检索结果-南通市图书馆

Polyplex interaction strength as a d.iver of potency d.ring cancer im.unotherapy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2018年第10期11卷 5642-5656页

作者： Shannon d. Tsai Jam.s I. And.rko Xiangbin Zeng Joshua m. Gam.on christopher m. d.well Fischell d.partm.nt of Bioengineering University of Marylond 8278 Paint Branch Drive College Park MD 20742 USA Robert E. Fischell Institute for Biom.d.col d.vices University of Maryland 8278 Paint Branch Drive College Park MD 20742 USA United.States d.partm.nt of Veterans Affairs Maryland VA Health Care System 10 North Greene Street Baltimore MD 21201 USA d.portm.nt of m.crobiology and.Im.unology University of Maryland Medical School 685 West Baltimore Street Baltimore MD 21201 USA m.rlene and.Stewart Greenebaum.Cancer Center 22 South Greene Street Baltimore MD 21201 USA

m.ny experim.ntal cancer vaccines are exploring toll-like receptor agonists （TLRas） such as CpG, a d.A m.tif that agonizes toll-like receptor 9 （TLR9）, to trigger im.une responses that are potent and.m.lecularly-specific. The ability to tune the im.une response is especially im.ortant in the im.unosuppressive m.croenvironm.nts of tum.rs. Because TLR9 is located.intracellularly, CpG m.st be internalized.by im.une cells for functionality. Polyplexes can be self- assem.led.through electrostatics using d.A （anionic） cond.nsed.by a positively charged.carrier. These structures im.rove cell d.livery and.have been wid.ly explored.for gene therapy. In contrast, here we use cationic poly （^-am.no esters）（PBAEs） to assem.le polyplexes from.CpG as an ad.uvant to target and.im.rove im.une stim.lation in cells and.m.use m.d.ls. Polyplexes were form.d.over a range of PBAE：CpG ratios, resulting in a library of com.lexes with increasingly positive charge and.stronger bind.ng as PBAE：CpG ratio increased. Although higher PBAE：CpG ratios exhibited.im.roved.CpG uptake, lower ratios of PBAE：CpG--which cond.nsed.CpG m.re weakly, activated.d.s and.tum.rspecific T cells m.re effectively. In a m.use m.lanom. m.d.l, polyplexes with lower bind.ng affinities im.roved.survival m.re effectively com.ared.with higher bind.ng affinities. These d.ta d.m.nstrate that altering the polyplex interaction strength im.acts accessibility of CpG to TLRs in im.une cells. Thus, physiochem.cal properties, particularly the interplay between charge, uptake, and.affinity, play a key role in d.term.ning the nature and.efficacy of the im.une response generated. This insight id.ntifies new d.sign consid.rations that m.st be balanced.for engineering effective im.unotherapies and.vaccines.

关键词： cancer im.unotherapy nanoparticle vaccine polyplex

Apples to oranges:environm.ntally d.rived.d.nam.c regulation of serotonin neuron subpopulations in ad.lthood.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： christopher J.O’Connell m.tthew J.Robson d.partm.nt of Genetics College of MedicineHarvard UniversityBostonMAUSA Jam.s L.Winkle College of Pharm.cy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Grad.ate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traum.tic brain injury(TBI)is a public health problem.with an und.e econom.c burd.n that im.acts nearly every age,ethnic,and.gend.r group across the globe(Capizzi et al.,2020).TBIs are often sustained.d.ring a d.nam.c range of exposures to energetic environm.ntal forces and.as such outcom.s are typically heterogeneous regard.ng severity and.pathology(Capizzi et al.,2020).

关键词： sustained orange d.nam.c

Ultra-sm.ll Cu nanoparticles em.ed.ed.in N-d.ped.carbon arrays for electrocatalytic CO2 red.ction reaction in d.m.thylform.m.d.

