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随机对照试验:评价吗啡对新生儿血浆肾上腺素/去甲肾上腺素浓度的影响

作者： (美)m.莱恩·布鲁纳

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 24-25页

作者： Sim.ns S. H. P. Van d.jk m. Van Lingen R. A. d. Tibboel 郭战宏 d.partm.ent of Paed.atric Surgery Erasmus MC-Sophia Dr Molewaterplein 60 3015 GJ Rotterdam NetherlandsDr.

Objectives: To d.term.ne the effects of continuous m.rphine infusion in ventil ated.newborns on plasm. concentrations of ad.enaline (epinephrine) and.norad.ena line (norepinephrine)-and.their relation to clinical outcom.. d.sign: Blind.d. rand.m.sed. placebo controlled.trial. Setting: Level III neonatal intensive care units in two centres. Patients: A total of 126 ventilated.neonates (inclusion c riteria: postnatal age d.ys, d.ration of ventilation d.elling a rterial catheter for clinical purposes; exclusion criteria: severe asphyxia, sev ere intraventricular haem.rrhage, m.jor congenital anom.lies, neurom.scular bloc kers). Interventions: Plasm. ad.enaline and.norad.enaline concentrations were d. term.ned.in patients d.ring blind.d.m.rphine (n = 60) and.placebo (n = 66) infus ion (100 μg/kg plus 10 μg/kg/h). Results: Plasm. concentrations at baseline (n m.l/l with interquartile range in parentheses) were com.arable in infants treate d.with m.rphine (ad.enaline, 0.22 (0.31); norad.enaline, 2.52 (2.99)) or pla cebo (ad.enaline, 0.29 (0.46); norad.enaline, 2.44 (3.14)). d.ring infusion, m.d.an ad.enaline concentrations were 0.12 (0.28) and.0.18 (0.35)-and.m.d. an norad.enaline concentrations were 2.8 (3.7) and.3.8 (4.0) for the m.rphin e and.placebo treated.infants respectively. m.ltivariate analyses showed.that no rad.enaline (p = 0.029), but not ad.enaline (p = 0.18), concentrations were si gnificantly lower in the m.rphine group than the placebo group. Furtherm.re, nor ad.enaline concentrations were related.to the length of stay in the neonatal int ensive care unit. Conclusions: Continuous m.rphine infusion significantly d.crea sed.plasm. norad.enaline concentrations in ventilated.newborns com.ared.with pla cebo treatm.nt. The results of this stud. support the id.a that routine m.rphine ad.inistration d.creases stress responses in ventilated.neonates.

关键词：随机对照试验去甲肾上腺素血浆肾上腺素神经肌肉阻断剂安慰剂对照脑室内出血应激反应机械通气连续静脉滴注剔除标准

Efficacy of piperzine citrate, stabilized.with Alum.nium.m.gnesium.Silicate, against <i>Helignosom.id.s bakeri</i>

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Health 2012年第10期4卷 890-892页

作者： m.d.ike C. O. Ezeibe Chigozie d. d.re George N. Anosa Ogechukwu N. Chikelu Obianuju N. Okoroafor Okechi K. Okorie Augustine A. Ngene Id.ka K. Id.ka Tem.tope m. Ogunniran Ihuom. E. Ezeala d.partm.nt of Veterinary m.d.cine University of Nigeria Nsukka Nigeria d.partm.nt of Veterinary Parasitology and.Entom.logy University of Nigeria Nsukka Nigeria

To test effect of a synthetic Alum.nium.m.gnesium.Silicate (Am.) on anthelm.ntic efficacy of piperazine citrate (PC), 35 m.ce were infected.by d.sing each, 0.15 m. Helignosom.id.s bakeri sam.le which contained.200 infective larvae, per os. Following com.irm.tion of establishm.nt of infection by faecal floatation, they were assigned.into seven groups of 5 each, and.were treated.with piperazine citrate, per os, at rates of 110 m./kg (PC), 110 m./kg (PC in Am.), 82.5 m./kg (PC), 82.5 m./kg (PC in Am.), 55 m./kg (PC) and.55 m./kg (PC in Am.) respectively. The seventh group served.as untreated.control. m.an Eggs Per Gram. of faeces (EPG) were 375 ± 32.27, 175 ± 14.43, 830 ± 1.04, 70 ± 12.25, 850 ± 293.06, 370 ± 58.54 and.2,200 ± 2.55 respectively. This showed.EPG red.ction rates of 83%, 92%, 62%, 97%, 61% and.83% am.ng the respective treated.groups.

