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A d.tailed.comparison of the composition of(RE)-ba-Cu-O-Ag bulk supercond.ctors

Supercond.ctivity 2024年第1期9卷 87-94页

作者： J.v.J.Congreve Y.shi A.R.d.nnis H.d.uiff N.C.Tutt d.A.Card.ell J.H.d.rrell d.partment of Engineering University of CambridgeCambridgeUK

The homogeneity of the microstructure and.composition are critical in d.termining the properties of rare earthbarium‐cuprate,single grain bulk supercond.ctors[(RE)BCO].The magnitud. of the trapped.magnetic field.achieveable in these technologically important materials,in particular,is influenced.heavily by the size and.d.stribution of(RE)_(2)baCuO_(x)(RE‐211)flux pinning inclusions in the bulk microstructure,whereas the size and.d.stribution of silver agglomerates present within the bulk supercond.cting matrix correlate d.rectly with improved.mechanical *** careful engineering,these materials have significant potential for application in range of d.vices related.to energy storage,med.cine,electro‐magnetic machinery and.microelectronic *** of(RE)BCO bulk supercond.ctors typically involves heating a powd.r compact above its peritectic d.composition temperature followed.by slow cooling to facilitate the growth of a single ***(RE)BCO composition has a d.fferent peritectic temperature and.growth rate,which,therefore,necessitates d.fferent requirements in the heating *** fabrication temperature and.growth rate,for example,may have an effect on the RE‐211 and.silver d.stribution,which may,in turn,affect the supercond.cting properties of the resulting single *** this work we compare the d.stributions of silver and.RE‐211 in the single grain microstructures of YBCOAg,Gd.CO‐Ag,EuBCO‐Ag and.SmBCO‐Ag bulk supercond.ctors using optical microscopy,scanning electron microscopy and.energy d.spersive X‐ray *** observe that the d.stributions are very similar along both the a/b‐axis and.c‐axis of these *** suggests that factors other than the maximum temperature used.to achieve peritectic d.composition and.the rate of single grain growth are particularly influential in d.termining the properties of the as‐processed.samples in the top seed.d.melt growth *** observation d.monstrates there is freed.m to us

关键词： YBCO‐Ag Gd.CO‐Ag SmBCO‐Ag EuBCO‐Ag Composition Bulk supercond.ctor

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Robust tantalum tuned.perovskite oxygen electrod. for reversible protonic ceramic electrochemical cells

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Rare Metals 2024年第7期43卷 3055-3065页

作者： Yu-shi Feng Yu Shen Fang Wang Chuan Tian Qin-Yi Hu Qian d.an Jing-Wei Li d. bao School of Materials Science and.Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan Institute of Changchun University of Science and.Technology Zhongshan528437China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Key Laboratory of Preparation and.Applications of Environmental Friend.y Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxid.s with d.verse composition and.structure have exhibited.grand.ad.ances in boosting the oxygen red.ction and.evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward.the sustainable hyd.ogen prod.ction and.***,enhancement of their activity and.stability remains ***,we d.velop the Ta-regulated.baCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrod.(ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abund.nt oxygen d.fects and.achieve the simultaneous enhancement in the electrocatalytic activity and.stability toward.ORR and.***-fabricated.R-PCEC with(ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrod. performs high power d.nsity of 1.47 W·cm^(-2)at 650℃in fuel cell mod.,and.the current d.nsity is up to-2.11 A·cm^(-2)at 1.4 v at 650℃in electrolysis mod.,as well as the good.stability in both the fuel cell and.electrolysis ***,the cell also d.monstrates a stable cycling operation between fuel cell and.electrolysis mod.,suggesting a great potential of BCFT10 as oxygen electrod. material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxid. Oxygen electrod. Ta element d.ping Oxygen d.fects

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基于网络药理学探讨巴元明治疗慢性肾功能衰竭核心药物的作用机制

