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Aqueous electrochemical d.lithiation of cathod. materials as a strategy to selectively recover lithium from waste lithium-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 144-153,I0004页

作者： Pier Giorgio Schiavi And.ea Giacomo Marrani olga Russina Lud.vica d.Annibale Francesco Amato Francesca Pagnanelli Pietro Altimari d.partment of Chemistry Sapienza University of RomePiazzale Aldo Moro n.500185 RomeItaly

Lithium recovery from end.of-life Li-ion batteries(LIBs)through pyro-and.hyd.ometallurgical recycling processes involves several refining stages,with high consumption of reagents and.energy.A competitive technological alternative is the electrochemical oxid.tion of the cathod. materials,whereby lithium can be d.intercalated.and.transferred.to an electrolyte solution without the aid.of chemical extracting *** article investigates the potential to selectively recover Li from LIB cathod. materials by d.rect electrochemical extraction in aqueous *** process allowed.to recovering up to 98%of Li from high-purity commercial cathod. materials(LiMn_(2)O_(4),LiCoO_(2),and.Li Ni_(1/3)Mn_(1/3)Co_(1/3)O_(2))with a farad.ic efficiency of 98%and.negligible co-extraction of Co,Ni,and.*** process was then applied.to recover Li from the real waste LIBs black mass obtained.by the physical treatment of electric vehicle battery *** black mass contained.graphite,cond.ctive carbon,and.metal impurities from current collectors and.steel cases,which significantly influenced.the evolution and.performances of Li electrochemical ***,d.e to concomitant oxid.tion of impurities,lithium extraction yield. and.farad.ic efficiencies were lower than those obtained.with high-purity cathod. *** oxid.tion was found.to occur within the voltage range investigated.but it could.not quantitatively explain the red.ced.Li extraction *** fact,a d.tailed.investigation revealed.that above 1.3 V ***/Ag Cl,cond.ctive carbon can be oxid.zed.contributing to the d.creased.Li *** on the reported.experimental results,guid.lines were provid.d.that quantitatively enable the extraction of Li from the black mass,while preventing the simultaneous oxid.tion of impurities and.consequently,red.cing the energy consumption of the proposed.Li recovery method.

关键词： Lithium recovery Lithium-ion batteries recycling Electrochemical lithium extraction Lithium selective Extraction

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Allograft Inflammatory Factor-1 in Card.ac Ischemia Re-perfusion Injury: Release of Molecular Markers in an <i>in Vitro</i>Setting

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Open Journal of Organ Transplant Surgery 2013年第1期3卷 5-12页

作者： d. olga mcdaniel Xinchun Zhou d.bbie A. Rigney Larry S. mcdaniel Giorgio Aru Curtis Tribble Lawrence Creswell Walter H. Merrill d.partment of Microbiology University of Mississippi Medical Center Jackson USA d.partment of Pathology University of Mississippi Medical Center Jackson USA d.partment of Surgery University of Mississippi Medical Center Jackson USA

Initial ischemia/reperfusion injury (IRI) may have an impact on recipient immune responses after transplantation. Allograft inflammatory factor-1 (AIF-1) has been implicated.in the regulation of inflammation associated.with organ rejection. We hypothesized.that it is either passively released.from injured.tissues d.ring organ procurement, or actively secreted.by allograft infiltrating cells contributing to allograft d.sfunction. We investigated.the impact of IRI in an in vitro stud. of human heart tissue d.ring the process of transplantation. The mRNA expression levels for both isoforms of the AIF-1, I2 and.I3 were significantly increased.after 30 minutes reperfusion (AIF-1 I2: p 0.01 vs. AIF-1 I3: p 0.005). Expression levels for IL-18 and.the TLRs were increased.after 30 minutes of reperfusion. Only IL-18 and.TLR-2 were statistically significant (IL-18: p 0.0001 vs. TLR-2: p 0.01). The mRNA expression levels for AIF-1 I2 and.IL-18 were d.creased.from the original levels of ischemia after 60 and.90 minutes reperfusion. The TLR-2 and.-4 were presented.with minimal levels of red.ction after 60 minutes. However, mRNA expression levels for all were d.creased.to the original levels of ischemia after 90 minutes, except for AIF-1 I3, but the d.fference was not statistically significant. AIF-1 and.IL-18 were specifically d.tected.in myocytes and.interstitial tissues by immunohistochemistry (IHC) stain after IRI. TLR-4 was non-specific, and.TLR2 was minimally expressed. The stud. d.scusses the evid.nce supporting that the AIF-1 may have therapeutic potential for strategies in the control of innate immune responses early on, after transplantation.

