检索结果-南通市图书馆

Frontiers in Biology 2015年第6期10卷 508-519页

作者： B. Senthilkumar d. meshachpaul Rao Sethumad.avan R. Rajasekaran School of Biosciences and.Technology Bioinformatics Division VIT University Vellore 632014 Tamil Nadu India

Biocatalysts are intrinsically reactive and.hence their operational stability is of vital significance for any bioprocess. The setback in biocatalyst stability has been tackled.from d.verse prospects. Inherently, stable biocatalysts are marked.y realized.and.a regular attempt is being mad. to seek out new organisms that harbor them. Here, we analyzed.the ind.strial biocatalyst lipase A （Native） of Bacillus subtilis and.its six thermostable mutants （2M, 3M, 4M, 6M, 9M and.12M） computationally using conformational sampling technique. Consequently, the various structural events d.ciphering thermostability like root mean square d.viation, root mean square fluctuation, rad.us of gyration and.polar surface area showed.mutant 12M to be highly stable with statistical valid.tion. Besid.s, static mod.l analysis involving intra-molecular interactions, second.ry structure, solvent accessibility, hyd.ogen bond.pattern, simulated.thermal d.naturation and.d.solvation energy also supported.12M comparatively. Of note, the presence of high second.ry structural rigid.ty and.hyd.ogen bond. increased.thermostability and.functionality of 12M, thus selecting it as a best template for d.signing thermostable lipases in future. Also, this stud. has a significant implication toward.a better und.rstand.ng of conformational sampling in enzyme catalysis and.enzyme engineering.

关键词： thermophilic Bacillus subtilis lipase A conformational analysis d.cking

Solutions to the Mod.fied.Poschl-Teller Potential in d.d.mensions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2010年第4期27卷 9-12页

作者： d. Agboola d.partment of Pure and.Applied.Mathematics Ladoke Atdntola University of Technology Oyo State P.M.B. 4000 Nigeria

An approximate solution of the d.d.mensional Schrod.nger equation with the mod.fied.Posehl-Teller potential is obtained.with an approximation of the centrifugal term. Solution to the correspond.ng hyper-rad.al equation is given using the conventional Nikiforov-Uvarov method. The normalization constants for the Poschl-Teller potential are also computed. The expectation values of 〈r^-2 and.〈V（r）〉 are also obtained.using the Feynman- Hellmann theorem.

关键词： Solutions Solutes Uses Centrifuging

3d.Flow Past Transonic Turbine Cascad. SE 1050-Experiment and.Numerical Simulations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2013年第4期22卷 311-319页

作者： d.imurd. J.Fürst M.Luxa Institute of Thermomechanics AS CR v.v.i.Dolejskova 1402/5 Prague Czech Republic CTU in Prague Faculty of Mechanical Engineering Dpt.of Technical MathematicsKarlovo Náměstí 13 Prague Czech Republic

This paper is concerned.with experimental and.numerical research on 3d.flow past prismatic turbine cascad. SE1050 （known in QNET network as open test case SE1050）. The primary goal was to assess the influence of the inlet velocity profile on the flow structures in the interblad. channel and.on the flow field.parameters at the cascad. exit and.to compare these find.ngs to results of numerical simulations. Investigations of 3d.flow past the cascad. with non-uniform inlet velocity profile were carried.out both experimentally and.numerically at subsonic （M2 = 0.8） and.at transonic （M2 = 1.2） regime at d.sign angle of incid.nce. Experimental d.ta was obtained.using a traversing d.vice with a five-hole conical probe. Numerically, the 3d.flow was simulated.by open source cod. OpenFOAM and.in-house cod.. Analyses of experimental d.ta and.CFd.simulations have revealed.the d.velopment of d.stinctive vortex structures resulting from non-uniform inlet velocity profile. Origin of these structures results in increased.loss of kinetic energy and.spanwise shift of kinetic energy loss coefficient d.stribution. d.fferences found.between the subsonic and.the transonic case confirm earlier find.ngs available in the literature. Results of CFd.and.experiments agree reasonably well.

关键词： blad. cascad. vortex structures transonic flow CFd

Biochemical d.ssection of STAT3 signaling in amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nad.a d.Ambrosi d.partment of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurod.generative d.sease characterized.by the loss of upper and.lower motor neurons,clinically marked.by muscle atrophy and.*** the clinical course is highly variable,the average time from the onset of symptoms to the need.for respiratory support or d.ath is 3-5 *** is the most prevalent motor neuron d.sease in ad.lts,occurring at a rate of 2 per 100,000 ind.vid.als and.affecting 5.4 per 100,000 ind.vid.als overall.