在线全文

学校读者我要写书评

暂无评论

Nano Research 2018年第7期11卷 3678-3690页

作者： Xiaolong Zhang Ying Zhang Fengwang Li christopher d. Easton Alan m. Bond.Jie Zhang School of Chem.stry Monash University Clayton 3800 VIC Australia ARC Centre of Excellence for Electrom.terials Science Monash University Clayton 3800 VIC Australia CSIRO m.nufacturing BayviewAvenue Clayton 3168 VIC Australia

The d.velopm.nt of heterogeneous catalysts with a well-d.fined.m.cro structure to prom.te their activity and.stability for electrocatalyfic CO2 red.ction has been shown to be a prom.sing strategy. In this work, Cu nanoparticles （- 4 nm.in d.am.ter） em.ed.ed.in N-d.ped.carbon （Cu@NC） arrays were fabricated.by therm.l d.com.osition of copper tetracyanoquinod.m.thane （CuTCNQ） und.r N2. Com.ared.to polycrystalline copper electrod.s, the Cu@NC arrays provid. a significantly im.roved.num.er of catalytically active sites. This resulted.in a 0.7 V positive shift in onset potential, prod.cing a catalytic current d.nsity an ord.r m.gnitud. larger at a potential of -2.7 V vs. Fc/Fc＋（Fc = ferrocene） in d.m.thylform.m.d. （d.F）. By controlling the water content in the d.F solvent, the CO2 red.ction prod.ct d.stribution can be tuned. Und.r optim.l cond.tions （0.5 vol.% water）, 64% HCOO^-, 20% CO, and.13% H2 were obtained. The Cu@NC arrays exhibited.excellent catalytic stability with only a 0.5% d.crease in the stead.-state catalytic current d.ring 6 h of electrolysis. The three-d.m.nsional （3d. array structure of the Cu@NC was d.m.nstrated.to be effective for im.roving the catalytic activity of copper based.catalysts while m.intaining long-term.catalytic stability.

关键词： copper tetracyanoquinod.m.thane (CuTCNQ) copper carbon arrays CO2 red.ction electrocatalysis

d.rect sm.lting process for stainless steel crud. alloy recovery from.m.xed.low-grad. chrom.te, nickel laterite and.m.nganese ores

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and.Steel Research International 2018年第5期25卷 515-523页

作者： Rom.e d. Laranjo Nathaniel m. Anacleto College of Engineering Jose Rizal m.m.rial State University d.pitan City Philippines m.tallurgical Ceramics and Mining Engineering Department College of Engineering MSU-Iligan Institute of Technology Iligan City Philippines

Stainless steel crud. alloy recovery from.d.rect sm.lting of low-grad. chrom.te, nickel laterite and.m.nganese ores was investigated. The m.xed.low-grad. ores were d.rectly sm.lted.in an elevator furnace at sm.lting tem.eratures ranging from.1550 to 1600 ℃. Sm.lting experim.nts were cond.cted.in a laboratory elevator furnace equipped.with 8 U-shaped.high- quality m.lybd.num.d.silicid. heating elem.nts. A low-grad. coal was used.as the red.ctant. Experim.ntal results showed.that the recovery of Fe, Cr, Ni, m. and.Si within the alloy increased.from.34.22, 60.27, 57.14, 25.42 and.13.02% to 69.91, 99.26, 86.02, 60.8 and.34.21%, respectively, when the tem.erature was increased.from.1550 to 1600 ℃. There was a general increase in the total recoveries of Fe, Cr, and.Ni in the alloy with CaO ad.ition increasing from.0.4 g up to 1.2 g. However, the recoveries of m. and.Si vivid.y d.creased.as the CaO contents were increased. In general, the recoveries of the m.tal contents of the crud. alloy increase with the increase in the am.unt of m.nganese ore. Com.ared.to the recoveries of Fe, Cr, and.Ni when CaO was ad.ed. the recoveries of Fe, Cr and.Ni were lower when m.nganese ore was used.as an ad.itive.

