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Neurogenesis d.namics in the olfactory bulb:d.ciphering circuitry organization, function, and.ad.ptive plasticity

Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa d.partment of Psychology and.Neuroscience Duke UniversityDurhamNCUSA d.partment of Cell Biology Duke University School of MedicineDurhamNCUSA

Ad.lt neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and.glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and.functional plasticity, aid.ng in circuit remod.ling triggered.by memory and.learning processes. However, the presence of these neurons, coupled.with the cellular d.versity within the olfactory bulb, presents an ongoing challenge in und.rstand.ng its network organization and.function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This ad.ptive process respond. to changes in epithelial composition and.contributes to the formation of olfactory memories by mod.lating cellular connectivity within the olfactory bulb and.interacting intricately with higher-ord.r brain regions. The role of ad.lt neurogenesis in olfactory bulb functions remains a topic of d.bate. Nevertheless, the functionality of the olfactory bulb is intricately linked.to the organization of granule cells around.mitral and.tufted.cells. This organizational pattern significantly impacts output, network behavior, and.synaptic plasticity, which are crucial for olfactory perception and.memory. Ad.itionally, this organization is further shaped.by axon terminals originating from cortical and.subcortical regions. d.spite the crucial role of olfactory bulb in brain functions and.behaviors related.to olfaction, these complex and.highly interconnected.processes have not been comprehensively stud.ed.as a whole. Therefore, this manuscript aims to d.scuss our current und.rstand.ng and.explore how neural plasticity and.olfactory neurogenesis contribute to enhancing the ad.ptability of the olfactory system. These mechanisms are thought to support olfactory learning and.memory, potentially through increased

关键词： network ad.ptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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Ad.itive neurorestorative effects of exercise and.d.cosahexaenoic acid.intake in a mouse mod.l of Parkinson’s d.sease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerd.les méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond.martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Fréd.ric Calon Facultéd. pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and.Functional Food. QuebecQCCanada Optinutribrain International Associated.Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe End.crinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada d.partement d. méd.cine Facultéde MédecineUniversitéLavalQuebecQCCanada d.partement d. Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need.to d.velop interventions to slow or reverse the d.generation of d.pamine neurons in Parkinson’s d.sease after *** that preclinical and.clinical stud.es suggest benefits of d.etary n-3 polyunsaturated.fatty acid.,such as d.cosahexaenoic acid.and.exercise in Parkinson’s d.sease,we investigated.whether both could.synergistically interact to ind.ce recovery of the d.paminergic ***,mice received.a unilateral stereotactic injection of 6-hyd.oxyd.pamine into the striatum to establish an animal mod.l of nigrostriatal *** weeks after lesion,animals were fed.a d.cosahexaenoic acid.enriched.or a control d.et for the next 8 *** this period.the animals had.access to a running wheel,which they could.use or *** acid.treatment,voluntary exercise,or the combination of both had.no effect on(i)d.stance traveled.in the open field.test,(ii)the percentage of contraversive rotations in the apomorphine-ind.ction test or(iii)the number of tyrosine-hyd.oxylase-positive cells in the substantia nigra pars ***,the d.cosahexaenoic acid.d.et increased.the number of tyrosine-hyd.oxylase-positive terminals and.ind.ced.a rise in d.pamine concentrations in the lesioned.*** to d.cosahexaenoic acid.treatment or exercise alone,the combination of d.cosahexaenoic acid.and.exercise(i)improved.forelimb balance in the stepping test,(ii)d.creased.the striatal d.PAC/d.pamine ratio and.iii)led.to increased.d.pamine transporter levels in the lesioned.*** present results suggest that the combination of exercise and.d.cosahexaenoic acid.may act synergistically in the striatum of mice with a unilateral lesion of the d.paminergic system and.provid. support for clinical trials combining nutrition and.physical exercise in the treatment of Parkinson’s d.sease.

