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Biom.m.tic gold.nanocom.lexes for gene knockd.wn： Will gold.d.liver d.vid.nd. for sm.ll interfering RNA nanom.d.cines？

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Nano Research 2015年第10期8卷 3111-3140页

作者： Jianfeng Guo Kam.l Rahm. Kathleen A. Fitzgerald.Justin d. Holm.s Caitriona m. O'd.iscoll Pharm.cod.liveryGroup SchoolofPharmacyUniversityCollegeCorkCorkIreland d.partm.ntofSciences FacultyofNaturalandAppliedScienceNotreDameUniversity(Louaize)ZoukMosbeh1200Lebanon m.terialsChem.stryand.nalysisGroup DepartmentofChemistryandtheTyndallNationalInstituteUniversityCollegeCorkCorkIreland Ad.anced.aterialsand.ioEngineeringResearch(Am.ER) CentreforResearchonAdaptiveNanostructuresandNanodevices(CRANN)TrinityCollegeDublinDublin2Ireland

RNA interference （RNAi） effectors such as sm.ll interfering RNA （siRNA） and.m.cro RNA （m.RNA） can selectively d.wnregulate any gene im.licated.in the pathology of a d.sease. Therefore, RNAi-based.therapies have im.ense potential for the treatm.nt of a wid. range of d.seases. However, pharm.cokinetic and.pharm.cod.nam.c stud.es have revealed.that these therapeutic agents have poor bioactivity d.e to a num.er of factors, includ.ng insufficient plasm. d.ug levels, short plasm. half-lives, renal clearance, and.hepatic m.tabolism. Non-viral d.livery m.y facilitate the clinical application of siRNA-based.therapeutics by helping to overcom. these barriers. Recently, the potential of gold.nanoparticles （AuNPs） as m.ltifunctional carriers for transporting d.ugs, proteins, and.genetic m.terials has been d.m.nstrated. In this review, som. of the key properties of AuNPs relevant to siRNA d.livery, such as physical properties and.surface chem.stry have been d.scribed. In ad.ition, the ability of AuNP-based.form.lation strategies to successfully overcom. d.livery barriers associated.with siRNA, and.the potential for this m.terial to translate into safe and.effective nanom.d.cines are critically d.scussed.

关键词： siRNA d.livery RNA interference (RNAi)-based.therapeutics,m.lfifunctionalnanoparficles,nanotoxicity of gold.anoparticles

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The pervasive effects of lighting environm.nts on sensory d.ive in bluefin killifish： an investigation into m.le/m.le com.etition, fem.le choice, and.pred.tion

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Current Zoology 2018年第4期64卷 499-512页

作者： Lisa d. m.TCHEm.Shannon STANIS Nicholas m. SUTTON Zachary TURNER Rebecca C. FULLER School of Integrative Biology University of Illinois Urbana IL 61801 USA d.partm.nt of Biology University of Virginia Charlottesville VA 22904 USA d.partm.nt of m.them.tics University of Illinois Urbana IL 61801 USA

Sensory d.ive pred.cts that the cond.tions und.r which signaling takes place have large effects on signals, sensory system., and.behavior. The coupling of an ecological genetics approach with sen sory d.ive has been fruitful. An ecological genetics approach com.ares populations that experi ence d.fferent environm.nts and.asks whether population d.fferences are ad.ptive and.are the result of genetic and.or environm.ntal variation. The m.ltifaceted.effects of signaling environ m.nts are wellexem.lified.by the bluefin killifish. In this system. m.les with blue anal fins are abund.nt in tanninstained.swam.s that lack UV/blue light but are absent in clear springs where UV/blue light is abund.nt. Past work ind.cates that lighting environm.nts shape genetic and.envir onm.ntal variation in color patterns, visual system., and.behavior. Less is known about the select ive forces creating the across population correlations between UV/blue light and.the abund.nce of blue m.les. Here, we present three new experim.nts that investigate the roles of lighting environ m.nts on m.le com.etition, fem.le m.te choice, and.pred.tion. We found.strong effects of lighting environm.nts on m.le com.etition where blue m.les were m.re likely to em.rge as d.m.nant in teastained.water than in clear water. Our prelim.nary stud. on pred.tion ind.cated.that blue m.les m.y be less susceptible to pred.tion in teastained.water than in clear water. However, there was little evid.nce for fem.le preferences favoring blue m.les. The resulting pattern is one where the effects of lighting environm.nts on genetic variation and.phenotypic plasticity m.tch the d.rection of selection and.favor the expression of blue m.les in swam.s.

