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中华高血压杂志 2015年第11期23卷 1098-1098页

作者：练桂丽叶鹏 van sloten TT czernichow s Houben AJ Protogerou AD Henry RM Muris DM schram MT sep sJ Dagnelie PC van der Kallen CJ schaper NC Blacher J Hercberg s Levy BI stehouwer CD

已有假设认为,动脉僵硬度导致广泛微血管功能障碍,2型糖尿病（type 2diabetes,T2DM）患者对动脉僵硬度的有害作用更为敏感。然而,缺乏动脉僵硬度与微血管功能障碍标志物的相关性证据。

关键词：动脉僵硬度血管功能障碍脉搏波传导速度反应性充血 carotid 静脉淤血毛细血管密度马斯特里赫特 femoral 抗氧化剂

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Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

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World Journal of Gastroenterology 2012年第22期18卷 2805-2812页

作者： Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela sutton Caroline Méjean Paule Latino-Martel serge Hercberg Pilar Galan sébastien czernichow INsERM U577(National Institute of Health and Medical Research) Inra Cnam University of Paris 13 (UREN) SMBH 74 rue Marcel Cachin F-93017 Bobigny France Department of Biochemistry Jean Verdier Hospital F-93140 Bondy France INsERM U698 University of Paris 13 F-93017 Bobigny France Department of Public Health Avicenne Hospital (AP-HP) University of Paris 13 F-93017 Bobigny France Department of Nutrition Ambroise Paré Hospital (AP-HP) University of Versailles Saint Quentin F-92100 Boulogne-Billancourt France

AIM： To examine the relationships between pre-diag- nostic biomarkers and colorectal cancer risk and assess their relevance in predictive ***： A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the sUpplemen- tation en VItamines et Min^raux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases （n = 50） were matched with two randomly selected con- trols （n = 100）. Conditional logistic regression models were used to investigate the associations between pre- diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 （sVCAM-1）, soluble intercellular adhesion molecule-I, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves （AUC） and relative integrated discrimination improvement （RIDI） statistics were used to assess the discriminatory poten- tial of the models. REsULTs： Plasma adiponectin level was associated with decreased colorectal cancer risk （P for linear trend -- 0.03）. Quartiles of sVCAM-1 were associated with increased colorectal cancer risk （P for linear trend = 0.02）. No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction （P for AUC improve- ment = 0.01, RIDI = 26.5%）. CONCLUsION： These results suggest that pre-diag- nostic plasma adiponectin and sVCAM-1 levels are as- sociated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies.

关键词： Colorectal cancer Adiponectin soluble vascu-lar cell adhesion molecule-l Nested case-control study Prospective study

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