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distant metastasis of hepatocellular carcinoma to Meckel’s cave and cranial nerves:A case report and review of literature

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World Journal of Hepatology 2021年第6期13卷 709-716页

作者： Soo Ki Kim Takako Fujii Ryouhei Komaki Hisato kobayashi Toyokazu Okuda Yumi Fujii Takanobu Hayakumo Kanako Yuasa Masahiro Takami Aya Ohtani Yuka Saijo Yu-Ichiro Koma Soo Ryang Kim department of Gastroenterology Kobe Asahi HospitalKobe 653-0801HyogoJapan division of Neurology Kobe University Graduate School of MedicineKobe 650-0017HyogoJapan department of Radiology Kobe Asahi HospitalKobe 653-0801HyogoJapan department of Pharmacy Kobe Asahi HospitalKobe 653-0801HyogoJapan department of Pathology Kobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUNd Metastasis occurs as a late event in the natural history of hepatocellular carcinoma(HCC),and most patients die of liver failure attributed to the tumor supplanting the ***,the brain is a less common metastatic *** SUMMARY We describe a rare case of hepatitis C virus-related multiple HCC metastasizing to the cavernous sinus,Meckel’s cave,and the petrous bone involving multiple cranial nerves in an 82-year-old *** admission imaging studies including Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging(MRI)revealed multiple HCC nodules in both right and left *** guided biopsy of the left lobe revealed moderately differentiated *** targeted therapy with Lenvatinib(8 mg/d for 94 d,per os)and Ramucirumab(340 mg/d and 320 mg/d,two times by intravenous injection)were administered for 4 mo,resulting in progression of the *** months after the start of molecular target therapy,the patient presented with symptoms of hyperalgesia of the right face and limited abduction of the right eye,indicating disturbances in the right trigeminal and abducens *** MRI disclosed a mass involving the cavernous sinus,Meckel’s cave and the petrous ***-enhanced MRI with gadolinium-chelated contrast medium revealed a well-defined mass with abnormal enhancement around the right cavernous sinus and the right Meckel’s *** The diagnosis of metastatic HCC to the cavernous sinus,Meckel’s cave,and the petrous bone was made based on neurological findings and imaging studies including MRI,but not on histological *** studies may provide insights into various methods for diagnosing HCC metastasizing to the craniospinal area.

关键词： Meckel’s cave Abducens nerve Trigeminal nerve Hepatocellular carcinoma Magnetic resonance imaging Case report

Antimicrobial Oil-in-Water Nanoemulsions： Synergistic Effect of Nisin and Carvacrol against Bacillus subtilis

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Journal of Food Science and Engineering 2016年第2期6卷 63-74页

作者： Marcos Antonio Neves Porsry Ung Kunihiko Uemura Chieko Takahashi Isao kobayashi Patrizia Romano Mitsutoshi Nakajima Graduate School of Life and Environmental Sciences Alliance for Research on North Africa University of Tsukuba 1-1-1Tennodai Tsukuba lbaraki 305-8572 Japan Food Engineering division National Food Research Institute NARO 2-1-12 Kannondai Tsukuba lbaraki 305-8642 Japan International Master EdAMUS - Sustainable Management of Food Quality Univ. of Montpellier 15 Av. Charles Flahault B.P.14491 34093 Montpellier France School of Agricultural Forest Food and Environmental Sciences (SAFE) University of Basilicata Via Ateneo Lucano 10 85104 IPotenza ltaly

The aim of this study was to elucidate the mode of action of two antimicrobial compounds, nisin, which is hydrophilic, and the lipophilic compound carvacrol. For that purpose, both antimicrobials were loaded into Oil-in-/Water nanoemulsions, and their antimicrobial activity against Bacillus subtilis was investigated. The experimental results indicated that the O/W nanoemulsions loaded with both, nisin and carvacrol, having Sauter mean diameter （d3,2） of around 120 nm, were considerably stable under the conditions investigated （up to 1 week storage at room temperature）. The interfacial tension between nisin aqueous solutions and soybean oil could be reduced up to 12 mN/m, as compared to that of pure water and soybean oil （21 mN/m）, so that demonstrating the potential of nisin to be used as emulsifier. The results obtained for O/W nanoemulsions loaded with both antimicrobial compounds indicated a reduction of nearly two log cycles （around 100 times） on B. subtilis population upon incubation for 24 h, compared to the blank （10 mM phosphate buffer）.