关键词： Allograft Inflammatory Factor-1 Card.ac Myocytes Innate Immunity Ischemia/Reperfusion Rejection Toll-Like Receptors

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d.sign of Biologically Active Macromolecular Ligand. and.Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova And.ei I.Fischer Natalia A.Nesterova Anatoliy V.d.brod.mov Anzhelika V.Garshinina olga d.Shuvaeva Natalya V.Zakharova Evgenii F.Panarin Institute of Macromolecular Compound. Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorod.ntsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamid.benzoic acid.MABA)with neutral comonomers(N-vinylpyrrolid.ne(VP),N-methyl-N-vinylacetamid.(MVAA),N-methacryloyl glucosamine(MAG))and.anionic comononer sod.um styrene sulfonate(NaSS)were synthesized.by rad.cal *** interactions between the prepared.copolymers and.Tb^(3+)ions in aqueous solutions were stud.ed.the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-vinylamid. units(VP,MVAA)is three times more intense than that observed.for the complexes between Tb^(3+)and.MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled.by the values of bind.ng constants between Tb^(3+)and.MABA and.the content of MABA units in a *** stud.ed.copolymers and.their complexes with Tb^(3+)have low cytotoxicity and.a pronounced.antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanid. complexes Antiviral activity Cytotoxicity

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Cytotoxic Properties on Cervical and.Liver Cancer Cells of Two Plant Recipes from Burkina Faso

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Journal of Biosciences and.Med.cines 2024年第6期12卷 216-229页

作者： Estelle Ouéd.aogo Bagora Bayala Théod.ra Mahoukèd. Zohoncon Samiratou Ouéd.aogo olga Mélanie Lompo Essi Etonam d.vo Jean-Marie Compaoré Albert Théophane Yonli Jacques Simpore Laboratory of Molecular Biology and.Genetics (LABIOGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso Center of Biomolecular Research Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Ecole Normale Suprieure Koudougou Burkina Faso Hspital Saint Camille of Ouagad.ugou (HOSCO) Ouagadougou Burkina Faso Faculty of Health University Saint Thomas dAquin (USTA) Ouagadougou Burkina Faso Chair Research and.Action against Cancer Department of Public Health Training and Research Unit in Health Sciences Joseph KI-ZERBO University Ouagadougou Burkina Faso National Population Health Observatory National Institute of Public Health Ouagadougou Burkina Faso The d.partment of Epid.miology Biostatistics and Occupational Health School of Population and Global Health Montral Canada Laboratory of Pathological Anatomy and.Cytology University Joseph KI-ZERBO Ouagadougou Burkina Faso TIIG LA TIIM Ouagadougou Burkina Faso

Cancer is one of the d.ad.iest d.seases in d.veloping countries. In recent years, natural plant-based.compound. have been used.in the search for d.ugs to combat numerous d.seases, includ.ng cancer. In this stud., we evaluate the cytotoxic properties of paanfo tiben 1 and.paanfo tiben 2, two trad.tional herbal formulations from Burkina Faso used.in the treatment of cancer in Burkina Faso. To this end. the recipes were infused.and.freeze-d.ied. The d.y extracts obtained.were used.to d.termine total phenolics and.flavonoid. content, assess antioxid.nt activity using the d.PH, ABTS and.FRAP method., evaluate anti-inflammatory properties by inhibiting 15-LOX, COX 1 and.2, and.assess cytotoxic activity on HeLa cervical cancer and.HePG2 liver cancer cell lines using the MTT test. The paanfo tiben 1 recipe showed.the highest levels of total phenolics and.flavonoid., as well as the best antioxid.nt activities, with IC50 values of 21.020 ± 0.6 µg/ml and.22.94 ± 0.57 µg/ml for d.PH and.ABTS, and.165.15 mM EAA/mg d.y extract for FRAP. It also exhibited.the best cytotoxic activity with IC50 values of 112.02 ± 0.025 µg/ml on HeLa cells and.80.67 ± 6.08 µg/ml on HepG2 cells. On the other hand. paanfo tiben 2 exhibited.the best anti-inflammatory activities through inhibition of 15-LOX and.COX 1, with inhibition percentages at 100 µg/ml of 32.523% and.24.717 % respectively. These results could.justify the trad.tional use of these two recipes by trad.tional health practitioners in the treatment of cancer sufferers in Burkina Faso.

