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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie d.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Stability Analysis of Network Controlled Temperature Control System with Additive delays

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Computer Modeling in Engineering & Sciences 2018年第3期114卷 321-334页

作者： v.venkatachalam d.Prabhakaran department of Chemical Engineering Coimbatore Institute of TechnologyCoimbatore-641014India

This paper presents,using Lyapunov-Krasovskii functional technique combined with reciprocal convex lemma is considered for a networked control temperature control system with additive *** the stability analysis,a new LK functional is assumed,and take the time-derivative of the(LK)functional,using reciprocal convex combination technique was employed to obtain less conservative stability ***,the proposed stability analysis culminates into a stability criterion in the LMI(linear matrix inequalities)*** results obtained are in accordance with the theoretically obtained in the temperature control system and they are closer to the standard benchmark temperature-control system.

关键词： delay-dependent stability time-varying additive delays temperature control heat exchanger lyapunov-krasovskii functional linear matrix inequality reciprocal convex lemma

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SCIENTIFIC PRINCIPLES FOR MOdIFICATION OF WATER-SOLUBLE POLYMERS. FORMATION OF MACROMOLECULAR COMPLEXES

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Chinese Journal of Polymer Science 1998年第3期16卷 268-278页

作者： PAUTOv v.d. ANUFRIEvA E.v. KRAKOvYAK M.G. Institute of Macromolecular Compounds RAS Bolshoy pr. 31 St. Petersburg 199004 RussiaInstitute of Macromolecular Compounds RAS Bolshoy pr. 31 St. Petersburg 199004 RussiaInstitute of Macromolecular Compounds RAS Bolshoy pr. 31 St. Petersburg 199004 Russia

The study of nanosecond dynamics of macromolecules with the lumines-cent methods make it possible to investigate the formation and functioning of polymericcomplexes, polymeric conjugates and macromolecular metal complexes, which are widelyused for solving many practical tasks. The nanosecond dynamics of macromolecules are ahighly sensitive indicator of interpolymer complexes (IPC) formation. It enables us to solvethe problems of studying IPC formation and stability and to investigate the interpolymerreactions of exchange and substitution. The investigation of changes in the rotational mo-bility of globular protein molecules as a whole makes it possible to determine the complexcomposition and its stability, and to control the course of polymer-protein conjugate forma-tion reaction. The nanosecond dynamics of polymers interacting with surfacants' ions (S)are the sensitive indicator of the S-polymer complex formation. A method for determin-ing the equilibrium constants of the S-polymer complex formation was developed on thebasis of the study of polymer chains mobility. It is established that nanosecond dynamicsinfluences the course of chemical reactions in polymer chains. Moreover, the marked effectof the nanosecond dynamics is also revealed in the study of photophysical processes (theformation of excimers and energy migration of electron excitation) in polymers with pho-toactive groups. It was found that the efficiency of both processes increases with increasingthe mobility of side chains, the carriers of photoactive groups.

关键词： Modification of water-soluble polymers Formation of complexes

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Stability Analysis of Cyber-Physical Micro Grid Load Frequency Control System with Time-varying delay and Non-Linear Load Perturbations

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Computer Modeling in Engineering & Sciences 2019年第12期121卷 801-813页

作者： d.vijeswaran v.Manikandan department of Electrical and Electronics Engineering Coimbatore Institute of TechnologyCoimbatore 641014India 不详

In a cyber-physical micro-grid system,wherein the control functions are executed through open communication channel,stability is an important issue owing to the factors related to the time-delay encountered in the data *** of feedback variable as discrete data packets in communication network invariably introduces inevitable time-delays in closed loop control *** delay,depending upon the network traffic condition,inherits a time-varying characteristic;nevertheless,it adversely impacts the system performance and *** load perturbations in a micro-grid system are considerably influenced by the presence of fluctuating power generators like wind and solar *** these non-conventional energy sources are integrated into the power grid through power electronic interface circuits that usually works at high switching frequency,noise signals are introduced into the micro-grid system and these signals gets super-imposed to the load *** on this back ground,in this paper,the delay-dependent stability issue of networked micro-grid system combined with time-varying feedback loop delay and uncertain load perturbations is investigated,and a deeper insight has been presented to infer the impact of time-delay on the variations in the system *** classical Lyapunov-Krasovskii method is employed to address the problem,and using a standard benchmark micro-grid system,and the proposed stability criterion is validated.

关键词： delay-dependent stability time-varying delay open communication network nonlinear perturbations Lyapunov-Krasovskii functional linear Matrix Inequality(LMI)

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Relativistic Landau quantization in the spiral dislocation spacetime

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Communications in Theoretical Physics 2021年第2期73卷 68-72页

作者： A v d M Maia K Bakke departamento de Fisica Universijade Federal da ParaibaCaixa Postal 500858051-900Joao PessoaPBBrazil

We analyse the interaction of a relativistic electron with a uniform magnetic field in the spiral dislocation *** show that analytical solutions to the dirac equation can be obtained,where the spectrum of energy corresponds to the relativistic Landau *** also analyse the influence of the spiral dislocation on the relativistic Landau levels by showing that there exists an analogue of the Aharonov–Bohm effect for bound states.

关键词： spiral dislocation spacetime relativistic Landau quantization Aharonov-Bohm effect relativistic wave equations dirac equation

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Coarsening rate of microstructure in semi-solid aluminium alloys

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Transactions of Nonferrous Metals Society of China 2010年第9期20卷 1672-1676页

作者： H.v.ATKINSON d.LIU Mechanics of Materials Research Group Department of EngineeringUniversity of LeicesterUniversity Rd. Now with Wolfson Microelectronics PLC.

