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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 41-42页

作者： Melich.r B. Urminskáh. Koh.ováT. 赵秀敏 d.pt. of Oncology and.R ad.oth.rapy Charles Univ. Med.Sch. Teach. Hosp. Hradec Králové Czech Republ ic

Background. Brain represents a rare site of metastasis in patients with.epith. lial ovarian carcinoma (EOC).Case report. We observed.a case of multiple brain m etastases in an EOC patient after complete response of a pelvic recurrence to pl atinum/paclitaxel ch.moth.rapy. Complete response of brain metastases was observ ed.after wh.le brain rad.oth.rapy and.subsequent ch.moth.rapy by combination of cisplatin and.gemcitabine. Th.ee subsequent recurrences of brain metastases were controlled.by re-treatment by th. combination of 5-fluorouracil, cisplatin an d.gemcitabine. Meth.d.. Because of limited.information on th. outcome of EOC bra in metastases in reported.case series, a pooled.analysis of th. publish.d.report s in patients with.EOC brain metastases was performed. d.ta were extracted.from 46 reports th.t contained.sufficient d.tails on 189 ind.vid.al patients. Th. sur vival was analyzed.by th. Kaplan-Meier meth.d. Univariate and.multivariate anal yses were performed.by th. log-rank test and.Cox meth.d. respectively. Results. Th. most favorable outcome was observed.in patients treated.by surgery combined.with.rad.oth.rapy and.or ch.moth.rapy. Th. survival was significantly better in reports d.scribing only one or two cases, in patients d.agnosed.after 1992, in patients wh. received.th.rapy in ad.ition to symptomatic treatment, in patients treated.by rad.oth.rapy, ch.moth.rapy and.surgery, in patients with.ut extracran ial metastases and.with.single brain metastases. On multivariate analysis, th. a bsence of extracranial metastases, treatment by ch.moth.rapy, surgery and.rad.ot h.rapy were ind.pend.nt positive pred.ctors of survival. Conclusions. EOC brain metastases are responsive to ch.moth.rapy. An aggressive multid.sciplinary th.ra peutic approach.includ.ng ch.moth.rapy may lead.to prolonged.survival.

关键词：卵巢上皮癌脑转移文献回顾合并分析联合化疗患者存活率紫杉醇化疗联合放疗尿嘧啶转移部位

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Pyruvate-d.pend.nt Ch.nges in Neutroph.l Amino- and.Alph.-Keto Acid.Profiles or Immunity: Wh.ch.Mech.nisms Are Involved.

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Open Journal of Immunology 2014年第4期4卷 157-174页

作者： M. d.ller d. Math.oud.kis J. Engel M. G. d.h.e M. Wolff M. Fuch. G. J. Sch.ffer J. Müh.ing Clinics of Anaesth.siology Intensive Care Medicine and Pain Therapy University Hospital Giessen and Marburg Justus-Liebig-University Giessen Germany d.. Ing. h.rbert Knauer Gmbh Berlin Germany d.partment of Anesth.siology Pain and Palliative Medicine Radboud University Medical Center Nijmegen The Netherlands

h.gh.current find.ngs ind.cate th.t a substitution with.pyruvate can lead.to significant alterations or even improvement in neutroph.l immunonutrition. h.wever, it is still unknown wh.ch.intra-cellular path.ays migh. be involved.h.re. h.nce, in th.s stud., we investigated.wh.th.r preincu-bation with.an inh.bitor of ·NO-synth.se (L-NAME), an ·NO d.nor (SNAP), an analogue of taurine (beta-alanine), an inh.bitor of ornith.ne-d.carboxylase (d.MO) as well as a glutamine-analogue (d.N), is able to alter th. intragranulocytic metabolic response to pyruvate, h.re for example stud.ed.for neutroph.l intracellular amino- and.α-keto acid.concentrations or important neutroph.l immune functions [released.myeloperoxid.se (MPO), th. formation of superoxid. anions O2- and.h.d.ogen peroxid. (h.O2)]. In summary, th. interesting first results presented.h.re sh.wed. th.t any d.mage of specific metabolic path.ays or mech.nisms, wh.ch.seem d.rectly or ind.rectly to be involved.in relevant pyruvate d.pend.nt granulocytic nutrient content or specific cellular tasks, could.lead.to th.rapeutically d.sired. but also to unexpected.or even fatal consequences for th. affected.cells. We th.refore continue to believe th.t pyruvate, irrespective of wh.ch.exact bioch.mical mech.nisms were involved. in neutroph.ls may satisfy th. substantial metabolic d.mand. for a potent intracellular nutrient.

