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Real-time four-dimensional scanning transmission electron microscopy through sparse sampling

Chinese Physics B 2024年第11期33卷 34-38页

作者： A W Robinson J Wells A Moshtaghpour d nicholls C Huang A Velazco-Torrejon G Nicotra A I Kirkland N d Browning 无 SenseAI Innovations Ltd. LiverpoolUK Centre for doctoral Training University of LiverpoolLiverpoolUK Correlative Imaging Group Rosalind Franklin InstituteOxfordUK CNR-IMM Z.I.VIII Strada 5Catania95121Italy department of Mechanical Materialsand Aerospace EngineeringUniversity of LiverpoolLiverpoolUK

Four-dimensional scanning transmission electron microscopy(4-d STEM)is a state-of-the-art image acquisition mode used to reveal high and low mass elements at atomic *** acquisition of the electron momenta at each real space probe location allows for various analyses to be performed from a single dataset,including virtual imaging,electric field analysis,as well as analytical or iterative extraction of the object induced phase ***,the limiting factor in 4-d STEM is the speed of acquisition which is bottlenecked by the read-out speed of the camera,which must capture a convergent beam electron diffraction(CBEd)pattern at each probe position in the *** developments in sparse sampling and image inpainting(a branch of compressive sensing)for STEM have allowed for real-time recovery of sparsely acquired data from fixed monolithic detectors,Further developments in compressive sensing for 4-d STEM have also demonstrated that acquisition speeds can be increased,i.e.,live video rate 4-d imaging is now *** this work,we demonstrate the first practical implementations of compressive 4-d STEM for real-time inference on two different scanning transmission electron microscopes.

关键词： compressive sensing 4-d STEM inpainting

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生物力能学

生物力能学

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作者： d.G.·尼柯尔斯(d.G. nicholls)

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生物力能学

生物力能学

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作者： d.G.·尼柯尔斯(d.G. nicholls)

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Ultrathin monolithic 3d printed optical coherence tomography endoscopy for preclinical and clinical use

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Light(Science & Applications) 2020年第1期9卷 753-762页

作者： Jiawen Li Simon Thiele Bryden C.Quirk Rodney W.Kirk Johan W.Verjans Emma Akers Christina A.Bursill Stephen J.nicholls Alois M.Herkommer Harald Giessen Robert A.McLaughlin Australian Research Council Centre of Excellence for Nanoscale BioPhotonics Adelaide Medical SchoolUniversity of AdelaideAdelaideSA 5005Australia Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideSA 5005Australia Institute of Applied Optics(ITO)and Research Center SCoPE University of Stuttgart70569 StuttgartGermany South Australian Health and Medical Research Institute(SAHMRI) AdelaideSA 5000Australia Royal Adelaide Hospital AdelaideSA 5000Australia Monash Cardiovascular Research Centre Monash UniversityMelbourneVIC 3168Australia th Physics Institute and Research Center SCoPE University of Stuttgart70569 StuttgartGermany

Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via *** endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to ***,current fabrication methods limit the imaging performance of highly miniaturized probes,restricting their widespread *** overcome this limitation,we developed a novel ultrathin probe fabrication technique that utilizes 3d microprinting to reliably create side-facing freeform micro-optics(diameter)on single-mode *** this technique,we built a fully functional ultrathin aberration-corrected optical coherence tomography *** is the smallest freeform 3d imaging probe yet reported,with a diameter of 0.457 mm,including the catheter *** demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse *** ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease.

关键词： smallest utilize overcome

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一天

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2018年

作者： (英)大卫·尼克斯

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A Novel Virus detected In Papillomatous And Carcinomatous Lesions Of The Endangered Western Barred Bandicoot （Perameles Bougainville） Exhibits Genomic Features Of Both The Papillomaviridae And Polyomaviridae

A Novel Virus Detected In Papillomatous And Carcinomatous Le...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Lucy Woolford Annabel Rector Marc Van Ranst Andrea ducki Mark d Bennett Philip K nicholls Kristin S Warren Ralph A Swan Graham E Wilcox Amanda J O’Hara Murdoch University Laboratory of Clinical and Epidemiological Virology Department of Microbiology and ImmunologyRega Institute for Medical Research.University of LeuvenBelgium Laboratory of Clinical and Epidemiological Virology Department of Microbiology and ImmunologyRega Institute for Medical Research.University of LeuvenBelgium School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia

＜正＞Conservation efforts to prevent the extinction of the endangered western barred bandicoot（Perameles bougainville）are currently hindered by a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome observed in captive and wild *** this study we have detected a novel virus,tentatively designated the Bandicoot papillomatosis carcinomatosis virus type 1（BPCV1）,in lesional tissue from affected western barred bandicoots using multiply

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一种口服脂蛋白(a)形成的小分子抑制药莫伐倍林的1期临床研究

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中国临床药理学杂志 2023年第21期39卷 3091-3091页

作者： nicholls S J 戴荣源

澳大利亚蒙纳士维多利亚心脏研究所nicholls研究团队开展莫伐倍林的安全性、耐受性、药代动力学和药效作用的临床研究。该研究采用单次递增剂量评估了具有任何脂蛋白(a)[lipoprotein(a),Lp(a)]水平的健康参与者服用单次剂量的莫伐倍林1~... 详细信息

澳大利亚蒙纳士维多利亚心脏研究所nicholls研究团队开展莫伐倍林的安全性、耐受性、药代动力学和药效作用的临床研究。该研究采用单次递增剂量评估了具有任何脂蛋白(a)[lipoprotein(a),Lp(a)]水平的健康参与者服用单次剂量的莫伐倍林1~800 mg或安慰剂的效果;多次递增剂量评估了Lp(a)水平≥30 mg·dL^(-1)的患者连续14 d每日服用莫伐倍林30~800 mg或安慰剂的效果。

关键词：抑制药安慰剂单次剂量药代动力学剂量评估药效作用维多利亚耐受性

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2019年及以后的航空测绘——现代测绘系统与技术

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中国测绘 2019年第6期 80-84页

作者：彭嘉婷 Brian nicholls daniel Kruimel

实景3d模型、激光雷达点云、超高分辨率航拍图像和航空影像中的人工智能等,这些只是2019年航空测绘GIS产品中的一小部分.尽管存在许多高分辨率地球观测卫星和呈指数增长地用于航空测绘的无人机,但是大多数大中型的“地测”和GIS地图数... 详细信息

实景3d模型、激光雷达点云、超高分辨率航拍图像和航空影像中的人工智能等,这些只是2019年航空测绘GIS产品中的一小部分.尽管存在许多高分辨率地球观测卫星和呈指数增长地用于航空测绘的无人机,但是大多数大中型的“地测”和GIS地图数据仍来自有人驾驶飞机(固定翼和旋转翼).但是,众多的测绘系统和处理方式让选择一个适合项目要求的航空测绘技术变得困难.本文简要介绍了最新的航空测绘系统和处理方式,以及不断从中衍生出来的产品和服务.

关键词：地图系统高分辨率测绘旋转翼航空

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大剂量他汀类药物治疗对冠状动脉粥样硬化消退的影响:ASTEROId试验

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 5-6页

作者： Nissen S. E. nicholls S. J. Sipahi I. 任付先(译) 唐玉敏(校) department of Cardiovascular Medicine Cleveland Clinic Foundation 9500 Euclid Ave Cleveland OH 44195 United States 不详

Context: Prior intravascular ultrasound(IVUS) trials have demonstrated slowing or halting of atherosclerosis progression with statin therapy but have not shown convincing evidence of regression using percent atheroma volume(PAV), the most rigorous IVUS measure of disease progression and regression. Objective: To assess whether very intensive statin therapy could regress coronary atherosclerosis as determined by IVUS imaging. design and Setting: Prospective, open-label blinded endpoints trial(A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-derived Coronary Atheroma Burden[ASTEROId]) was performed at 53 community and tertiary care centers in the United States, Canada, Europe, and Australia. A motorized IVUS pullback was used to assess coronary atheroma burden at baseline and after 24 months of treatment. Each pair of baseline and follow-up IVUS assessments was analyzed in a blinded fashion. Patients: Between November 2002 and October 2003, 507 patients had a baseline IVUS examination and received at least 1 dose of study drug. After 24 months, 349 patients had evaluable serial IVUS examinations. Intervention: All patients received intensive statin therapy with rosuvastatin, 40 mg/d. Main Outcome Measures: Two primary efficacy parameters were prespecified: the change in PAV and the change in nominal atheroma volume in the 10-mm subsegment with the greatest disease severity at baseline. A secondary efficacy variable, change in normalized total atheroma volume for the entire artery, was also prespecified. Results: The mean(Sd) baseline low-density lipoprotein cholesterol(LdL-C) level of 130.4(34.3) mg/dL declined to 60.8(20.0) mg/dL, a mean reduction of 53.2%(Pd) high-density lipoprotein cholesterol(HdL-C) level at baseline was 43.1(11.1) mg/dL, increasing to 49.0(12.6) mg/dL, an increase of 14.7%(Pd) change in PAV for the entire vessel was -0.98%(3.15%), with a median of-0.79%(97.5%CI,-1.21%to-0.53%)(P<.001 vs

关键词：冠状动脉粥样硬化药物治疗 d试验他汀类大剂量消退冠状动脉粥样斑块低密度脂蛋白胆固醇

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Semiclassical Molecular dynamics Investigation of 1,3-Cyclohexadiene （CHd）

Semiclassical Molecular Dynamics Investigation of 1,3-Cycloh...

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中国化学会第九届全国量子化学学术会议

作者： Lei Yibo, dou Yusheng, Zhai Gaohong, Wen Zhenyi Chemistry department, Northwest University, Xi''an 710069, China department of Physical Science, nicholls State University, Thibodaux, LA 70310,U.S.A. Institute of Modern Physics, Northwest University, Xi''an 710069, China

＜正＞The ring-opening reaction of 1,3-cyclohexadiene （CHd） serves as model for a wide-variety of photochemical reactions, including that in the synthesis of vitamin-d. Upon excitation with ultraviolet light, CHd forms a close hexatriene （HT） structure. This structure then rapidly isomerizes to form a longer open chain. This reaction has been studied by a variety of non-linear spectroscopy, such as pump-probe experiments as well as by time-resolved electronic diffraction in the gas phase. For the last few

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