检索结果-南通市图书馆

Paed.atric g.llstones and.laparoscopic cholecystectomy

Health 2010年第1期2卷 67-69页

作者： d. g. samuel N. N. Nag.ib A. Y. Izzid.en 不详

Introd.ction: g.ll stones d.sease is a rare oc-currence in paed.atric patients and.the d.ag.o-sis is often overlooked. Patients often present with non-specific symptoms of abd.minal pain and.the classic features of g.llstones are some-times absent [1]. The aim of our stud. is to in-crease the awareness of cholecystitis and.acute pancreatitis being.a possible occurrence in the paed.atric ag. g.oup and.should.therefore be in the d.fferential d.ag.osis of acute abd.minal pain in child.en. We und.rtook a retrospective analy- sis of all the paed.atric patients record.d.as hav- ing.had.a laparoscopic Cholecystectomy per-formed.at Prince Charles Hospital. 8 paed.atric patients und.rwent Laparoscopic cholecysteco- my between 2000 and.2008 consisting.of 5 fe-male patients and.3 male patients. The averag. ag. of the cohort was 14.1 years [12-16]. Pre- morbid.obesity was a feature in 4 patients and.all patients reported.hig. fat d.et. Abd.minal Ul- trasound.used.to assess all 8 patients who pre- sented.with acute abd.men showed.g.llstones to be present in all. 7 patients und.rwent an ele- ctive proced.re 3-6 months after the initial d.-ag.osis was mad. and.1 patient had.laparosco- pic Cholecystectomy within 72 hours of initial presentation. 1 patient was found.to have an in- herited.haematolog.cal d.sord.r and.2 of the pa- tients were sisters with a family history of g.ll- stone d.sease. 2 patients presented.with acute pancreatitis. g.llstone related.cholecystitis is a rare occurrence among.t paed.atric patients and.is often overlooked.as a d.fferential d.ag.osis. We report 8 patients over an 8 year period. Con- clusion: It is important that clinicians includ. cholecystitis and.biliary colic in the d.fferential d.ag.osis of patients presenting.with acute ab-d.men in child.ood.not explained.by other d.-ag.oses. Laparoscopic Cholecystectomy is the treatment of choice and.has minimal complica-tions.

关键词： g.llstones Cholecystitis Paed.atrics Laparoscopic Cholecystecomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

Neural Reg.neration Research 2025年第2期20卷 366-377页

作者： samuel Abokyi d.nnis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and.Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal ag.ng.has been recog.ized.as a sig.ificant risk factor for various retinal d.sord.rs,includ.ng.d.abetic retinopathy,ag.-related.macular d.g.neration,and.g.aucoma,following.a g.owing.und.rstand.ng.of the molecular und.rpinning. of their *** comprehensive review explores the mechanisms of retinal ag.ng.and.investig.tes potential neuroprotective approaches,focusing.on the activation of transcription factor *** meta-analyses have d.monstrated.promising.outcomes of transcription factor EB-targ.ted.strateg.es,such as exercise,calorie restriction,rapamycin,and.metformin,in patients and.animal mod.ls of these common retinal *** review critically assesses the role of transcription factor EB in retinal biolog. d.ring.ag.ng.its neuroprotective effects,and.its therapeutic potential for retinal *** impact of transcription factor EB on retinal ag.ng.is cell-specific,influencing.metabolic reprog.amming.and.energ. homeostasis in retinal neurons throug. the reg.lation of mitochond.ial quality control and.nutrient-sensing.*** vascular end.thelial cells,transcription factor EB controls important processes,includ.ng.end.thelial cell proliferation,end.thelial tube formation,and.nitric oxid. levels,thereby influencing.the inner blood.retinal barrier,ang.og.nesis,and.retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting.vascular calcification and.*** retinal pig.ent epithelial cells,transcription factor EB mod.lates functions such as autophag.,lysosomal d.namics,and.clearance of the ag.ng.pig.ent lipofuscin,thereby promoting.photoreceptor survival and.reg.lating.vascular end.thelial g.owth factor A expression involved.in *** cell-specific functions of transcription factor EB sig.ificantly impact retinal ag.ng.mechanisms encompassing.proteostasis,neuronal synapse plasticity,energ. metabolism,microvasculature,and.inflammation,ultimately offering.pro

关键词： ag.-related.macular d.g.neration anti-ag.ng.interventions autophag. calorie restriction d.abetic retinopathy exercise g.aucoma neuromod.lation phag.cytosis photoreceptor outer seg.ent d.g.ad.tion retinal ag.ng transcription factor EB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermod.namic analysis for a third.g.ad. fluid.throug. a vertical channel with internal heat g.neration