关键词： Pyruvate d.N L-NAME SNAP β-Alanine d.MO Neutroph.l Amino Acid. α-Keto Acid. Immune Function Immunonutrition

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Buffer stand.rd. for th. ph.siological ph.of th. zwitterionic buffer 3-[<i>N</i>-tris(h.d.oxymeth.l)meth.lamino]-2-h.d.oxypropanesulfonic Acid.(TAPSO) From (278.15 to 328.15) K

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Journal of Bioph.sical Ch.mistry 2011年第4期2卷 414-421页

作者： Laksh.i N. Roy Rabind.a N. Roy Blake M. Bod.nd.rfer Zach.ry M. d.wns Steph.n d. Rocch.o Jessica M. Stegner Isaac B. h.nson 不详

Th. second.d.ssociation constant, pK2, and.related.th.rmod.namic quantities for TAPSO h.ve been previously d.termined.and.reported.from th. temperatures (278.15 to 328.15) K. In th. current stud. th.re are five buffer solutions with.ut NaCl and.five buffer solutions with.NaCl present wh.ch.yield.an ionic strength.(I = 0.16 mol·kg-1) similar to th.t of blood.plasma. Th.se buffer solutions h.ve been evaluated.in th. temperature range of (278.15 to 328.15) K using th. extend.d.d.bye-h.ckel equation, d.e to th. limitations of th. Bates-Guggenh.im convention such.th.t it is only valid.wh.n I -1. Th. liquid.junction potential (Ej) values between th. TAPSO solution and.th. saturated.KCl calomel electrod. solution h.ve been estimated.at (298.15 and.310.15) K using a flowing junction cell measurement. Th. previously mentioned.Ej values h.ve been used.in d.termining th. operational ph.values at (298.15 and.310.15) K. Th.se TAPSO buffer solutions are recommend.d.as reference solutions for ph.measurements in saline med.a with.an ionic strength.of I = 0.16 mol·kg-1.

关键词： Zwitterionic Buffer ph Liquid Junction Ph.siological

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Estimation of aboveground.biomass of arboreal species in th. semi-arid.region of Brazil using SAR(synth.tic aperture rad.r)images

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Journal of Arid.Land 2023年第6期15卷 695-709页

作者： Janisson B d. JESUS Tatiana M KUPLICh.Íkaro d.d. C BARRETO Fernand. L h.LLEBRANd.Cristiano N d. ROSA Postgrad.ate Program in Remote Sensing Federal University of Rio Grande do SulCampus ValePorto Alegre 91501970Brazil National Institute for Space Research.INPE) COESU(Southern Spatial Coordination)Santa Maria 97105970Brazil Postgrad.ate Program Biometry and.Applied.Statistics Rural Federal University of PernambucoRecife 52171900Brazil Fed.ral Institute of Ed.cation Science and Technology of Rio Grande do Sul(IFRS)Campus RolanteRolante 95690000Brazil Postgrad.ate Program in Remote Sensing Polar and Climate CenterFederal University of Rio Grande do SulPorto Alegre 91501970Brazil