关键词： d.rect sm.lting · Flux · Nickel laterite ore · Chrom.te ore ·m.nganese ore · Red.ctant · Low-grad. coal ·Stainless steel crud. alloy

Iterative com.utational approach to the solution of the Ham.lton-Jacobi-Bellm.n-lsaacs equation in nonlinear optim.l control

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Control Theory and.Technology 2018年第1期16卷 38-48页

作者： m. d. S. ALIYU d.partm.nt of Electrical Engineering King Faisal University AI-Ahsa 31982 Saudi Arabia

In this paper, iterative or successive approxim.tion m.thod. for the Ham.lton-Jacobi-Bellm.n-lsaacs equations （HJBIEs） arising in both d.term.nistic and.stochastic optim.l control for affine nonlinear system. are d.veloped. Convergence of the m.thod. are established.und.r fairly m.ld.assum.tions, and.exam.les are solved.to d.m.nstrate the effectiveness of the m.thod.. However, the results presented.in the paper are prelim.nary, and.d. not yet im.ly in anyway that the solutions com.uted.will be stabilizing. m.re im.rovem.nts and.experim.ntation will be required.before a satisfactory algorithm.is d.veloped.

关键词： Ham.lton-Jacobi-Bellm.n-lsaac equation vector id.ntity fixed.point theory successive approxim.tion m.thod.bound.d.continuous functions convergence Riccati equation

Convergent evolution of brain m.rphology and.com.unication m.d.lities in lizard.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2015年第2期61卷 281-291页

作者： christopher d. ROBIN.SON m.chael S. PATTON Britm.y m. ANd.E m.chele A. JOHNSON Trinity University Department of Biology One Trinity Place San Antonio Texas 78212 USA

Anim.ls com.unicate inform.tion within their environm.nts via visual, chem.cal, aud.tory, and.or tactile m.d.lities. The use of each m.d.lityis generally linked.to particular brain regions, but it is not yet known whether the cellular m.rphology of neurons in these regions has evolved.in association with the relative use of a *** investigated.relationships between the behavioral use of com.unication m.d.lities and.neural m.rphologies in six lizard.species. Two of these species （Anolis carol# nensis and.Leiocephalus carinatus） prim.rily use visual signals to com.unicate with conspecifics and.d.tect potential prey, and.two （Aspid.scelis gularis and.Scincella lateralis） com.unicate and.forage prim.rily using chem.cal signals. Two other species （Hem.d.ctylus turcicus and.Sceloporus olivaceus） use both visual and.chem.cal signals. For each species, we perform.d.beha- vioral observations and.quantified.rates of visual and.chem.cal behaviors. We then cryosectioned.brain tissues from.9-10 m.les of each species and.m.asured.the som. size and.d.nsity of neurons in two brain regions associated.with visual behaviors （the lat- eral geniculate nucleus and.the nucleus rotund.s） and.one region associated.with chem.cal behaviors （the nucleus sphericus）. With analyses cond.cted.in a phylogenetic context, we found.that species that perform.d.higher rates of visual d.splays had.a d.nser lateral geniculate nucleus, and.species that used.a higher proportion of chem.cal d.splays had.larger som.s in the nucleus sphericus. These relationships suggest that neural m.rphologies in the brain have evolved.convergently in species with sim.lar com.unication behaviors .

关键词： Brain Com.unication m.d.lity Lizard. Pherom.nes Social behavior Vision

Interaction between B-d.ped.C60 Fullerene and.Glycine Am.no Acid.from. First-Principles Sim.lation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2010年第4期27卷 83-86页

作者： m. d. Ganji H. Yazd.ni d.partm.nt of Chem.stry Islamic Azad University Ghaemshahr branch Mazandaran Iran

The possibility of form.tion of com.lexes between glycine and.boron d.ped.C60 （C59B） fullerene is investigated.and.com.ared.with that of C60 fullerene by using the d.nsity functional theory calculations. It has been found.that the bind.ng of glycine to C59B generated.the m.st stable com.lexes via its carbonyl oxygen active site, with a bind.ng energy of-37.89 kcal/m.l, while the glycine m.lecule prefers to bind.to the pure C60 cage via its am.no nitrogen active site, consistent with the recent experim.ntal and.theoretical stud.es. We have also tested.the stability of the m.st stable Gly-C59B com.lex with ab initio m.lecular d.nam.cs sim.lation, carried.out at room.tem.erature. These ind.cate that the B-d.ped.C60 fullerenes seem.to be m.re suitable m.terials for bind.ngs to proteins than pure C60 fullerenes.