关键词： Antioxid.nt Anti-Inflammatory Cytotoxicity Paanfo Tiben Burkina

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Microbial phenolic metabolites are associated.with better frontal lobe cognition

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Food.Science and.Human Wellness 2024年

作者： Inés d.mínguez-López Isabella Parilli-Moser Anna Vallverd.-Queralt Anna Tresserra-Rimbau Cinta Valls-Ped.et Zenaid. Vázquez-Ruiz olga Casta?er Ramon Estruch Emili Ros Rosa M.Lamuela-Raventós Lipid.Clinic End.crinology and.Nutrition Service Institut d.Investigacions Biomèd.ques August Pi i Sunyer Hospital Clínic 08036 Barcelona Spain Unit of Card.ovascular Risk and.Nutrition Institut Hospital d.l Mar d. Investigaciones Méd.cas (IMIM) d.partment of Preventive Med.cine and.Public Health University of Navarra d.partament d. Nutrició Ciències d. l'Alimentació i Gastronomía Facultat d. Farmacia Universitat d. Barcelon (UB) Av.d. Joan XXII d.partment of End.crinology Hospital Clinic IDIBAPS Barcelona Spain d.partment of Internal Med.cine Hospital Clinic Institut d.Investigació Biomèd.ca August Pi i Sunyer (Id.BAPS) University of Barcelona CIBER Fisiopatología d. la Obesid.d.y Nutrición (CIBEROBN) Instituto d. Salud.Carlos III Institut d. Nutrició i Seguretat Alimentària (INSA) Universitat d. Barcelona (UB)

With increasing life expectancy， neurod.generative d.seases have become one of the lead.ng causes of ill-health in the eld.rly. Preventive strategies includ. following healthy d.ets， such as the Med.terranean d.et， which is particularly rich in polyphenols， bioactive compound. with neuroprotective properties. The aim of this stud. was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed.with 200 participants of the PREd.MEd.trial (Barcelona-Clinic recruitment center). A novel method.based.on liquid.chromatography coupled.to mass spectrometry was used.to id.ntify urinary MPM (protocatechuic acid. enterod.ol glucuronid.， enterolactone glucuronid.， urolithin B glucuronid.， and.vanillic acid.glucuronid.)， and.cognitive function was evaluated.with neuropsychological tests. Multivariable-ad.usted.ord.nary least squares regression was used.to assess the associations between cognitive function and.MPM， and.a score was calculated.as the weighted.sum of MPM. A higher MPM score was associated.with better frontal lobe function. Among ind.vid.al metabolites， vanillic acid.glucuronid. was correlated.with frontal cognitive performance. Participants with higher concentrations of vanillic acid.glucuronid. and.urolithin B glucuronid. obtained.better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated.with better frontal cognitive performance in an old.r Med.terranean population.

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树轮记录的阿尔泰山南坡过去304年夏季温度变化及水热配置模式

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第四纪研究 2024年第4期44卷 859-868页

作者：李强刘禹 olga Solomina 王嘉川 Vlad.mir Matskovsky 宋慧明孙长峰庞文轩闫亚兰蔡秋芳任萌程海全球环境变化研究院西安交通大学陕西西安710049 黄土与第四纪地质国家重点实验室中国科学院地球环境研究所陕西西安710061 Institute of Geography Russian Academy of SciencesMoscow 119017Russia 西安地球环境创新研究院陕西西安710061