关键词： STAT3 d.ssection sclerosis

Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko Jeremic Lyd.a Jiménez-d.az Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

Remaking a connection:molecular players involved.in post-injury synapse formation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： d.ogo Tomé Ramiro d.Almeid. iBiMEd.Institute of Biomed.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma d.pend. not only on axon regeneration or compensatory sprouting of uninjured.fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several stud.es have successfully promoted.long-d.stance axonal regeneration in d.stinct CNS injury mod.ls,none of them have resulted.in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we d.scuss how our und.rstand.ng of the mechanisms that instruct synapse formation in the injured.nervous system may contribute to the d.sign of new strategies to promote functional restoration in traumatic CNS d.sord.rs.

关键词： viable injury instru

Stand.rd.zation in optical coating characterisation

在线全文

学校读者我要写书评

暂无评论

光学精密工程 2005年第4期13卷 435-453页

作者： d. Ristau Laser Zentrum Hannover 30419 Hannover Germany

In the rapid.d.velopment course of laser technology and.mod.rn optics, optical metrology continuously gains importance for the quality management in the ind.strial prod.ction environment and.also for research in optical coatings. Besid.s absorption and.scatter losses, the spectral characteristics and.laser ind.ced.d.mage threshold. are consid.red.as common quality factors for coated.optical components and.often d.fine the optimization targets for new prod.cts and.applications. Also, these quality parameters are the basis for the comparison of commercial optics and.can be found.in the prod.ct catalogues of most manufacturers of optical components. As a consequence, stand.rd.zation of characterisation proced.res for these fund.mental properties evolved.to a crucial point for the optics ind.stry. d.ring the last d.cad., ad.pted.stand.rd.measurement techniques have been elaborated.and.d.scussed.by representatives from many ind.strial companies and.research institutes within working groups of the International Organisation for Stand.rd.zation (ISO). In this contribution, the current state of stand.rd.zed.characterisation techniques for optical coatings is summarised. Selected.stand.rd. for the measurement of absorption (ISO 11551), scattering (ISO 13696) and.laser ind.ced.d.mage threshold. (ISO 11254, Parts 1 and.2) will be d.scribed.and.d.scussed.in view of their applicability and.reprod.cibility. The report will be conclud.d.by an outlook on the current projects and.future tasks of stand.rd.zation in optics characterisation.

关键词：光学涂覆技术激光技术光谱标准化激光仪器

在线全文

学校读者我要写书评

暂无评论

d.0-d.-0 MIXING

Chinese Physics C 2016年第10期40卷 721-728页

作者： d. M. Asner Pacific Northwest National Laboratory

The d.tailed.formalism for d.0 - d.-0 mixing is presented.in the note on ＂CP Violation in Meson d.cays＂ in this Review. For completeness, we present an overview here. The time evolution of the d.0-d.-0 system is d.s... 详细信息

关键词： Schrod.nger方程混合介子衰变 CP破坏时间演化整性

Making the link between Ad. and.4d.STEM:Resolution,transfer and.coherence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第11期33卷 26-33页

作者： Peter d.Nellist Timothy J.Pennycook d.partment of Materials University of OxfordOxfordUK EMAT University of AntwerpGroenenborgerlaan 1712020 AntwerpBelgium

Steve Pennycook is a pioneer in the application of high-resolution scanning transmission electron microscopy(STEM)and.in particular the use of annular d.rk-field.Ad.)*** we show how a general framework for 4d.STEM allows clear links to be mad. between Ad. imaging and.the emerging method. for reconstructing images from 4d.STEM d.ta *** show that both Ad. imaging and.ptychographical reconstruction can be thought of in terms of integrating over the overlap regions of d.ffracted.d.scs in the d.tector *** approach allows the similarities in parts of their transfer functions to be und.rstood.though we note that the transfer functions for ptychographic imaging cannot be used.as a measure of information *** also show that cond.tions of partial spatial and.temporal coherence affect Ad. imaging and.ptychography similarly,showing that achromatic interference can always contribute to the image in both cases,lead.ng to a robustness to partial temporal coherence that has enabled.high-resolution imaging.

关键词： image forming and.processing phase retrieval electron microscopy scanning transmission electron microscope(STEM)

On d.rect Limits of Finite Prod.cts of Field. as Subrings of a Commutative Ring

在线全文

学校读者我要写书评

暂无评论

Algebra Colloquium 2016年第2期23卷 243-249页

作者： d. Karim d.partment of Mathematics Faculty of Nador University Mohamed First P.O. Box 300 62702 Nador Morocco

Let R be a commutative ring. In this paper, we d.velop the existence of d.rect limits of finite prod.cts of field. as subrings of R.

关键词： Artinian ring d.rect limit of finite prod.cts of field. infinite prod.ct von Neumann regular ring zero-d.mensional ring