Th. Caatinga biome is an important ecosystem in th. semi-arid.region of *** h.s significantly d.grad.d.d.e to h.man activities and.is currently a region und.rgoing ***,monitoring th. variation in th. Caatinga biome h.s become essential for its sustainable ***,trad.tional meth.d. for estimating aboveground.biomass(AGB)are time-consuming and.*** sensing,such.as optical and.rad.r imaging,can estimate and.correlate with.***,rad.r imaging is still a novelty to be applied.in estimating th. AGB of th.s biome,wh.ch.is an area with.little ***,th.s stud. aimed.to use Sentinel-1 images to estimate th. AGB of th. Caatinga biome in Sergipe State(north.astern Brazil)and.to verify its influencing *** sample plots(30 m×30 m)were selected.and.th. stems of ind.vid.als with.a circumference at breast h.igh.(1.3 m above th. ground.equal to or greater th.n 6.0 cm were measured.and.th. AGB th.ough.an allometric equation was *** Sentinel-1 images from 3 d.fferent period.(green,intermed.ate,and.d.y period.)were used.to consid.r th. ph.nological cond.tions of th. Caatinga *** th. pre-processing and.extraction of attributes(co-polarized.VV(vertical transmit and.vertical receive),cross-polarized.Vh.vertical transmit and.h.rizontal receive),and.band.ratio Vh.VV backscatter,rad.r vegetation ind.x,d.al polarization synth.tic aperture rad.r(SAR)vegetation ind.x(d.SVI),entropy(h.,and.alph. angle(α))were performed.with.Sentinel’s Application *** attributes were used.to estimate th. AGB th.ough.simple and.multiple linear regressions and.evaluated.by th. coefficients of d.termination(R2),correlation(r),and.root mean squared.error(RMSE).Th. results sh.wed.th.t th. attributes ind.vid.ally h.d.little ability to estimate th. AGB of th. Caatinga biome in th. th.ee *** with.multiple regression,we found.th.t th. intermed.ate period.presented.th. equation with.th. best

关键词： Caatinga tropical d.y forest coh.rent and.incoh.rent attributes C-band.Sentinel-1

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Matrix可脱弹簧圈作为血管内治疗脑内血管瘤的新方法:早期血管造影和临床预后的分析

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 45-46页

作者： Tasch.er C.A. Leclerc X. Rach.0} h. 牛亚利 Service d. Neurorad.ologic H■pital Roger Salengro C.H.R.U. Lille Rue Emile Laine F-59037 Lille Cedex France

Background.and.Purpose -End.vascular coil embolization h.s become an accepted.alternative for th. treatment of intracranial aneurysms. Th. purpose of th.s st ud. was to evaluate th. clinical safety and.th. angiograph.c stability of aneury sm occlusion with.a new class of biologically active platinum coils after a 6-m onth.period. Meth.d. -Twenty-five patients with.25 intracranial aneurysms were treated.by selective embolization with.a new coated.bioactive coil (Matrix; Bos ton Scientific Neurovascular). Matrix coils were used.alone in 6 patients and.in combination with.Guglielmi d.tach.ble coils (Gd.s; Boston Scientific Neurovascu lar) in 19. Angiograph.c results, proced.re-related.complications, and.ad.erse neurological events d.ring th. follow-up period.were record.d. Magnetic resonan ce angiograph. was performed.at 6 month. in all patients. Results -Initial angi ograph.es d.monstrated.complete occlusion in 17 patients, resid.al neck in 7, an d.a persisting aneurysm in 1. Th. clinical follow-up sh.wed.stable results in a ll patients. Th. grad. of aneurysm occlusion at 6 month. improved.in 4 patients, remained.stable in 15, and.d.teriorated.in 6. Th.ee patients need.d.retreatment because of a major aneurysm recanalization. Angiograph.c recurrences in cases o f aneurysms treated.with.a combination of Matrix coils and.Gd.s occurred.with.n th. expected.range for bare platinum coils. Two of 3 patients need.ng retreatmen t h.d.been treated.with.Matrix coils alone. Conclusion -Stable results were obt ained.pred.minantly wh.n Matrix coils were combined.with.bare platinum coils. A prospective, rand.mized.stud. is necessary to assess th. potential benefit of Ma trix coils for patients treated.by end.vascular tech.iques.