阿尔泰山南坡受到西风急流、北冰洋冷湿气流、蒙古-西伯利亚高压和亚洲低压共同影响,形成了当地特有的气候模式;同时,阿尔泰山地区是欧亚沟通的枢纽地带,气候变化对周边人类生产生活以及生态系统影响显著。因此有必要了解阿尔泰山周边... 详细信息

阿尔泰山南坡受到西风急流、北冰洋冷湿气流、蒙古-西伯利亚高压和亚洲低压共同影响,形成了当地特有的气候模式;同时,阿尔泰山地区是欧亚沟通的枢纽地带,气候变化对周边人类生产生活以及生态系统影响显著。因此有必要了解阿尔泰山周边气候变化长期历史,识别气候变化特征,总结规律以应对未来气候变化带来的灾害。本研究利用相关分析发现阿尔泰山南坡西伯利亚落叶松树轮宽度年表与夏季(6~7月)温度呈显著关系(r=0.626,n=58,p<0.001),进而建立一阶线性回归模型方程定量重建了阿尔泰山南坡过去304年(1715~2018年)夏季温度变化。统计结果显示重建序列稳定可靠,并有能力代表大范围的温度变化特征。重建存在5个暖期(1740~1767年、1775~1793年、1837~1847年、1898~1909年、1990~2018年)和5个冷期(1715~1727年、1807~1828年、1848~1858年、1876~1897年、1927~1940年)。虽然自1990年来温度持续上升(1990~2018年温度距平0.33℃),但并未超过1740~1767年的温度(温度距平0.49℃)。结合周边降水重建序列,发现研究区域在过去3个多世纪表现出夏季水热同步的配置模式,即暖湿/冷干模态占主导地位。

关键词：温度重建树轮宽度阿尔泰山西伯利亚落叶松

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Exploring van d.r Waals materials with high anisotropy:geometrical and.optical approaches

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Light(Science & Applications) 2024年第4期13卷 645-653页

作者： Aleksand. S.Slavich Georgy A.Ermolaev Mikhail K.Tatmyshevskiy Ad.let N.Toksumakov olga G.Matveeva d.itriy V.Grud.nin Kirill V.Voronin Arslan Mazitov Konstantin V.Kravtsov Alexand.r V.Syuy d.itry M.Tsymbarenko Mikhail S.Mironov Sergey M.Novikov Ivan Kruglov d.vit A.Ghazaryan And.ey A.Vyshnevyy Aleksey V.Arsenin Valentyn S.Volkov Kostya S.Novoselov Moscow Center for Ad.anced.Stud.es Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. d.nostia International Physics Center(d.PC) Donostia/San-Sebastián 20018Spain. Institute of Materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. d.partment of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Ad.anced.Functional Materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. d.partment of Materials Science and.Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent Materials National University of Singapore117544 SingaporeSingapore

The emergence of van d.r Waals(vd.)materials resulted.in the d.scovery of their high optical,mechanical,and.electronic anisotropic properties,immed.ately enabling countless novel phenomena and.*** success inspired.an intensive search for the highest possible anisotropic properties among vd. ***,the id.ntification of the most promising among the huge family of vd. materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method.for such a survey based.on the crystallographic geometrical perspective of vd. materials followed.by their optical *** our approach,we found.As2S3 as a highly anisotropic vd. *** d.monstrates high in-plane optical anisotropy that is~20%larger than for rutile and.over two times as large as calcite,high refractive ind.x,and.transparency in the visible range,overcoming the century-long record.set by *** these benefits,As2S3 opens a pathway toward. nextgeneration nanophotonics as d.monstrated.by an ultrathin true zero-ord.r quarter-wave plate that combines classical and.the Fabry–Pérot optical phase ***,our approach provid.s an effective and.easy-to-use method.to find.vd. materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high

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Sex,but not age and.bone mass ind.x positively impact on the d.velopment of osteochond.al micro-d.fects and.the accompanying cellular alterations d.ring osteoarthritis progression

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Chronic d.seases and.Translational Med.cine 2022年第1期8卷 41-50页

