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International Journal of digital Earth 2023年第1期16卷 1707-1724页

作者： dávid Abriha Szilárd szab. department of Physical Geography and Geoinformatics Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Building extraction from remote sensing data is an important topic in urban studies and the deep learning methods have an increasing role due to their minimal requirements in training data to reach outstanding *** aimed to investigate the original U-Net architecture’s efficiency in building segmentation with different number of training images and the role of data augmentation based on multisource remote sensing data with varying spatial and spectral resolutions(WorldView-2[WV2],WorldView-3[WV3]images and an aerial orthophoto[ORTHO]).When the trainings and predictions were conducted on the same image,U-Net provided good results with very few training images(validation accuracies:94-97%;192 images).Combining the ORTHO’s and WV2’s training data for prediction on WV3 provided poor results with low F1-score(0.184).However,the inclusion of only 48 WV3 training images significantly improved the F1-score(0.693),thus,most buildings were correctly ***,using only independent reference data(other than the target image)is not enough to train an accurate *** our case,the reference from WW2 and ORTHO images did not provide an acceptable basis to train a good model,but a minimal number of training images from the targeted WV3 improved the accuracy(F1-score:69%).

关键词： Building segmentation U-Net remote sensing urban analysis

deductive way of reasoning about the internet AS level topology

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Chinese Physics B 2015年第11期24卷 633-642页

作者： dávid szab. Attila Korsi József Bíró András Gulyás High Speed Networks Laboratory Budapest University of Technology and Economics MTA-BME Information Systems Research Group Budapest University of Technology and Economics MTA-BME Future Internet Research Group Budapest University of Technology and Economics

Our current understanding about the AS level topology of the Internet is based on measurements and inductive-type models which set up rules describing the behavior （node and edge dynamics） of the individual ASes and generalize the consequences of these individual actions for the complete AS ecosystem using induction. In this paper we suggest a third, deductive approach in which we have premises for the whole AS system and the consequences of these premises are determined through deductive reasoning. We show that such a deductive approach can give complementary insights into the topological properties of the AS graph. While inductive models can mostly reflect high level statistics （e.g., degree distribution, clustering, diameter）, deductive reasoning can identify omnipresent subgraphs and peering likelihood. We also propose a model, called YEAS, incorporating our deductive analytical findings that produces topologies contain both traditional and novel metrics for the AS level Internet.

关键词： internet topology complex network analysis model

Landslide inventory validation and susceptibility mapping in the Gerecse Hills, Hungary

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Geo-Spatial Information Science 2021年第3期24卷 498-508页

作者： dávid Gerzsenyi Gáspár Albert department of Cartography and Geoinformatics Eötvös Loránd UniversityBudapestHungary

Landslides pose a threat to property both in the populated and cultivated areas of the Gerecse Hills (Hungary). The currently available landslide inventory database holds the records from many sites in the area, but the database is out-of-date. Here we address the problem of revising the National Landslides Cadastre landslide inventory database by creating a landslide suscept-ibility map with a multivariate model based on likelihood ratio functions. The model is applied to the TandEM-X dEM (0.4″ res.), the current landslide inventory of the area, and data acquired from geological maps. By comparing the distributions of four variables in the landslide and non-landslide area with grid computation methods, the model yields landslide susceptibility estimates for the study area. The estimations show to what extent a certain area is similar to the sample areas, therefore, its likelihood to be affected by landslides in the future. The accuracy of the model predictions was checked in the field and compared to the results of our previous study using the SRTM-1 dEM for a similar analysis. The model gave accurate estimates when certain correction measures were applied to the input datasets. The limitations of the model, the input datasets, and the suggested correction measures are also discussed.