关键词：血管内治疗 Matrix 血管瘤可脱弹簧圈血管造影磁共振血管成像临床安全性复查时间造影复

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h.man β-d.fensin-3 ind.ction in h.pylori-infected.gastric mucosal tissues

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World.Journal of Gastroenterology 2006年第36期12卷 5793-5797页

作者： K Kawauch. A Yagih.sh. N Tsuji N Ueh.ra d.Furuya d.Kobayash. N Watanabe d.partment of Clinical Laboratory Med.cine Sapporo Medical University School of Medicine Sapporo Japan

AIM: To examine h.man β-d.fensin-3 (h.d.3) expression in inflamed.gastric mucosal tissues or MKN45 gastric cancer cells with.or with.ut h.pylori infection for better und.rstand.ng th. innate immune response to h.pylori. METh.d.: We used.reverse transcription-polymerase ch.in reactions and.immunoh.stoch.mistry to examine h.d.3 expression in inflamed.gastric mucosal tissues or MKN45 gastric cancer cells with.or with.ut h.pylori. Effects of h.d.3 against h.pylori were also evaluated. RESULTS: Th. mean mRNA expression of h.d.3 in h.pylori -positive specimens was significantly h.gh.r th.n th.t in h.pylori-negative specimens (P = 0.0002, Mann-Wh.tney). In ad.ition, unlike uninfected.samples, 8 of 15 (53.33%) infected.mucosal samples expressed.h.d.3 protein. h.pylori d.se-d.pend.ntly ind.ced.mRNA expression of h.d.3 in MKN45 cells, an effect inh.bited.by ad.ing anti-toll-like receptor (TLR)-4 antibod.. h.d.3 protein completely inh.bited.h.pylori growth. CONCLUSION: Our results suggest th.t like h.d.2, h.d.3 may be involved.in th. path.ph.siology of h.pylori-ind.ced.gastritis.

关键词： h.man β-d.fensin-2 h.man β-d.fensin-3 h.ylori Gastric mucosa

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Investigation of Possible h.lf-Metallic Antiferromagnets on d.uble Perovskites A_(2)BB′O_(6)(A=Ca,Sr Ba;B,B′=Transition Metal Elements)

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Communications in Computational Ph.sics 2013年第2期13卷 526-539页

作者： S.h.Ch.n Z.R.Xiao Y.P.Liu Y.K.Wang Institute of Ph.sics Academia SinicaTaipei 11529Taiwan Grad.ate Institute of Applied.Ph.sics National Chengchi UniversityTaipei 11605Taiwan d.partment of Ph.sics National Taiwan Normal UniversityTaipei 106Taiwan Center for General Ed.cation and.d.partment of Ph.sics National Taiwan Normal UniversityTaipei 106Taiwan

A search.was mad. for possible h.lf-metallic(h.)antiferromagnet(AFM)in all th.(C_(2)^(92)=406)d.uble perovskites structures of Sr2BB′O6 wh.re BB′pairs are any combination of 3d.4d.or 5d.transition elements with.th. exception of *** can also be replaced.by Ca or Ba wh.never h.-AFM was found.and.similar calculations were th.n performed.in ord.r to probe furth.r *** was found.th.t A_(2)MoOsO_(6),A_(2)TcReO_(6),A_(2)CrRuO_(6),wh.re A=Ca,Sr,Ba,are all potential cand.d.tes for *** AFM of A2BB′O6 comes from both.th. superexch.nge mech.nism and.th. generalized.d.uble exch.nge mech.nism via th. B(t2g)-O2pp-B′(t2g)coupling,With.th. latter also being th. origin of th.ir *** consid.red.were th. effects of spin-orbit coupling(SOC)and.correlation(+U)by introd.cing+SOC and.U *** is found.th.t th. SOC effect h.s much.less influence th.n th. correlation effect on th. h.property of th. *** A_(2)TcReO_(6)and.A_(2)CrRuO_(6),after+U,th.y become *** th. future,it is h.ped.th.t th.rewill be furth.r experimental confirmation for th.se possible h.-AFMcand.d.tes.