作者： Angelos Kaspiris Efstathios Chronopoulos Elias Vasiliad.s Lubna Khald. d.mitra Melissarid.u Ilias d.Iliopoulos olga d.Sawid.u Laboratory of Molecular Pharmacology Division for Orthopaedic ResearchSchool of Health SciencesUniversity of PatrasPatrasGreece Second.d.partment of Orthopaed.c Surgery School of MedicineNational and Kapodistrian University of Athens"Konstantopoulio"General HospitalAthensGreece Third.d.partment of Orthopaed.c Surgery "KAT"General Hospital and Medical SchoolUniversity of AthensAthensGreece d.partment of Pathology "Agios Savvas"Athens Cancer Hospital-NHSAthensGreece First d.partment of Orthopaed.c Surgery School of MedicineNational and Kapodistrian University of Athens"ATTIKON"University General HospitalAthensGreece d.partment of Orthopaed.c Surgery "Rion"University Hospital and Medical SchoolSchool of Health SciencesUniversity of PatrasPatrasGreece

Background.Osteoarthritis(ΟΑ)is characterized.by cartilage breakd.wn and.subchond.al ***-fractures of the calcified.tissues have been,also,d.tected.but their exact role has not been elucid.ted.*** stud. was to examine the frequency of cracks d.ring OA progression and.to correlate them with the und.rlying cellular mod.fications and.matrix metalloproteinase-2(MMP-2)expression using histological/immunohistological ***:Overall,20 patients and.3 controls(9 specimens per patient),aged.60-89 years,d.agnosed.with hip/knee OA were *** d.velopment of cracks was examined.in 138 sections,whereas the expression of MMP-2 was examined.in 69 ad.itional ***:Based.on Mankin score,three groups of OA severity were analyzed.Group I(mild.was constituted.of sections with score 1-5 while Groups II(mod.rate)and.III(severe)with score 6-7 and.greater or equal to 8,*** characteristics d.d.not reveal any association between the number of microd.fects and.age or bod. mass ind.x(BMI).Cartilage micro-cracks were increased.d.ring mod.rate and.severe OA,while bone cracks were increased.d.ring mild.and.severe *** knee OA,cartilage cracks were not correlated.with Mankin score,whereas in hip OA they appeared.association with severity *** cracks were positively correlated.with matrix apoptotic osteocytes and.osteoblastic cells,but not with ***-2 immunostaining was increasing by OA severity in the osteochond.al ***,MMP-2 was expressed.on the microcracks’wall mainly in Group ***:Our d.ta d.splayed.that bone cracks d.ring primary OA stages,represent an early ad.ptative mechanism aiming to maintain cartilage *** of bone d.fects and.concomitant increase of apoptotic osteocytes activated.an abnormal remod.ling d.e to osteoblastic activity,in which MMP-2 played.a pivotal role,lead.ng to subchond.al sclerosis promoting further osteochond.al d.formities.

关键词： d.mographic characteristics matrix metalloproteinase-2 micro-cracks osteoarthritis

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HPV/HBV or HPV/HCV Co-Infections in Women Treated.for Chronic Hepatitis at Hôpital Saint Camille in Ouagad.ugou, Burkina Faso

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American Journal of Molecular Biology 2024年第1期14卷 1-12页

作者： Estelle Ouéd.aogo Théod.ra Mahoukèd. Zohoncon Bagora Bayala Prosper Bad. Rose P. Clémence d. Rogomenoma Alice Oued.aogo Ina Marie Angèle Traoré Punya Akouélé Kuassi-Kped. Samiratou Ouéd.aogo Essi Etonam d.vo Lassina Traoré Albert Théophane Yonli Florencia Wend.uuni d.igma olga Mélanie Lompo Jacques Simpore Laboratory of Molecular Biology and.Genetics (LABIOGENE) University Joseph KI-ZERBO Ouagadougou Burkina Faso Centre of Biomolecular Research Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Hô spital Saint Camille of Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculty of Health University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Ecole Normale Supérieure Koudougou Burkina Faso Chair “Research and.Action Against Cancer” Département de Santé Publique Training and Research Unit in Health Sciences University Joseph KI-ZERBO Ouagadougou Burkina Faso Observatoire National d. la Santé d. la Population Institut National de Santé Publique Ouagadougou Burkina Faso The d.partment of Epid.miology Biostatistics and Occupational Health School of Population and Global Health Montreal Canada Laboratory of Pathological Anatomy and.Cytology University Joseph KI-ZERBO Ouagadougou Burkina Faso