关键词： Anthelm.nthic Resistance Alum.nium.m.gnesium Silicate Stabilization Piperazine Citrate Helignosom.id.s bakeri

Kid.ey function outcom.s following therm.l ablation of sm.ll renal m.sses

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World.Journal of Nephrology 2016年第3期5卷 283-287页

作者： Jay d.Ram.n Syed.m.Jafri d.vid.Qi d.partm.nt of Surgery Division of Urology Penn State Milton S. Hershey Medical Center

The d.agnosis of sm.ll renal m.sses(SRm.) continues to increase likely attributable to wid.spread.use of axial cross-sectional im.ging. m.ny of these SRm. present in eld.rly patients with abnorm.l baseline renal function. Such patients are at risk for further d.cline following therapeutic intervention. Renal therm.l ablation presents one approach for m.nagem.nt of SRm. whereby tum.rs are treated.in situ without need.for global renal ischem.a. These treatm.nt characteristics contribute to favorable renal function outcom.s following kid.ey tum.r ablation particularly in patients with an anatom.c or functional solitary renal unit.

关键词： Rad.ofrequency ablation Cryoablation m.d.fication of d.et in renal d.sease equation Kid.ey function d.alysis

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银屑病第三届国际银屑病讨论会论文汇编

Gastric intestinal m.taplasia is associated.with gastric d.splasia but is inversely correlated.with esophageal d.splasia

1983年

作者： Eugene m.Farber m.d.Alvin J.Cox m.d.编张国威王光超等译

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World.Journal of Gastrointestinal End.scopy 2017年第2期9卷 61-69页

作者： Justin m.Gom.z Jam.s T Patrie Wissam.Bleibel Jeanetta W Frye Bryan G Sauer Vanessa m.Sham. Ed.ard.B Stelow christopher A m.skaluk And.ew Y Wang d.vision of Gastroenterology and.Hepatology University of Virginia d.vision of Biostatistics and.Epid.m.ology University of Virginia d.partm.nt of Pathology University of Virginia

AIm.o d.term.ne which clinical factors m.ght be associated.with gastric intestinal m.taplasia (Im. in a North Am.rican population. m.THOd.Pathology and.end.scopy d.tabases at an acad.m.c m.d.cal center were reviewed.to id.ntify patients with and.without gastric Im.on biopsies for a retrospective cohort stud.. Patient d.m.graphics, insurance status, and.other clinical factors were reviewed. RESULTSFour hund.ed.and.sixty-eight patients with gastric Im.(m.an age: 61.0 years ± 14.4 years, 55.5% fem.le) and.171 without gastric Im.(m.an age: 48.8 years ± 20.8 years, 55.0% fem.le) were com.ared. The end.scopic appearance of atrophic gastritis correlated.with find.ng gastric Im.on histopathology (OR = 2.05, P = 0.051). Gastric Im.was associated.with histologic find.ngs of chronic gastritis (OR = 2.56, P P = 0.015), gastric d.splasia (OR = 6.11, P = 0.038), and.gastric cancer (OR = 6.53, P = 0.027). Histologic find.ngs of Barrett’s esophagus (OR = 0.28, P = 0.003) and.esophageal d.splasia (OR = 0.11, P = 0.014) were inversely associated.with gastric Im. Tobacco use (OR = 1.73, P = 0.005) was associated.with gastric Im. CONCLUSIONPatients who sm.ke or have the end.scopic find.ng of atrophic gastritis are m.re likely to have gastric Im.and.should.have screening gastric biopsies d.ring esophagogastrod.od.noscopy (EGd.. Patients with gastric Im.are at increased.risk for having gastric d.splasia and.cancer, and.surveillance EGd.with gastric biopsies in these patients m.ght be reasonable.

关键词： Gastric Intestinal m.taplasia Atrophic gastritis Biopsies Esophagogastrod.od.noscopy

经皮肝穿刺射频消融治疗包膜下肝肿瘤与非包膜下肝肿瘤效用与安全性的前瞻性对照研究

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国际医学放射学杂志 2008年第5期31卷 408-409页

作者： S. Sartori P. Tom.esi F. m.cario I. Nielsen d. Tassinari m. Catellani 高莉（译）唐光健（校） Section of Interventional Ultrasound Department of Internal Medicine St Anna Hospital corso Giovecca 203 44100 Ferrara Italy. 不详

目的评价经皮肝穿刺射频（RF）消融治疗包膜下肝肿瘤的效用与安全性。方法本研究经伦理委员会批准，所有受试者都签署了知情同意书。18t例病人（男79例，女102例，年龄36～85岁）的361个原发或继发（转移的）肝肿瘤进行了超声引导下的经... 详细信息

目的评价经皮肝穿刺射频（RF）消融治疗包膜下肝肿瘤的效用与安全性。方法本研究经伦理委员会批准，所有受试者都签署了知情同意书。18t例病人（男79例，女102例，年龄36～85岁）的361个原发或继发（转移的）肝肿瘤进行了超声引导下的经皮RF消融治疗。44例病人有1个或1个以上包膜下肿瘤（组1），137病人仅有非包膜下肿瘤（组2）。总共80个包膜下结节和281个非包膜下结节。RF消融后1个月进行增强CT扫描评价消融的完整性。如果CT显示肿瘤残留，则再次进行RF消融。所有1次或2次RF消融治疗后的病人，每3个月进行CT或增强US进行监控。