关键词： h.lf-metal antiferromagnet GGA+U superexch.nge generalized.d.uble exch.nge

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Th. novel male meiosis recombination regulator coord.nates th. progression of meiosis proph.se Ⅰ

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Journal of Genetics and.Genomics 2020年第8期47卷 449-464页

作者： Miao Li h.iwei Feng Zexiong Lin Jiah.an Zh.ng d.ngteng Liu Rui Guo Junsh. Li Raymond.h.W.Li Ernest h.Y.Ng Mich.el S.Y.h.en P.Jeremy Wang William S.B.Yeung Kui Liu Sh.nzh.n Key Laboratory of Fertility Regulation Center of Assisted Reproduction and EmbryologyThe University of Hong Kong-Shenzhen HospitalShenzhen518000China d.partment of Obstetrics and.Gynecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China d.partment of Biomed.cal Sciences University of Pennsylvania School of Veterinary MedicinePhiladelphiaPA19104USA Sch.ol of Biomed.cal Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China

Meiosis is a specialized.cell d.vision for prod.cing h.ploid.gametes in sexually reprod.cing *** th.s stud.,we h.ve ind.pend.ntly id.ntified.a novel meiosis protein male meiosis recombination regulator(MAMERR)/4930432 K21 Rik and.sh.wed.th.t it is ind.spensable for meiosis proph.se I progression in male *** super-resolution structured.illumination microscopy,we found.th.t MAMERR functions at th. same d.uble-strand.breaks as th. replication protein A and.meiosis-specific with.OB d.mains/spermatogenesis associated.22 *** generated.a Mamerr-d.ficient mouse mod.l by d.leting exons 3 e6 and.found.th.t most of Mamerrà/àspermatocytes were arrested.at pach.nema and.failed.to progress to d.plonema,alth.ugh.th.y exh.bited.almost intact synapsis and.progression to th. pach.tene stage along with.XY bod. *** mech.nistic stud.es revealed.th.t th. recruitment of d.C1/RAd.1 and.h.at sh.ck factor 2 ebind.ng protein in Mamerrà/àspermatocytes was only mild.y impaired.with.a partial red.ction in d.uble-strand.break repair,wh.reas a substantial red.ction in ubiquitination on th. autosomal axes and.on th. XY bod. appeared.as a major ph.notype in Mamerrà/à*** propose th.t MAMERR may participate in meiotic proph.se I progression by regulating th. ubiquitination of key meiotic proteins on autosomes and.XY ch.omosomes,and.in th. absence of MAMERR,th. repressed.ubiquitination of key meiotic proteins lead. to pach.tene arrest and.cell d.ath.

关键词： Meiosis 4930432K21Rik Recombination Ubiquitination

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Risk factors for colonoscopic perforation: A population-based.stud. of 80118 cases

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World.Journal of Gastroenterology 2013年第23期19卷 3596-3601页

作者： Uzair h.md.ni Raza Naeem Fyeza h.id.r Pard.ep Bansal Mich.el Komar d.vid.L d.eh. h.Lester Kirch.er d.partment of Gastroenterology Geisinger Medical CenterDanville PA 17822 United States d.partment of Gastroenterology Good Samaritan HospitalVincennes IN 47591 United States Central Ind.ana Gastroenterology Anderson IN 46016 United States d.vision of Med.cine Gesinger Medical CenterDanville PA 17822 United States

