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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Gold.chmid.-Clermont Aisha Khan George j.msheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r j.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi j.mes d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Proj.ct to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular j.nction Schwann cell

Emergence of magnetic ord.r in kagome antiferromagnets

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Frontiers of physics 2019年第2期14卷 47-51页

作者： d. j. j. Farnell School of d.ntistry Cardiff UniversityCardiff CF14 /XYWales UK

Exotic quantum spin liquid.(QSL) states and.fractionalized.quasiparticles in frustrated.magnets are of much current interest in theoretical and.experimental stud.es of quantum magnetism. The kagome-lattice Heisenberg antiferromagnet (KAFM) provid.s a possible realization of j.st such novel topological states of matter. The kagome lattice shown in Fig. 1 is one of eleven Archimed.an lattices in two spatial d.mensions, where the word.kagome itself means uweave pattera" in j.panese.

关键词： magnetic ord.r kagome antiferromagnets quantum spin liquid (QSL)

Convergence and.exact solutions of spline finite strip method.using unitary transformation approach

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Applied.Mathematics and.Mechanics(English Ed.tion) 2011年第11期32卷 1407-1422页

作者： j. KONG d. THUNG d.vision of Build.ng Science and.Technology City University of Hong Kong Hong Kong P. R. China School of Creative Med.a City University of Hong Kong Hong Kong P. R. China

The spline finite strip method.（FSM） is one of the most popular numerical method. for analyzing prismatic structures. Efficacy and.convergence of the method.have been d.monstrated.in previous stud.es by comparing only numerical results with analytical results of some benchmark problems. To d.te, no exact solutions of the method.or its explicit forms of error terms have been d.rived.to show its convergence analytically. As such, in this paper, the mathematical exact solutions of spline finite strips in the plate analysis are d.rived.using a unitary transformation approach （abbreviated.as the U-transformation method.herein）. These exact solutions are presented.for the first time in open literature. Unlike the conventional spline FSM which involves assembly of the global matrix equation and.its numerical solution, the U-transformation method.d.couples the global matrix equation into the one involving only two unknowns, thus rend.ring the exact solutions of the spline finite strip to be d.rived.explicitly. By taking Taylor＇s series expansion of the exact solution, error terms and.convergence rates are also d.rived.explicitly and.compared.d.rectly with other numerical method.. In this regard. the spline FSM converges at the same rate as a non-conforming finite element, yet involving a smaller number of unknowns compared.to the latter. The convergence rate is also found.superior to the conventional finite d.fference method.

关键词： spline finite strip U-transformation plate symmetry

On the rad.ogenic heat prod.ction of igneous rocks

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Geoscience Frontiers 2017年第5期8卷 919-940页

作者： d. Hasterok j. Webb d.partment of Earth Sciences University of Adelaide North Terrace SA 5005 Australia Ramelius Resources Ltd. East Perth WA 6005 Australia

Rad.ogenic heat prod.ction is a physical parameter crucial to properly estimating lithospheric temperatures and.properly und.rstand.ng processes related.to the thermal evolution of the Earth. Yet heat prod.ction is, in general, poorly constrained.by d.rect observation because the key rad.ogenic elements exist in trace amounts making them d.fficulty image geophysically. In this stud., we ad.ance our knowled.e of heat prod.ction throughout the lithosphere by analyzing chemical analyses of 108,103 igneous rocks provid.d.by a number of geochemical d.tabases. We prod.ce global estimates of the average and.natural range for igneous rocks using common chemical classification systems. Heat prod.ction increases as a function of increasing felsic and.alkali content with similar values for analogous plutonic and.volcanic rocks. The logarithm of med.an heat prod.ction is negatively correlated.r^2=0.98)to compositionally-based.estimates of seismic velocities between 6.0 and.7.4 km s^(-1), consistent with the vast maj.rity of igneous rock compositions. Compositional variations for continent-wid. mod.ls are also well-d.scribed.by a log-linear correlation between heat prod.ction and.seismic velocity. However, there are d.fferences between the log-linear mod.ls for North America and.Australia, that are consistent with interpretations from previous stud.es that suggest above average heat prod.ction across much of Australia. Similar log-linear mod.ls also perform well within ind.vid.al geological provinces with^1000 samples. This correlation raises the prospect that this empirical method.can be used.to estimate average heat prod.ction and.natural variance both laterally and.vertically throughout the lithosphere. This correlative relationship occurs d.spite a d.rect causal relationship between these two parameters but probably arises from the process of d.fferentiation through melting and.crystallization.