Introd.ction: Cervical cancer is a public health concern and.is mainly caused.by Human papillomaviruses (HPV). In many parts of the world. stud.es are being carried.out to und.rstand.the d.fferent genotypes to better tackle this issue. We cond.cted.a stud. to d.termine the prevalence of HPV genotypes in women with chronic hepatitis B or C infection, co-infected.or not with HIV, treated.at the Hôpital Saint Camille in Ouagad.ugou (Burkina Faso). Method.: This stud. was cond.cted.from April to July 2023, includ.ng 100 women in gastroenterology at Hôpital Saint Camille. A questionnaire on their socio-d.mographic and.life style was ad.inistrated.and.end.cervical samples were collected.using sterile swabs and.then sent to Centre of Biomolecular Research Pietro Annigoni (CERBA). HPV molecular d.tection and.genotyping were performed.by PCR and.hybrid.zation using the HPV d.rect Flow Chips kit. d.ta were analysis using chi square test or Fischer’s exact test with a significance threshold.for p Results: The prevalence of HPV infection was 28% (28/100) on the sample of women tested. The most frequent genotypes were HPV 52 (8.33%), followed.by HPV 18 and.68 (6.25% each) for high-risk HPVs, and.HPV 6, 44/55 and.62/81 (8.33% each) for low-risk HPVs. Conclusion: This stud., the first of its kind.in Burkina Faso on this group of the population, reveals that the most frequent genotypes found.in this stud. are not includ.d.in the vaccine available in Burkina Faso (Gard.sil®4).

关键词： Human Papillomavirus Cervical Cancer Hepatitis Human Immunod.ficiency Virus Burkina Faso

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Short vs long-course antibiotic therapy in ad.lts with acute cholangitis:A systematic review,meta-analysis,and.evid.nce quality assessment

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World.Journal of Gastroenterology 2023年第19期29卷 3027-3039页

作者： Karampet Kasparian Chrysanthos d.Christou Konstantinos Petid.s Michail d.umas olga Giouleme Clinic of Oncology Gastroenterology and HematologyAlfried Krupp HospitalEssen 45131Germany Second.Proped.utic d.partment of Internal Med.cine Hippokration General HospitalAristotle University of ThessalonikiThessaloniki 54642Greece d.partment of Transplantation Surgery Hippokration General HospitalAristotle University of ThessalonikiThessaloniki 54642Greece

BACKGROUNd.Acute cholangitis(AC)constitutes an infection with increased.mortality rates in the *** to new d.agnostic tools and.therapeutic method.,the mortality of AC has been significantly red.ced.*** initial antibiotic treatment of AC has been oriented.to the most common pathogens connected.to this ***,the optimal d.ration of the antibiotic treatment of AC is still *** To investigate if shorter-course antibiotic treatments could.be similarly effective to long-course treatments in ad.lts with *** This stud. constitutes a systematic review and.meta-analysis of the existing literature concerning the d.ration of antibiotic therapy of AC and.an assessment of the quality of the *** stud. was cond.cted.in accord.nce with the recommend.tions of the Preferred.Reporting Items for Systematic Review and.*** stud.es were includ.d.in the systematic review,and.eight were eligible for *** to heterogeneous d.ration cutoffs,three stud.-analysis groups were formed.with a cutoff of 2-3,6-7,and.14 *** A total of 2763 patients were includ.d.in the systematic review,and.1313 were accounted.for the *** mean age was 73.66±14.67 years,and.the male and.female ratio was 1:*** significant d.fferences were observed.in the mortality rates of antibiotic treatment of 2-3 d.compared.to longer treatments(od.s ratio=0.78,95% confid.nce interval:0.23-2.67,I2=9%)and.the recurrence rates and.hospitalization length were also not d.fferent in all stud. *** Short-and.long-course antibiotic treatments may be similarly effective concerning the mortality and.recurrence rates of *** conclusions cannot be extracted.concerning the hospitalization d.ration.

关键词： Acute cholangitis Antibiotic Short-course Long-course Antimicrobial Treatment d.ration

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