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国际医学放射学杂志 1981年第5期 278-285页

作者： Gelfand d.W. ,dtt d.j ,Hunt TH ,刘连祥

胃肠道的钡剂检查是放射科医生最常进行的一种造影检查。硫酸钡的惰性以及它的不溶性混悬液的应用,使胃肠道造影检查为X 线造影检查的最安全的方法。虽然胃肠道钡剂检查的合并症也有过报告,但发生率还是非常低的。

关键词：合并症并发症胃肠道出血胆影葡胺口服胆囊造影胆管造影造影剂 X光乳剂胆管梗阻胆管疾病钡剂检查

Liquid-liquid extraction and separation of total rare earth(RE) metals from polymetallic manganese nodule leaching solution

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journal of Rare Earths 2015年第2期33卷 207-213页

作者： P.K.Parhi K.H.Park C.W.Nam j.T.Park Mineral Resources Research division Korea Institute of Geoscience & Mineral Resources (KIGAM)Daejeon 305-350 Republic of Korea School of Applied Science and Center of Industrial Technology KIIT UniversityBhubaneswar 751024 Odisha India

The study on the solvent extraction for quantitative and selective separation of total rare earth metals from the polymetallic nodule leach liquor was investigated. The typical leach liquor bearing 0. 094 g/L total rare earth, 0. 23 g/L Mn, 0.697 g/L Cu, 0.2 g/L Fe, 0.01 g/L Co and 0.735 g/L Ni was subjected to the removal iron content by precipitation method using Ca（OH）2 at pH 3.95, prior to solvent extraction of rare earth metals. Three different organo-phosphoric acid reagents（d2EHPA, PC88 A, Cyanex 272） were used to ascertain their performances and selectivity towards the loading of rare earth metals in presence of other base metals. Based on the results of eq. pH effect, the performances of above three extractants followed the order as： d2EHPA〉PC88A〉Cyanex 272. To ensure the absence of extraction of base metals（Cu, Co, Ni）, the eq. pH of the solution was optimized at the level of 2.21, though higher rare earth metal extraction efficiency was observed at higher eq. pH with either of the extractants. The complete process flow diagram for substantial recovery of total rare earth was developed using d2 EHPA. Extraction isotherm plot was constructed at A：O=12：1, 3-stages and pHe=2.21, using 0.8 mol/L d2 EHPA and the predicted condition of this study was further confirmed by 6-Cycles Counter Current Simulation（CCS） study. The stripping of total rare earth from loaded organic phase（LO） was conducted using HCl solution. Mc-Cabe Thiele diagram study carried out at A：O=1：5 using 4 mol/L HCl showed that three theoretical stages were needed for quantitative stripping of total rare earth. The subsequent stripped solution resulted thus led to contain total rare earth of 5.6 g/L indicating a very high enrichment of total metals by solvent extraction（SX） process.

关键词： total rare earth (RE) metals SX d2EHPA HCl deep sea nodule

Immunoprofiling of drosophila Hemocytes by Single-cell Mass Cytometry

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 243-252页

作者： jozsef A.Balog Viktor Honti Eva Kurucz Beata Kari Laszlo G.Puskas Istvan Ando Gabor j.Szebeni Laboratory of Functional Genomics Institute of GeneticsBiological Research CentreSzeged H-6726Hungary University of Szeged Ph.D.School in BiologySzeged H-6726Hungary Immunology Unit Institute of GeneticsBiological Research CentreSzeged H-6726Hungary department of Physiology Anatomy and NeuroscienceFaculty of Science and InformaticsUniversity of SzegedSzeged H-6726Hungary

