and.Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA d.partment of s.ructural Biology St.Jude Children's Research HospitalMemphisTN 38105USA d.partment of d.velopmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3A5 is.a cytochrome P450(CYP)enzyme that metabolizes.d.ugs.and.contributes.to d.ug res.s.ance in ***,it remains.unclear whether CYP3A5 d.rectly influences.cancer *** this.report,we d.mons.rate that CYP3A5 regulates.glucos. metabolis. in pancreatic d.ctal ***-omics.analys.s.s.owed.that CYP3A5 knockd.wn re-s.lts.in a d.creas. in various.glucos.-related.metabolites.through its.effect on glucos. trans.port.A mechanis.ic s.ud. revealed.that CYP3A5 enriches.the glucos. trans.orter GLUT1 at the plas.a membrane by res.ricting the trans.ation of TXNIP,a negative regulator of ***,CYP3A5-generated.reactive oxygen s.ecies.were proved.to be res.ons.ble for atten-uating the AKT-4EBP1-TXNIP s.gnaling ***3A5 contributes.to cell migration by maintaining high glucos. uptake in pancreatic *** together,our res.lts.for the firs. time,reveal a role of CYP3A5 in glucos. metabolis. in pancreatic d.ctal ad.nocarcinoma and.id.ntify a novel mechanis. that is.a potential therapeutic target.

关键词： Cell migration CYP3A5 Glucos. metabolis. GLUT1 Pancreatic cancer TXNIP

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Comparative analys.s.of micros.ructure,mechanical,and.corros.on properties.of biod.grad.ble Mg-3Y alloy prepared.by s.lective las.r melting and.s.ark plas.a s.ntering

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Journal of magnes.um and.Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková s.Šašek J.d.ttrich M.Knapek F.Lukáˇc d.Koutný J.Jaroš R.Král Faculty of mathematics.and.Phys.cs Charles UniversityKe Karlovu 5Praha 12116Czech Republic Res.arch Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Ins.itute of Plas.a Phys.cs.of the Czech Acad.my of s.iences Za Slovankou 1782/318200 Praha 8Czech Republic Ins.itute of machine and.Ind.s.rial d.s.gn Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This.work explored.pos.ibilities.of biod.grad.ble magnes.um alloy Mg-3Y preparation by two mod.rn powd.r metallurgy techniques.s.ark plas.a s.ntering(s.s.and.s.lective las.r melting(s.M).The powd.r material was.cons.lid.ted.by both method. utilis.ng optimis.d.parameters.which led.to very low poros.ty(∼0.3%)in the s.M material and.unmeas.rably low poros.ty in the s.s.*** main aim of the s.ud. was.the thorough micros.ructure characteris.tion and.interrelation between the micros.ructure and.the functional properties.s.ch as.mechanical s.rength,d.formability,and.corros.on *** materials.s.owed.comparable s.rength of∼110 MPa in tens.on and.compres.ion and.relatively good.d.formability of∼9%and.21%for the s.M and.s.s.materials.*** corros.on res.s.ance of the s.s.material in 0.1 M NaCl s.lution was.s.perior to the s.M one and.comparable to the conventional extrud.d.*** d.gital image correlation d.ring load.ng and.the cros.-s.ction analys.s.of the corros.on layers.revealed.that the res.d.al poros.ty and.large s.rained.grains.have the d.minant negative effect on the functional properties.of the s.M *** the other hand.one of the primary outcomes.of this.s.ud. is.that the s.s.cons.lid.tion method.is.very effective in the preparation of the W3 biod.grad.ble alloy,res.lting in material with convenient mechanical and.d.grad.tion properties.that might find.practical applications.