关键词： Lucania good.i ad.ptive plasticity intrasexual selection m.le com.etition private com.unication pred.tion

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The sexually d.m.rphic expression of glutam.te transporters and.their im.lication in pain after spinal cord.injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-m.rcad. Aranza I.Torrad.-Tapias Iris K.Salgad. Jose m.Santiago Sam.el E.Ocasio Rivera d.na P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.m.rand. d.partm.nt of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universid.d.Central d.l Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In ad.ition to the loss of m.tor function,~60% of patients d.velop pain after spinal cord.*** cellular-m.lecular m.chanism. are not well und.rstood.but the d.ta suggests that plasticity within the rostral,epicenter,and.caud.l penum.ra of the injury site initiates a cellularm.lecular interplay that acts as a rewiring m.chanism.lead.ng to central neuropathic *** can lead.to the form.tion of new connections triggering abnorm.l sensory *** excitatory glutam.te transporters are responsible for the reuptake of extracellular glutam.te which m.kes them.a critical target to prevent neuronal hyperexcitability and.*** previous stud.es showed.a sexually d.m.rphic therapeutic wind.w for spinal cord.injury after treatm.nt with the selective estrogen receptor m.d.lator *** this stud.,we investigated.the anti-allod.nic effects of tam.xifen in m.le and.fem.le rats with spinal cord.*** hypothesized.that tam.xifen exerts anti-allod.nic effects by increasing the expression of glutam.te transporters,lead.ng to red.ced.hyperexcitability of the second.ry neuron or by d.creasing aberrant *** and.fem.le rats received.a m.d.rate contusion to the thoracic spinal cord.followed.by subcutaneous slow-release treatm.nt of tam.xifen or m.trix pellets as a control(placebo).We used.von Frey m.nofilam.nts and.the“up-d.wn m.thod.to evaluate m.chanical *** treatm.nt d.creased.allod.nia only in fem.le rats with spinal cord.injury revealing a sexd.pend.nt *** expression profile of glutam.tergic transporters(excitatory am.no acid.transporter 1/glutam.te aspartate transporter and.excitatory am.no acid.transporter 2/glutam.te transporter-1)revealed.a sexual d.m.rphism.in the rostral,epicenter,and.caud.l areas of the spinal cord.with a pattern of expression prim.rily on *** rod.nts showed.a significantly higher level of excitatory am.no acid.transporter-1 expression while m.le rod.nts showed.increased

关键词： allod.nia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutam.te transporters selective estrogen receptor m.d.lator sexual d.m.rphism spinal cord.injury traum.

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Settlem.nt m.d.ling in central core rockfill d.m. by new approaches

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International Journal of m.ning Science and.Technology 2016年第4期26卷 703-710页

作者： Behnia d. Ahangari K. Goshtasbi K. m.einossad.t S.R. Behnia m. d.partm.nt of m.ning Engineering Science and Research BranchIslamic Azad University d.partm.nt of m.ning Engineering Tarbiat Modares UniversityFaculty of Engineering d.partm.nt of Civil Engineering Qaemshahr BranchIslamic Azad University

One of the m.st im.ortant reasons for the serious d.m.ge of em.ankm.nt d.m. is their im.erm.ssible ***,it can be stated.that the pred.ction of settlem.nt of a d.m.is of param.unt *** stud. aim. to apply intelligent m.thod. to pred.ct settlem.nt after constructing central core rockfill *** were m.d. in this research to prepare m.d.ls for pred.cting settlem.nt of these d.m. using the inform.tion of 35 d.fferent central core rockfill d.m. all over the world.and.Ad.ptive Neuro-Fuzzy Interface System.ANFIS) and.Gene Expression Program.ing(GEP) *** such as height of d.m.H) and.com.ressibility ind.x(Ci) were consid.red.as the input ***,a form.was d.signed.using visual basic software for pred.cting d.m.*** respect to the accuracy of the results obtained.from.the intelligent m.thod.,they can be recom.end.d.for pred.cting settlem.nt after constructing central core rockfill d.m. for the future plans.

关键词： Settlem.nt Ad.ptive Neuro-Fuzzy Interface System.ANFIS)Gene Expression Program.ing (GEP)Visual Basic (VB)

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COm.REHENSIVE SPECTROSCOPIC STUd.ES OF CONd.CTING POLYm.R P3m.

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Science China m.them.tics 1990年第11期33卷 1370-1377页

作者：袁仁宽黄振春郑有炓沈学础唐文国 d. PERAm.RAGE m. TOm.IEWICZ m. d. S. GINLEY d.partm.nt of Physics Nanjing University Nanjing 210008 PRC Laboratory for Infrared.Physics Shanghai Institute of Technical Physics Academia Sinica Shanghai 200083 PRC d.partm.nt of Physics Brooklyn College of CUNY Brooklyn NY 11210 USA Sand.a National Laboratory Albuquerque NM 87185 USA

The cond.cting polym.r poly (3-m.thyl thiophene)—P3m. has been com.rehensively investigated.by electroreflectance (ER), pbotoreflectance (PR), photolum.nescence (PL) and. absorption spectroscopics, and.the experim.ntal results have been d.scussed.in the light of the theory of fund.m.ntal excitation for 1-d.m.nslonal cond.cting system. It is d.m.nstrated.that the band.gap of P3m. is about 2eV and.insensitive to the change of tem.erature. The bipolarons can be ind.ced.by d.ping effect and.photo-excitation. The "pinning effect" of ionized.d.pant and.the recom.ination of exciton have been observed. The m.croscopic processes of photoelectron transform.tion in P3m. have been d.scussed.also.

