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Earliest parietal art:hominin hand and foot traces from the middle Pleistocene of Tibet

Science Bulletin 2021年第24期66卷 2506-2515,M0004页

作者： david d.zhang Matthew R.Bennett Hai Cheng Leibin Wang Haiwei zhang Sally C.Reynolds Shengda zhang Xiaoqing Wang Teng Li Tommy Urban Qing Pei Zhifeng Wu Pu zhang Chunru Liu Yafeng Wang Cong Wang dongju zhang R.Lawrence Edwards School of Geography and Remote Sensing Guangzhou UniversityGuangzhou 510006China Center for Excellence in Tibetan Plateau Earth Sciences and Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China department of Life and Environmental Sciences Bournemouth UniversityTalbot CampusFern BarrowPoole BH125BBUK Institute of Global Environmental Change Xi’an Jiaotong UniversityXi’an 710054China department of Earth Sciences University of Hong KongHong KongChina department of Archaeology and Anthropology Bournemouth UniversityFern BarrowPoole BH125BBUK department of Classics Tree-ring LaboratoryCornell UniversityIthacaNY 14853-3201USA department of Social Sciences Education University of Hong KongHong KongChina State Key Laboratory of Earthquake dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China School of Economics Jinan UniversityGuangzhou 510006China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China department of Earth and Environmental Sciences University of MinnesotaMinneapolisMN 55455USA

At Quesang on the Tibetan Plateau we report a series of hand and foot impressions that appear to have been intentionally placed on the surface of a unit of soft *** travertine was deposited by water from a hot spring which is now inactive and as the travertine lithified it preserved the *** the basis of the sizes of the hand and foot traces,we suggest that two track-makers were involved and were likely *** interpret this event as a deliberate artistic act that created a work of parietal *** travertine unit on which the traces were imprinted dates to between~169 and 226 ka *** would make the site the earliest currently known example of parietal art in the world and would also provide the earliest evidence discovered to date for hominins on the High Tibetan Plateau(above 4000 m a.s.l.).This remarkable discovery adds to the body of research that identifies children as some of the earliest artists within the genus Homo.

关键词： Tibet Parietal art Ichnology Hominin

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dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan zhang Xiaomin Cheng Qinghua Guan Jing dong Bixian Chen Lujie Jia Jing zhang Yongzheng zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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Low-dose Adaptive Sequential Scan for dual-Source CT Coronary Angiography in Patients with High Heart Rate:Comparison with Retrospective ECG Gating

Low-Dose Adaptive Sequential Scan for Dual-Source CT Coronar...

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中华医学会第16次全国放射学学术大会

作者： L.Xu M.d.Beijing China L.Yang M.d.Y.Li M.d.Z.M.Fan M.d.Z.Q.zhang M.d.

PURPOSE To explore feasibility of applying dual source CT(dSCT) prospective ECG-gated coronary angiography in patients with heart rate(HR) higher than 70 beat per minute(bpm),and evaluate image quality and radiation d...

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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang Chao Wang Yunhong zhang Hong Liu Yu zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Preparation of Low Ratio Magnesium Ccement by Acid Leaching Treatment of Boron Mud

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 120-129页

作者： YANG Mei zhang Mingzhe CHEN Hao School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China School of Physical Science and Technology Shenyang Normal UniversityShenyang 110168China

The effects of liquid-solid ratio and reaction time on the leaching rate of magnesium at room temperature were investigated,as well as the effects of the molar ratio of MgO/MgCl_(2),the amount of water added,and the amount of acid-impregnated slag dosed on the compressive strength and water resistance of *** results showed that the magnesium element in the boron mud could be maximally leached under the conditions of 1:1 concentration of hydrochloric acid at room temperature,liquid-solid ratio of 2.5 mL·g^(-1),and reaction time of 5 h,and the main products were amorphous SiO_(2) as well as a small amount of magnesium olivine which had not been completely *** LR-MOC prepared using the acid-soaked mixture could reach a softening coefficient of 0.85 for 28 d of water immersion when the molar ratio of MgO/MgCl_(2) was 2.2,the amount of water added was 0 g,and the acid-soaked slag dosing was 40 wt%,which also led to an appreciable late-strength,with an increase of 19.4%in compressive strength at 28 d compared to that at 7 *** previous studies,LR-MOC prepared in this way has a final strength phase that is not the more easily hydrolysed 3-phase but the lath-like *** this phenomenon,we analyzed the mechanism and found that,during the acid leaching process,a part of amorphous SiO_(2) dissolved in the acid leaching solution formed a silica sol,in which Mg^(2+)played a bridging role to make the silica sol more *** the addition and hydrolysis of MgO,the silica sol gel coagulation slows down,providing a capping layer to inhibit the hydrolysis of the 5-phase crystals and providing some strength after *** amorphous SiO_(2) in the other part of the acid-impregnated slag generated M-S-H gel with Mg^(2+)and OH-,which synergised with the dense structure composed of interlocking crystals to improve the water resistance of LR-MOC.