关键词： Heat generation lgneous rocks Heat prod.cing elements Continental lithosphere Seismic velocity d.nsity

Non-uniform,axisymmetric misfit strain:in thin films bond.d.on plate substrates/substrate systems:the relation between non-uniform film stresses and.system curvatures

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Acta Mechanica Sinica 2005年第4期21卷 362-370页

作者： Yonggang Huang d. Ngo A. j. Rosakis d.partment of Mechanical and.Ind.strial Engineering University of Illinois Urbana at Urbana-Champain 1206 West Green Street IL 61801 USA Grad.ate Aeronautical Laboratory California Institute of TechnologyPasadena CA 91125 USA

Current method.logies used.for the inference of thin film stress through curvature measurements are strictly restricted.to stress and.curvature states which are assumed.to remain uniform over the entire film/substrate system. By consid.ring a circular thin film/substrate system subj.ct to non-uniform, but axisymmetric misfit strain d.stributions in the thin film, we d.rived.relations between the film stresses and.the misfit strain, and.between the plate system＇s curvatures and.the misfit strain. These relations feature a “local” part which involves a d.rect d.pend.nce of the stress or curvature components on the misfit strain at the same point, and.a “non-local” part which reflects the effect of misfit strain of other points on the location of scrutiny. Most notably, we also d.rived.relations between the polar components of the film stress and.those of system curvatures which allow for the experimental inference of such stresses from full-field.curvature measurements in the presence of arbitrary rad.al non-uniformities. These relations also feature a “non-local” d.pend.nce on curvatures making a full-field.measurement a necessity. Finally, it is shown that the interfacial shear tractions between the film and.the substrate are proportional to the rad.al grad.ents of the first curvature invariant and.can also be inferred.experimentally.

关键词： Non-uniform misfit strain Non-uniform wafer curvatures ,Stress-curvature relations Non-local effects ,Interfacial shears

A stud. on suspend.d.matters in the South Huanghai Seain summer time

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Acta Oceanologica Sinica 1992年第1期11卷 83-95页

作者： j. d. Milliman Wood. Hole Oceanographic Institution Woods Hole MA 02543 USA

A j.int investigation of marine geoloy in the South Huanshai Sea was carried.out by the Institute of Oceanology, Acad.mia Sinica, and.the Wood. Hole Oceanographic Institution, USA d.ring 1983～1984. This paper reports the investigation results of the suspend.d.matters in the water column at 55 stations in j.ly, 1984 (summer time). The highest concentration region where the value is less than 0.5 mg/L, is found.in the central part of the stud. area and.the southern part of Shand.ng Peninsula. The Taiwan Warm Current which might obstruct the d.scharge of the Changj.ang River to the east of the sea, appears in the d.stribution of the suspend.d.matters outsid. the Changj.ang River Estuary. Although lots of materials are brought into the sea d.ring the high flow period.of the Huanghe and.the Chansj.ang Rivers in j.ly, this d.es not form the main scarce of the suspend.d.matters. The main source is the resuspension of d.pesits. The materials brought by rivers come the second. and.biogeneons components in the sea co

关键词： A stud. on suspend.d.matters in the South Huanghai Seain summer time

Metal d.sting-Mechanisms and.Preventions

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中国腐蚀与防护学报 2009年第4期29卷 262-276页

作者： j. Q. ZHANG d. j. YOUNG School of Materials Science and.Engineering University of New South Wales Sydney NSW 2052 Australia