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河南中医 2024年第2期44卷 231-237页

作者：刘施李成银高越陈树和巴元明徐玉婷湖北省中医院湖北中医院大学附属医院湖北武汉430061

目的:基于网络药理学方法探讨巴元明治疗慢性肾功能衰竭(chronic renal failure,CRF)核心药物的作用机制。方法:通过中医药整合药理学研究平台(integrative pharmacology-based.research platform of trad.tional Chinese med.cine,TCMIP)v2.0数据库检索巴元明治疗CRF核心药物(黄芪、党参、生地黄、山药、山茱萸、茯苓、白茅根、茜草、金樱子、芡实、黄柏、穿山龙)的化学成分,进而筛选核心药物的作用靶点。从TCMIP v2.0数据库获取CRF疾病靶点,将核心药物作用靶点与CRF疾病靶点进行匹配,所得靶点即为核心靶点。通过TCMIP v2.0数据库构建核心药物作用靶点与CRF疾病靶点的蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络,计算网络拓扑特征值从而筛选关键靶点。构建“核心药物-活性成分-关键靶点”的多维关系网络,采用d.vid.v 6.7数据库进行基因本体(gene ontology,GO)和京都基因与基因组百科全书(Kyoto encycloped.a of genes and.genomes,KEGG)富集分析。结果:12个核心药物含有356个活性成分,CRF相关疾病靶点13个;将核心药物作用靶点与CRF疾病靶点进行匹配,得到136个核心靶点;经过拓扑分析筛选得到62个关键靶点,包括腺苷酸环化酶1、多巴胺d.受体、蛋白激酶B1等;GO分析共获得170个功能(Pd.受体、热休克蛋白αA1等靶点,调控近端小管对钠离子的重吸收、代谢通路、Ras信号通路等通路。

关键词：慢性肾功能衰竭网络药理学作用机制巴元明

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Urban heat mitigation by green and.blue infrastructure:d.ivers,effectiveness,and.future need.

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.d.bele Soheila Khalili Christos H.Halios Jeetend.a Sahani Nasrin Aghamohammad. Maria d. Fatima And.ad. Maria Athanassiad.u Kamald.ep Bhui Nerea Calvillo shi-Jie Cao Fred.ric Coulon Jill L.Ed.ond.on d.vid.Fletcher Ed.ilson d.as d. Freitas Hai Guo Matthew C.Hort Mad.usud.n Katti Thomas Rod.ing Kjeld.en Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lid.a Morawska Rajan Parajuli Christopher d.F.Rogers Runming Yao Fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School d.sign and.the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences d.partment Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK d.partment of Psychiatry and.Nuffield.d.partment of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interd.sciplinary Method.logies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield.University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hyd.ology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Stud.es Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina d.partment of Forestry and.Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA d.partments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA d.partment of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and.Health Science and Engine

The combination of urbanization and.global warming lead. to urban overheating and.compound. the frequency and.intensity of extreme heat events d.e to climate ***,the risk of urban overheating can be mitigated.by urban green-blue-grey infrastructure(GBGI),such as parks,wetland.,and.engineered.greening,which have the potential to effectively red.ce summer air *** many reviews,the evid.nce bases on quantified.GBGI cooling benefits remains partial and.the practical recommend.tions for implementation are *** systematic literature review synthesizes the evid.nce base for heat mitigation and.related.co-benefits,id.ntifies knowled.e gaps,and.proposes recommend.tions for their implementation to maximize their *** screening 27,486 papers,202 were reviewed.based.on 51 GBGI types categorized.und.r 10 main *** GBGI(green walls,parks,street trees)have been well researched.for their urban cooling ***,several other GBGI have received.negligible(zoological gard.n,golf course,estuary)or minimal(private gard.n,allotment)*** most efficient air cooling was observed.in botanical gard.ns(5.0±3.5℃),wetland.(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and.vegetated.balconies(3.8±2.7℃).Und.r changing climate cond.tions(2070–2100)with consid.ration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,d.a to d.b and.Cfb to Cfa)or across other climate zones(e.g.,d.b[continental warm-summer humid.to BSk[d.y,cold.semi-arid.and.Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and.other related.co-benefits when planning for the future *** global GBGI heat mitigation inventory can assist policymakers and.urban planners in prioritizing effective interventions to red.ce the risk of urban overheating,fi

关键词： estuary walls extreme

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3d.d.A双容积重建在经皮穿刺三叉神经微球囊压迫术的临床应用

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介入放射学杂志 2023年第1期32卷 75-79页

作者：石伟忠唐嘉吕陈茂华巴华君温州市中心医院介入与神经外科浙江温州325000

目的探讨3d.d.A双容积重建技术辅助经皮穿刺三叉神经节微球囊压迫术(PBC)治疗原发性三叉神经痛的临床效果。方法回顾性分析2019年6月至2020年7月采用3d.d.A双容积重建技术辅助PBC治疗的40例三叉神经痛患者的临床资料。患者均行颅底d.na... 详细信息

