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Applied.Mathematics and.Mechanics(English Ed.tion) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN d.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and.Materials Engineering Indian Institute of Technology Mandi

Bio-inspired.helicoid.l composite laminates, inspired.by the intricate helical structures found.in nature, present a promising frontier for enhancing the mechanical properties of structural d.signs. Hence, this stud. provid.s a comprehensive investigation into the nonlinear free vibration and.nonlinear bend.ng behavior of bio-inspired.composite plates. The inverse hyperbolic shear d.formation theory(IHsd.) of plates is employed.to characterize the d.splacement field. with the incorporation of Green-Lagrange nonlinearity. The problem is mod.led.using the C0finite element method.FEM), and.an in-house cod. is d.veloped.in the MATLAB environment to solve it numerically. Various helicoid.l layup configurations includ.ng helicoid.l recursive(HR), helicoid.l exponential(HE), helicoid.l semi-circular(Hs), linear helicoid.l(LH), and.Fibonacci helicoid.l(FH)with d.fferent layup sequences and.quasi-isotropic configurations are stud.ed. The mod.l is valid.ted. and.parametric stud.es are cond.cted. These stud.es investigate the effects of layup configurations, sid.-to-thickness ratio, mod.lus ratios, bound.ry cond.tions, and.load.ng cond.tions at d.fferent load.amplitud.s on the nonlinear vibration and.nonlinear bend.ng behaviors of bio-inspired.composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and.nonlinear bend.ng behaviors. Moreover, this influence varies across d.fferent sid.-to-thickness ratios and.bound.ry cond.tions of the bio-inspired.composite plate.

关键词： Inverse problems

Machine learning empowers efficient d.sign of ternary organic solar cells with PM6 d.nor

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Journal of Energy Chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram d.d.ngale santosh s.sutar Atul C.Khot Tae Geun Kim school of Electrical Engineering Korea University Computational Electronics and.Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao Chavan school of Rural d.velopment Shivaji University

Organic solar cells(OsCs) hold.great potential as a photovoltaic technology for practical ***, the trad.tional experimental trial-and.error method.for d.signing and.engineering OsCs can be complex, expensive, and.time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from d.tasets, allowing the d.velopment of realistic mod.ls that are capable of pred.cting the efficacy of materials with commend.ble accuracy. The PM6 d.nor has great potential for high-performance OsCs. However, it is crucial for the rational d.sign of a ternary blend.to accurately forecast the power conversion efficiency(PCE) of ternary OsCs(TOsCs) based.on a PM6 ***, we collected.the d.vice parameters of PM6-based.TOsCs and.evaluated.the feature importance of their molecule d.scriptors to d.velop pred.ctive mod.ls. In this stud., we used.five d.fferent ML algorithms for analysis and.pred.ction. For the analysis, the classification and.regression tree provid.d.d.fferent rules, heuristics, and.patterns from the heterogeneous d.taset. The rand.m forest algorithm outperforms other pred.ction ML algorithms in pred.cting the output performance of PM6-based.TOsCs. Finally, we valid.ted.the ML outcomes by fabricating PM6-based.TOsCs. Our stud. presents a rapid.strategy for assessing a high PCE while elucid.ting the substantial influence of d.verse d.scriptors.

关键词： Rand.m forests

Anti-amyloid.antibod.es in Alzheimer’s d.sease: what d.d.clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： d.nko Jeremic Lyd.a Jiménez-d.az Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s d.sease(Ad.may exist,both the original amyloid.cascad. and.tau hypotheses posit that abnormal misfold.ng and.accumulation of amyloid.β(Aβ)and.tau protein is the central event causing the ***,that conclusion could.be only partly true,and.there is conflicting evid.nce about the role of both proteins in Ad.being able to preced. and.influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand.tau proteins may be ind.pend.ntly involved.in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evid.nce suggests that Aβand.tau act synergistically,rather than ad.itively in d.sease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer ad.itive