引用

Journal of Hyd.od.namics 2015年第2期27卷 264-272页

作者： Ad.SANYA samuel O. MAKINd. Oluwole d. d.partment of Mathematical Sciences Redeemer's University Faculty of Military Science Stellenbosch University

This paper makes the thermod.namic analysis in forced.convective flow of a third.g.ad. fluid.throug. a vertical channel. d.e to the reactive nature of the fluid. the effect of internal heat g.neration is consid.red.and.assumed.to be a linear function of temperature. The coupled.nonlinear d.mensionless ord.nary d.fferential equations g.verning.the fluid.flow are solved.by using.the Ad.mian d.composition method.Ad.）. The effects of various physical parameters such as third.g.ad. material parameter, buoyancy parameter and.heat g.neration parameter on the thermal structure of flow are presented.and.d.scussed.

关键词： energ. conservation vertical channel third.g.ad. fluid internal heat g.neration Ad.mian d.composition method.Ad.)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The sexually d.morphic expression of g.utamate transporters and.their implication in pain after spinal cord.injury

引用

Neural Reg.neration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercad. Aranza I.Torrad.-Tapias Iris K.Salg.d. Jose M.Santiag. samuel E.Ocasio Rivera d.na P.Bracho-Rincon Luis H.Pag.n Rivera Jorg. d.Mirand. d.partment of Physiolog. University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universid.d.Central d.l Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiolog. San JuanPRUSA

In ad.ition to the loss of motor function,~60% of patients d.velop pain after spinal cord.*** cellular-molecular mechanisms are not well und.rstood.but the d.ta sug.ests that plasticity within the rostral,epicenter,and.caud.l penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring.mechanism lead.ng.to central neuropathic *** can lead.to the formation of new connections trig.ering.abnormal sensory *** excitatory g.utamate transporters are responsible for the reuptake of extracellular g.utamate which makes them a critical targ.t to prevent neuronal hyperexcitability and.*** previous stud.es showed.a sexually d.morphic therapeutic wind.w for spinal cord.injury after treatment with the selective estrog.n receptor mod.lator *** this stud.,we investig.ted.the anti-allod.nic effects of tamoxifen in male and.female rats with spinal cord.*** hypothesized.that tamoxifen exerts anti-allod.nic effects by increasing.the expression of g.utamate transporters,lead.ng.to red.ced.hyperexcitability of the second.ry neuron or by d.creasing.aberrant *** and.female rats received.a mod.rate contusion to the thoracic spinal cord.followed.by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used.von Frey monofilaments and.the“up-d.wn method.to evaluate mechanical *** treatment d.creased.allod.nia only in female rats with spinal cord.injury revealing.a sexd.pend.nt *** expression profile of g.utamaterg.c transporters(excitatory amino acid.transporter 1/g.utamate aspartate transporter and.excitatory amino acid.transporter 2/g.utamate transporter-1)revealed.a sexual d.morphism in the rostral,epicenter,and.caud.l areas of the spinal cord.with a pattern of expression primarily on *** rod.nts showed.a sig.ificantly hig.er level of excitatory amino acid.transporter-1 expression while male rod.nts showed.increased

关键词： allod.nia central neuropathic pain EAAT-1/g.AST EAAT-2/g.T-1 g.utamate transporters selective estrog.n receptor mod.lator sexual d.morphism spinal cord.injury trauma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

g.Alg.bra Structure on the Hig.er Ord.r Hochschild.Cohomolog. H*_(S)^(2)(A,A)

引用

Alg.bra Colloquium 2022年第1期29卷 113-124页

作者： samuel Carolus Mihai d.Staic d.partment of Mathematics and.Statistics Ohio Northern University AdaOH 45810USA d.partment of Mathematics and.Statistics Bowling Green State University Bowling GreenOH 43403USA Institute of Mathematics of the Romanian Acad.my PO.BOX 1-764 RO-70700 BucharestRomania

We present a d.formation theory associated.to the hig.er Hochschild.coho-molog. H*_(S)^(2)(A,A).We also stud. a g.alg.bra structure associated.to this d.formation theory.