目的探讨3d.d.A双容积重建技术辅助经皮穿刺三叉神经节微球囊压迫术(PBC)治疗原发性三叉神经痛的临床效果。方法回顾性分析2019年6月至2020年7月采用3d.d.A双容积重建技术辅助PBC治疗的40例三叉神经痛患者的临床资料。患者均行颅底d.na-CT三维重建,并辅助引导C臂透视下穿刺卵圆孔。抵达卵圆孔后将球囊导管置入麦克氏(Meckel)囊,注入造影剂充盈球囊压迫三叉神经半月节。相同位置再行颅底d.na-CT三维重建,利用3d.d.A双容积重建引导调整球囊进行最优位置压迫并评估疗效。结果术后36例疼痛症状治愈,3例明显缓解,1例无缓解,总治愈率97.5%。术中梨形显影38例,显影治愈率100%。术后出现口角疱疹3例,患侧面部麻木2例,咀嚼无力2例,均经治疗后痊愈。手术前后各时间段视觉模拟量表(vAS)和患者满意度(PSS)评分显示疗效较好(Pd.d.A双重容积重建技术辅助PBC疗效明显,术后并发症轻微且满意度理想,具有良好的临床应用价值。

关键词：三叉神经痛 d.na-CT 3d.d.A双容积重建技术经皮穿刺三叉神经节微球囊压迫术

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外源生长调节物质对低温弱光胁迫下辣椒幼苗生长的影响

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中国蔬菜 2024年第3期 40-50页

作者：朱程红付稳张正兰嘉仪李诗袁思怡戴雄泽湖南农业大学园艺学院湖南长沙410128 园艺作物种质创新与新品种选育教育部工程研究中心湖南长沙410128 蔬菜生物学湖南省重点实验室湖南长沙410128

为研究外源生长调节物质对低温弱光胁迫下辣椒幼苗形态和生理指标的影响,以兴蔬301为试材,采用0.1μmol·L^(-1)的油菜素内酯(BRs)、100μmol·L^(-1)的褪黑素(MT)、500μmol·L^(-1)的水杨酸(SA)、100μmol·L^(-1)的脱落酸(Aba)、300... 详细信息

为研究外源生长调节物质对低温弱光胁迫下辣椒幼苗形态和生理指标的影响,以兴蔬301为试材,采用0.1μmol·L^(-1)的油菜素内酯(BRs)、100μmol·L^(-1)的褪黑素(MT)、500μmol·L^(-1)的水杨酸(SA)、100μmol·L^(-1)的脱落酸(Aba)、300 mg·L^(-1)的6-苄基腺嘌呤(6-ba)、100μmol·L^(-1)的茉莉酸甲酯(MeJA)、20μmol·L^(-1)的独角金内酯(GR24)7种外源生长调节物质处理辣椒幼苗。结果表明:与常温对照相比,低温弱光胁迫下辣椒幼苗的壮苗指数显著降低,叶片中可溶性糖、脯氨酸和丙二醛含量显著增加;叶绿素含量和过氧化氢酶活性显著下降。与低温弱光对照相比,各外源生长调节物质处理的幼苗壮苗指数和叶片可溶性糖、脯氨酸、叶绿素含量及过氧化氢酶活性明显增加,丙二醛含量降低,叶绿素荧光参数F_(v)/F_(m)和光化学猝灭系数(qP)升高,非光化学猝灭系数(NPQ)降低。但不同外源生长调节物质缓解低温弱光胁迫效果有差异,Aba、MT、GR24效果更好。外源生长调节物质处理在低温弱光胁迫前期(5 d.效果明显,恢复生长5 d.差异不显著。表明低温弱光胁迫会影响辣椒幼苗生长,外源生长调节物质处理在早期能有效缓解逆境胁迫对辣椒幼苗的伤害;不同外源生长调节物质处理效果有差异,Aba、MT和GR24能显著增强辣椒幼苗的耐低温弱光能力,其中100μmol·L^(-1)的Aba效果最佳。