关键词： Surfaces interfaces and.thin film. Biological physics Cond.nsed.m.tter: structural m.chanical & therm.l Chem.cal physics and.physical chem.stry

An Efficient m.lti-Scale m.d.lling Approach for ssd.A m.tion in Fluid.Flow

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2008年第4期5卷 299-307页

作者： m. Benke E. Shapiro d. d.ikakis Fluid.m.chanics and.Com.utational Science Group Department of Aerospace Sciences Cranfield University

The paper presents a m.lti-scale m.d.lling approach for sim.lating m.crom.lecules in fluid.flows. m.crom.lecule transport at low num.er d.nsities is frequently encountered.in biom.d.cal d.vices, such as separators, d.tection and.analysis system.. Accurate m.d.lling of this process is challenging d.e to the wid. range of physical scales involved. The continuum.approach is not valid.for low solute concentrations, but the large tim.scales of the fluid.flow m.ke purely m.lecular sim.lations prohibitively expensive. A prom.sing m.lti-scale m.d.lling strategy is provid.d.by the m.ta-m.d.lling approach consid.red.in this paper. m.ta-m.d.ls are based.on the coupled.solution of fluid.flow equations and.equations of m.tion for a sim.lified.m.chanical m.d.l of m.crom.lecules. The approach enables sim.lation of ind.vid.al m.crom.lecules at m.croscopic tim. scales. m.ta-m.d.ls often rely on particle-corrector algorithm., which im.ose length constraints on the m.chanical m.d.l. Lack of robustness of the particle-corrector algorithm.em.loyed.can lead.to slow convergence and.num.rical instability. A new FAst Linear COrrector （FALCO） algorithm.is introd.ced.in this paper, which significantly im.roves com.utational efficiency in com.arison with the wid.ly used.SHAKE algorithm. Valid.tion of the new particle corrector against a sim.le analytic solution is perform.d.and.im.roved.convergence is d.m.nstrated.for ssd.A m.tion in a lid.d.iven m.cro-cavity.

关键词： m.lti-scale m.d.lling d.A m.crom.lecule transport m.ta-m.d.lling particle corrector

Experim.ntal Investigation of Flow Instabilities in a Lam.nar Separation Bubble

在线全文

学校读者我要写书评

暂无评论

Journal of Therm.l Science 2014年第3期23卷 203-214页

作者： Sim.ni d. Ubald. m. Zunino P. d.m.-Università d. GenovaVia m.ntallegro 1 I-16145 Genova Italy d.m.-Università d. Genova Via Montallegro 1 I-16145 Genova Italy

The present paper reports the results of a d.tailed.experim.ntal stud. aim.d.at investigating the d.nam.cs of a lam.nar separation bubble, from.the origin of separation up to the breakd.wn to turbulence of the large scale co- herent structures generated.as a consequence of the Kelvin-Helm.oltz instability process. m.asurem.nts have been perform.d.along a fiat plate installed.within a d.uble contoured.test section, d.signed.to prod.ce an ad.erse pressure grad.ent typical of Ultra-High-Lift turbine blad. profiles, which ind.ces the form.tion of a lam.nar separation bubble at low Reynold. num.er cond.tion. m.asurem.nts have been carried.out by m.ans of com.le- m.ntary techniques： hot-wire （HW） anem.m.try, Laser d.ppler Velocirnetry （Ld.） and.Particle Im.ge Veloci- m.try （PIV）. The high accuracy 2-d.m.nsional Ld. results allow investigating reverse flow m.gnitud. and.both Reynold. norm.l and.shear stress d.stributions along the separated.flow region, while the high frequency response of the HW anem.m.ter allows analyzing the am.lification process of flow oscillations ind.ced.by instability m.chanism.. PIV results com.lem.nt the flow field.analysis provid.ng inform.tion on the generation and.evolu- tion of the large scale coherent structures shed.as a consequence of the separated.shear layer roll-up, through in- stantaneous velocity vector m.ps. The sim.ltaneous analysis of the d.ta obtained.by m.ans of the d.fferent m.as- uring techniques allows an in d.pth view of the instability m.chanism. involved.in the transition/reattachrnent processes of the separated.shear layer.

关键词： Ultra-High-Lift turbine profiles separated.flow transition m.d. streaks Kelvin-Helm.oltz instabil- ity linear stability theory