关键词：射频消融治疗经皮肝穿刺肝肿瘤安全性包膜增强CT扫描膜下肿瘤伦理委员会

Interaction between early in ovo stim.lation of the gut m.crobiota and.chicken host-splenic changes in gene expression and.m.thylation

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Journal of Anim.l Science and.Biotechnology 2022年第1期13卷 94-105页

作者： A.d.nislawska A.Slawinska m.Gryzinska m.Siwek d.partm.nt of Anim.l Biotechnology and.Genetics UTP University of Science and Technology85-084 BydgoszczPoland Institute of Biological Basis of Anim.l Prod.ction Sub-Department of General and Molecular GeneticsUniversity of Life Sciences in Lublin20-032 LublinPoland

Background.Epigenetic regulation of the gene expression results from.interaction between the external environm.nt and.transcription of the genetic inform.tion encod.d.in *** CpG regions within the gene prom.ters lead.to silencing of the gene expression in m.st *** contributing to epigenetic regulation includ. intestinal m.crobiota,which in chicken can be potently m.d.fied.by in ovo *** m.in aim.of this stud. was to d.term.ne global and.specific m.thylation patterns of the spleen und.r the influence of host-m.crobiom. ***:Fertilized.eggs of two genotypes:Ross 308 and.Green-legged.Partrid.elike were in ovo stim.lated.on d.12 of *** injected.com.ound. were as follows:probiotic-Lactococcus lactis *** IBB477,prebiotic-galactooligosaccharid.s,and.synbiotic-com.ination of *** were sacrificed.on d.42 *** was collected.RNA and.d.A were isolated.and.intend.d.to gene expression,gene m.thylation and.global m.thylation *** have proved.that negative regulation of gene expression after ad.inistration of bioactive substances in ovo m.ght have epigenetic *** changes d.pend.on the genotype and.the substance ad.inistered.in ***:Epigenetic nature of m.crobial reprogram.ing in poultry and.extension of issues related.to hostm.crobiom. interaction is a new d.rection of this research.

关键词： Gene expression Host-m.crobiom. im.une tissue Interaction m.thylation level

Stud. and.Evaluation of Alum.num.Capsules to Irrad.ation of Gaseous Sam.les in Nuclear Reactor

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Journal of Physical Science and.Application 2015年第4期5卷 263-267页

作者： Osvald. Luiz d. Costa Anselm. Feher Joao A. m.ura Carla d. Souza Rod.igo Tiezzi d.iane C. B. d. Souza Ed.ard. S. m.ura Henrique B. Oliveira Carlos A. Zeituni m.ria Elisa C. m. Rostelato Nuclear and.Energy Research Institute IPEN Av. Professor Lineu Prestes 2242 Cidade Universitazria Sao Paulo SP 05508-000 Brazil

Gas irrad.ation in research nuclear reactors is an im.ortant way to prod.ce rad.onuclid.s. Although som. nuclear reactors centers offer this type of service, there are few publications about capsules to irrad.ation of gaseous sam.les. This paper d.scribes a m.thod.to fabricate and.evaluate alum.num.capsules to irrad.ate gaseous sam.les in nuclear reactor. A sem.-circular slotted.d.e from.a hyd.aulic presshead.was m.d.fied.to seal alum.num.tubes. The alum.num.capsules were subjected.to leak d.tection tests, which d.m.nstrated.the accord.nce with stand.rd.ISO 9978.

关键词： Alum.num.capsules gas irrad.ation ISO 9978 research nuclear reactor tightness.

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日粮成分对生长猪饮水量的影响

国外畜牧学（猪与禽） 2007年第6期27卷 25-28页

作者： m. I. Shaw A. d. Beaulieu J. F. Patience 陈春月（译）覃矜（校）樊薛安（摘）加拿大Prairie猪中心研究公司加拿大萨斯卡彻温大学畜禽科学系不详

1 前言历史上,人们一直把水看成是充裕而廉价的资源,所以缺乏确定猪需水量或对影响水利用情况因素进行研究（Fraser等,1990）的积极性。现在,人类社会正越来越意识到水是有限的资源,而家畜生产行业却又是一个主要的耗水行业之一。对肉... 详细信息

1 前言历史上,人们一直把水看成是充裕而廉价的资源,所以缺乏确定猪需水量或对影响水利用情况因素进行研究（Fraser等,1990）的积极性。现在,人类社会正越来越意识到水是有限的资源,而家畜生产行业却又是一个主要的耗水行业之一。对肉猪生产者来说，过度用水会产生过多的厩粪，而厩粪储存和田间施用的费用都很高。因此，肉猪生产者日益有兴趣于既能减少用水量又不危害猪生长性能的管理方法。日粮调整不失为一个可能解决问题的策略。

关键词：饮水量生长猪日粮成分利用情况人类社会家畜生产生长性能日粮调整