The rate of microstructural coarsening of recrystallisation and partial melting (RAP) and cooling slope (CS) processed materials in the semi-solid state is compared with rates found in the *** rate of coarsening depended on the liquid fraction but RAP route 2014 alloy with 37% liquid coarsened slightly more slowly than the CS route 2014 alloy with a lower liquid fraction of 17%, contrary to *** the CS route, an increase in liquid fraction resulted in faster coarsening.A modified 2014 alloy with Fe, Mn and Zn stripped out of the composition gave a relatively high coarsening *** coarsening rate was also relatively high for CS 201 alloy in comparison with either RAP 2014 or CS *** coarsening rates are thought to be associated with the presence of particles which inhibit the migration of liquid film grain *** could be the result of pinning or of the liquid film impeding diffusion at the boundary.

关键词： coarsening semi-solid metal 2014 alloy recrystallisation and partial melting cooling slope

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Interacting tachyonic scalar field

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Communications in Theoretical Physics 2021年第2期73卷 102-107页

作者： A Kundu S d Pathak v K Ojha department of Physies Lovely Professional UniversityPhagwaraPunjab144411India School of Sciences SAGE University BhopalMadhya Pradesh462022India

We discuss the coupling between dark energy and matter by considering a homogeneous tachyonic scalar field as a candidate for dark *** obtained the functional form of scale factor by assuming that the coupling strength depends linearly on the Hubble parameter and energy *** also estimated the cosmic age of the Universe for different values of coupling constant.

关键词： dark energy dark matter scalar field achyonic scalar field

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Optical theorem,crossing property,and derivative dispersion relations:implications on the asymptotic behavior of σ_(tot)(s) and ρ(s)

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Chinese Physics C 2022年第8期46卷 72-90页

作者： S.d.Campos v.A.Okorokov Applied Mathematics Laboratory-CCTS/dFQM Federal University of São CarlosSorocaba CEP 18052-780Brazil Moscow Engineering Physics Institute National Research Nuclear University MEPhI115409 MoscowRussia

In this paper,we present some results on the behavior of the total cross section and p-parameter at asymptotic energies in proton-proton(pp) and antiproton-proton(pp) ***,we consider three of the main theoretical results in high energy physics:the crossing property,derivative dispersion relation,and optical *** use of such machinery facilitates the derivation of analytic formulas for a wide set of the measured global scattering parameters and some important relations between *** suggested parameterizations approximate the energy dependence for the total cross section and ρ-parameter for pp and pp with a statistically acceptable quality in the multi-Tev ***,the qualitative description is obtained for important interrelations,namely difference,sum,and ratio of the antiparticle-particle and particle-particle total cross *** the reduced number of experimental data for the total cross section and p-parameter at the Tev-scale,which complicates any prediction for the beginning of the asymptotic domain,the fitting procedures indicates that asymptotia occur in the energy range 25.5-130 ***,in the asymptotic regime,we obtain α_(P)=1.A detailed quantitative study of the energy behavior of the measured scattering parameters and their combinations in the ultra-high energy domain indicates that the scenario with the generalized formulation of the Pomeranchuk theorem is more favorable with respect to the original formulation of this theorem.

关键词： optical theorem derivative dispersion relations asymptotic behavior Pomeranchuk theorem

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Charge self-trapping in two strand biomolecules:Adiabatic polaron approach

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Chinese Physics B 2023年第1期32卷 253-263页

作者： d Chevizovich S Zdravković A v Chizhov Z Ivić University of Belgrade Vinča Institute of Nuclear SciencesP.O.Box 522Belgrade 11001Serbia Joint Institute for Nuclear Research Laboratory for Radiation BiologyDubna 141980Russia dubna State University Dubna 141980Russia department of Physics University of CreteP.O.Box 2208Heraklion 71003Greece National University of Science and Technology MISiS Leninsky prosp.4Moscow 119049Russia

We investigate the properties of the excess charge(electron, hole) introduced into a two-strand biomolecule. We consider the possibility that the stable soliton excitation can be formed due to interaction of excess charge with the phonon subsystem. The influence of overlap of the molecular orbitals between adjacent structure elements of the macromolecular chain on the soliton properties is discussed. Special attention is paid to the influence of the overlapping of the molecular orbitals between structure elements placed on the different chains. Using the literature values of the basic energy parameters of the two-chain biomolecular structures, possible types of soliton solutions are discussed.

关键词： charge self-trapping adiabatic polaron soliton two-stranded biomolecules

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design, Synthesis and Evaluation of Substituted N-（3-Arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides as Potent MdR Reversal Agents in Cancer

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Chinese Journal of Chemistry 2011年第3期29卷 504-510页

作者： velingkar, v. S. dandekar, v. d. department of Pharmaceutical Chemistry Prin. K. M. Kundnani College of Pharmacy Cuffe Parade Mumbai 4000005 India

A novel class of molecules with structure N-（3-arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides （20- 29） were designed by generating a pharmacophore for potent MdR reversal activity using phase drug design software. The designed molecules were synthesized by a novel synthesis route and evaluated for their inhibitory effects on the transport activity of P-glycoprotein （P-gp） by standard Hoechst 33342 assay method. Based on the pIC50 values of ten title compounds screened, three compounds exhibited better activity as compared to verapamil used as standard.

关键词： N-(3-arylpropyl)-9,10-dihydro-9-oxo-acridine-4-carboxamides MdR reversal agents pharmacophore,phase drug design software structure-activity relationships structure elucidation

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