关键词： Antimicrobial nanoemulsion nisin carvacrol synergy Bacillus spp.

dNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain

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World Journal of Biological Chemistry 2015年第4期6卷 389-408页

作者： Yuka kobayashi Sofya P Kulikova Junko Shibato Randeep Rakwal Hiroyuki Satoh didier Pinault Yoshinori Masuo department of Biomolecular Science Faculty of ScienceToho University Health Technology Research Center National Institute of Advanced Industrial Science and Technology INSERM U1114 Neuro-psychologie Cognitive et Physiopathologie de la SchizophrénieFMTS (Fédération de Médecine Translationnelle de Strasbourg)Faculté de MédecineUniversité de Strasbourg department of Anatomy School of MedicineShowa University Laboratory of Exercise Biochemistry and Neuroendrocrinology Institute of Health and Sport SciencesUniversity of Tsukuba Global Research Center for Innovative Life Science Peptide Drug InnovationSchool of Pharmacy and Pharmaceutical SciencesHoshi University Organization for Educational Initiatives University of Tsukuba Faculty of Health and Sport Sciences and Tsukuba International Academy for Sport Studies University of Tsukuba Laboratory of Neuroscience Department of BiologyFaculty of ScienceToho University

AIM:To investigate the impact of MK-801 on gene expression patterns genome wide in rat brain regions. METHOdS:Rats were treated with an intraperitoneal injection of MK-801 [0.08(low-dose) and 0.16(highdose) mg/kg] or NaC l(vehicle control). In a first series of experiment,the frontoparietal electrocorticogram was recorded 15 min before and 60 min after injection. In a second series of experiments,the whole brain of each animal was rapidly removed at 40 min post-injection,and different regions were separated:amygdala,cerebral cortex,hippocampus,hypothalamus,midbrain and ventral striatum on ice followed by dNA microarray(4 × 44 K whole rat genome chip) ***:Spectral analysis revealed that a single systemic injection of MK-801 significantly and selectively augmented the power of baseline gamma frequency(30-80 Hz) oscillations in the frontoparietal electroencephalogram. dNA microarray analysis showed the largest number(up- and down- regulations) of gene expressions in the cerebral cortex(378),midbrain(376),hippocampus(375),ventral striatum(353),amygdala(301),and hypothalamus(201) under low-dose(0.08 mg/kg) of MK-801. Under high-dose(0.16 mg/kg),ventral striatum(811) showed the largest number of gene expression changes. Gene expression changes were functionally categorized to reveal expression of genes and function varies with each brain ***:Acute MK-801 treatment increases synchrony of baseline gamma oscillations,and causes very early changes in gene expressions in six individual rat brain regions,a first report.

关键词： dizocilpine dye-swap Gene expression Microarray MK

Edge and Core Impurity Transport Study With Spectroscopic Instruments in LHd

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Plasma Science and Technology 2009年第4期11卷 402-408页

作者： Shigeru MORITA Motoshi GOTO Masahiro kobayashi Sadatsugu MUTO Malay Bikas CHOWdHURI 董春凤周航宇崔正英 Keisuke FUJII Akihiro FURUZAWA Masahiro HASUO AtsushiI WAMAE 揭银先 Mohammed KOUBITI Ikuya SAKURAI Yuzuru TAWARA 万宝年吴振伟 Naohiro YAMAGUCHI National Institute for Fusion Science department of Fusion Science Graduate University for Advanced Studies Southwestern Institute of Physics department of Engineering Physics Kyoto University EcoTopia Science Institute Nagoya University Institute of Plasma Physics Chinese Academy of Sciences PIIM University of Province Physics Laboratory Graduate School of Medicine and Pharmaceutical SciencesUniversity of Toyama

Impurity transport was investigated at both edge and core regions in large helical de- vice （LHd） with developed spectroscopic instruments which can measure one- and two-dimensional distributions of impurities. The edge impurity behavior was studied recently using four carbon resonant transitions in different ionization stages of CIII （977A）, CIV （1548A）, CV （40.3A） and CVI （33.7A）. When the line-averaged electron density, ne, is increased from 1 to 6 × 10^13 cm-3, the ratio of （CIII^CIV）/ne increases while the ratio of （CV＋CVI）/ne decreases. Here, CIII^CIV （CV＋CVI） expresses the sum of CIII （CV） and CIV （CVI） intensities. The CIII＋CIV indicates the carbon influx and the CV＋CVI indicates the emissions through the transport in the ergodic layer. The result thus gives experimental evidence on the impurity screening by the ergodic layer in LHd, which is also supported by a three-dimensional edge particle simulation. The core impu- rity behavior is also studied in high-density discharges （ne 〈 1 × 10^15 cm 3） with multi H2-pellets injection. It is found that the ratio of V/d （V： convection velocity, d： diffusion coefficient） decreases after pellet injection and Zeff profile shows a flat one at values of 1.1,-1.2. These results confirm no impurity accumulation occurs in high-density discharges. As a result, the iron density, rife, is analyzed to be 6 × 10^-7（=- nFe/ne） of which the amount can be negligible as radiation source even in such high-density discharges. One- and two-dimensional impurity distributions from space-resolved VUV and EUV spectrometers newly developed for further impurity transport study are also presented with their preliminary results.