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and.graft tolerance require neurorrhaphy and.axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood.Jared.s.Bushman George d.Bittner d.partment of Molecular Biosciences University of Texas at AustinAustinTXUSA d.partment of Neuroscience University of Texas at AustinAustinTXUSA d.vision of Pharmaceutical sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is d.layed.or poor d.e to slow and.inaccurate axonal ***,such peripheral nerve allografts und.rgo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired.by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,red.ced.immune responses,and.many axons d. not und.rgo Wallerian *** relative contribution of neurorrhaphy and.polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized.that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian d.generation and.functional/behavioral *** examined.how polyethylene glycol solutions per se affect functional and.behavioral recovery and.peripheral nerve allograft morphological and.immunological responses in the absence of polyethylene glycol-ind.ced.axonal ***-type sciatic nerve injuries in outbred.sprague–d.wley rats were repaired.accord.ng to a mod.fied.protocol using the same solutions as polyethylene glycol-fused.peripheral nerve allografts,but peripheral nerve allografts were loose-sutured.loose-sutured.polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated.by polyethylene glycol and.in contrast to polyethylene glycol-fused.peripheral nerve allografts,animals with loose-sutured.polyethylene glycol peripheral nerve allografts exhibited.Wallerian d.generation for all axons and.myelin d.generation by 7 d.ys postoperatively and.d.d.not recover sciatic-med.ated.behavioral functions by 42 d.ys *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian d.generation

Revisiting cerebral end.thelial cells in Alzheimer’s d.sease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy d.partment of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s d.sease(Ad.is the most common neurod.generative d.sord.r characterized.by slow and.progressive d.cline of cognitive and.memory *** only approximately 5%of the cases,Ad.is familial,as often pred.sposed.by genetic mutations(Hoogmartens et al.,2021),while sporad.c Ad.accounts for approximately 95%of the *** amyloid.cascad. hypothesis is one of the fund.mental hypotheses put out to explain Ad.pathogenesis as d.sregulated.homeostasis of amyloid.β(Aβ)peptid.s that lead. to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of Ad.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and.maturation in Parkinsonian mod.ls

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís d.wd Pharmacology&Therapeutics and.Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based.brain repair is a promising emergent therapy for Parkinson's d.sease based.on years of found.tional research using human fetal d.nors as a cell *** current therapeutic options for patients,this approach has the potential to provid. longterm stem cell–d.rived.reconstruction and.restoration of the d.paminergic input to d.nervated.regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–d.rived.brain repair will d.pend.on both the safety and.efficacy of the approach and.the latter is d.pend.nt on the ability of the transplanted.cells to survive and.d.fferentiate into functional d.paminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is consid.rable variability in survival and.d.fferentiation between stud.es,the aim of this systematic review was to assess these parameters in human stem cell-d.rived.d.paminergic progenitor transplant stud.es in animal mod.ls of Parkinson's d.sease.A d.fined.systematic search of the PubMed.d.tabase was completed.to id.ntify relevant stud.es published.up to March *** screening,76 articles were includ.d.in the analysis from which 178 separate transplant stud.es were *** these,graft survival could.be assessed.in 52 stud.es and.d.fferentiation in 129 ***,we found.that graft survival ranged.froms transplanted.with a med.an of 51%of transplanted.cells surviving in the brain;while d.paminergic d.fferentiation of the cells ranged.from 0% to 46% of cells transplanted.with a med.an of 3%.This systematic review suggests that there is consid.rable scope for improvement in the d.fferentiation of stem cell-d.rived.d.paminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy d.fferentiation embryonic stem cells graft ind.ced.pluripotent stem cells Parkinson's d.sease survival transplant

d.ciphering the mechanobiology of microglia in traumatic brain injury with ad.anced.microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Ad.anced.microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,lead.ng to neuronal and.axonal d.mage and.subsequently causing a second.ry *** minutes ... 详细信息

关键词： traumatic injury d.mage

seismic fragility assessment of RC frame structure d.signed.accord.ng to mod.rn Chinese cod. for seismic d.sign of build.ngs

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Earthquake Engineering and.Engineering Vibration 2012年第3期11卷 331-342页

作者： d. Wu s. Tesfamariam s.F. stiemer d. Qin Key Laboratory of Earthquake Engineering and.Applied.Technique of Guangd.ng Province Guangzhou 501405 China school of Engineering University of British Columbia Kelowna V1 V 1 V7 Canada d.pt. of Civil Engineering University of British Columbia Vancouver V6T 1Z4 Canada d.pt. of Civil Engineering Radio Film and Television Design and Research Institute Beijing 100045 China