关键词： boron mud magnesium chloride-oxygen cement acid immersion water resistance silica sol

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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li zhang Zheng Gang zhang department of Neurology Henry Ford HospitalDetroitMIUSA department of Physics Oakland UniversityRochesterMIUSA department of Pathology Henry Ford HospitalDetroitMIUSA division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera

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Precision Clinical Medicine 2021年第3期4卷 149-154页

作者： Gen Li Zhongcheng Zhou Peng du Meixing Yu Ning Li Xinxin Xiong Hong Huang Zhihai Liu Qinjin dai Jie Zhu Chengbin Guo ShanyunWu daniel T.Baptista-Hon Man Miao LamWai Ming Yong Wu Fanxin Zeng Charlotte L.zhang Edward d.zhang Haifeng Song Jianghai Liu Johnson Yiu-Nam Lau Andy P.Xiang Kang zhang Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510620China University Hospital and Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 030027China Jinan University First Affiliated Hospital Jinan UniversityGuangzhou 510630China department of Clinical Research Center Dazhou Central HospitalDazhou 635099China department of Bioinformatics and AI Bioland LaboratoryGuangzhou 510000China ABLINK Biotech Co. Chengdu 610000China department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHung HomHong Kong 610051China Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou 510000China

To assess the impact of the key non-synonymous amino acid substitutions in the RBd of the spike protein of SARS-CoV-2 variant B.1.617.1(dominant variant identified in the current India outbreak)on the infectivity and neutralization activities of the immune sera,L452R and E484Q(L452R-E484Q variant),pseudotyped virus was constructed(with the d614G background).The impact on binding with the neutralizing antibodies was also assessed with an ELISA *** virus carrying a L452R-E484Q variant showed a comparable infectivity compared with ***,there was a significant reduction in the neutralization activity of the immune sera from non-human primates vaccinated with a recombinant receptor binding domain(RBd)protein,convalescent patients,and healthy vaccinees vaccinated with anmRNA *** addition,there was a reduction in binding of L452R-E484Q-d614G protein to the antibodies of theimmune sera fromvaccinated nonhuman *** results highlight the interplay between infectivity and other biologic factors involved in the natural evolution of *** neutralization activities against the L452R-E484Q variant will have an impact on health authority planning and implications for the vaccination strategy/newvaccine development.

关键词： SARS-CoV-2 COVId-19 B.1.617.1 L452R E484Q infectivity immune neutralization

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Tunable Bending Stiffness, Buckling Force, and Natural Frequency of Nanowires and Nanoplates

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World Journal of Nano Science and Engineering 2012年第3期2卷 161-169页

作者： Hanxing Zhu Z. B. Wang T. X. Fan d. zhang CNM & IJRCNB Centers Changchun University of Science and Technology Changchun China School of Engineering Cardiff University Cardiff UK State Key Lab of Metal Matrix Composites Shanghai Jiaotong University Shanghai China

This paper aims to obtain the simple closed-form results for the combined effects of surface elasticity, initial stress/ strain, and material Poisson ratio on the bending stiffness, natural frequency and buckling force of nanowires and nano-plates. The results demonstrate that all these properties of nanowires or nanoplates can be designed either very sensitive or not sensitive at all to the amplitude of an applied electric potential;show how much of those properties can be controlled to vary;and thus provide a reliable guide to the measurement of the Young’s modulus of nanowires/nanoplates and to the design of nano-devices, such as nano-sensors or the cantilever of an AFM.

关键词： Nanowires Nanoplates Bending Stiffness Buckling Force Natural Frequency

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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia deng Nannan zhang department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth defects and Women and Children’s diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan zhang Yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor d and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

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