关键词： impurity transport screening effect VUV spectroscopy

Clinical and computed tomography findings of appendiceal diverticulitis vs acute appendicitis

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世界胃肠病学杂志：英文版 2015年第13期21卷 3921-3927页

作者： daisuke Ito Kenji Miki Shimizu Seiichiro Shojiro Hata Kaoru kobayashi Masanori Teruya Michio Kaminishi department of Gastro- intestinal Surgery Showa General HospitalTokyo 187--8510Japan department of Pathology Showa General HospitalTokyo 187-8510Japan

AIM: To study the clinical features and computed tomography(CT) findings of appendiceal diverticulitis vs acute ***: We retrospectively reviewed the records of 451 patients who had undergone appendectomy inour in stitution from January 2007 to September 2012. Patient demographics, clinical features, pathological findings, and surgical outcomes were analyzed. We also compared preoperative CT images of 25 patients with appendiceal diverticulitis with those of 25 patients with acute ***: Among 451 patients, 44(9.7%) were diagnosed to have appendiceal diverticulitis and 398(86.9%) to have acute appendicitis. Patients with appendiceal diverticulitis were older(59 vs 37 years, P d had a longer duration of the illness(4.0 d vs 1.0 d, P diceal diverticulitis were higher(68% vs 27%, P dix could be visualized in only 13 patients(52%) among the appendiceal diverticulitis cases, but in all acute appendicitis cases. CT findings suggestive of appendiceal diverticulitis included the absence of fluid collection in the appendix(84% vs 12%, P dicolith(92% vs 52%, P = 0.005), and formation of abscess(68% vs 16%, P diceal diverticula were identified in 6 patients(24%).CONCLUSION: Among patients who had undergone appendectomy, 9.7% had appendiceal diverticulitis. Patients with appendiceal diverticulitis had different clinical features and CT findings from patients with acute appendicitis.

关键词： Appendiceal diverticulitis Acute appendicitis Comp

FACE条件下大气O_3浓度增高对小麦花后剑叶显微结构的影响

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应用生态学报 2012年第6期23卷 1613-1619页

作者：朱新开高春艳张如标李春燕郭文善朱建国 Kazuhiko kobayashi 扬州大学江苏省作物遗传生理重点实验室江苏扬州225009 中国科学院南京土壤研究所南京210013 东京大学农学院

2008—2009年,应用FACE研究平台,采用烟农19、扬麦16、嘉兴002和扬辐麦2号4个小麦品种,以O3自然浓度为对照,研究了大气O3浓度增高50%对不同基因型小麦剑叶显微结构、叶绿素含量和粒重的影响.结果表明:在开花期,大气O3浓度增高对小麦产... 详细信息

2008—2009年,应用FACE研究平台,采用烟农19、扬麦16、嘉兴002和扬辐麦2号4个小麦品种,以O3自然浓度为对照,研究了大气O3浓度增高50%对不同基因型小麦剑叶显微结构、叶绿素含量和粒重的影响.结果表明:在开花期,大气O3浓度增高对小麦产生轻微伤害,剑叶的叶肉细胞和叶绿体结构开始遭到破坏,基粒片层断裂并且开始松散;花后21d,与对照的叶片微结构差异显著增大,剑叶内膜系统基本解体,叶绿体基本解散,基粒片层消失,加速了剑叶的衰老进程,剑叶的叶绿素含量、净光合速率和成熟期粒重均低于对照.小麦剑叶微结构和光合功能对大气O3浓度增高的响应存在明显的基因型差异,嘉兴002对O3胁迫的耐受性较好,而扬辐麦2号对O胁迫的反应较敏感.