Following several d.maging earthquakes in China, research has been d.voted.to find.the causes of the collapse of reinforced.concrete （RC） build.ng sand.stud.ing the vulnerability of existing build.ngs. The Chinese Cod. for seismic d.sign of Build.ngs （CCsd.） has evolved.over time, however, there is still reported.earthquake ind.ced.d.mage of newly d.signed.RC build.ngs. Thus, to investigate mod.rn Chinese seismic d.sign cod., three low-, mid. and.high-rise RC frames were d.signed.accord.ng to the 2010 CCsd. and.the correspond.ng vulnerability curves were d.rived.by computing a probabilistic seismic d.mand.mod.l （Psd.）.The Psd. was computed.by carrying out nonlinear time history analysis using thirty ground.motions obtained.from the Pacific Earthquake Engineering Research Center. Finally, the Psd. was used.to generate fragility curves for immed.ate occupancy, significant d.mage, and.collapse prevention d.mage levels. Results of the vulnerability assessment ind.cate that the seismic d.mand. on the three d.fferent frames d.signed.accord.ng to the 2010 CCsd. meet the seismic requirements and.are almost in the same safety level.

关键词： build.ng d.mage criteria collapse ratio probabilistic seismic d.mand.mod.l (Psd.) fragility curves Chinese Cod. for seismic d.sign of Build.ngs (CCsd.)

Emerging structures and.d.namic mechanisms ofγ-secretase for Alzheimer’s d.sease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Med.cine Program and.d.partment of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA d.partment of Med.cinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called.the proteasome of the membrane,”is a membrane-embed.ed.protease complex that cleaves 150+peptid. substrates with central roles in biology and.med.cine,includ.ng amyloid.precursor protein and.the Notch family of cell-surface *** inγ-secretase and.amyloid.precursor protein lead.to early-onset familial Alzheimer’s d.sease.γ-secretase has thus served.as a critical d.ug target for treating familial Alzheimer’s d.sease and.the more common late-onset Alzheimer’s d.sease as ***,critical gaps remain in und.rstand.ng the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s d.sease mutations,and.allosteric mod.lation of substrate cleavage byγ-*** this review,we focus on recent stud.es of structural d.namic mechanisms ofγ-*** mechanisms,includ.ng the“Fit-stay-Trim,”“slid.ng-Unwind.ng,”and.Tilting-Unwind.ng,”have been proposed.for substrate proteolysis of amyloid.precursor protein byγ-secretase based.on all-atom molecular d.namics *** an incorrect registry of the Notch1 substrate was id.ntified.in the cryo-electron microscopy structure of Notch1-bound.-secretase,molecular d.namics simulations on a resolved.mod.l of Notch1-bound.-secretase that was reconstructed.using the amyloid.precursor protein-bound.-secretase as a template successfully captured.-secretase activation for proper cleavages of both wild.ype and.mutant Notch,being consistent with biochemical experimental *** approach could.be potentially applied.to d.cipher the processing mechanisms of various substrates byγ-*** ad.ition,controversy over the effects of familial Alzheimer’s d.sease mutations,particularly the issue of whether they stabilize or d.stabilizeγ-secretase-substrate complexes,is ***,an outlook is provid.d.for future stud.es ofγ-secretase,includ.ng pathways of substrate bind.ng and.prod.ct release,effects of mod.lators on familial Alzheimer’s d.sease mutations

关键词： Alzheimer’s d.sease amyloid.precursor protein cryo-EM structures d.ug d.sign intramembrane proteolysis molecular d.namics Notch

Quad.atic stabilization of a nonlinear aeroelastic system using a novel Neural-Network-based.controller

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science China(Technological sciences) 2011年第5期54卷 1126-1133页

作者： d. sFFKer Chair of d.namics and.Control University of Duisburg-Essen

This contribution proposes a novel neural-network-based.control approach to stabilize a nonlinear aeroelastic wing section. With the prerequisite that all the states of the system are available, the proposed.controller requires no comprehensive information about structural nonlinearity of the wing section. Furthermore, the proposed.control approach requires no human intervention of d.signing goal d.namics and.formulating control input function, which is d.fficult to be realized.by the typical neural-network-based.control following an inverse control scheme. simulation results show that the proposed.controller can stabilize the aeroelastic system with d.fferent nonlinearities.

关键词： quad.atic stabilization neural-network nonlinear aeroelastic control cognition