Single-cell mass cytometry(SCMC)combines features of traditional flow cytometry(i.e.,fluorescence-activated cell sorting)with mass spectrometry,making it possible to measure several parameters at the single-cell level for a complex analysis of biological regulatory *** this study,we optimized SCMC to analyze hemocytes of the drosophila innate immune *** used metal-conjugated antibodies(against cell surface antigens H2,H3,H18,L1,L4,and P1,and intracellular antigens 3A5 and L2)and anti-IgM(against cell surface antigen L6)to detect the levels of antigens,while anti-GFP was used to detect crystal cells in the immune-induced *** investigated the antigen expression profile of single cells and hemocyte populations in naive states,in immune-induced states,in tumorous mutants bearing a driver mutation in the drosophila homologue of janus kinase(hopTum)and carrying a deficiency of the tumor suppressor gene lethal(3)malignant blood neoplasm-1[l(3)mbn1],as well as in stem cell maintenance-defective hdcd84 mutant *** analysis enabled the discrimination of the functionally different major hemocyte subsets for lamellocytes,plasmatocytes,and crystal cells,and delineated the unique immunophenotype of drosophila *** have identified subpopulations of L2^(+)/P1^(+)and L2^(+)/L4^(+)/P1^(+)transitional phenotype cells in the tumorous strains l(3)mbn1 and hopTum,respectively,and a subpopulation of L4^(+)/P1^(+)cells upon immune *** results demonstrated for the first time that SCMC,combined with multidimensional bioinformatic analysis,represents a versatile and powerful tool to deeply analyze the regulation of cell-mediated immunity of drosophila.

关键词： Mass cytometry Innate immunity drosophila Single-cell analysis Hemocyte

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海底多金属硫化矿床中的金

国外火山地质 1988年第2期 24-38页

作者： M.d.Hannington j.M.PeterS.d.Scott 谢华光黄宾

东太平洋海底扩张中心七个多金属硫化矿床中48个热液沉淀物样品的金化学分析显示出独特的金富集作用,从两个多金属硫化矿床的样品中发现高的金含量:阿克西亚尔海山（北纬45°57′,西经130°02′）和埃克斯普洛雷洋脊南部（北纬49°45.6... 详细信息

东太平洋海底扩张中心七个多金属硫化矿床中48个热液沉淀物样品的金化学分析显示出独特的金富集作用,从两个多金属硫化矿床的样品中发现高的金含量:阿克西亚尔海山（北纬45°57′,西经130°02′）和埃克斯普洛雷洋脊南部（北纬49°45.6′,西经130°16.2′）。阿克西亚尔海山矿床顶部由二氧化硅、重晶石和闪锌矿组成的重160公斤的大样 Au 分析值高达6,700PPb,平均值为4,900PPb,埃克斯普洛雷洋脊南部中相似的样品 Au 分析值最高达1,500PPb,平均值为660PPb,这两个地区大范围样品的详细矿物学研究和金化学分析表明元素共生组合明显控制了金的沉积。金富集约200PPb 时,与高的 Cu(>1Wt%和 Mo（高达470ppm）有关;金富集>800ppb,与高的 Zn（>0.1Wt%）、Ba（>3Wt%）和 SiO2（>20Wt%）有关;金富集>1,200ppb,与高的pb（>0.1Wt%）、Ag（>100ppm）、As（>300ppm）和 Sb（50—100ppm）有关。这两个地区金分析值最高的样品中,含有产在非品质二氧化硅基质中的晚期泉华状低温 pb、As、Sb、Ag 硫盐和 S,这些硫盐是金的可能携带者。已发表的其它产于玄武岩中的海底矿床（北纬21°,加拉帕戈斯裂谷,胡安·德富卡洋脊南部,因代沃洋脊）贫金（300℃）、富铜铁硫化物中初步富集到约20ppb,后经晚期持续的低温（<250℃）流体活化转移,在近地表富二氧化硅、钡、锌的沉淀物中富集。使金活化需要合适的流体成分,而使金富集则需要有利的沉积机制。这些观测能解释在陆上一些古块状硫化矿床特定的矿石类型中出现金的高度富集。