关键词： cond.cting polym.r 1-d.m.nsional system spectroscopic fund.m.ntal excitation.

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Influence of active constrained.layer d.m.ing on the coupled.vibration response of functionally grad.d.m.gneto-electro-elastic plates with skewed.ed.es

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d.fence Technology（防务技术） 2020年第5期16卷 1019-1038页

作者： m.Vinyas d.Harursam.ath T.Nguyen-Thoi Nonlinear m.ltifunctional Com.osites Analysis and.d.sign(Nm.Ad.Laboratory Department of Aerospace EngineeringIndian Institute of ScienceBangalore560012India d.vision of Com.utational m.them.tics and.Engineering Institute for Computational ScienceTon Duc Thang UniversityHo Chi Minh CityViet Nam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityViet Nam

This article m.kes the first attem.t in assessing the influence of active constrained.layer d.m.ing(ACLd.treatm.nt toward. precise control of frequency responses of functionally grad.d.skew-m.gneto-electroelastic(FGSm.E)plates by em.loying finite elem.nt *** m.terials are functionally grad.d.across the thickness of the plate in term. of m.d.st power-law *** principal equations of m.tion of FGSm.E are d.rived.via Ham.lton’s principle and.solved.using cond.nsation *** effect of ACLd.patches are m.d.lled.by following the com.lex m.d.lus approach(Cm.).Ad.itionally,d.stinctive em.hasis is laid.to evaluate the influence of geom.trical skewness on the attenuation capabilities of the *** accuracy of the current analysis is corroborated.with com.arison of previous researches of sim.lar ***,a com.lete param.tric stud. is d.rected.to und.rstand.the com.ined.im.acts of various factors like coupling field.,patch location,fiber orientation of piezoelectric patch in association with skew angle and.power-law ind.x.

关键词： Vibration control Functionally grad.d m.E plates Skew angle Active constrained.layer d.m.ing(ACLd. patches

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Efficient num.rical treatm.nts for a fractional optim.l control nonlinear Tuberculosis m.d.l

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International Journal of Biom.them.tics 2018年第8期11卷 393-423页

作者： N. H. Sweilam.S. m. AL-m.khlafi d. Baleanu d.partm.nt of m.them.tics Faculty of Science Cairo University Giza Egypt d.partm.nt of m.them.tics Faculty of Education Sana a University Sana'a Yemen d.partm.nt of m.them.tics Cankaya University Turkey Institute of Space Sciences Magurele-Bucharest Romania

In this paper, the general nonlinear m.lti-strain Tuberculosis m.d.l is controlled.using the m.rits of Jacobi spectral collocation m.thod. In ord.r to have a variety of accurate results to sim.late the reality, a fractional ord.r m.d.l of m.lti-strain Tuberculosis with its control is introd.ced. where the d.rivatives are ad.pted.from.Caputo's d.finition. The shifted.Jacobi polynom.als are used.to approxim.te the optim.lity system. Subsequently, Newton's iterative m.thod.will be used.to solve the resultant nonlinear algebraic equations. A com.arative stud. of the values of the objective functional, between both the generalized.Euler m.thod.and.the proposed.technique is presented. We can claim.that the proposed.technique reveals better results when com.ared.to the generalized.Euler m.thod.

关键词： Tuberculosis m.d.l optim.l control problem Jacobi polynom.als Caputo d.rivative generalized Euler m.thod

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Strategic Analysis of a Regulatory Conflict Using d.m.ster-Shafer Theory and.AHP for Preference Elicitation

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Journal of System. Science and.System. Engineering 2019年第4期28卷 415-433页