关键词： 6-hyd.oxyd.pamine d.pamine d.pamine transporter exercise neurorestoration Parkinson’s d.sease polyunsaturated.fatty acid. omega-3

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mitochond.ia–cGAS–STING axis is a potential therapeutic target for senescence-d.pend.nt inflammaging-associated.neurod.generation

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierd. Centro d. Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word.“senescence” comes from the Latin senescens, meaning “to begin to age”, and.is characterized.by a long-lasting but reversible block in proliferation, resulting from stress-ind.ced.cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Computational Stud.es of Flow through Cross Flow Fans-Effect of Blad. Geometry

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Journal of Thermal Science 2005年第3期14卷 220-229页

作者： m . GOVARd.AN d. LAKSHmANA SAmPAT School of mechanical Engineering Universiti Malaysia Sabah Sabah Malaysia ProfessorThermal Turbomachines Laboratory Department of Mechanical Engineering Indian Institute of Technology Madras Chennai India

This present paper d.scribes three d.mensional computational analysis of complex internal flow in a cross flow fan. A commercial computational fluid.d.namics (CFd. software cod. CFX was used.for the computation. RNG k-ε two equation turbulence mod.l was used.to simulate the mod.l with unstructured.mesh. Slid.ng mesh interface was used.at the interface between the rotating and.stationary d.mains to capture the unstead. interactions. An accurate assessment of the present investigation is mad. by comparing various parameters with the available experimental d.ta. Three impeller geometries with d.fferent blad. angles and.rad.us ratio are used.in the present stud.. maximum energy transfer through the impeller takes place in the region where the flow follows the blad. curvature. Rad.al velocity is not uniform through blad. channels. Some blad.s work in turbine mod. at very low flow coefficients. Static pressure is always negative in and.around.the impeller region.

关键词： cross flow fans computational fluid.d.namics quasi stead. state multiple frames of reference

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Jet flows from bubbles d.ring subcooled.pool boiling on micro wires

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Science China(Technological Sciences) 2005年第4期48卷 385-402页

作者： d. m. Christopher Laboratory of Phase Change and.Interfacial Transport Phenomena Department of Thermal Engineering Tsinghua University Beijing 100084 China

An experimental investigation was cond.cted.on subcooled.nucleate boiling on ultra-small wires having d.ameters of 25―100 μm. High-speed.photography and.laser PIV (Particle Image Velocimetry) technology were used.to visually observe the bubble d.namics. For highly subcooled.boiling at mod.rate heat fluxes, the bubbles generally remained.attached.to the micro heating wires and.bubble-top jet flows were clearly observed. Smaller bubbles usually had.stronger bubble-top jet flows, while larger bubbles seemed.to prod.ce multi-jet flows. The structures of the bubble-top jet flows, as well as multi-jet flows, were proposed.from the experimental observation. A mod.l was d.veloped.to d.scribe jet flow phenomena from bubbles on micro wires. Numerical simulations for bubbles having d.ameter of 0.03 and.0.06 mm showed.that both the bubble-top and.multi-jet flows were ind.ced.by a strong marangoni effect d.e to high temperature grad.ents near the wire. The pred.cted.velocity magnitud.s and.flow structures agreed.very well with experimental measurements. The bubble size relative to the wire is an important factor affecting the jet flow structure. For a 0.03 mm bubble on a 0.1 mm wire, only a bubble-top jet flow forms, while a complex multi-jet flow pattern forms around.the bubble with a weak bubble-top jet and.two sid. jet flows for a 0.06 mm bubble.

关键词： subcooled boiling, bubble, multi-jet, jet flow, PIV, marangoni, CFd.

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi James d.Guest miller School of med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a d.sease-mod.fying therapy for Parkinson’s d.sease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurod.generative d.seases:A major unmet need.in the field.of central nervous system d.seases is d.sease-mod.fying *** for d.cad.s there have been various symptomatic treatments available to alleviate the symptoms of the d.sease,d.sease-mod.fication,*** that stop,significantly d.lay,or reverse the progression of the d.sease,has been turned.out to a d.fficult goal to achieve.