关键词：矿床亚尔硫化物富集二氧化硅非晶质矿藏硫化合物阿克西海脊洋脊流体

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帮助运动员支持1天进行2次训练

体育科学 2001年第1期21卷 91-94页

作者： j.Markdavis MikeGentry daveKennedy deanKleinschmidt A.T.C. RodWalterss d.A. ClydeWilliams 常翠青陈吉棣南卡罗莱那州立大学运动科学系南卡罗莱那州哥伦比亚维吉尼亚技术学校力量和身体条件训练教练维吉尼亚州布来克斯堡俄亥俄州立大学力量和身体条件训练教练俄亥俄州克伦斯勃斯新奥尔良圣城运动训练主任路易斯安那州新奥尔良南卡罗莱那州立大学运动训练系南卡罗莱那州哥伦比亚乐波罗大学娱乐管理运动科学和体育系英国来塞斯特遐迩不详

前言

关键词：训练运动员身体条件队友橄榄球技能发展赛季高能量伤口心理应激

Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide

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World journal of Gastroenterology 2022年第26期28卷 3177-3200页

作者： María Belén Novoa díaz Pedro Carriere Graciela Gigola Ariel Osvaldo Zwenger Natalia Calvo Claudia Gentili departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Centro de Estudios Clínicos SAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUNd Parathyroid hormone-related peptide(PTHrP)plays a key role in the development and progression of many *** found that in colorectal cancer(CRC)HCT116 cells,the binding of PTHrP to its receptor PTHR type 1(PTHR1)activates events associated with an aggressive *** HCT116 cell xenografts,PTHrP modulates the expression of molecular markers linked to tumor *** evidence suggests that the Met receptor is involved in the development and evolution of *** on these data,we hypothesized that the signaling pathway trigged by PTHrP could be involved in the transactivation of Met and consequently in the aggressive behavior of CRC *** To elucidate the relationship among PTHR1,PTHrP,and Met in CRC *** For in vitro assays,HCT116 and Caco-2 cells derived from human CRC were incubated in the absence or presence of PTHrP(1-34)(10-8 M).Where indicated,cells were pre-incubated with specific kinase inhibitors or dimethylsulfoxide,the vehicle of the *** protein levels were evaluated by Western blot ***-time polymerase chain reaction(RT-qPCR)was carried out to determine the changes in gene *** healing assay and morpho logical monitoring were performed to evaluate cell migration and changes related to the epithelialmesenchymal transition(EMT),*** number of viable HCT116 cells was counted by trypan blue dye exclusion test to evaluate the effects of irinotecan(CPT-11),oxaliplatin(OXA),or doxorubicin(dOXO)with or without *** in vivo tests,HCT116 cell xenografts on 6-wk-old male N:NIH(S)_nu mice received daily intratumoral injections of PTHrP(40μg/kg)in 100μL phosphate-buffered saline(PBS)or the vehicle(PBS)as a control during 20 *** slaughter was carried out and the tumors were removed,weighed,and fixed in a 4%formaldehyde solution for subsequent treatment by *** evaluate the expression of molecular markers in human tumor samples,we studied 23 specimens ob

关键词： PTHrP MET receptor tyrosine kinase Parathyroid hormone receptor type 1 Colorectal cancer drug resistance

Growth phenology adjusts to seasonal changes in water availability in coexisting evergreen and deciduous mediterranean oaks

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Forest Ecosystems 2023年第5期10卷 535-546页

作者： Filipe Campelo Alvaro Rubio-Cuadrado Fernando Montes Michele Colangelo Cristina Valeriano j.julio Camarero department of Life Sciences University of CoimbraCalçada Martim de FreitasCoimbra3000-456Portugal departamento de Sistemas y Recursos Naturales Escuela Tecnica Superior de Ingeniería de MontesForestal y Del Medio NaturalUniversidad Politecnica de MadridCiudad Universitaria S/n28040MadridSpain Instituto Pirenaico de Ecología(IPE-CSIC) Avda.Montanana 1005E-50192ZaragozaSpain departamento de dinamica y Gestion Forestal Instituto de Ciencias Forestales(ICIFOR-INIA-CSIC)Ctra.La Coruna Km 7.528040MadridSpain Scuola di Scienze Agrarie ForestaliAlimentari e AmbientaliUniversita Della BasilicataViale Dell’Ateneo Lucano 1085100PotenzaItaly