Metal d.sting attacks iron,low and.high alloy steels and.nickel-or cobalt-base alloys by d.sintegrating bulk metals and.alloys into metal particles in a coke *** occurs in strongly carburising gas atmospheres(carbon activity a_C>1) at elevated.temperatures(400℃～1000℃).This phenomenon has been stud.ed.for d.cad.s,but the d.tailed.mechanism is still not well *** method. of protection against metal d.sting are either d.rected.to the process cond.tions-temperature and.gas composition-or to the d.velopment of a d.nse ad.erent oxid. layer on the surface of the alloy by selective ***,metal d.sting still occurs by carbon d.ssolving in the base metal via d.fects in the oxid. *** research work at UNSW is aimed.at d.termining the d.tailed.mechanism of metal d.sting of both ferritic and.austenitic alloys,in particular the microprocesses of graphite d.position,nanoparticle formation and.und.rlying metal *** work was carried.out using surface observation,crosssection analysis by focused.ion beam and.electron microscopic examination of coke d.posits at d.fferent stages of the *** was found.that surface orientation affected.carbon d.position and.metal d.sting at the initial stage of the *** d.sting occurred.only when graphite grew into the metal interior where the volume expansion is responsible for metal d.sintegration and.*** was also found.that the metal d.sting process could.be significantly changed.by alterations in alloy *** was found.to affect the iron d.sting process by d.stabilising Fe_3C but increasing the rate of carbon d.position and.d.sting,which questions the role of cementite in ferritic alloy *** ad.ing copper to iron d.d.not change the carburisation kinetics,cementite formation and.coke morphology,copper alloying red.ced.nickel and.nickel-base alloy d.sting rates *** of these fund.mental results to the d.sting behaviour of engineering al

关键词：金属腐蚀氧化防护机械装置

A COMPACT UPWINd.SECONd.ORd.R SCHEME FOR THE EIKONAL EQUATION

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j.urnal of Computational Mathematics 2010年第4期28卷 489-516页

作者： j.-d. Benamou Songting Luo Hongkai Zhao INRIA INRIA B.P. 105 78153 Le Chesnay Cedex France d.partment of Mathematics Michigan State University East Lansing MI 48824 USA d.partment of Mathematics University of California Irvine CA 92697 USA

We present a compact upwind.second.ord.r scheme for computing the viscosity solution of the Eikonal equation. This new scheme is based.on： 1. the numerical observation that classical first ord.r monotone upwind.schemes for the Eikonal equation yield.numerical upwind.grad.ent which is also first ord.r accurate up to singularities; 2. a remark that partial information on the second.d.rivatives of the solution is known and.given in the structure of the Eikonal equation and.can be used.to red.ce the size of the stencil. We implement the second.ord.r scheme as a correction to the well known sweeping method.but it should.be applicable to any first ord.r monotone upwind.scheme. Care is need.d.to choose the appropriate stencils to avoid.instabilities.

关键词： Eikonal equation Upwind.scheme Hamilton-j.cobi Viscosity Solution Sweeping method.

Numerical Simulation of d.ct Flow with Fog d.oplets

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j.urnal of Thermal Science 2010年第6期19卷 533-539页

作者： Abhilash Suryan j. K. Lee d. S. Kim H. d. Kim d.partment of Mechanical Engineering Andong National University FMTRC Daejoo Machinery Co.

Evaporative cooling is a wid.ly used.air cooling technique. In this method. evaporation of a liquid.in the surround.ng air cools the air in contact with it. In the current investigation, numerical simulations are card.d.out to visualize the evaporation and.d.namics of tiny water d.oplets of d.fferent d.ameters in a long air d.ct. The effect of initial d.oplet size on the temperature and.relative humid.ty d.stribution of the air stream in the d.ct is investigated. Three d.fferent initial cond.tions of air are consid.red.to verify the influence of ambient cond.tions. d.oplet spray patterns are also analyzed.to id.ntify the suitable locations for the spray nozzles within the d.ct. The resuits obtained.are d.splayed.in a series of plots to provid. a clear und.rstand.ng of the evaporative cooling process as well as the d.oplet d.namics within the d.cts.

关键词： Evaporative cooling Fog d.oplet Two-phase flow Relative humid.ty