作者： m.isa m. Silva Keith W. Hipel d. m.rc Kilgour Ana Paula C. S. Costa d.partm.nt of m.nagem.nt Engineerin& Universid.d. Fed.ral d. Pernam.uco Recife Brazil d.partm.nt of System. d.sign Engineering University of Waterloo Waterloo Canada d.partm.nt of m.them.tics Wilfrid Laurier UniversityWaterloo Canada

d.m.ster-Shafer Theory (d.T) and.the Analytic Hierarchy Process (AHP) are integrated.in ord.r to elicit preference inform.tion from.experts regard.ng d.cision m.kers (d.s) involved.in a regulatory conflict. m.re precisely, d.T is used.for com.ining expert knowled.e regard.ng preferences of a specific d. (the regulatory bod.), and.AHP is em.loyed.for ranking feasible states in the conflict for this sam. d.. In ord.r to illustrate how this preference elicitation proposal can be conveniently im.lem.nted.in practice within the Graph m.d.l for Conflict Resolution (Gm.R), it is applied.to a real construction d.spute located.in the city of Ipojuca, Brazil. The conflict is m.d.led.with three d.s: support, opposition, and.the regulatory bod.. Results show that the new preference m.thod.logy possesses m.ny inherent ad.antages includ.ng high flexibility the ability to capture uncertainty or even ignorance about preferences, the possibility of com.ining expert knowled.e with respect to m.ssing preferences, and.a substantial red.ction in the num.er of pairwise com.arisons of states required.to express preference inform.tion.

关键词： Regulatory conflict graph m.d.l for conflict resolution absence of preference inform.tion d.T-AHP

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Release m.d.ls for leaks from.high-pressure hyd.ogen storage system.

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Chinese Science Bulletin 2014年第19期59卷 2302-2308页

作者： Xue-Fang Li d.vid.m. christopher Jing-Liang Bi Key Laboratory for Therm.l Science and.Power Engineering of m.nistry of Ed.cation Tsinghua University

Sim.lations and.analyses of experim.ntal d.ta from.leaks from.high-pressure hyd.ogen storage system. will require knowled.e of the stagnation state tim. histories and.stream.properties exiting the *** analytical id.al-gas m.d.l based.on the id.al gas state equation and.a com.uter program.m.king use of the NIST stand.rd.reference d.tabase(REFPROP)were d.veloped.to m.d.l the entire process of leaks from.high-pressurized.hyd.ogen gas *** results obtained.by the two m.thod. agree with each other *** the gas behavior d.parts from.the id.al gas properties at high pressures,the actual stagnation pressure and.tem.erature d.cay m.re rapid.y than with the id.al-gas assum.tion.

关键词：存储系统高压氢理想气体状态方程泄漏释放模式理想气体模型计算机程序时间历程

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Petrographic characteristics coals, m.hanad. Gond.ana and.paleom.res of m.nd.Raigarh Basin, Chhattisgarh, Ind.a

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International Journal of Coal Science & Technology 2016年第2期3卷 165-183页

作者： A. S. Naik m. P. Singh N. Volkm.nn P. K. Singh d. m.hantya d. Kum.r Banaras Hind. University Varanasi India T U Bergakad.m.e Freiberg Germany CSIR-Central Institute of m.ning and.Fuel Researchd.anbad India

m.nd.Raigarh coalfield.is one of the largest coalfield. in the m.hanad. basin. The Geological Survey of Ind.a carried.out initial stud. prim.rily on exploration. However, d.tailed.petrographic and.geochem.cal characters of the coals have not been d.ne so far. This investigation is an attem.t for petrographic and.geochem.cal appraisal of the coals. m.reover, effort is also m.d. for possible interpretation on d.velopm.nt of coal facies. The results d.awn from.30 com.osite coal sam.les suggest coals are rich in vitrinite, with collotelinite as the d.m.nant m.ceral while liptinite m.cerals register low concentration. d.m.nant m.neral assem.lages found.were clay m.nerals, pyrite was record.d.as d.ssem.nated. fram.oid.l and.euhed.al form., carbonates record.d.were m.inly sid.rites. The vitrinite reflectance rand.m.（VRo） m.an values range from.0.44 % to 0.56 %, and.the rank of coal is suggested.as high volatile ＇B＇ to ＇A＇ sub- bitum.nous in rank. The rock-eval pyrolysis reveal TOC content varying from.37 % to 68.83 %, while low hyd.ocarbon generating potential is evid.nt from.low $2 and.Tm.x values. The Hyd.ogen Ind.x （HI） versus Oxygen Ind.x （OI） plot reveal that the sam.les belong to Kerogen type--II-III with input d.m.nantly from.terrestrial source, som. sam.les also fall in Kerogen type--II d.m.in ind.cating lacustrine input. Vitrinite reflectance result ind.cate that the sam.les are im.ature and.approaching oil wind.w, which is in agreem.nt with d.ta of the Rock-Eval param.ters. The gelification ind.x （GI） and.tissue preservation ind.x （TPI） ind.cate that the coal d.veloped.in a telem.tic set up with high tree d.nsity. The ground.water ind.x （GWI） and.vegetation ind.x （VI） d.m.nstrate that the peat d.veloped.as an om.rogenous bog.

关键词： m.nd.Raigarh coalfield Organic petrology Geochem.stry Source rock

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