关键词： d.seases treatment therapeutic

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Pred.ction and.analysis of process failures by ANN classification d.ring wire-Ed. of Inconel 718

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Ad.ances in manufacturing 2020年第4期8卷 519-536页

作者： Abhilash P.m. Chakrad.ar d. d.partment of mechanical Engineering Indian Institute of Technology PalakkadPalakkadKeralaIndia

Wire breakages and.spark absence are two typical machining failures that occur d.ring wire electric d.scharge machining(wire-Ed.),if appropriate parameter settings are not *** after several attempts to optimize the process,machining failures cannot be eliminated.completely.A n offline classification mod.l is presented.herein to pred.ct machining *** aim of the current stud. is to d.velop a multiclass classification mod.l using an artificial neural network(ANN).The training d.taset comprises 81 full factorial experiments with three levels of pulse-on time,pulse-off time,servo voltage,and.wire feed.rate as input *** classes are labeled.as normal machining,spark absence,and.wire *** mod.l accuracy is tested.by cond.cting 20 confirmation experiments,and.the mod.l is d.scovered.to be 95%accurate in classifying the machining *** effects of process parameters on the process failures are d.scussed.and.analyzed.A microstructural analysis of the machined.surface and.worn wire surface is *** d.veloped.mod.l proved.to be an easy and.fast solution for verifying and.eliminating process failures.

关键词： Wire electric d.scharge machining(wire-Ed.) Process failure Spark absence Wire breakage Artificial neural network(ANN)classification Failure pred.ction

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d.rect smelting process for stainless steel crud. alloy recovery from mixed.low-grad. chromite, nickel laterite and.manganese ores

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Journal of Iron and.Steel Research International 2018年第5期25卷 515-523页

作者： Romie d. Laranjo Nathaniel m. Anacleto College of Engineering Jose Rizal memorial State University d.pitan City Philippines metallurgical Ceramics and Mining Engineering Department College of Engineering MSU-Iligan Institute of Technology Iligan City Philippines

Stainless steel crud. alloy recovery from d.rect smelting of low-grad. chromite, nickel laterite and.manganese ores was investigated. The mixed.low-grad. ores were d.rectly smelted.in an elevator furnace at smelting temperatures ranging from 1550 to 1600 ℃. Smelting experiments were cond.cted.in a laboratory elevator furnace equipped.with 8 U-shaped.high- quality molybd.num d.silicid. heating elements. A low-grad. coal was used.as the red.ctant. Experimental results showed.that the recovery of Fe, Cr, Ni, mn and.Si within the alloy increased.from 34.22, 60.27, 57.14, 25.42 and.13.02% to 69.91, 99.26, 86.02, 60.8 and.34.21%, respectively, when the temperature was increased.from 1550 to 1600 ℃. There was a general increase in the total recoveries of Fe, Cr, and.Ni in the alloy with CaO ad.ition increasing from 0.4 g up to 1.2 g. However, the recoveries of mn and.Si vivid.y d.creased.as the CaO contents were increased. In general, the recoveries of the metal contents of the crud. alloy increase with the increase in the amount of manganese ore. Compared.to the recoveries of Fe, Cr, and.Ni when CaO was ad.ed. the recoveries of Fe, Cr and.Ni were lower when manganese ore was used.as an ad.itive.

关键词： d.rect smelting · Flux · Nickel laterite ore · Chromite ore ·manganese ore · Red.ctant · Low-grad. coal ·Stainless steel crud. alloy

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Search for microglia-specific peptid.s:ad.ances in the d.scovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss d.partment of Surgery University of ArizonaTucsonAZUSA

Uncontrolled.and.chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurod.generative pathology and.every injury or stroke-related.*** key med.ators of these neuroinflammatory states are glial cells known as microglia,the resid.nt immune cell at the core of the inflammatory event,and.astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based.on the responses of said.microglia,their phenotypes are suggested.to follow those of macrophages;m1 and.m2 are opposites of pro-and.***,microglial phenotypes have been id.ntified.to be on an inflammatory spectrum encompassing d.velopmental,homeostatic,and.reparative behaviors as opposed.to their ability to affect d.vastating cell d.ath cascad.s and.scar tissue formation.

关键词： inflammation pathology d.ath

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