different leaf(evergreen *** habit)and xylem(***-porous wood)traits represent contrasting strategies to face seasonal changes in water availability and ***,how contrasting leaf and xylem habits of coexisting tree species affect stem wood formation and tree-ring development remains poorly ***,we investigated the spatio-temporal patterns of wood formation in two deciduous oaks(Quercus faginea and Quercus petraea)and two evergreen oaks(Quercus ilex and Quercus suber)coexisting in seasonally dry Mediterranean forests along an aridity gradient in *** hypothesized that growth responses to drought and intra-and inter-annual growth patterns would differ between functional *** simulated intra-and interannual growth using a modified version of the Vaganov-Shashkin(VS)process-based,growth *** VS model simulations were used to estimate growth changes under a high emission scenario(RCP 8.5)for the current distribution of the study oak species and to forecast their future performance under warm(4.8℃)conditions in the Iberian *** simulations indicate that climate warming would induce a shortening of the ringgrowth season and a reduction of radial growth in evergreen and deciduous Mediterranean oaks,particularly in dry sites from southern and eastern Iberia currently occupied by *** and *** oaks may better recover after dry periods than deciduous oaks by resuming growth after the summer *** soil water availability in spring would be more detrimental to growth of deciduous ***-based growth models should be refined and validated to better forecast changes in tree growth as a function of climate.

关键词： Process-based growth model Quercus ilex Quercus suber Quercus faginea Quercus petraea Tree-ring growth

A simple catalyst for aqueous phase Suzuki reactions based on palladium nanoparticles immobilized on an ionic polymer

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Science China Chemistry 2016年第4期59卷 482-486页

作者： Saeideh Ghazali-Esfahani Emilia Paunescu Mojtaba Bagherzadeh Zhaofu Fei Gabor Laurenczy Paul j.dyson Institut des Sciences et Ingénierie Chimiques Ecole Polytechnique Fédérale de LausanneLausanne CH-I O15Switzerland Chemistry department Sharif University of TechnologyTehran 11155-3615lran

Palladium nanoparticles immobilized on a cross-linked imidazolium-containing polymer were evaluated as a catalyst for Suzuki carbon-carbon cross-coupling reactions using water as the solvent. The nanocatalysts show good catalytic activities for aryl iodides and aryl bromides and moderate activity with aryl chloride substrates. Coupling of sterically hindered substrates could also be achieved in reasonable yields. The heterogeneous catalyst is stable, can be stored without precautions to exclude air or moisture, and can be easily recycled and reused.

关键词： catalysis biphasic catalysis polymeric ionic liquids nanoparticles aqueous phase catalysis Suzuki reaction

Optimization and control of synchrotron emission in ultraintense laser–solid interactions using machine learning

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高功率激光科学与工程:英文版 2023年第3期11卷 15-31页

作者： j.Goodman M.King E.j.dolier R.Wilson R.j.Gray P.McKenna SUPA department of Physics University of StrathclydeGlasgowUK The Cockcroft Institute Sci-Tech DaresburyWarringtonUK

The optimum parameters for the generation of synchrotron radiation in ultraintense laser pulse interactions with planar foils are investigated with the application of Bayesian optimization,via Gaussian process regression,to 2d particle-incell *** properties of the synchrotron emission,such as the yield,are maximized,and simultaneous mitigation of bremsstrahlung emission is achieved with multi-variate objective *** angle-of-incidence of the laser pulse onto the target is shown to strongly influence the synchrotron yield and angular profile,with oblique incidence producing the optimal *** is further explored in 3d simulations,in which additional control of the spatial profile of synchrotron emission is demonstrated by varying the polarization of the laser *** results demonstrate the utility of applying a machine learning-based optimization approach and provide new insights into the physics of radiation generation in laser-foil interactions,which will inform the design of experiments in the quantum electrodynamics(QEd)-plasma regime.

关键词： Bayesian optimization gamma rays laser-solid interactions machine learning radiation reaction