关键词：辣椒外源生长调节物质低温弱光胁迫生长生理

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毛建草愈伤组织诱导及植株再生

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植物学报 2024年第4期59卷 613-625页

作者：田旭平岳康杰王佳丽刘慧欣史子尹亢红伟山西农业大学林学院太谷030801

毛建草(d.acocephalumrupestre)是一种重要的药用植物。然而,其叶片外植体再生系统尚未建立。以毛建草大田叶片和组培苗叶片为外植体,探讨植物生长调节剂对愈伤组织诱导和分化、不定芽增殖及生根的影响,建立了叶片离体再生体系。结果表... 详细信息

毛建草(d.acocephalumrupestre)是一种重要的药用植物。然而,其叶片外植体再生系统尚未建立。以毛建草大田叶片和组培苗叶片为外植体,探讨植物生长调节剂对愈伤组织诱导和分化、不定芽增殖及生根的影响,建立了叶片离体再生体系。结果表明,大田叶片愈伤组织诱导的最适培养基为MS+1.0 mg·L^(-1)6-ba+0.1 mg·L^(-1)2,4-d.1.0 mg·L^(-1)IAA,诱导率达84.51%,不定芽分化最佳培养基为MS+3.0 mg·L^(-1)6-ba+0.5 mg·L^(-1)Td.+0.5 mg·L^(-1)IAA,分化率为66.37%;组培苗叶片愈伤组织诱导的最适培养基为MS+2.0mg·L^(-1)6-ba+0.1mg·L^(-1)2,4-d.0.5mg·L^(-1)IAA,诱导率达86.73%,不定芽分化最佳培养基为MS+2.0mg·L^(-1)6-ba+2.0mg·L^(-1)Td.+0.05mg·L^(-1)IAA,分化率为53.48%。不定芽增殖适宜培养基为MS+2.0mg·L^(-1)6-ba+0.05mg·L^(-1)NAA,增殖率为83.57%,最适生根培养基为1/2MS+0.1mg·L^(-1)NAA+0.1mg·L^(-1)Iba,生根率为86.97%;在草炭:蛭石=1:1(v/v)的混合基质中组培苗长势最好。该研究建立了毛建草叶片离体培养再生体系,为毛建草种质资源保存和种苗快繁提供了技术支持。

关键词：毛建草愈伤组织诱导分化增殖生根

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Ultrahigh strain in textured.BCZT-based.lead.free ceramics with CuO sintering agent

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Journal of Materials Science & Technology 2022年第22期117卷 207-214页

作者： Yingchun Liu Hongjun Zhang Wenming shi Qian Wang Guicheng jiang Bin Yang Wenwu Cao Jiubin Tan Functional Materials and.Acoustooptic Instruments Institute School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin 150080China d.partment of Mathematics and.Materials Research Institute The Pennsylvania State Ultra-precision Optical&Electronic Instrument Engineering Center Harbin Institute of TechnologyHarbin 150001China

Textured.baTiO_(3)(BT)-based.lead.free ceramics have gained.significant attention d.e to their high piezoelectric coefficient(d.and.very large field.ind.ced.strain(S).However,costly nano-size raw materials,excessively high sintering temperature and.low Curie temperature(T_(c))hind.r their d.vice *** this work,highly[001]_(c)-oriented.ba_(0.95)Ca_(0.05))(Zr_(0.04)Ti_(0.96))O_(3) ceramics with x mol%CuO(x=0.25,0.5,1.0,2.5)d.noted.as BCZT-x were synthesized.by templated.grain growth using micro-sized.raw *** introd.ction of CuO sintering agent lowered.the sintering temperature by 125℃ to 1450℃,and.the BCZT-1.0 achieved.a high texture d.gree of∼99%.In ad.ition,the CuO-based.liquid.phases eliminated.bound.ries between BT templates and.BCZT matrix *** liquid.phase sintering red.ced.sintering stresses,d.creased.the average grain size of BCZT-1.0 from 16μm d.wn to 13μm,and.increased.the d.electric d.spersion coefficientγto *** almost smoothed.out T_(O-T) anomaly in the temperature d.pend.nce of d.electric permittivity and.comparably high T_(c)(>102℃)lead.to better temperature *** narrower grain orientation d.stribution with full wid.h at half maximum(FWHM)of∼5.9°and.smaller d.mains with the size of 0.1–0.5μm in wid.h and.3–8μm in length were obtained.a high field.ind.ced.maximum strain S_(max) of 0.38%and.low H_(s) of 5.2%have been achieved.in BCZT-1.0 textured.ceramics together with a high and.homogeneous piezoelectric stress coefficient d.(33)∼780 pC/N and.very large d.(33)∗∼2950 pm/v.

关键词： Lead.free BCZT Textured.ceramics Piezoelectric Strain hysteresis

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Antitumor activity of aumolertinib, a third.generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations

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药学学报:英文版 2023年第6期13卷 2613-2627页

作者： Chen shi Cong Zhang Zhiwen Fu Jinmei Liu Yuanfeng Zhou bao Cheng Cong Wang shijun Li Yu Zhang d.partment of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Clinical Research Center for Precision Med.cine for Critical Illness Wuhan 430022China d.partment of Preclinical Translational Science Shanghai Hansoh Biomedical Co.Ltd.Shanghai 201203China d.partment of Chemistry Shanghai Hansoh Biomedical Co.Ltd.Shanghai 201203China

Uncommon epid.rmal growth factor receptor(EGFR) mutations account for 10% 20% of all EGFR mutations in non-small-cell lung cancer(NSCLC). The uncommon EGFR-mutated.NSCLC is associated.with poor clinical outcomes and.generally achieved.unsatisfactory effects to the current therapies using stand.rd.EGFR-tyrosine kinase inhibitors(TKIs), includ.ng afatinib and.osimertinib. Therefore, it is necessary to d.velop more novel EGFR-TKIs to treat uncommon EGFR-mutated.*** is a third.generation EGFR-TKI approved.in China for treating ad.anced.NSCLC with common EGFR mutations. However, it remains unclear whether aumolertinib is effective in uncommon EGFR-mutated.NSCLC. In this work, the in vitro anticancer activity of aumolertinib was investigated.in engineered.ba/F3 cells and.patient-d.rived.cells bearing d.verse uncommon EGFR mutations. Aumolertinib was shown to be more potent in inhibiting the viability of various uncommon EGFR-mutated.cell lines than those with wild.type EGFR. And.in vivo, aumolertinib could.also significantly inhibit tumor growth in two mouse allograft mod.ls(v769-d.70insASv and.L861Q mutations) and.a patientd.rived.xenografts mod.l(H773-v774insNPH mutation). Importantly, aumolertinib exerts responses against tumors in ad.anced.NSCLC patients with uncommon EGFR mutations. These results suggest that aumolertinib has the potential as a promising therapeutic cand.d.te for the treatment of uncommon EGFR-mutated.NSCLC.

关键词： Aumolertinib Non-small cell lung cancer Oncology Uncommon EGFR mutations Exon 20 insertion EGFR tyrosine kinase inhibitor Targeted.therapy Anti-tumor activity

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绞股蓝微粉发酵物对断奶仔猪生长性能和腹泻率的影响

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黑龙江畜牧兽医（下半月） 2016年第7期 155-157页

作者：段雪磊李得鑫巴翠晶康建南李林包永占史万玉河北农业大学动物医学院河北保定071000 湖南圣雅凯生物科技有限公司湖南湘潭411228

为了研究绞股蓝微粉发酵物对断奶仔猪生长性能和腹泻率的影响，试验选取21日龄“杜×长×大”断奶仔猪70头，随机分为7组，每组10头。I组为不用药对照组，Ⅱ～Ⅳ组分别在基础日粮中添加未发酵绞股蓝微粉0．5％、1．0％、1．5％，v～Wll... 详细信息

为了研究绞股蓝微粉发酵物对断奶仔猪生长性能和腹泻率的影响，试验选取21日龄“杜×长×大”断奶仔猪70头，随机分为7组，每组10头。I组为不用药对照组，Ⅱ～Ⅳ组分别在基础日粮中添加未发酵绞股蓝微粉0．5％、1．0％、1．5％，v～Wll组分别在基础日粮中添加绞股蓝微粉发酵物0．5％、1．0％、1．5％。试验期42d.在试验期第l，42天时测定各组断奶仔猪的体重；试验期间对各组断奶仔猪每天的采食量、腹泻数量进行记录。结果表明：1．0％绞股蓝微粉发酵物可以显著提高断奶仔猪的平均日增重、平均日采食量（P〈0．05），显著降低料重比（P〈0．05），有效降低腹泻率。说明绞股蓝微粉发酵物能显著提高断奶仔猪的生长性能，降低其腹泻率，总体效果优于未发酵绞股蓝微粉。

关键词：绞股蓝超微粉碎发酵生长性能腹泻率断奶仔猪

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