关键词： hig.er Hochschild.cohomolog. operad g.alg.bra

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

One ring.is sufficient to inhibit α-synuclein ag.reg.tion

引用

Neural Reg.neration Research 2022年第3期17卷 508-511页

作者： samuel Peña-d.az Salvad.r Ventura Institut d. Biotecnolog.a i Biomed.cina Universitat Autònoma de BarcelonaBellaterraSpain d.partament d. Bioquímica i Biolog.a Molecular Universitat Autònoma de BarcelonaBellaterraSpain InstitucióCatalana d. Recerca i Estud.s Avançats(ICREA) BarcelonaSpain

Parkinson's d.sease,the second.most prevalent neurod.g.nerative d.sord.r world.id.,is characterized.by a prog.essive loss of d.paminerg.c neurons in substantia nig.a pars compacta,causing.motor *** d.sord.r's main hallmark is the formation of intraneuronal protein inclusions,named.Lewy bod.es and.*** major component of these arrang.ments is α-synuclein,an intrinsically d.sord.red.and.soluble protein that,in patholog.cal cond.tions,can form toxic and.cell-to-cell transmissible amyloid.*** α-synuclein ag.reg.tion has attracted.sig.ificant effort in the search for a d.sease-mod.fying.therapy for Parkinson's *** molecules like Synu Clean-d.epig.llocatechin g.llate,trod.squemine,or anle138 b exemplify this therapeutic ***,we d.scribe a subset of compound. containing.a sing.e aromatic ring.like d.pamine,ZPd.,g.llic acid.or entacapone,which act as molecular chaperones ag.inst α-synuclein *** simplicity of their structures contrasts with the complexity of the ag.reg.tion process,yet the block efficiently α-synuclein assembly into amyloid.fibrils,in many cases,red.recting.the reaction toward. the formation of non-toxic off-pathway ***,some of these compound. can d.sentang.e mature α-synuclein amyloid.*** simple structures allow structure-activity relationship analysis to elucid.te the role of d.fferent functional g.oups in the inhibition of α-synuclein ag.reg.tion and.fibril d.smantling.making.them informative lead.scaffold. for the rational d.velopment of efficient d.ug..

关键词： amyloid aromatic ring. d.pamine inhibition neurod.g.neration olig.mers Parkinson's d.sease protein ag.reg.tion α-synuclein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

End.tid.l capnometry d.ring.emerg.ncy d.partment proced.ral sed.tion and.analg.sia： a rand.mized. controlled.stud.

引用

World.Journal of Emerg.ncy Med.cine 2016年第1期7卷 13-18页

作者： samuel g. Campbell Kirk d. Mag.e Peter J. Zed.Patrick Froese g.enn Etsell Alan LaPierre d.nna Warren Robert R. MacKinley Michael B. Butler g.org. Kovacs d.vid.A. Petrie d.partment of Emerg.ncy Med.cine and.Anesthesia Dalhousie University Halifax Nova Scotia Canada Faculty of Pharmaceutical Sciences and.d.partment of Emerg.ncy Med.cine University of British Columbia Vancouver BC Canada Charles V. Keating.Emerg.ncy and.Trauma Centre Halifax Nova Scotia Canada d.partment of Emerg.ncy Med.cine Anesthesia and Anatomy Dalhousie University Halifax Nova Scotia Canada

BACKg.OUNd.This prospective,rand.mized.trial was und.rtaken to evaluate the utility of ad.ing.end.tid.l capnometry(ETC)to pulse oximetry(PO)in patients und.rg.ing.proced.ral sed.tion and.analg.sia(PSA)in the emerg.ncy d.partment(Ed..METHOd.:The patients were rand.mized.to monitoring.with or without ETC in ad.ition to the current stand.rd.of *** end.oints includ.d.respiratory ad.erse events,with second.ry end.oints of level of sed.tion,hypotension,other PSA-related.ad.erse events and.patient ***:Of 986 patients,501 were rand.mized.to usual care and.485 to ad.itional ETC *** this series,48%of the patients were female,with a mean ag. of 46 *** manipulations(71%),card.oversion(12%)and.abscess incision and.d.ainag.(12%)were the most common proced.res,and.propofol and.fentanyl were the sed.tive/analg.sic combination used.for most *** was no d.fference in patients experiencing.d.-saturation(Sa O2g.oups;however,patients in the ETC g.oup were more likely to require airway repositioning.12.9%vs.9.3%,P=0.003).Hypotension(SBPg.org.if baselineg.was observed.in 16(3.3%)patients in the ETC g.oup and.7(1.4%)in the control g.oup(P=0.048).CONCLUSIONS:The ad.ition of ETC d.es not appear to chang. any clinically sig.ificant *** found.an increased.incid.nce of the use of airway repositioning.maneuvers and.hypotension in cases where ETC was *** d. not believe that ETC should.be recommend.d.as a stand.rd.of care for the monitoring.of patients und.rg.ing.PSA.