关键词： Landslide susceptibility landslide inventory TandEM-X Gerecse Hills landslides geomorphometry

Joins of 1-Planar Graphs

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Acta Mathematica Sinica,English Series 2014年第11期30卷 1867-1876页

作者： Július CZAP dvid HUdK Tom MAdARAS department of Applied Mathematics and Business Informatics Faculty of Economics Technical University of KoiceNěmcovej 32040 01 KoiceSlovakia VSL Software a.s.Lomen 8040 01 KoiceSlovakia Institute of Mathematics Faculty of SciencePavol Jozef afrik University Jesenn 5040 01 KoiceSlovakia

A graph is called 1-planar if it admits a drawing in the plane such that each edge is crossed at most *** this paper,we study 1-planar graph *** prove that the join G ＋ H is 1-planar if and only if the pair [G,H] is subgraph-majorized by one of pairs [C3 ∪ C3,C3],[C4,C4],[C4,C3],[K2,1,1,P3] in the case when both elements of the graph join have at least three *** one element has at most two vertices,then we give several necessary/sufficient conditions for the bigger element.

关键词： 1-Planar graph join product

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Bending Analysis of a Filament-Wound Composite Tube

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Modern Mechanical Engineering 2018年第1期8卷 66-77页

作者： Gyula szab. Károly Váradi dávid Felhos department of Machine and Product design Budapest University of Technology and EconomicsBudapestHungary

The aim of this paper is to present finite element model of a filament-wound composite tube subjected to three-point bending and bending in accordance with standard EN?15807:2011?(railway applications-pneumatic half couplings) along with its experimental verification. In the finite element model, composite reinforcement plies have been characterized by linear orthotropic material model, while rubber liners have been described by a two-parameter MooneyRivlin model. Force-displacement curves of three-point bending show fairly good agreement between simulation results and experimental data. Reaction forces of FE simulation and experiment of standard bending test are in good agreement.

关键词： Filament-Wound Composite Tube Three-Point Bending Test Bending Analysis Finite Element Model

Finite Element Model of a Filament-Wound Composite Tube Subjected to Uniaxial Tension

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Modern Mechanical Engineering 2017年第4期7卷 91-112页

作者： Gyula szab. Károly Váradi dávid Felhos department of Machine and Product design Budapest University of Technology and EconomicsBudapestHungary

The aim of this paper is to demonstrate the mechanical behaviour of a filament-wound composite tube subjected to uniaxial tension by finite element analysis. Uniaxial tensile test experiments have been carried out on standard specimen and hose piece in order to verify finite element models and material properties and also to assess failure mode of composite plies. Composite reinforcement plies are modeled as linear orthotropic, while elastomer liners are described by hyperelastic material model. Results of finite element models and experiments show good agreement in the initial phase of uniaxial tension, which justifies utilized material models in the operating range. Results of finite element models show that transverse tension and shear load are dominant under tension. It is determined that principal failure mode of reinforcement plies is intra-ply yarn-matrix debonding caused by intensive shear of rubber matrix.

关键词： Filament-Wound Composite Tube Uniaxial Tension Tensile Test debonding damage Finite Element Analysis

desorption isotherms and isosteric heat of anaerobic fermentation residues

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2510-2517页

作者： Tibor Poós Viktor szab. department of Building Services and Process Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsBertalan Lajos u.4-6H-1111 BudapestHungary

This paper presents the equilibrium desorption isotherms and the isosteric heat of sorption of a mixture containing mechanically dewatered fermentation residue(obtained from a blend of chicken,swine and cattle manure)used in biogas plants and corn spoiled silage in a ratio of 2:*** moisture desorption isotherms of the fermentation residue were determined at 32°C,40°C and 80°C and in the relative humidity range of 0.057/1 using static gravimetric *** equations were used to analyze the desorption data of Modified Henderson,Modified Halsey,Modified Oswin,Modified Chung–Pfost and Modified GAB *** constants of the model equations were calculated by non-linear regression *** Modified Henderson model fitted to the desorption isotherm data *** the proposed function,the final moisture content of the material can be determined as long as it can be dried in infinite time with the drying gas in the given *** isosteric heat of desorption was calculated by using the Modified Henderson model in the studied temperature range based on the Clausius–Clapeyron *** isosteric heat varied between 46 k J·mol-1 and 67 k J·mol-1 at moisture levels 1.91 b XedP-1 for the material.

关键词： desorption Equilibrium Model Measurement Isosteric heat

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell