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血栓性血小板减少性紫癜患者vWF裂解蛋白酶抗原和活性的检测及意义

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中华血液学杂志 2006年第3期27卷 154-157页

作者：刘芳 BF Hendrik 董宁征白霞 V Karen d hans 阮长耿苏州大学附属第一医院江苏省血液研究所215006 Laboratory for Thrombosis Research IRCK U Leuven Capus KortrigkBelgium

目的研究血管性血友病因子裂解蛋白酶(AdAMTS13)抗原含量和活性在血栓性血小板减少性紫癜(TTP)患者及遗传性 TTP 家族突变携带者中变化的情况。方法用残余胶原结合实验(RCBA)检测13例 TTP 患者共28份血浆标本[含血浆置换(PE)前后]及10... 详细信息

目的研究血管性血友病因子裂解蛋白酶(AdAMTS13)抗原含量和活性在血栓性血小板减少性紫癜(TTP)患者及遗传性 TTP 家族突变携带者中变化的情况。方法用残余胶原结合实验(RCBA)检测13例 TTP 患者共28份血浆标本[含血浆置换(PE)前后]及10例携带者的 AdAMTS13活性;用新近建立的三抗体夹心酶联免疫反应法检测标本的 AdAMTS13抗原含量。结果正常对照组 AdAMTS13含量为(600.93±145.36)mU/ml(设白种人混合血浆的 AdAMTS13抗原含量为1000mU/ml),活性为(74.79±11.81)%。遗传性 TTP 患者 AdAMTS13抗原含量和活性治疗前和发病间期均明显减低,PE 后恢复;其家族中携带者 AdAMTS13抗原含量为(331.40±109.85)mU/ml,活性为(66.79±12.82)%(与对照组比较,P 值分别0.05);原发性 TTP 患者 PE 前 AdAMTS13抗原含量为(98.7±82.08)mU/ml,活性为(22.23±19.07)%(与对照组比较,P 值均dAMTS13 抗原含量为(449.4±232.33)mU/ml,活性为(60.92±22.33)%(与对照组比较,P 值分别0.05);1例继发性 TTP 患者 PE 后 AdAMTS13抗原含量远高于正常,活性仅为6.00%结论治疗前的 TTP 患者 AdAMTS13抗原含量和活性均明显减低。大多数患者两指标变化趋势一致,也有个别患者两指标变化趋势相反,前者可能因为遗传因素或体内免疫系统的廓清作用,后者可能因为抗 AdAMTS13抗体仅抑制了 AdAMTS13的活性而未影响其抗原的含量或其他未知原因所致。

关键词：紫癜,血栓性血小板减少性血管性血友病因子裂解蛋白酶活性抗原

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气雾剂指令当今和未来的法律框架

气雾剂通讯 2010年第6期 16-20页

作者： hans d＇Hhooge

介绍·谁在负责欧洲委员会的气雾剂指令（Add）？·dG企业和工业。

关键词：气雾剂指令框架法律欧洲委员会

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长期服用甲氟喹啉预防疟疾的效果和耐药性

美国医学会杂志（中文版） 1991年第4期10卷 213-215,212页

作者： hans,d Kenn.,WB

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早期的地质记录和生命的起源

世界地质 1985年第2期 146-148页

作者： hans d Pflug 刘建新

根据目前所获得的证据表明,古老的沉积物中所含的大量有机物是生命的起源。没有任何迹象表示这些有机物是通过非生物过程形成的。也没有证据支持太古代地球历史上所记载的那种认为曾经发生过一些前生

关键词：微体化石地质记录碳质微化石碳酸盐碳化合物岩石生命

Low-density lipoprotein receptor-related protein 2(LRP2)is required for lipid export in the midgut of the migratory locust,Locusta migratoria

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Journal of Integrative Agriculture 2024年第5期23卷 1618-1633页

作者： Yiyan Zhao Weimin Liu Xiaoming Zhao Zhitao Yu Hongfang Guo Yang Yang hans Merzendorfer Kun Yan Zhu Jianzhen Zhang Research Institute of Applied Biology Shanxi Key Laboratory of Nucleic Acid BiopesticidesShanxi UniversityTaiyuan 030006China College of Life Science Shanxi UniversityTaiyuan 030006China Interfaculty Institute of Cell Biology University of TubingenTubingen 72076Germany Institute of Biology University of SiegenSiegen 57076Germany department of Entomology Kansas State UniversityManhattanKS 66506USA

Low-density lipoprotein receptor-related protein 2(LRP2)is a multifunctional endocytic receptor expressed in epithelial *** mammals,it acts as an endocytic receptor that mediates the cellular uptake of cholesterol-containing apolipoproteins to maintain lipid ***,little is known about the role of LRP2 in lipid homeostasis in *** the present study,we investigated the function of LRP2 in the migratory locust Locusta migratoria(LmLRP2).The mRNA of LmLRP2 is widely distributed in various tissues,including integument,wing pads,foregut,midgut,hindgut,Malpighian tubules and fat body,and the amounts of LmLRP2 transcripts decreased gradually in the early stages and then increased in the late stages before ecdysis during the nymphal developmental *** immunohistochemistry revealed that the LmLRP2 protein is mainly located in cellular membranes of the midgut and *** RNAi to silence LmLRP2 caused molting defects in nymphs(more than 60%),and the neutral lipid was found to accumulate in the midgut and surface of the integument,but not in the fat body,of dsLmLRP2-treated *** results of a lipidomics analysis showed that the main components of lipids(diglyceride and triglyceride)were significantly increased in the midgut,but decreased in the fat body and ***,the content of total triglyceride was significantly increased in the midgut,but markedly decreased in the fat body and hemolymph in dsLmLRP2-injected *** results indicate that LmLRP2 is located in the cellular membranes of midgut cells,and is required for lipid export from the midgut to the hemolymphand fat body in locusts.

关键词： Locusta migratoria low-density lipoprotein receptor-related protein 2 midgut lipids transport RNAi

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Snapshot imaging of ultrashort electron bunches

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Light(Science & Applications) 2024年第7期13卷 1226-1228页

作者： Andreas döpp Ludwig-Maximilian-Universität München Am Coulombwall 185748GarchingGermany Max Planck Institut für Quantenoptik Hans-Kopfermann-Strasse 1Garching85748Germany

New measurements combine spatial and temporal information from optical transition radiation to estimate the three-dimensional structure of electron bunches from a laser wakefield accelerator.

关键词： ultrashort Snapshot electron

IMAGING CALCANEUS ULTRASOUNd IN PATIENTS WITH CERVICAL OR INTERTROCHANTERIC FRACTURES

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IMAGING CALCANEUS ULTRASOUND IN PATIENTS WITH CERVICAL OR IN...

Optimizing laser coupling,matter heating,and particle acceleration from solids using multiplexed ultraintense lasers

The Third International Congress on Osteoporosis

作者： B.Fan d.hans C.Njeh Y.He E.Tsuda J.Li T.Fuerst H.K.Genant Osteoporosis and Arthritis Research Group University of California at San Francisco

＜正＞Purpose:To evaluate the ability of a newly developed imaging quantitative ultrasound device to discriminate hip fracture patients from controls,as well as the impact of type of fracture,and to compare the results with hip dXA. Snbject and Methods:34 female patients（mean age 73.618.7） who sustained a hip fracture（22 cervical fracture and 12 trochanteric fracture） and 34 healthy women of similar age（75.5±5.6） were recruited for the *** hip fractures had resulted from a fall from standing position or *** and SOS of the contralateral（for fracture patients） or left（for controls） foot were measured using a newly developed imaging ultrasound system,the UBIS 3000（dMS,France）,and BMd of the same hip were also measured by dXA（4500A Hologic,USA）. Student’s T-test was used to analyze the differences of height,weight,BMd and QUS parameters between patients and *** ratio were calculated using regression *** and specificity of BMd and QUS parameters were evaluated using Receiver Operator Characteristics（ROC） analysis.

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Matter and Radiation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki Nakatsutsumi Sébastien Buffechoux Patrizio Antici Marco Borghesi Andrea Ciardi Sophia N.Chen Emmanuel d’Humières Laurent Gremillet Robert Heathcote Vojtech Horny Paul McKenna Mark N.Quinn Lorenzo Romagnani Ryan Royle Gianluca Sarri Yasuhiko Sentoku hans-Peter Schlenvoigt Toma Toncian Olivier Tresca Laura Vassura Oswald Willi Julien Fuchs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Institute for Physics and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom department of Physics University of NevadaRenoNevada 89557USA Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur Laser und Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intensity lasers for particle and radiation generation will require multi-beam arrangements due to technology ***,we investigate how to optimize their coupling with solid ***,we show that overlapping two intense lasers in a mirror-like configuration onto a solid with a large preplasma can greatly improve the generation of hot electrons at the target front and ion acceleration at the target *** underlying mechanisms are analyzed through multidimensional particle-in-cell simulations,revealing that the self-induced magnetic fields driven by the two laser beams at the target front are susceptible to reconnection,which is one possible mechanism to boost electron *** addition,the resistive magnetic field generated during the transport of the hot electrons in the target bulk tends to improve their *** simulations also indicate that such effects can be further enhanced by overlapping more than two laser beams.

关键词： laser acceleration particle

POTENTIAL IMPACT OF FOOT LENGTH ON QUS MEASUREMENT:A PILOT STUdY.

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POTENTIAL IMPACT OF FOOT LENGTH ON QUS MEASUREMENT:A PILOT S...