关键词： Proced.ral sed.tion and.analg.sia Capnog.aphy Ad.erse events Emerg.ncy med.cine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimizing.biliary outcomes in living.d.nor liver transplantation:Evolution toward. stand.rd.zation in a hig.-volume center

引用

Hepatobiliary & Pancreatic d.seases International 2020年第4期19卷 324-327页

作者： Tsan-Shiun Lin Jeffrey samuel Co Chao-Long.Chen Ald.in d.Ong Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial Hospital123 Ta-Pei RoadNiao SungKaohsiung 833TaiwanChina

Biliary complications have always been a d.ead.d.cause of morbid.ty after living.d.nor liver *** intrinsic variations in both g.aft and.recipient biliary anatomy remain a sig.ificant factor to the d.fficulty of biliary reconstruction,our institution has taken ad.antag. of its hig. volume of cases to critically review and.evaluate mod.fiable operative risk factors,in particular,our surg.cal *** present herein,the evolution of our reconstructive biliary technique from conventional method. to our current stand.rd.of microsurg.cal biliary reconstruction for both g.aft and.recipient *** this period.of transition,our center has created.a classification system for biliary reconstruction that d.creased.the biliary complication rates from 40.0%to 10.2%.

关键词： Living.d.nor liver transplantation Biliary reconstruction Microsurg.cal biliary reconstruction Biliary classification Biliary complications

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neurotrophic frag.ents as therapeutic alternatives to ameliorate brain ag.ng

引用

Neural Reg.neration Research 2023年第1期18卷 51-56页

作者： Itzel Ortiz Flores samuel Treviño Alfonso d.az d.partment of Health Sciences School of MedicineUniversity of the Americas PueblaPueblaMexico Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico

Ag.ng.is a g.obal phenomenon and.a complex biolog.cal process of all living.being. that introd.ces various *** this physiolog.cal process,the brain is the most affected.org.n d.e to chang.s in its structural and.chemical functions,such as chang.s in plasticity and.d.crease in the number,d.ameter,leng.h,and.branching.of d.nd.ites and.d.nd.itic ***,it presents a g.eat red.ction in volume resulting.from the contraction of the g.ay ***,ag.ng.can affect not only cog.itive functions,includ.ng.learning.and.memory,but also the quality of life of old.r *** a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed.which provid. a therapeutic alternative for people und.r cond.tions of ag.ng.or some neurod.g.nerative *** is important to ind.cate that in recent years the use of molecules with neurotrophic activity has shown interesting.results when evaluated.in in vivo *** review aims to d.scribe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihyd.oxystilbene),neurotrophins(brain-d.rived.neurotrophic factor),and.neurotrophic-type compound. such as the terminal carboxyl d.main of the heavy chain of tetanus toxin,cerebrolysin,neuropeptid.-12,and.*** of these molecules have been evaluated.by our research *** sug.est that these molecules exert an important therapeutic potential,restoring.brain function in ag.ng.cond.tions or mod.ls of neurod.g.nerative ***,our interest is in d.scribing.the current scientific evid.nce that supports the therapeutic potential of these molecules with active neurotrophic.

关键词： Alzheimer’s d.sease brain cerebral cortex cog.itive function d.nd.itic spines HC-TeTx hippocampus neurod.g.neration neuronal survival neurotrophins

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Small molecules to prevent the neurod.g.neration caused.by α-synuclein ag.reg.tion

引用

Neural Reg.neration Research 2020年第12期15卷 2260-2261页

作者： samuel Pena-d.az Jord. Pujols Salvad.r Ventura Institut d. Biotecnolog.a i Biomed.cina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

Parkinson’s d.sease (Pd. is a neurod.g.nerative d.sord.r belong.ng.to a g.oup of human patholog.es known as synucleinopathies,which includ.s multiple system atrophy or d.mentia with Lewy bod.es (Spillantini et al.,1998).These d.seases share a common neuropatholog.cal feature,the presence ofα-synuclein (α-Syn) d.posits,althoug. they d.ffer in the cellular and.anatomical compartment in whichα-Syn inclusions *** affects more than 1% of people over 60 years of ag.,thus being.the second.most prevalent neurod.g.nerative d.sease in the world.and.the most common synucleinopathy.

关键词： al. d.seases atrophy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：