关键词：小麦 FACE 剑叶显微结构光合功能粒重

Early effects of oral administration of omeprazole and roxatidine on intragastric pH

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 29-34页

作者： Hiroshi IIdA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENdO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEdA Tomoko KOIdE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi kobayashi Kensuke KUBOTA Eiji GOTOH Shin MAEdA Atsushi NAKAJIMA Masahiko INAMORI Gastroenterology division Yokohama City University School of Medicine department of Medical Education Yokohama City University School of Medicine Office of Postgraduate Medical Education Yokohama City University Hospital

Objective： The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress- related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg. Methods： Ten Heficobacterpylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral admini- stration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period. Results： during the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole （median： 4.45 vs. 2.65; P=0.0367）. Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg （median： 90.6% vs. 55.2%, P=-0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively）. Conclusions： In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.

关键词： Proton pump inhibitor H2-receptor antagonist Intragastric pH Omeprazole Roxatidine

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浮法玻璃窑炉的全氧燃烧技术

建筑玻璃与工业玻璃 2008年第5期28卷 6-11页

作者： William T．kobayashi 袁钧卢 James Yuan Jorge Visus Jacques Schyns Antonio d’Ettorre Abilio Tasca Praxair Inc Tonawanda纽约州美国普莱克斯（中国）投资有限公司上海 Praxair Espana．S L．Marid西班牙 Praxair N．V． Olen比利时 Rivoira S．p．A． Truin意大利 White Martins Gases Industries Ltda．圣保罗巴西

在过去的几年中，浮法玻璃熔窑用氧的例子一直在不断地增加，其目的一是利用全氧燃烧助熔燃烧器来提高玻璃液出料量，二是利用喷射氧或富氧以维持蓄热室的操作来延长窑炉的寿命。全氧燃烧助熔可以使600吨／天的高质量浮法玻璃窑炉提高... 详细信息

在过去的几年中，浮法玻璃熔窑用氧的例子一直在不断地增加，其目的一是利用全氧燃烧助熔燃烧器来提高玻璃液出料量，二是利用喷射氧或富氧以维持蓄热室的操作来延长窑炉的寿命。全氧燃烧助熔可以使600吨／天的高质量浮法玻璃窑炉提高玻璃液出料量约7％，单位能耗降低4％，并提高熔化得率，后者是由于窑炉墙温能得到更好控制的缘故。蓄热室喷射氧近来已成功地被用来缩短火焰长度，以及为有格子砖堵塞的蓄热室提供恰当数量的氧。射氧技术可以使窑炉在合适的燃烧率分布下操作，降低燃料消耗量和提高熔化得率。本文阐述了近年来在浮法玻璃窑炉上实施全氧燃烧助熔以及射氧的一些结果。

关键词：全氧燃烧技术浮法玻璃熔窑玻璃窑炉燃料消耗量蓄热室能耗降低火焰长度出料量

Impact of fecal occult blood on obscure gastrointestinal bleeding:Observational study

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World Journal of Gastroenterology 2015年第1期21卷 326-332页

作者： Yuka kobayashi Hirotsugu Watabe Atsuo Yamada Hirobumi Suzuki Yoshihiro Hirata Yutaka Yamaji Haruhiko Yoshida Kazuhiko Koike department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

AIM: To elucidate the association between small bowel diseases(SBds) and positive fecal occult blood test(FOBT) in patients with obscure gastrointestinal bleeding(OGIB).METHOdS: Between February 2008 and August 2013, 202 patients with OGIB who performed both capsule endoscopy(CE) and FOBT were enrolled(mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleeding, 106 with occult bleeding). All patients underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on FOBT results. The prevalence of SBds was compared between patients with positive and negative ***: CE revealed SBds in 72 patients(36%). FOBT was positive in 100 patients(50%) and negative in 102(50%). The prevalence of SBds was significantly higher in patients with positive FOBT than those with negative FOBT(46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBds was higher in positive FOBT group than negative FOBT group(45% vs 18%, P = 0.002). On the other hand, among patients with previous overt OGIB, there was no significant difference in the prevalence of SBds between positive and negative FOBT group(47% vs 33%, P = 0.18). In disease specific analysis among patients with occult OGIB, the prevalence of ulcer and tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a predictive factors of SBds in patients with OGIB(OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evidentam on g patients with occult OGIB who underwent FOBT on the same day or a day before CE. The prevalence of SBds in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who underwent FOBT on the same day or the day before CE(P = 0.001), while there was no significant difference between positive and negative FOBT group in those who underwent FOBT two or more d

关键词： Capsule endoscopy Fecal occult blood test Obscure