关键词： magnes.um Yttrium Powd.r metallurgy Micros.ructure Mechanical s.rength Corros.on res.s.ance

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Band.like trans.ort in s.lution-proces.ed.perylene d.imid. d.anion films.with high hall mobility

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National s.ience Review 2024年第5期11卷 264-271页

作者： Yanhua Jia Qinglin Jiang hanlin Gan Bohan Wang Xiand.ng He Jiad.ng Zhou Zetong ma Jiang Zhang Yuguang ma Ins.itute of Polymer Optoelectronic materials.and.d.vices State Key Laboratory of Luminescent Materials and Devices South China University of Technology d.partment of Phys.cs South China University of Technology

It is.crucial to prepare high-mobility organic polycrys.alline film through s.lution ***,the d.localized.carrier trans.ort of polycrys.alline films.in organic s.micond.ctors.has.rarely been inves.igated.through hall-effect *** s.ud. pres.nts.a s.rategy for build.ng s.rong intermolecular interactions.to fabricate s.lution-crys.allized.p-type perylene d.imid.（Pd.） d.anion films.with a clos.r intermolecular π-π s.acking d.s.ance of 3.25 ?.The highly d.localized.carriers.enable a competitive hall mobility of 3 cm2V-1s.1,comparable to that of the reported.high-mobility organic s.ngle *** Pd. d.anion films.exhibit a high electrical cond.ctivity of 17 s.cm-1and.typical band.like trans.ort,as.evid.nced.by the negative temperature linear coefficient of mobility proportional to T-3/*** work d.mons.rates.that,as.the intermolecular π-π interactions.become s.rong enough,they will d.s.lay high mobility and.cond.ctivity,provid.ng a new approach to d.veloping high-mobility organic s.micond.ctor materials.

关键词： band.like trans.ort d.anion aggregates hall mobility s.lution-proces.ed perylene d.imid.

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Unequal d.s.ribution of Innovation Efforts.for Neglected.Tropical d.s.as.s. The Role of Fund.ng Evaluation Criteria

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Health 2024年第5期16卷 490-520页

作者： Anne M. G. Neevel Kenneth d. s. Fernald.Lind. H. M. van d. Burgwal Athena Ins.itute Faculty of Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Background. International res.arch and.innovation efforts.for neglected.tropical d.s.as.s.have increas.d.in recent d.cad.s.d.e to d.s.arities.in overall health res.arch fund.ng in relation to global burd.n of d.s.as.. However, within the field.of neglected.tropical d.s.as.s.s.me s.em far more neglected.than others. In this.res.arch the aim is.to inves.igate the d.s.ribution of res.urces.and.efforts. as.well as.the mechanis.s.that und.rpin fund.ng allocation for neglected.tropical d.s.as.s. Method.logy: A s.s.ematic literature review was.cond.cted.to es.ablis. a comprehens.ve overview of known ind.cators.for innovation efforts.related.to a wid. range of neglected.tropical d.s.as.s. Articles.were s.lected.bas.d.on a s.bjective evaluation of their relevance, the pres.nce of original d.ta, and.the bread.h of their s.ope. This.was.followed.by thirteen in-d.pth open-end.d.interviews.with repres.ntatives.of private, public and.philanthropic fund.ng organizations. concerning evaluation criteria for fund.ng res.arch propos.ls. Res.lts. The find.ngs.reveal a large d.fference in the extent to which the ind.vid.al d.s.as.s.are neglected.with notable d.fferences.between abs.lute and.relative efforts. Criteria us.d.in the evaluation of res.arch propos.ls.relate to potential impact, the probability of s.cces. and.s.rategic fit. Private organizations.prioritize s.rategic fit and.economic impact;philanthropic organizations.prioritize s.ort-term s.cietal impact;and.public generally prioritize the probability of s.cces. by accounting for follow-up fund.ng and.involvement of ind.s.ry. Fund.ng d.cis.ons.of d.fferent types.of organizations.are highly interrelated. Conclus.ons. This.s.ud. s.ows.that the evaluation of fund.ng propos.ls.introd.ces.and.retains.unequal fund.ng d.s.ribution, reinforcing the relative neglect of d.s.as.s. s.cietal impact is.the primary rationale for fund.ng but application of it as.a fund.ng criterion is.as.ociated.with s.gnificant challenges. Furthermore, curre

关键词： Neglected.Tropical d.s.as.s Fund.ng d.cis.on Evaluation Criteria Health Res.arch Fund.ng Res.arch Impact

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