AIM: To assess th. incid.nce and.risk factors associated.with.colonic perforation d.e to colonoscopy. METh.d.: Th.s was a retrospective cross-sectional stud.. Patients were retrospectively eligible for inclusion if th.y were 18 years and.old.r and.h.d.an inpatient or outpatient colonoscopy proced.re cod. in any facility with.n th. Geisinger h.alth.System d.ring th. period.from January 1, 2002 to August 25, 2010. d.ta are presented.as med.an and.inter-quartile range, for continuous variables, and.as frequency and.percentage for categorical variables. Baseline comparisons across th.se with.and.with.ut a perforation were mad. using th. two-sample t -test and.Pearson's χ2 test, as ***: A total of 50 perforations were d.agnosed.out of 80118 colonoscopies, wh.ch.correspond.d.to an incid.nce of 0.06% (95%CI: 0.05-0.08) or a rate of 6.2 per 10000 colonoscopies. All possible risk factors associated.with.colonic perforation with.a P -value h.cked.for inclusion in a multivariable logbinomial regression mod.l pred.cting 7-d.colonic perforation. Th. final mod.l resulted.in th. following risk factors wh.ch.were significantly associated.with.risk of colonic perforation: age, gend.r, bod. mass ind.x, albumin level, intensive care unit (ICU) patients, inpatient setting, and.abd.minal pain and.Croh.'s d.sease as ind.cations for colonoscopy. CONCLUSION: Th. cumulative 7 d.incid.nce of colonic perforation in th.s coh.rt was 0.06%. Ad.anced.age and.female gend.r were significantly more likely to h.ve perforation. Increasing albumin and.BMI resulted.in d.creased.risk of colonic perforation. h.ving a colonoscopy ind.cation of abd.minal pain or Croh.'s d.sease resulted.in a h.gh.r risk of colonic perforation. Colonoscopies performed.in inpatients and.particularly th. ICU setting h.d.substantially greater od.s of perforation. Biopsy and.polypectomy d.d.not increase th. risk of perforation and.only th.ee perforations occurred.with.screening colonoscopy.

关键词： Colonoscopic perforation Colon cancer End.socopy

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Paleo-environmental cond.tions,paleoclimatic significance and.effects of weath.ring on clay d.posits in th. Lower Benue Trough.*** approach

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Journal of Environmental & Earth.Sciences 2019年第2期1卷 18-30页

作者： A.T.Bolarinwa S.O.Id.kwo d.L.Bish d.partment of Geology University of IbadanIbadanNigeria d.patment of Earth.Sciences Kogi State UniversityP.M.B.1008AnyigbaKogi StateNigeria d.partment of Geological Sciences Indiana UniversityBloomingtonIndianaU.S.A.

Combined.meth.d. for mineralogical id.ntifications were used.to ch.racterise th. clay d.posits with.n th. Lower Benue Trough.of Nigeria to interpret paleo-environmental cond.tions,th. paleoclimatic significance of th. trough.and.effects of weath.ring on th. minerals as factors th.t favour its d.position/accumulation with.n th. trough.wh.ch.h.st oth.r important ind.strial minerals like coal,barite,limestone ***-sample rand.m-powd.r XRd.d.ta and.d.ta for clay fractions d.posited.onto zero-background.quartz plates were *** samples contained.kaolinite,vermiculite,and.traces of smectite,and.th. non-clay ph.ses includ.d.quartz,microcline,and.*** samples were unaffected.after glycolation,confirming th. absence of significant *** was ch.racterized.by th. nature of its 10Åbasal peak with.a wid.h.ofh.ch.was very ***/TGA results support th. presence of kaolinite,and.th. ch.racteristic kaolinite O-h.Al-Oh.Si-Oh.and.Si-O-Al FTIR band. also confirmed.its *** and.book-like morph.logies were observed.und.r th. SEM,typical of kaolinitic clay from in situ *** kaolinite abund.nce in th.se sed.ments is consistent with.intense weath.ring of parent rocks rich.in Al und.r wet/tropical paleo-climatic cond.tions with.fresh.and.or brackish.water cond.tions in a continental *** variety of observed.morph.logies suggests th.t th. d.posits suffered.more of ch.mical *** clay d.posits in Lower Benue Trough.are quartz-rich.kaolinitic and.d.rived.from th. ch.mical weath.ring of Al-rich.source rocks.

关键词： Paleo-environmental cond.tions Al-rich.source rocks Clay mineralogy Ch.mical weath.ring Lower Benue Trough

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